Published in Mol Cell Biol on April 07, 2008
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci (2010) 3.38
Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol Endocrinol (2008) 2.09
The Mediator complex: a central integrator of transcription. Nat Rev Mol Cell Biol (2015) 1.97
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol (2010) 1.38
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. EMBO J (2011) 1.33
Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab (2008) 1.31
Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells. Cancer Res (2012) 1.30
Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol (2010) 1.18
Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics. Mol Cell (2013) 1.17
Med1 plays a critical role in the development of tamoxifen resistance. Carcinogenesis (2012) 1.13
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
Mediator and human disease. Semin Cell Dev Biol (2011) 1.10
Coactivators in PPAR-Regulated Gene Expression. PPAR Res (2010) 1.04
Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem (2011) 0.98
Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. Mol Cell Biol (2012) 0.90
Message in a nucleus: signaling to the transcriptional machinery. Curr Opin Genet Dev (2008) 0.89
Muscle as a "mediator" of systemic metabolism. Cell Metab (2015) 0.89
Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif. J Biol Chem (2011) 0.86
Chromatin-tethered MAPKs. Curr Opin Cell Biol (2013) 0.86
Mediator phosphorylation prevents stress response transcription during non-stress conditions. J Biol Chem (2012) 0.85
The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. J Biol Chem (2013) 0.81
ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. PLoS One (2013) 0.80
Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis. Gene Expr (2014) 0.80
ERK oscillation-dependent gene expression patterns and deregulation by stress response. Chem Res Toxicol (2014) 0.78
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
Mediator and the mechanism of transcriptional activation. Trends Biochem Sci (2005) 4.79
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell (2001) 4.58
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. Science (1994) 4.22
Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52
Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol (2005) 3.44
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell (2004) 2.95
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell (2002) 2.32
Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol (2005) 2.17
A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res (2004) 2.15
Regulatory diversity among metazoan co-activator complexes. Nat Rev Mol Cell Biol (2004) 2.10
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
The structural and functional organization of the yeast mediator complex. J Biol Chem (2001) 1.71
A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem (2002) 1.66
Structure of eukaryotic Mediator complexes. Trends Biochem Sci (2005) 1.65
Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A (1999) 1.54
The mediator coactivator complex: functional and physical roles in transcriptional regulation. J Cell Sci (2003) 1.41
Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol (2004) 1.35
Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem (2001) 1.32
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol (2004) 1.31
The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A (2006) 1.30
Isolation and functional characterization of the TRAP/mediator complex. Methods Enzymol (2003) 1.28
Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors. Mol Cell Biol (2000) 1.23
Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. Mol Cell (2004) 1.21
Role of the mediator complex in nuclear hormone receptor signaling. Rev Physiol Biochem Pharmacol (2006) 1.20
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word? Mol Endocrinol (2003) 1.12
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase. J Biol Chem (2002) 1.12
Regulation of cell signalling cascades by steroid hormones. J Cell Biochem (2004) 1.07
Thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells. Am J Physiol (1999) 1.06
MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes. Mol Endocrinol (2006) 1.06
Retracted BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. Oncogene (2004) 1.03
Membrane receptors mediating thyroid hormone action. Trends Endocrinol Metab (2005) 1.02
Src is an initial target of sex steroid hormone action. Ann N Y Acad Sci (2002) 1.00
Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. J Biol Chem (2006) 0.99
Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. Mol Endocrinol (1999) 0.94
The mammalian Mediator complex. FEBS Lett (2005) 0.92
RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. Cancer Res (2000) 0.87
Gene activation by thyroid hormone receptor in vitro and purification of the TRAP coactivator complex. Methods Mol Biol (2002) 0.82
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Proc Natl Acad Sci U S A (2002) 1.93
A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem (2002) 1.66
Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. Oncogene (2002) 1.28
Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol (2010) 1.18
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters. Vitam Horm (2004) 1.09
Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. Mol Endocrinol (2005) 1.04
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. EMBO Rep (2011) 1.02
Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. J Biol Chem (2006) 0.99
A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression. Nucleic Acids Res (2009) 0.95
A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression. Cancer Res (2007) 0.95
Caveolin-1 binding motif of alpha-hemolysin: its role in stability and pore formation. Biochem Biophys Res Commun (2004) 0.95
Conditional over-expression of estrogen receptor alpha in a transgenic mouse model. Transgenic Res (2002) 0.90
Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells. J Biol Chem (2004) 0.88
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. Mol Cell Endocrinol (2011) 0.87
Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif. J Biol Chem (2011) 0.86
ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity. Mol Cancer Res (2013) 0.82
Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications. Endocrinology (2010) 0.82
PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex. PPAR Res (2010) 0.78
Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation. Altern Ther Health Med (2003) 0.77