Published in J Biol Chem on November 18, 2011
Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. Proc Natl Acad Sci U S A (2014) 1.46
Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem (2014) 0.94
MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand. Oncotarget (2015) 0.83
MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. Oncotarget (2015) 0.81
MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget (2016) 0.75
Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells. Sci Rep (2016) 0.75
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature (1997) 11.15
Transformation of mammalian cells by constitutively active MAP kinase kinase. Science (1994) 8.69
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature (1998) 8.33
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell (2005) 5.38
Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev (1998) 5.28
Mediator and the mechanism of transcriptional activation. Trends Biochem Sci (2005) 4.79
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J (1992) 4.69
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell (2006) 3.12
The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol (1998) 3.08
Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J (2000) 2.96
Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res (1999) 2.88
FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor. J Biol Chem (2000) 2.58
Androgen receptor structural and functional elements: role and regulation in prostate cancer. Mol Endocrinol (2007) 2.53
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance. Mol Cell (2004) 2.38
Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J (1999) 2.24
Identification of two transcription activation units in the N-terminal domain of the human androgen receptor. J Biol Chem (1995) 2.02
The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol Cell Biol (1999) 2.00
Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol (2004) 1.91
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol (1997) 1.85
Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2006) 1.78
Ligand-specific allosteric regulation of coactivator functions of androgen receptor in prostate cancer cells. Proc Natl Acad Sci U S A (2006) 1.77
Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res (2004) 1.75
Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer. J Biol Chem (2003) 1.73
The androgen receptor amino-terminal domain plays a key role in p160 coactivator-stimulated gene transcription. Mol Cell Biol (1999) 1.70
A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem (2002) 1.66
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. EMBO J (2003) 1.65
Ras signaling in prostate cancer progression. J Cell Biochem (2004) 1.62
Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. Cancer Res (2003) 1.56
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl Recept Signal (2008) 1.47
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth. EMBO J (2011) 1.33
The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. J Biol Chem (2006) 1.32
Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. Cancer Res (2008) 1.26
Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors. Mol Cell Biol (2000) 1.23
Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. Mol Cell (2004) 1.21
Role of the mediator complex in nuclear hormone receptor signaling. Rev Physiol Biochem Pharmacol (2006) 1.20
Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations. J Biol Chem (2001) 1.18
MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling. Mol Cell Biol (2008) 1.18
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
Generation and genetic characterization of immortal human prostate epithelial cell lines derived from primary cancer specimens. Cancer Res (1997) 1.10
Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res (2006) 1.10
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor. Mol Endocrinol (2004) 1.06
A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol (2005) 1.05
Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor. J Biol Chem (2010) 0.98
A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression. Nucleic Acids Res (2009) 0.95
A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression. Cancer Res (2007) 0.95
Dual function of an amino-terminal amphipatic helix in androgen receptor-mediated transactivation through specific and nonspecific response elements. J Biol Chem (2002) 0.95
Androgen stimulates mitogen-activated protein kinase in human breast cancer cells. Mol Cell Endocrinol (1999) 0.93
Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control. J Biol Chem (2002) 0.92
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. J Biol Chem (2004) 0.88
Mediator and post-recruitment regulation of RNA polymerase II. Transcription (2012) 0.87
Proteins interacting with an androgen-responsive unit in the C3(1) gene intron. Mol Cell Endocrinol (1993) 0.85
Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J (2003) 3.72
Fracture risk and zoledronic acid therapy in men with osteoporosis. N Engl J Med (2012) 3.51
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A (2004) 3.48
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Structural basis of androgen receptor binding to selective androgen response elements. Proc Natl Acad Sci U S A (2004) 1.97
Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. Proc Natl Acad Sci U S A (2002) 1.93
A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. J Biol Chem (2002) 1.66
Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol Genet Metab (2003) 1.37
The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor. Cancer Res (2007) 1.35
Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1. Oncogene (2002) 1.28
Sex steroid actions in male bone. Endocr Rev (2014) 1.26
Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. Cancer Res (2008) 1.26
MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling. Mol Cell Biol (2008) 1.18
Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol (2010) 1.18
The rules of DNA recognition by the androgen receptor. Mol Endocrinol (2010) 1.17
Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor. J Biol Chem (2004) 1.16
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res (2006) 1.10
Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters. Vitam Horm (2004) 1.09
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A (2007) 1.06
Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. Mol Endocrinol (2005) 1.04
Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor. Mol Cell Biol (2012) 1.03
Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. EMBO Rep (2011) 1.02
Looking at nuclear receptors from a new angle. Mol Cell Endocrinol (2013) 1.01
Inhibition of cathepsin K for treatment of osteoporosis. Curr Osteoporos Rep (2012) 1.00
Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. J Biol Chem (2006) 0.99
Implications of a polyglutamine tract in the function of the human androgen receptor. Biochem Biophys Res Commun (2003) 0.98
The hinge region in androgen receptor control. Mol Cell Endocrinol (2012) 0.98
Active vitamin D (1,25-dihydroxyvitamin D) and bone health in middle-aged and elderly men: the European Male Aging Study (EMAS). J Clin Endocrinol Metab (2013) 0.98
Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes. J Bone Miner Res (2012) 0.98
Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation. J Biol Chem (2007) 0.95
A novel androgen receptor-binding element modulates Cdc6 transcription in prostate cancer cells during cell-cycle progression. Nucleic Acids Res (2009) 0.95
A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression. Cancer Res (2007) 0.95
Dual function of an amino-terminal amphipatic helix in androgen receptor-mediated transactivation through specific and nonspecific response elements. J Biol Chem (2002) 0.95
A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels. Cell Mol Life Sci (2010) 0.93
Once-yearly zoledronic acid in older men compared with women with recent hip fracture. J Am Geriatr Soc (2011) 0.92
Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control. J Biol Chem (2002) 0.92
Osteoporosis in older men: recent advances in pathophysiology and treatment. Best Pract Res Clin Endocrinol Metab (2013) 0.92
Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction. Mol Pharmacol (2005) 0.91
Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. Cell Mol Life Sci (2011) 0.91
Structural basis for nuclear hormone receptor DNA binding. Mol Cell Endocrinol (2011) 0.90
Conditional over-expression of estrogen receptor alpha in a transgenic mouse model. Transgenic Res (2002) 0.90
Functional interplay between two response elements with distinct binding characteristics dictates androgen specificity of the mouse sex-limited protein enhancer. J Biol Chem (2002) 0.89
Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells. J Biol Chem (2004) 0.88
The genomic landscape of prostate cancer. Int J Mol Sci (2013) 0.88
Novel insights in the regulation and mechanism of androgen action on bone. Curr Opin Endocrinol Diabetes Obes (2013) 0.87
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. Mol Cell Endocrinol (2011) 0.87
Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element. Mol Endocrinol (2013) 0.87
Variations in the exome of the LNCaP prostate cancer cell line. Prostate (2011) 0.87
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol (2012) 0.87
The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation. Ann N Y Acad Sci (2004) 0.86
DNA recognition by the androgen receptor: evidence for an alternative DNA-dependent dimerization, and an active role of sequences flanking the response element on transactivation. Biochem J (2003) 0.86
Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod (2011) 0.86
Sensitive routine liquid chromatography-tandem mass spectrometry method for serum estradiol and estrone without derivatization. Anal Bioanal Chem (2013) 0.85
Androgens inhibit the osteogenic response to mechanical loading in adult male mice. Endocrinology (2015) 0.84
Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men. J Clin Endocrinol Metab (2015) 0.84
Repression of cardiac phospholamban gene expression is mediated by thyroid hormone receptor-{alpha}1 and involves targeted covalent histone modifications. Endocrinology (2010) 0.82
ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity. Mol Cancer Res (2013) 0.82
Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo. Nucleic Acids Res (2014) 0.81
Influence of bone remodelling rate on quantitative ultrasound parameters at the calcaneus and DXA BMDa of the hip and spine in middle-aged and elderly European men: the European Male Ageing Study (EMAS). Eur J Endocrinol (2011) 0.81
NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth. Invest New Drugs (2009) 0.81
Testosterone and the male skeleton: a dual mode of action. J Osteoporos (2011) 0.81
Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor. Mol Cell Endocrinol (2003) 0.80
Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis. J Bone Miner Res (2012) 0.79
Calcium and vitamin d supplementation in men. J Osteoporos (2011) 0.79
PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex. PPAR Res (2010) 0.78
Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes. Biochem J (2008) 0.78
Healthy birth after testicular extraction of sperm and ICSI from an azoospermic man with mild androgen insensitivity syndrome caused by an androgen receptor partial loss-of-function mutation. Clin Endocrinol (Oxf) (2012) 0.78
A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene. FASEB J (2012) 0.78
The natural compound atraric acid is an antagonist of the human androgen receptor inhibiting cellular invasiveness and prostate cancer cell growth. J Cell Mol Med (2009) 0.77
Identification and characterization of androgen response elements. Methods Mol Biol (2011) 0.77
Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation. Altern Ther Health Med (2003) 0.77
Identification and characterization of MEL-3, a novel AR antagonist that suppresses prostate cancer cell growth. Mol Cancer Ther (2012) 0.76
Comparison of different androgen bioassays in the screening for environmental (anti)androgenic activity. Environ Toxicol Chem (2005) 0.76
The discovery of novel human androgen receptor antagonist chemotypes using a combined pharmacophore screening procedure. ChemMedChem (2013) 0.76
Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol (2005) 0.75