Published in Nature on April 10, 2008
Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol (2011) 6.32
Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol (2008) 3.63
Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci (2009) 2.08
A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol (2009) 1.90
New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nat Rev Mol Cell Biol (2009) 1.75
Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure. Cell (2011) 1.71
Organization and execution of the epithelial polarity programme. Nat Rev Mol Cell Biol (2014) 1.67
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG. J Cell Biol (2012) 1.65
Clathrin mediates endocytosis and polar distribution of PIN auxin transporters in Arabidopsis. Plant Cell (2011) 1.53
The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell (2012) 1.47
Endocytosis and cancer. Cold Spring Harb Perspect Biol (2013) 1.40
Taking the scenic route: biosynthetic traffic to the plasma membrane in polarized epithelial cells. Traffic (2009) 1.39
Polarity and endocytosis: reciprocal regulation. Trends Cell Biol (2010) 1.36
Role of membrane traffic in the generation of epithelial cell asymmetry. Nat Cell Biol (2012) 1.33
Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord. PLoS Genet (2008) 1.32
Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol (2009) 1.31
Numb controls E-cadherin endocytosis through p120 catenin with aPKC. Mol Biol Cell (2011) 1.27
Clathrin and AP1B: key roles in basolateral trafficking through trans-endosomal routes. FEBS Lett (2009) 1.24
MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells. Nucleic Acids Res (2009) 1.23
Adaptor proteins involved in polarized sorting. J Cell Biol (2014) 1.22
Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons. J Neurosci (2008) 1.22
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells. Proc Natl Acad Sci U S A (2009) 1.21
Signal-mediated, AP-1/clathrin-dependent sorting of transmembrane receptors to the somatodendritic domain of hippocampal neurons. Neuron (2012) 1.20
Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B. Proc Natl Acad Sci U S A (2012) 1.18
LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network. Mol Biol Cell (2008) 1.18
A screen for endocytic motifs. Traffic (2010) 1.15
Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis. J Cell Biol (2013) 1.15
Extracellular vesicles shed by Trypanosoma cruzi are linked to small RNA pathways, life cycle regulation, and susceptibility to infection of mammalian cells. Parasitol Res (2013) 1.10
A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface. EMBO J (2012) 1.10
Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo. Dev Cell (2009) 1.10
Getting active: protein sorting in endocytic recycling. Nat Rev Mol Cell Biol (2012) 1.09
Search for inhibitors of endocytosis: Intended specificity and unintended consequences. Cell Logist (2012) 1.07
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Kidney Int (2010) 1.07
Hepatocyte polarity. Compr Physiol (2013) 1.06
Polarized sorting and trafficking in epithelial cells. Cell Res (2012) 1.06
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Mol Biol Cell (2011) 1.04
Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1. Mol Biol Cell (2008) 1.02
Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways. Mol Biol Cell (2008) 1.01
Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol (2014) 1.01
The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia. EMBO J (2013) 0.99
E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. J Biol Chem (2013) 0.98
AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell (2011) 0.96
Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates. Proc Natl Acad Sci U S A (2014) 0.95
Disease-causing mutations in BEST1 gene are associated with altered sorting of bestrophin-1 protein. Int J Mol Sci (2013) 0.94
Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia. Traffic (2011) 0.93
Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem (2010) 0.92
Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells. Mol Biol Cell (2011) 0.92
Clathrin and AP-1 regulate apical polarity and lumen formation during C. elegans tubulogenesis. Development (2012) 0.91
The polarized distribution of Na+,K+-ATPase: role of the interaction between {beta} subunits. Mol Biol Cell (2010) 0.90
Polar delivery in plants; commonalities and differences to animal epithelial cells. Open Biol (2014) 0.90
Plasma membrane protein polarity and trafficking in RPE cells: past, present and future. Exp Eye Res (2014) 0.89
Mechanism of polarized lysosome exocytosis in epithelial cells. J Cell Sci (2012) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic (2011) 0.87
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity. Biosci Rep (2015) 0.87
Phylogenetic analysis of the NEEP21/calcyon/P19 family of endocytic proteins: evidence for functional evolution in the vertebrate CNS. J Mol Evol (2009) 0.85
The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells. J Cell Biol (2013) 0.84
Role of the epithelial cell-specific clathrin adaptor complex AP-1B in cell polarity. Cell Logist (2015) 0.84
Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors. J Biol Chem (2014) 0.84
Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation (2012) 0.83
Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol (2009) 0.83
Polarization and myelination in myelinating glia. ISRN Neurol (2012) 0.82
Multiple motifs regulate apical sorting of p75 via a mechanism that involves dimerization and higher-order oligomerization. Mol Biol Cell (2013) 0.82
N-Glycosylation instead of cholesterol mediates oligomerization and apical sorting of GPI-APs in FRT cells. Mol Biol Cell (2011) 0.82
Clathrin is spindle-associated but not essential for mitosis. PLoS One (2008) 0.82
Myosin 1 controls membrane shape by coupling F-Actin to membrane. Bioarchitecture (2011) 0.82
Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes. Proc Natl Acad Sci U S A (2015) 0.81
A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking. Traffic (2010) 0.81
Clathrin mediates infectious hepatitis C virus particle egress. J Virol (2015) 0.81
Microfluidic approaches for epithelial cell layer culture and characterisation. Analyst (2014) 0.81
ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartments. PLoS One (2015) 0.81
Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis. Sci Adv (2015) 0.80
Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors. PLoS Genet (2016) 0.80
Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis. Mol Biol Cell (2013) 0.79
Intracellular trafficking and signaling in development. F1000 Biol Rep (2009) 0.78
Galectin-4-mediated transcytosis of transferrin receptor. J Cell Sci (2014) 0.78
Influenza entry pathways in polarized MDCK cells. Biochem Biophys Res Commun (2014) 0.78
Schwann cells induce cancer cell dispersion and invasion. J Clin Invest (2016) 0.78
Tyrosine motifs are required for prestin basolateral membrane targeting. Biol Open (2015) 0.77
Basolateral sorting of chloride channel 2 is mediated by interactions between a dileucine motif and the clathrin adaptor AP-1. Mol Biol Cell (2015) 0.77
Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes. J Neurochem (2012) 0.76
Cell biology: porter and sorter. Nature (2008) 0.76
Vesicular sorting controls the polarity of expanding membranes in the C. elegans intestine. Worm (2013) 0.76
The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells. Nat Commun (2016) 0.76
Dual pulse-chase microscopy reveals early divergence in the biosynthetic trafficking of the Na,K-ATPase and E-cadherin. Mol Biol Cell (2015) 0.76
The Apical Localization of Na(+), K(+)-ATPase in Cultured Human Retinal Pigment Epithelial Cells Depends on Expression of the β2 Subunit. Front Physiol (2016) 0.75
Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons. Sci Rep (2017) 0.75
Regulation of potassium channel trafficking in the distal nephron. Curr Opin Nephrol Hypertens (2013) 0.75
A Common Signal Patch Drives AP-1 Protein-dependent Golgi Export of Inwardly Rectifying Potassium Channels. J Biol Chem (2016) 0.75
How Schwann cells facilitate cancer progression in nerves. Cell Mol Life Sci (2017) 0.75
Regulated portals of entry into the cell. Nature (2003) 15.33
Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem (2003) 13.66
Polarized monolayers formed by epithelial cells on a permeable and translucent support. J Cell Biol (1978) 7.69
Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol (2003) 6.35
Adaptation of core mechanisms to generate cell polarity. Nature (2003) 5.64
A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell (1999) 5.19
Organization of vesicular trafficking in epithelia. Nat Rev Mol Cell Biol (2005) 4.79
Clathrin. Annu Rev Biochem (2000) 4.20
New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev (1999) 3.51
Coated vesicles transport newly synthesized membrane glycoproteins from endoplasmic reticulum to plasma membrane in two successive stages. Proc Natl Acad Sci U S A (1980) 3.51
Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells. Nature (1987) 3.46
Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol (2004) 3.41
Basolateral sorting of LDL receptor in MDCK cells: the cytoplasmic domain contains two tyrosine-dependent targeting determinants. Cell (1992) 3.38
A single amino acid change in the cytoplasmic domain alters the polarized delivery of influenza virus hemagglutinin. J Cell Biol (1991) 3.17
Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. J Cell Biol (2001) 3.05
Polarized epithelial membrane traffic: conservation and plasticity. Nat Cell Biol (2003) 2.94
Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. J Biol Chem (2003) 2.66
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat Cell Biol (2003) 2.50
Clathrin is required for the function of the mitotic spindle. Nature (2005) 2.45
Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett (1999) 2.37
Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein. Nat Cell Biol (2000) 2.37
A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells. EMBO J (1994) 2.19
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Nat Cell Biol (2002) 2.16
Vesicular stomatitis virus glycoprotein contains a dominant cytoplasmic basolateral sorting signal critically dependent upon a tyrosine. J Biol Chem (1993) 2.15
Clathrin requirement for normal growth of yeast. Science (1987) 2.01
cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network. EMBO J (2001) 2.00
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A (2007) 1.92
Studies on the development and maintenance of epithelial cell surface polarity with monoclonal antibodies. J Cell Biol (1984) 1.88
An internal deletion in the cytoplasmic tail reverses the apical localization of human NGF receptor in transfected MDCK cells. J Cell Biol (1991) 1.87
AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Nat Cell Biol (2002) 1.80
Structural requirements for basolateral sorting of the human transferrin receptor in the biosynthetic and endocytic pathways of Madin-Darby canine kidney cells. J Cell Biol (1997) 1.78
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem (2001) 1.59
In vitro formation of recycling vesicles from endosomes requires adaptor protein-1/clathrin and is regulated by rab4 and the connector rabaptin-5. Mol Biol Cell (2004) 1.44
Targeted chemical disruption of clathrin function in living cells. Mol Biol Cell (2003) 1.43
An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol (2007) 1.38
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell (2007) 1.35
The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium. Mol Biol Cell (2004) 1.27
Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA. Proc Natl Acad Sci U S A (2003) 1.22
Clathrin coat construction in endocytosis. Curr Opin Struct Biol (2000) 1.22
The neural cell adhesion molecule expresses a tyrosine-independent basolateral sorting signal. J Biol Chem (1997) 1.11
Efficient electroporation of DNA and protein into confluent and differentiated epithelial cells in culture. Traffic (2007) 0.92
Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol (2008) 2.93
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat Cell Biol (2003) 2.50
Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells. Dev Cell (2007) 2.19
The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci U S A (2002) 2.18
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Nat Cell Biol (2002) 2.16
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol (2004) 2.16
Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci (2009) 2.08
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A (2007) 1.92
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol (2005) 1.84
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell (2002) 1.54
The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell (2012) 1.47
Evolving endosomes: how many varieties and why? Curr Opin Cell Biol (2005) 1.47
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 1.45
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A (2005) 1.44
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell (2007) 1.35
The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium. Mol Biol Cell (2004) 1.27
Clathrin and AP1B: key roles in basolateral trafficking through trans-endosomal routes. FEBS Lett (2009) 1.24
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate. Proc Natl Acad Sci U S A (2008) 1.24
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells. Proc Natl Acad Sci U S A (2009) 1.21
Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXXPhi motif with the clathrin adaptors AP-1A and AP-1B. Proc Natl Acad Sci U S A (2012) 1.18
LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network. Mol Biol Cell (2008) 1.18
Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells. Proc Natl Acad Sci U S A (2004) 1.09
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem (2002) 1.07
The absence of a clathrin adapter confers unique polarity essential to proximal tubule function. Kidney Int (2010) 1.07
Apical budding of a recombinant influenza A virus expressing a hemagglutinin protein with a basolateral localization signal. J Virol (2002) 0.99
The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia. EMBO J (2013) 0.99
Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. Traffic (2006) 0.97
Four-dimensional live imaging of apical biosynthetic trafficking reveals a post-Golgi sorting role of apical endosomal intermediates. Proc Natl Acad Sci U S A (2014) 0.95
Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia. Traffic (2011) 0.93
Efficient electroporation of DNA and protein into confluent and differentiated epithelial cells in culture. Traffic (2007) 0.92
Mechanism of polarized lysosome exocytosis in epithelial cells. J Cell Sci (2012) 0.88
Bipolar assembly of caveolae in retinal pigment epithelium. Am J Physiol Cell Physiol (2005) 0.88
A molecular rheostat at the interface of cancer and diabetes. Biochim Biophys Acta (2013) 0.84
Modulation of E-cadherin monomer folding by cooperative binding of calcium ions. Biochemistry (2008) 0.83
Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells. Am J Physiol Cell Physiol (2002) 0.83
Unravelling protein sorting. Nat Cell Biol (2004) 0.83
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci U S A (2014) 0.82
Microfluidic approaches for epithelial cell layer culture and characterisation. Analyst (2014) 0.81
Cell biology: caught in the traffic. Nature (2007) 0.81
Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42. Mol Biol Cell (2012) 0.80
Response: the "tail" of the twin adaptors. Dev Cell (2013) 0.79
It takes two to tango to the melanosome. J Cell Biol (2009) 0.78
Open sesame! Coxsackieviruses conspire to trespass the tight junctional gate. Dev Cell (2006) 0.78