Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration.

PubWeight™: 2.92‹?› | Rank: Top 1%

🔗 View Article (PMC 1181910)

Published in Am J Hum Genet on December 19, 2003

Authors

Sudha K Iyengar1, Danhong Song, Barbara E K Klein, Ronald Klein, James H Schick, Jennifer Humphrey, Christopher Millard, Rachel Liptak, Karlie Russo, Gyungah Jun, Kristine E Lee, Bonnie Fijal, Robert C Elston

Author Affiliations

1: Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109-1998, USA. ski@po.cwru.edu

Articles citing this

Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44

Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet (2005) 4.91

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19

Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Ann Med (2006) 2.99

Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. Am J Hum Genet (2006) 2.89

Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am J Hum Genet (2004) 2.58

Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration. Annu Rev Genomics Hum Genet (2009) 2.40

Genetic factors of age-related macular degeneration. Prog Retin Eye Res (2004) 2.17

CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med (2005) 2.01

An update on the genetics of age-related macular degeneration. Mol Vis (2007) 1.95

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39

HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. Invest Ophthalmol Vis Sci (2008) 1.28

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. PLoS Med (2007) 1.27

Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12. BMC Genet (2004) 1.27

Resequencing of pooled DNA for detecting disease associations with rare variants. Genet Epidemiol (2010) 1.22

Epistatic module detection for case-control studies: a Bayesian model with a Gibbs sampling strategy. PLoS Genet (2009) 1.17

The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2007) 1.17

Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol (2011) 1.16

Genetics. Was the Human Genome Project worth the effort? Science (2005) 1.16

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun (2010) 1.16

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics. Mol Aspects Med (2012) 1.16

Mechanism of inflammation in age-related macular degeneration. Mediators Inflamm (2012) 1.14

Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. J Ocul Biol Dis Infor (2009) 1.13

Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. Hum Genomics (2011) 1.08

The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. Ophthalmology (2008) 1.07

Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. Invest Ophthalmol Vis Sci (2009) 1.07

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. PLoS One (2011) 1.05

Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration. Hum Genet (2010) 1.04

Genetics of immunological and inflammatory components in age-related macular degeneration. Ocul Immunol Inflamm (2012) 1.04

Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol (2013) 1.01

Progress in defining the molecular biology of age related macular degeneration. Hum Genet (2007) 1.01

Age-related macular degeneration-clinical review and genetics update. Clin Genet (2013) 1.00

Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration. Adv Exp Med Biol (2010) 1.00

Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Hum Mol Genet (2008) 0.99

Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach. Vision Res (2009) 0.95

Genetic variations strongly influence phenotypic outcome in the mouse retina. PLoS One (2011) 0.95

Genetic and functional dissection of ARMS2 in age-related macular degeneration and polypoidal choroidal vasculopathy. PLoS One (2013) 0.90

Age-related macular degeneration and changes in the extracellular matrix. Med Sci Monit (2014) 0.88

Expression of the diabetes risk gene wolframin (WFS1) in the human retina. Exp Eye Res (2009) 0.87

The impact of the human genome project on complex disease. Genes (Basel) (2014) 0.85

Prospective study of common variants in the retinoic acid receptor-related orphan receptor α gene and risk of neovascular age-related macular degeneration. Arch Ophthalmol (2010) 0.85

Analysis of Hemicentin-1, hOgg1, and E-selectin single nucleotide polymorphisms in age-related macular degeneration. Trans Am Ophthalmol Soc (2005) 0.83

Reduction of sample heterogeneity through use of population substructure: an example from a population of African American families with sarcoidosis. Am J Hum Genet (2006) 0.83

Incorporating prior knowledge to facilitate discoveries in a genome-wide association study on age-related macular degeneration. BMC Res Notes (2010) 0.83

Vitamin D: Implications for ocular disease and therapeutic potential. Exp Eye Res (2015) 0.82

Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Atten Defic Hyperact Disord (2010) 0.81

Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families. BMC Dermatol (2007) 0.80

Skin color in fish and humans: impacts on science and society. Zebrafish (2008) 0.80

The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review. J Clin Med (2016) 0.79

Dissection of chromosome 16p12 linkage peak suggests a possible role for CACNG3 variants in age-related macular degeneration susceptibility. Invest Ophthalmol Vis Sci (2011) 0.77

[Y402H polymorphism in complement factor H and age-related macula degeneration (AMD)]. Ophthalmologe (2005) 0.77

Genome-wide association studies: getting to pathogenesis, the role of inflammation/complement in age-related macular degeneration. Cold Spring Harb Perspect Med (2014) 0.76

Whole exome sequencing of extreme age-related macular degeneration phenotypes. Mol Vis (2016) 0.75

Gene ontology and KEGG enrichment analyses of genes related to age-related macular degeneration. Biomed Res Int (2014) 0.75

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment. Mol Immunol (2016) 0.75

Expression of recombinant protein encoded by LOC387715 in Escherichia coli. Protein Expr Purif (2007) 0.75

Articles cited by this

A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77

The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol (2001) 21.37

Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet (1999) 11.22

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93

Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology (1992) 10.88

An international classification and grading system for age-related maculopathy and age-related macular degeneration. The International ARM Epidemiological Study Group. Surv Ophthalmol (1995) 10.05

The Wisconsin age-related maculopathy grading system. Ophthalmology (1991) 7.62

Haseman and Elston revisited. Genet Epidemiol (2000) 7.23

The Beaver Dam Eye Study: visual acuity. Ophthalmology (1991) 6.87

The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology (1997) 6.47

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00

Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA (1994) 5.43

Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology (1996) 5.36

Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology (2002) 3.80

Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33

A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Nat Genet (1999) 3.32

Age-related macular degeneration--a genome scan in extended families. Am J Hum Genet (2003) 2.99

Is the incidence of registrable age-related macular degeneration increasing? Br J Ophthalmol (1996) 2.81

Changes in visual acuity in a population over a 10-year period : The Beaver Dam Eye Study. Ophthalmology (2001) 2.71

Fibulins: a versatile family of extracellular matrix proteins. Nat Rev Mol Cell Biol (2003) 2.55

Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet Epidemiol (1994) 2.39

The Beaver Dam Eye Study: the relation of age-related maculopathy to smoking. Am J Epidemiol (1993) 2.37

Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Arch Ophthalmol (1998) 2.19

A comprehensive survey of sequence variation in the ABCA4 (ABCR) gene in Stargardt disease and age-related macular degeneration. Am J Hum Genet (2000) 2.18

Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am J Hum Genet (2000) 2.14

A full genome scan for age-related maculopathy. Hum Mol Genet (2000) 1.96

Cause-specific prevalence of bilateral visual impairment in Victoria, Australia: the Visual Impairment Project. Ophthalmology (2001) 1.90

Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions. Am J Ophthalmol (2001) 1.88

Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. Am J Epidemiol (2002) 1.87

Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol (1993) 1.81

Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration. Arch Ophthalmol (2001) 1.68

Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration. Proc Natl Acad Sci U S A (2002) 1.67

Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions. Development (2001) 1.65

Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am J Epidemiol (1998) 1.65

Genetic influence on early age-related maculopathy: a twin study. Ophthalmology (2002) 1.57

Molecular genetics of age-related macular degeneration. Hum Mol Genet (2001) 1.55

A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study. Am J Hum Genet (2003) 1.53

Relation of smoking to the incidence of age-related maculopathy. The Beaver Dam Eye Study. Am J Epidemiol (1998) 1.47

Use of the robust sib-pair method to screen for single-locus, multiple-locus, and pleiotropic effects: application to traits related to hypertension. Am J Hum Genet (1991) 1.45

Relationship estimation by Markov-process models in a sib-pair linkage study. Am J Hum Genet (1999) 1.40

Prevalence of age-related maculopathy in the Atherosclerosis Risk in Communities Study. Arch Ophthalmol (1999) 1.32

Evaluating the results of genomewide linkage scans of complex traits by locus counting. Am J Hum Genet (2002) 1.30

Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs. Ann Hum Genet (2001) 1.29

Visual impairment and eye diseases in elderly institutionalized Australians. Ophthalmology (2000) 1.22

The prevalence and causes of bilateral and unilateral blindness in an elderly urban Danish population. The Copenhagen City Eye Study. Acta Ophthalmol Scand (2001) 1.21

Statistical validity of the Haseman-Elston sib-pair test in small samples. Genet Epidemiol (1993) 1.18

Visual impairment of age-related macular degeneration. An epidemiological study of 1000 aged individuals. Acta Ophthalmol (Copenh) (1990) 1.11

Exclusion of TIMP3 as a candidate locus in age-related macular degeneration. Invest Ophthalmol Vis Sci (1997) 1.10

Linkage of multilocus components of variance to polymorphic markers. Ann Hum Genet (1997) 1.07

Early detection and treatment of neovascular age-related macular degeneration. J Am Board Fam Pract (2002) 1.04

Risk of incident age-related eye diseases in people with an affected sibling : The Beaver Dam Eye Study. Am J Epidemiol (2001) 1.04

Prevalence of ocular disease and blindness in a rural area in the eastern region of Iceland during 1980 through 1984. Acta Ophthalmol Suppl (1987) 0.98

Association of zinc and antioxidant nutrients with age-related maculopathy. Arch Ophthalmol (1996) 0.96

The effect of five-year zinc supplementation on serum zinc, serum cholesterol and hematocrit in persons randomly assigned to treatment group in the age-related eye disease study: AREDS Report No. 7. J Nutr (2002) 0.93

Common eye diseases of elderly people: identifying and treating causes of vision loss. Gerontology (2002) 0.93

Visual handicap in south-east Scotland. J R Coll Surg Edinb (1995) 0.91

The potential preventive effects of vitamins for cataract and age-related macular degeneration. Int J Vitam Nutr Res (1999) 0.88

Cigarette smoking as a risk factor for cataract and age-related macular degeneration: a review of the literature. Optometry (2003) 0.87

Status of therapies in development for the treatment of age-related macular degeneration. IDrugs (2003) 0.86

Analysis of the Arg345Trp disease-associated allele of the EFEMP1 gene in individuals with early onset drusen or familial age-related macular degeneration. Clin Experiment Ophthalmol (2002) 0.83

Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings. Invest Ophthalmol Vis Sci (2002) 0.82

A practice-based survey of familial age-related maculopathy. Ophthalmic Genet (1998) 0.79

Familial cases with age-related macular degeneration. Jpn J Ophthalmol (2000) 0.79

New treatments for age-related macular degeneration. Minn Med (2003) 0.78

The ABCA4 gene and age-related macular degeneration: innocence or guilt by association. Arch Ophthalmol (2001) 0.78

Articles by these authors

Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol (2004) 13.78

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care (2012) 7.83

Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med (2009) 6.75

The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol (2004) 6.53

Optimal two-stage genotyping in population-based association studies. Genet Epidemiol (2003) 6.01

Diabetic retinopathy. N Engl J Med (2012) 5.79

Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol (2006) 4.68

The prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Arch Ophthalmol (2004) 4.64

A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46

The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol (2005) 4.46

Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA (2010) 4.41

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30

Retinopathy in diabetes. Diabetes Care (2004) 4.25

Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology (2007) 3.96

The impact of hearing loss on quality of life in older adults. Gerontologist (2003) 3.87

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Ten-year incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology (2002) 3.80

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78

Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol (2004) 3.78

A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol (2005) 3.74

Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology (2004) 3.53

Revised formulas for summarizing retinal vessel diameters. Curr Eye Res (2003) 3.47

Prevalence of olfactory impairment in older adults. JAMA (2002) 3.46

Relation between fasting glucose and retinopathy for diagnosis of diabetes: three population-based cross-sectional studies. Lancet (2008) 3.42

The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XXII the twenty-five-year progression of retinopathy in persons with type 1 diabetes. Ophthalmology (2008) 3.37

Improved power by use of a weighted score test for linkage disequilibrium mapping. Am J Hum Genet (2006) 3.36

Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences. Hum Hered (2003) 3.33

Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. Ophthalmology (2005) 3.28

Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11. Arch Ophthalmol (2003) 3.17

The 5-year incidence and progression of hearing loss: the epidemiology of hearing loss study. Arch Otolaryngol Head Neck Surg (2003) 3.17

Choosing an optimal method to combine P-values. Stat Med (2009) 3.15

The genetic basis of complex traits: rare variants or "common gene, common disease"? Methods Mol Biol (2007) 3.01

The 30-year natural history of type 1 diabetes complications: the Pittsburgh Epidemiology of Diabetes Complications Study experience. Diabetes (2006) 3.00

A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00

Diabetic retinopathy. Diabetes Care (2004) 2.97

Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. Ophthalmology (2006) 2.95

The economic burden of major adult visual disorders in the United States. Arch Ophthalmol (2006) 2.92

The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol (2006) 2.89

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. Lancet (2008) 2.89

Prevalence of age-related macular degeneration in the US population. Arch Ophthalmol (2011) 2.89

Retinal vascular caliber and the development of hypertension: a meta-analysis of individual participant data. J Hypertens (2014) 2.83

Detecting rare variants for complex traits using family and unrelated data. Genet Epidemiol (2010) 2.80

Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Hum Mol Genet (2005) 2.80

Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci (2006) 2.79

Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA (2002) 2.78

Changes in visual acuity in a population over a 15-year period: the Beaver Dam Eye Study. Am J Ophthalmol (2006) 2.77

Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA (2002) 2.72

Long-term use of aspirin and age-related macular degeneration. JAMA (2012) 2.72

Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diabetes Care (2002) 2.70

The Los Angeles Latino Eye Study: design, methods, and baseline data. Ophthalmology (2004) 2.68

Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera. Arch Ophthalmol (2004) 2.67

ACE-I and ARBs in early diabetic nephropathy. J Renin Angiotensin Aldosterone Syst (2002) 2.64

Quantitative retinal venular caliber and risk of cardiovascular disease in older persons: the cardiovascular health study. Arch Intern Med (2006) 2.60

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. JAMA (2013) 2.58

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet (2008) 2.49

The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology (2003) 2.49

The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. Ophthalmology (2007) 2.46

Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet (2013) 2.36

The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study. Ophthalmology (2003) 2.36

Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet (2005) 2.34

Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology (2004) 2.26

Detecting disease-causing genes by LASSO-Patternsearch algorithm. BMC Proc (2007) 2.25

The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study. Arch Ophthalmol (2008) 2.24

Linkage analysis of a complex disease through use of admixed populations. Am J Hum Genet (2004) 2.21

Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20

Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am J Hum Genet (2005) 2.18

Generational differences in the prevalence of hearing impairment in older adults. Am J Epidemiol (2009) 2.18

Retinal arteriolar diameter and risk for hypertension. Ann Intern Med (2004) 2.18

A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med (2006) 2.18