Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMID 18396172)

Published in Prog Lipid Res on March 15, 2008

Authors

Jeff S Volek1, Maria Luz Fernandez, Richard D Feinman, Stephen D Phinney

Author Affiliations

1: Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT 06269-1110, United States. jeff.volek@uconn.edu

Associated clinical trials:

Dietary Intervention in Type-2 Diabetes and Pre-Diabetes | NCT02519309

Articles citing this

Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial. Diabetes (2009) 1.01

Limited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate diet. Lipids (2010) 0.96

Fructose in perspective. Nutr Metab (Lond) (2013) 0.96

Effects of a moderate low-carbohydrate diet on preferential abdominal fat loss and cardiovascular risk factors in patients with type 2 diabetes. Diabetes Metab Syndr Obes (2011) 0.95

Tackling overweight and obesity: does the public health message match the science? BMC Med (2013) 0.92

The cardiometabolic consequences of replacing saturated fats with carbohydrates or Ω-6 polyunsaturated fats: Do the dietary guidelines have it wrong? Open Heart (2014) 0.90

Enhancement of a modified Mediterranean-style, low glycemic load diet with specific phytochemicals improves cardiometabolic risk factors in subjects with metabolic syndrome and hypercholesterolemia in a randomized trial. Nutr Metab (Lond) (2008) 0.89

Effects of dairy on metabolic syndrome parameters: a review. Yale J Biol Med (2014) 0.88

Response of C57Bl/6 mice to a carbohydrate-free diet. Nutr Metab (Lond) (2012) 0.87

Reducing vascular events risk in patients with dyslipidaemia: an update for clinicians. Ther Adv Chronic Dis (2011) 0.85

Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study. Nutr Metab (Lond) (2009) 0.85

Effects of consuming a high carbohydrate diet after eight weeks of exposure to a ketogenic diet. Nutr Metab (Lond) (2009) 0.82

Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet. Endocrinology (2010) 0.82

A Moderate Low-Carbohydrate Low-Calorie Diet Improves Lipid Profile, Insulin Sensitivity and Adiponectin Expression in Rats. Nutrients (2015) 0.82

Insulin signaling and autism. Front Endocrinol (Lausanne) (2011) 0.82

Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fat. Nutr Metab (Lond) (2010) 0.82

Differential effects of high-carbohydrate and high-fat diet composition on metabolic control and insulin resistance in normal rats. Int J Environ Res Public Health (2012) 0.81

Exercise and dietary-mediated reductions in postprandial lipemia. J Nutr Metab (2014) 0.80

Effect of a vegetable-oil emulsion on body composition; a 12-week study in overweight women on a meal replacement therapy after an initial weight loss: a randomized controlled trial. Eur J Nutr (2010) 0.80

Plasma phospholipid saturated fatty acids and heart failure risk in the Physicians' Health Study. Clin Nutr (2013) 0.80

Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients (2016) 0.79

Work and diet-related risk factors of cardiovascular diseases: comparison of two occupational groups. J Occup Med Toxicol (2010) 0.79

Three-graded stratification of carbohydrate restriction by level of baseline hemoglobin A1c for type 2 diabetes patients with a moderate low-carbohydrate diet. Nutr Metab (Lond) (2014) 0.78

Short term effects of a low-carbohydrate diet in overweight and obese subjects with low HDL-C levels. BMC Endocr Disord (2010) 0.76

Low HDL cholesterol is associated with increased atherogenic lipoproteins and insulin resistance in women classified with metabolic syndrome. Nutr Res Pract (2010) 0.76

Cholesterol-induced inflammation and macrophage accumulation in adipose tissue is reduced by a low carbohydrate diet in guinea pigs. Nutr Res Pract (2014) 0.75

Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial. Nutr J (2016) 0.75

Impact of Nutrition on Cerebral Circulation and Cognition in the Metabolic Syndrome. Nutrients (2015) 0.75

Maternal Food Restriction during Pregnancy and Lactation Adversely Affect Hepatic Growth and Lipid Metabolism in Three-Week-Old Rat Offspring. Int J Mol Sci (2016) 0.75

Articles by these authors

Weight loss with self-help compared with a structured commercial program: a randomized trial. JAMA (2003) 3.36

Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction. Nutr Metab (Lond) (2005) 1.59

Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids (2008) 1.57

Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids (2007) 1.45

Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutr Metab (Lond) (2008) 1.44

Low-carbohydrate nutrition and metabolism. Am J Clin Nutr (2007) 1.42

Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. Nutrition (2012) 1.39

Cardioprotective effects of dietary polyphenols. J Nutr (2005) 1.39

Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr (2005) 1.36

Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet. J Nutr (2008) 1.30

Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss. J Nutr (2008) 1.29

Thermodynamics and metabolic advantage of weight loss diets. Metab Syndr Relat Disord (2003) 1.28

Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women. J Nutr (2004) 1.26

Thermodynamics of weight loss diets. Nutr Metab (Lond) (2004) 1.17

Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico. Am J Clin Nutr (2004) 1.08

Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL, and HDL subfraction distribution and size in overweight men. J Nutr (2006) 1.06

Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs. Metabolism (2006) 1.05

The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase. J Nutr (2005) 1.04

Carbohydrate-restricted versus low-glycemic-index diets for the treatment of insulin resistance and metabolic syndrome. Nutr Rev (2009) 1.02

Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J Nutr (2003) 1.02

Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr (2012) 1.02

Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. J Nutr (2003) 1.02

Consuming eggs for breakfast influences plasma glucose and ghrelin, while reducing energy intake during the next 24 hours in adult men. Nutr Res (2010) 1.00

The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs. J Nutr (2006) 1.00

Rethinking fat as a fuel for endurance exercise. Eur J Sport Sci (2014) 0.99

SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs. Atherosclerosis (2003) 0.99

Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet. J Nutr Biochem (2009) 0.98

JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. BMC Cardiovasc Disord (2005) 0.98

Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge. J Am Coll Nutr (2002) 0.98

Whole egg consumption improves lipoprotein profiles and insulin sensitivity to a greater extent than yolk-free egg substitute in individuals with metabolic syndrome. Metabolism (2012) 0.98

Carbohydrate restriction, as a first-line dietary intervention, effectively reduces biomarkers of metabolic syndrome in Emirati adults. J Nutr (2009) 0.97

Limited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate diet. Lipids (2010) 0.96

1-[4-[4[(4R,5R)-3,3-Dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2]octane methanesulfonate (SC-435), an ileal apical sodium-codependent bile acid transporter inhibitor alters hepatic cholesterol metabolism and lowers plasma low-density lipoprotein-cholesterol concentrations in guinea pigs. J Pharmacol Exp Ther (2002) 0.96

Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge. J Nutr (2005) 0.95

Dietary strategies to reduce metabolic syndrome. Rev Endocr Metab Disord (2013) 0.95

Assessment of dietary and genetic factors influencing serum and adipose fatty acid composition in obese female identical twins. Lipids (2002) 0.95

A Mediterranean-style, low-glycemic-load diet decreases atherogenic lipoproteins and reduces lipoprotein (a) and oxidized low-density lipoprotein in women with metabolic syndrome. Metabolism (2011) 0.94

A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. J Clin Lipidol (2011) 0.92

Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation. Metabolism (2009) 0.92

High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification. Metabolism (2004) 0.92

Effects of resistance training on the inflammatory response. Nutr Res Pract (2010) 0.92

A lutein-enriched diet prevents cholesterol accumulation and decreases oxidized LDL and inflammatory cytokines in the aorta of guinea pigs. J Nutr (2011) 0.92

A Mediterranean-style low-glycemic-load diet increases plasma carotenoids and decreases LDL oxidation in women with metabolic syndrome. J Nutr Biochem (2011) 0.91

Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Int (2009) 0.91

Biomedical effects of grape products. Nutr Rev (2010) 0.91

Oral contraceptive use and increased plasma concentration of C-reactive protein. Life Sci (2003) 0.91

Metabolic syndrome and low-carbohydrate ketogenic diets in the medical school biochemistry curriculum. Metab Syndr Relat Disord (2003) 0.91

Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet. Nutr Res Pract (2012) 0.90

Nutrition education: a questionnaire for assessment and teaching. Nutr J (2005) 0.90

Exploring the factors that affect blood cholesterol and heart disease risk: is dietary cholesterol as bad for you as history leads us to believe? Adv Nutr (2012) 0.90

Guinea pigs as models to study the hypocholesterolemic effects of drugs. Cardiovasc Drug Rev (2004) 0.90

Egg consumption modulates HDL lipid composition and increases the cholesterol-accepting capacity of serum in metabolic syndrome. Lipids (2013) 0.90

Effects of a carbohydrate-restricted diet on emerging plasma markers for cardiovascular disease. Nutr Metab (Lond) (2006) 0.89

Macronutrient composition and increased physical activity modulate plasma adipokines and appetite hormones during a weight loss intervention. J Womens Health (Larchmt) (2010) 0.89

Egg intake improves carotenoid status by increasing plasma HDL cholesterol in adults with metabolic syndrome. Food Funct (2013) 0.89

Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet. Int J Food Sci Nutr (2010) 0.88

Exercise improves plasma lipid profiles and modifies lipoprotein composition in guinea pigs. J Nutr Biochem (2002) 0.88

Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction. Nutr Metab (Lond) (2006) 0.87

Determinants of fasting plasma glucose and glycosylated hemoglobin among low income Latinos with poorly controlled type 2 diabetes. J Immigr Minor Health (2011) 0.87

Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutr Metab (Lond) (2008) 0.87

Carbohydrate restriction alters hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet. J Nutr (2007) 0.86

Plasma LDL and HDL characteristics and carotenoid content are positively influenced by egg consumption in an elderly population. Nutr Metab (Lond) (2006) 0.86

Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in Guinea pigs. Comp Med (2012) 0.85

Are the current dietary guidelines regarding egg consumption appropriate? J Nutr (2004) 0.85

Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids Health Dis (2008) 0.85

The seeds from Plantago ovata lower plasma lipids by altering hepatic and bile acid metabolism in guinea pigs. J Nutr (2002) 0.85

Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men. Nutr Res (2009) 0.85

Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk. Metabolism (2007) 0.85

Effects of carbohydrate restriction and dietary cholesterol provided by eggs on clinical risk factors in metabolic syndrome. J Clin Lipidol (2013) 0.85

Weight loss associated with reduced intake of carbohydrate reduces the atherogenicity of LDL in premenopausal women. Metabolism (2005) 0.84

Weight loss favorably modifies anthropometrics and reverses the metabolic syndrome in premenopausal women. J Am Coll Nutr (2005) 0.84

Retracted High intake of saturated fat and early occurrence of specific biomarkers may explain the prevalence of chronic disease in northern Mexico. J Nutr (2005) 0.84

Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake. Atherosclerosis (2005) 0.83

Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat. Nutr Metab (Lond) (2008) 0.83

Metabolic syndrome prevalence, dietary intake, and cardiovascular risk profile among overweight and obese adults 18-50 years old from the United Arab Emirates. Metab Syndr Relat Disord (2010) 0.83

The food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanol. Adv Nutr (2013) 0.82

Cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase activities in hispanic and anglo postmenopausal women: associations with total and regional body fat. Metabolism (2003) 0.82

SC-435, an ileal apical sodium-codependent bile acid transporter inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J Nutr Biochem (2005) 0.82

Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol diet. Atherosclerosis (2009) 0.82

When is a high fat diet not a high fat diet? Nutr Metab (Lond) (2005) 0.81

Sex and hormonal status influence the effects of psyllium on lipoprotein remodeling and composition. Metabolism (2002) 0.81

Replacing dietary carbohydrate with protein and fat decreases the concentrations of small LDL and the inflammatory response induced by atherogenic diets in the guinea pig. J Nutr Biochem (2008) 0.81

Hypercholesterolemia induces adipose dysfunction in conditions of obesity and nonobesity. Adv Nutr (2014) 0.81

Whatever happened to the second law of thermodynamics? Am J Clin Nutr (2004) 0.81

Fatty acids, inflammation, and the metabolic syndrome. Am J Clin Nutr (2005) 0.81

A combination of psyllium and plant sterols alters lipoprotein metabolism in hypercholesterolemic subjects by modifying the intravascular processing of lipoproteins and increasing LDL uptake. J Nutr (2007) 0.81

Low-carbohydrate diet disrupts the association between insulin resistance and weight gain. Metabolism (2009) 0.81

Platelet surface glutathione reductase-like activity. Blood (2004) 0.80

Diets high in total antioxidant capacity improve risk biomarkers of cardiovascular disease: a 9-month observational study among overweight/obese postmenopausal women. Eur J Nutr (2013) 0.80

Dietary carbohydrate and cholesterol influence the number of particles and distributions of lipoprotein subfractions in guinea pigs. J Nutr Biochem (2006) 0.80

Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. J Nutr (2009) 0.80

Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients (2012) 0.80

Coronary heart disease risk factors in college students. Adv Nutr (2014) 0.80