Published in PLoS One on April 02, 2008
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol (2011) 4.59
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol (2014) 1.75
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS One (2011) 1.63
Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci (2011) 1.57
Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion. Mol Biol Cell (2009) 1.25
Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep (2013) 1.22
Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med (2013) 0.92
Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol. Elife (2014) 0.92
Differential effect of actomyosin relaxation on the dynamic properties of focal adhesion proteins. PLoS One (2013) 0.91
Systems microscopy approaches to understand cancer cell migration and metastasis. Cell Mol Life Sci (2010) 0.89
Plasticity in the macromolecular-scale causal networks of cell migration. PLoS One (2014) 0.82
Recapitulation and Modulation of the Cellular Architecture of a User-Chosen Cell of Interest Using Cell-Derived, Biomimetic Patterning. ACS Nano (2015) 0.79
Unanchoring integrins in focal adhesions. Nat Cell Biol (2012) 0.78
Dissecting cell adhesion architecture using advanced imaging techniques. Cell Adh Migr (2011) 0.77
Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions. PLoS One (2016) 0.75
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci U S A (1999) 35.16
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol (1999) 21.92
Quantum dots for live cells, in vivo imaging, and diagnostics. Science (2005) 21.62
A guide to choosing fluorescent proteins. Nat Methods (2005) 18.55
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
Computational prediction of proteotypic peptides for quantitative proteomics. Nat Biotechnol (2006) 7.56
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell (2004) 6.24
Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci (2001) 5.77
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85
Analyzing proteome topology and function by automated multidimensional fluorescence microscopy. Nat Biotechnol (2006) 4.71
Integrative analysis of the cancer transcriptome. Nat Genet (2005) 4.44
Molecular diversity of cell-matrix adhesions. J Cell Sci (1999) 4.33
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med (2001) 3.94
In vivo molecular and cellular imaging with quantum dots. Curr Opin Biotechnol (2005) 3.92
Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nat Rev Drug Discov (2006) 3.83
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
Spectral imaging and its applications in live cell microscopy. FEBS Lett (2003) 3.67
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol (2006) 3.37
Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. J Cell Biol (2001) 3.28
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells. J Cell Biol (2005) 2.46
Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion. J Cell Sci (2004) 2.12
Probing molecular processes in live cells by quantitative multidimensional microscopy. Trends Cell Biol (2001) 1.57
Spectral karyotyping analysis of human and mouse chromosomes. Nat Protoc (2006) 1.52
Evolving endosomes: how many varieties and why? Curr Opin Cell Biol (2005) 1.47
Imaging mass spectrometry at cellular length scales. Nat Protoc (2007) 1.15
Quantitative analysis of cytoskeletal organization by digital fluorescent microscopy. Cytometry A (2003) 1.08
Molecular diversity of plaques of epithelial-adhering junctions. Ann N Y Acad Sci (2000) 1.02
Six-color segmentation of multicolor images in the infection studies of Listeria monocytogenes. Microsc Res Tech (2007) 0.88
Five-colour in vivo imaging of neurons in Caenorhabditis elegans. J Microsc (2004) 0.88
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol (2003) 6.08
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr Opin Cell Biol (2006) 3.21
Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol (2011) 2.54
Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43
Fast live simultaneous multiwavelength four-dimensional optical microscopy. Proc Natl Acad Sci U S A (2010) 2.17
The switchable integrin adhesome. J Cell Sci (2010) 2.12
How do microtubules guide migrating cells? Nat Rev Mol Cell Biol (2002) 1.93
Cell mechanosensitivity controls the anisotropy of focal adhesions. Proc Natl Acad Sci U S A (2004) 1.85
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci (2006) 1.83
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Supramolecular crafting of cell adhesion. Biomaterials (2007) 1.66
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading. Cell Motil Cytoskeleton (2004) 1.59
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A (2007) 1.59
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci (2011) 1.57
Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. J Cell Sci (2002) 1.50
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS One (2009) 1.50
Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow. J Cell Sci (2005) 1.49
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J Cell Sci (2006) 1.47
Richardson-Lucy algorithm with total variation regularization for 3D confocal microscope deconvolution. Microsc Res Tech (2006) 1.45
Diverse niches within multiple myeloma bone marrow aspirates affect plasma cell enumeration. Br J Haematol (2006) 1.45
Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett (2008) 1.43
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. J Cell Biol (2009) 1.36
Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption. J Cell Sci (2003) 1.32
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton (2009) 1.29
Engineering vessel-like networks within multicellular fibrin-based constructs. Biomaterials (2011) 1.28
The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res (2008) 1.28
Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells. Biophys J (2003) 1.26
Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan. Biophys J (2002) 1.26
Spatial and temporal sequence of events in cell adhesion: from molecular recognition to focal adhesion assembly. Chembiochem (2004) 1.21
miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci U S A (2010) 1.19
Nano-topography sensing by osteoclasts. J Cell Sci (2010) 1.19
Molecular engineering of cellular environments: cell adhesion to nano-digital surfaces. Methods Cell Biol (2007) 1.18
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J Biol Chem (2003) 1.14
Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy. Epigenetics Chromatin (2008) 1.13
Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp Eye Res (2005) 1.13
Temperature-sensitive micrometer-thick layers of hyaluronan grafted on microspheres. J Am Chem Soc (2006) 1.13
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
The molecular dynamics of osteoclast adhesions. Eur J Cell Biol (2005) 1.10
Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp Eye Res (2004) 1.09
Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton. J Biol Chem (2004) 1.08
Quantitative analysis of cytoskeletal organization by digital fluorescent microscopy. Cytometry A (2003) 1.08
Human heparanase is localized within lysosomes in a stable form. Exp Cell Res (2002) 1.07
Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells. Exp Eye Res (2006) 1.06
Cell interactions with hierarchically structured nano-patterned adhesive surfaces. Soft Matter (2009) 1.05
Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp Eye Res (2006) 1.04
Anomalous features of EMT during keratinocyte transformation. PLoS One (2008) 1.03
Signaling from adherens-type junctions. Eur J Cell Biol (2005) 1.02
Involvement of the Rho-mDia1 pathway in the regulation of Golgi complex architecture and dynamics. Mol Biol Cell (2011) 1.01
Attenuation of the p53 response to DNA damage by high cell density. Oncogene (2004) 1.01
Involvement of actin polymerization in podosome dynamics. J Cell Sci (2012) 0.99
Allicin inhibits cell polarization, migration and division via its direct effect on microtubules. Cell Motil Cytoskeleton (2007) 0.98
Signaling function of alpha-catenin in microtubule regulation. Cell Cycle (2008) 0.98
Development and application of automatic high-resolution light microscopy for cell-based screens. Methods Enzymol (2006) 0.96
Application of microscope-based FRET to study molecular interactions in focal adhesions of live cells. Methods Mol Biol (2005) 0.95
Surface-induced regulation of podosome organization and dynamics in cultured osteoclasts. Chembiochem (2009) 0.93
High-throughput screening of cellular features using high-resolution light-microscopy; application for profiling drug effects on cell adhesion. J Struct Biol (2007) 0.92
Dynamic study of the transition from hyaluronan- to integrin-mediated adhesion in chondrocytes. EMBO J (2006) 0.91
Differential effect of actomyosin relaxation on the dynamic properties of focal adhesion proteins. PLoS One (2013) 0.91
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant. J Clin Invest (2015) 0.90
Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. Exp Cell Res (2004) 0.90
Enteropathogenic Escherichia coli induces modification of the focal adhesions of infected host cells. Cell Microbiol (2002) 0.89
Resolving and classifying haematopoietic bone-marrow cell populations by multi-dimensional analysis of flow-cytometry data. Br J Haematol (2005) 0.89
Identification of novel pro-migratory, cancer-associated genes using quantitative, microscopy-based screening. PLoS One (2008) 0.88
Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts. PLoS One (2011) 0.87
Parametric blind deconvolution for confocal laser scanning microscopy. Conf Proc IEEE Eng Med Biol Soc (2007) 0.87
Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton. Eur J Cell Biol (2010) 0.87
The generation and regulation of functional diversity of malignant plasma cells. Cancer Res (2006) 0.86
Effects of surface microtopography on the assembly of the osteoclast resorption apparatus. J R Soc Interface (2011) 0.86
Frontiers of microscopy-based research into cell-matrix adhesions. Curr Opin Cell Biol (2010) 0.86
Identification of plant cytoskeleton-interacting proteins by screening for actin stress fiber association in mammalian fibroblasts. Plant J (2006) 0.85
Magnesium-containing nanostructured hybrid scaffolds for enhanced dentin regeneration. Tissue Eng Part A (2014) 0.84
The role of integrin-linked kinase in the molecular architecture of focal adhesions. J Cell Sci (2013) 0.83
Discovery of novel proteasome inhibitors using a high-content cell-based screening system. PLoS One (2009) 0.83
Blind image deconvolution using machine learning for three-dimensional microscopy. IEEE Trans Pattern Anal Mach Intell (2010) 0.81
Measurement of protein tyrosine phosphorylation in cell adhesion. Methods Mol Biol (2005) 0.80
Shear flow-induced formation of tubular cell protrusions in multiple myeloma cells. J Cell Physiol (2011) 0.78