Published in J Allergy Clin Immunol on April 08, 2008
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet (2009) 2.96
Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci (2009) 2.71
Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev (2011) 2.62
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol (2009) 2.20
One remarkable molecule: filaggrin. J Invest Dermatol (2011) 2.10
A common variant on chromosome 11q13 is associated with atopic dermatitis. Nat Genet (2009) 1.91
Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol (2010) 1.85
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol (2009) 1.76
An update on the genetics of atopic dermatitis: scratching the surface in 2009. J Allergy Clin Immunol (2010) 1.73
The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort. J Allergy Clin Immunol (2012) 1.52
Skin barrier disruption: a requirement for allergen sensitization? J Invest Dermatol (2012) 1.40
Role of macrophage migration inhibitory factor (MIF) in pollen-induced allergic conjunctivitis and pollen dermatitis in mice. PLoS One (2015) 1.39
Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice. J Allergy Clin Immunol (2014) 1.38
Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. J Allergy Clin Immunol (2010) 1.23
Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis. J Allergy Clin Immunol (2009) 1.22
Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects. J Allergy Clin Immunol (2013) 1.12
Increased risk of pertussis in patients with asthma. J Allergy Clin Immunol (2011) 1.11
Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. Br J Dermatol (2009) 1.10
Pediatric asthma: a different disease. Proc Am Thorac Soc (2009) 1.08
Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort. BMC Dermatol (2012) 1.04
Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol (2014) 1.02
Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol (2009) 0.98
Filaggrin gene defects are independent risk factors for atopic asthma in a Polish population: a study in ECAP cohort. PLoS One (2011) 0.97
Allergy as an epithelial barrier disease. Clin Transl Allergy (2011) 0.96
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. Hum Mol Genet (2013) 0.95
The link between allergies and eosinophilic esophagitis: implications for management strategies. Expert Rev Clin Immunol (2010) 0.95
Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population. PLoS One (2014) 0.94
Eczema in early life: genetics, the skin barrier, and lessons learned from birth cohort studies. J Pediatr (2010) 0.90
Assessment of the association between atopic conditions and tympanostomy tube placement in children. Allergy Asthma Proc (2012) 0.90
Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age. PLoS One (2012) 0.90
Management of itch in atopic dermatitis. Semin Cutan Med Surg (2011) 0.89
Application of genetic/genomic approaches to allergic disorders. J Allergy Clin Immunol (2010) 0.86
Long term treatment concepts and proactive therapy for atopic eczema. Ann Dermatol (2012) 0.86
Context-specific protein network miner--an online system for exploring context-specific protein interaction networks from the literature. PLoS One (2012) 0.83
Genetics of allergic diseases. Immunol Allergy Clin North Am (2014) 0.83
Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients. Ann Dermatol (2011) 0.82
Influence of asthma epidemiology on the risk for other diseases. Allergy Asthma Immunol Res (2012) 0.81
Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence. J Allergy Clin Immunol (2014) 0.81
Epicutaneous exposure to staphylococcal superantigen enterotoxin B enhances allergic lung inflammation via an IL-17A dependent mechanism. PLoS One (2012) 0.81
Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol (2008) 0.80
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis. BMC Med Genet (2012) 0.80
Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. J Allergy Clin Immunol (2014) 0.80
Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance. PLoS Genet (2015) 0.79
A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children. Hum Mutat (2013) 0.78
Consensus Conference on Clinical Management of pediatric Atopic Dermatitis. Ital J Pediatr (2016) 0.78
Atopic conditions other than asthma and risk of the 2009 novel H1N1 infection in children: a case-control study. Allergy Asthma Proc (2013) 0.78
The frequency of polymorphic variants of filaggrin gene and clinical atopic dermatitis. Postepy Dermatol Alergol (2016) 0.78
Management of patients with atopic dermatitis: the role of emollient therapy. Dermatol Res Pract (2012) 0.77
Current trends in aetiological asthma research. Eur J Epidemiol (2009) 0.77
Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice. Part Fibre Toxicol (2015) 0.77
Lower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important? Wien Klin Wochenschr (2010) 0.76
Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study. Mayo Clin Proc (2013) 0.76
Mutations in the filaggrin gene and food allergy. Prz Gastroenterol (2014) 0.76
Pimecrolimus cream in the management of patients with atopic eczema. Clin Cosmet Investig Dermatol (2009) 0.75
Atopic dermatitis and the atopic march: what is new? J Allergy (Cairo) (2011) 0.75
Filaggrin gene mutations and new SNPs in asthmatic patients: a cross-sectional study in a Spanish population. Allergy Asthma Clin Immunol (2016) 0.75
Do early skin care practices alter the risk of atopic dermatitis? A case-control study. Pediatr Dermatol (2011) 0.75
Association of common filaggrin null mutations with atopy but not chronic rhinosinusitis. Ann Allergy Asthma Immunol (2015) 0.75
Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clin Transl Allergy (2016) 0.75
Association of filaggrin variants with asthma and rhinitis: is eczema or allergic sensitization status an effect modifier? Int Arch Allergy Immunol (2014) 0.75
Reliability and validity of genotyping filaggrin null mutations. J Dermatol Sci (2012) 0.75
Treating atopic dermatitis: safety, efficacy, and patient acceptability of a ceramide hyaluronic acid emollient foam. Clin Cosmet Investig Dermatol (2012) 0.75
[Pathophysiology of atopic blepharokeratoconjunctivitis]. Ophthalmologe (2017) 0.75
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet (2006) 9.99
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med (2002) 9.14
The asthma epidemic. N Engl J Med (2006) 8.60
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
Exposure to environmental microorganisms and childhood asthma. N Engl J Med (2011) 6.38
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet (2008) 5.23
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One (2007) 4.92
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet (2008) 4.67
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet (2006) 4.55
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet (2007) 4.54
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am J Hum Genet (2011) 4.52
Variants of DENND1B associated with asthma in children. N Engl J Med (2009) 4.18
Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet (2006) 4.13
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet (2007) 3.94
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med (2004) 3.63
SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol (2009) 3.55
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Filaggrin mutations associated with skin and allergic diseases. N Engl J Med (2011) 3.40
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One (2013) 3.19
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Analyses of case-control data for additional outcomes. Epidemiology (2007) 3.10
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet (2009) 2.96
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Intermediate filament proteins and their associated diseases. N Engl J Med (2004) 2.84
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet (2006) 2.81
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet (2011) 2.73
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci (2009) 2.71
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70