Published in Proc Natl Acad Sci U S A on August 18, 2010
MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol (2012) 2.05
Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell (2013) 1.62
MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis. Proc Natl Acad Sci U S A (2011) 1.17
MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther (2011) 1.11
Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier. Mol Ther Nucleic Acids (2013) 1.10
Regulation of cancer metastasis by cell-free miRNAs. Biochim Biophys Acta (2014) 1.02
MicroRNAs as regulatory elements in immune system logic. Nat Rev Immunol (2016) 0.97
miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway. RNA Biol (2015) 0.97
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis. Elife (2014) 0.94
MicroRNAs as novel regulators of stem cell fate. World J Stem Cells (2013) 0.94
myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis. Development (2014) 0.94
miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration. J Biol Chem (2013) 0.92
Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol (2015) 0.91
MicroRNAs as regulators of bone homeostasis and bone metastasis. Bonekey Rep (2014) 0.90
The role of microRNAs in osteoclasts and osteoporosis. RNA Biol (2014) 0.87
MicroRNAs and Osteolytic Bone Metastasis: The Roles of MicroRNAs in Tumor-Induced Osteoclast Differentiation. J Clin Med (2015) 0.86
MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemia. J Cell Mol Med (2012) 0.86
Dark matters in AMD genetics: epigenetics and stochasticity. Invest Ophthalmol Vis Sci (2011) 0.84
Do epigenetic marks govern bone mass and homeostasis? Curr Genomics (2012) 0.83
Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate. Sci Rep (2014) 0.80
MicroRNAs' Involvement in Osteoarthritis and the Prospects for Treatments. Evid Based Complement Alternat Med (2015) 0.79
CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells. Biomed Res Int (2015) 0.79
Pathway analysis of microRNA expression profile during murine osteoclastogenesis. PLoS One (2014) 0.78
MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression. RNA Biol (2014) 0.78
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia. Mol Cell Biochem (2014) 0.77
microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One (2015) 0.76
MicroRNA 874-3p Exerts Skeletal Anabolic Effects Epigenetically during Weaning by Suppressing Hdac1 Expression. J Biol Chem (2015) 0.76
Mitf regulates osteoclastogenesis by modulating NFATc1 activity. Exp Cell Res (2014) 0.75
MicroRNAs: Potential Biomarkers and Therapeutic Targets for Alveolar Bone Loss in Periodontal Disease. Int J Mol Sci (2016) 0.75
Transforming Growth Factor β1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression. Mol Cells (2017) 0.75
Bone marrow stroma-derived miRNAs as regulators, biomarkers and therapeutic targets of bone metastasis. Bonekey Rep (2015) 0.75
Identification of the microRNA networks contributing to macrophage differentiation and function. Oncotarget (2016) 0.75
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun (2017) 0.75
MiRNA-340 Inhibits Osteoclast Differentiation via repression of MITF. Biosci Rep (2017) 0.75
MicroRNAs and Periodontal Homeostasis. J Dent Res (2017) 0.75
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science (2005) 20.51
Osteoclast differentiation and activation. Nature (2003) 18.59
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. Cell (2005) 15.38
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16
Nitric oxide and the immune response. Nat Immunol (2001) 10.00
TLR signaling. Semin Immunol (2007) 8.16
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol (2007) 8.05
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med (2008) 5.97
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A (1999) 5.78
Functional macrophage cell lines transformed by Abelson leukemia virus. Cell (1978) 5.76
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
Canalization of development by microRNAs. Nat Genet (2006) 5.46
Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A (2009) 5.30
Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene (2001) 5.14
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum (2008) 4.08
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell (2008) 3.84
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway. Nucleic Acids Res (2008) 2.04
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by down-regulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem (2009) 1.74
MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem (2007) 1.53
Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem (2008) 1.53
Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice. Mol Cell (2001) 1.45
The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor. J Biol Chem (2006) 1.12
Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation. J Biol Chem (2001) 1.11
Signals involved in interleukin 1 synthesis and release by lipopolysaccharide-stimulated monocytes/macrophages. Cytokine (1990) 1.08
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Gene (2008) 1.07
Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity. FEBS Lett (2008) 1.02
Shhh! Silencing by microRNA-155. Philos Trans R Soc Lond B Biol Sci (2009) 1.02
Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF. J Cell Biochem (2008) 0.89
Regulation of IL-1 gene expression: differential responsiveness of murine macrophage lines. Cytokine (1993) 0.85
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Identification of hundreds of conserved and nonconserved human microRNAs. Nat Genet (2005) 15.96
The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol (2008) 7.86
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44
Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J (2007) 6.26
Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol (2003) 6.08
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J Cell Sci (2003) 4.85
miR-148 targets human DNMT3b protein coding region. RNA (2008) 4.56
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev (2009) 4.15
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. J Cell Sci (2006) 3.71
eRNAs are required for p53-dependent enhancer activity and gene transcription. Mol Cell (2012) 3.63
Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J (2007) 3.57
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell (2005) 3.35
Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. Curr Opin Cell Biol (2006) 3.21
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res (2008) 3.06
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol (2011) 2.54
A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol (2010) 2.53
Focal adhesions as mechanosensors: a physical mechanism. Proc Natl Acad Sci U S A (2005) 2.43
Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37
The tumor-suppressive functions of the human INK4A locus. Cancer Cell (2003) 2.31
Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells (2005) 2.24
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell (2012) 2.14
The switchable integrin adhesome. J Cell Sci (2010) 2.12
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem (2004) 2.07
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle (2011) 2.06
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation (2011) 1.99
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
How do microtubules guide migrating cells? Nat Rev Mol Cell Biol (2002) 1.93
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol (2002) 1.90
Cell mechanosensitivity controls the anisotropy of focal adhesions. Proc Natl Acad Sci U S A (2004) 1.85
miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A (2010) 1.83
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. J Cell Sci (2006) 1.83
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood (2012) 1.82
BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol (2010) 1.76
miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors. EMBO J (2011) 1.75
Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol (2010) 1.72
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer (2010) 1.69
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol (2011) 1.67
Supramolecular crafting of cell adhesion. Biomaterials (2007) 1.66
A biological solution to a fundamental distributed computing problem. Science (2011) 1.62
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreading. Cell Motil Cytoskeleton (2004) 1.59
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A (2007) 1.59
Dynamic regulation of the structure and functions of integrin adhesions. Dev Cell (2013) 1.57
Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci (2011) 1.57
MicroRNA expression patterns and function in endodermal differentiation of human embryonic stem cells. PLoS One (2008) 1.56
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle (2009) 1.56
Interplay between microRNAs and RNA-binding proteins determines developmental processes. Cell Cycle (2008) 1.51
Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. J Cell Sci (2002) 1.50
A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS One (2009) 1.50
Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow. J Cell Sci (2005) 1.49
MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34. J Neurosci (2011) 1.47
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J Cell Sci (2006) 1.47
Major role for mRNA stability in shaping the kinetics of gene induction. BMC Genomics (2010) 1.46
Diverse niches within multiple myeloma bone marrow aspirates affect plasma cell enumeration. Br J Haematol (2006) 1.45
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci (2002) 1.44
Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett (2008) 1.43
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown. J Cell Biol (2009) 1.36
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol (2013) 1.33
Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption. J Cell Sci (2003) 1.32
The heel and toe of the cell's foot: a multifaceted approach for understanding the structure and dynamics of focal adhesions. Cell Motil Cytoskeleton (2009) 1.29
The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res (2008) 1.28
The miRNA-192/194 cluster regulates the Period gene family and the circadian clock. FEBS J (2009) 1.27
Organization and adhesive properties of the hyaluronan pericellular coat of chondrocytes and epithelial cells. Biophys J (2003) 1.26
Initial stages of cell-matrix adhesion can be mediated and modulated by cell-surface hyaluronan. Biophys J (2002) 1.26
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy (2012) 1.25
The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS One (2009) 1.25
E2F mediates enhanced alternative polyadenylation in proliferation. Genome Biol (2012) 1.24
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. Cell Cycle (2013) 1.23
Tumorigenicity of the miR-17-92 cluster distilled. Genes Dev (2010) 1.22
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. Mol Cell Biol (2005) 1.21
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev (2010) 1.21
Spatial and temporal sequence of events in cell adhesion: from molecular recognition to focal adhesion assembly. Chembiochem (2004) 1.21
Classifying microRNAs in cancer: the good, the bad and the ugly. Biochim Biophys Acta (2006) 1.20
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun (2011) 1.20
Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions. PLoS One (2008) 1.19
Nano-topography sensing by osteoclasts. J Cell Sci (2010) 1.19
Design principle of gene expression used by human stem cells: implication for pluripotency. FASEB J (2004) 1.18
Molecular engineering of cellular environments: cell adhesion to nano-digital surfaces. Methods Cell Biol (2007) 1.18
MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis. Proc Natl Acad Sci U S A (2011) 1.17
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. Am J Pathol (2009) 1.17
Noncoding RNAs and cancer. Cell (2013) 1.16
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Adv Exp Med Biol (2007) 1.15
Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J (2004) 1.15
MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R. PLoS One (2011) 1.15
Telomerase-independent regulation of ATR by human telomerase RNA. J Biol Chem (2006) 1.15
Diverse ways to control p27Kip1 function: miRNAs come into play. Cell Cycle (2007) 1.14
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J Biol Chem (2003) 1.14