Published in J Biol Chem on April 16, 2008
Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer (2010) 5.26
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol (2012) 5.12
Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J (2010) 4.47
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell (2009) 3.68
MicroRNAs add a new dimension to cardiovascular disease. Circulation (2010) 3.64
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab (2009) 3.30
MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res (2009) 2.93
Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem (2009) 2.66
MicroRNA and cancer--focus on apoptosis. J Cell Mol Med (2009) 2.44
AngiomiRs--key regulators of angiogenesis. Curr Opin Genet Dev (2009) 2.40
MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33
Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J Clin Invest (2010) 2.32
MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation (2010) 2.32
MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle (2010) 2.18
MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med (2009) 2.12
miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ (2010) 2.09
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med (2008) 1.93
Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer (2012) 1.92
Tumour angiogenesis regulation by the miR-200 family. Nat Commun (2013) 1.90
An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem (2009) 1.90
MiR-210--micromanager of the hypoxia pathway. Trends Mol Med (2010) 1.90
Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res (2011) 1.85
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol (2011) 1.81
Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells. PLoS One (2009) 1.79
Global microRNA depletion suppresses tumor angiogenesis. Genes Dev (2014) 1.76
Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol (2011) 1.71
Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem (2013) 1.62
Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J Cell Mol Med (2009) 1.59
MicroRNAs: opening a new vein in angiogenesis research. Sci Signal (2009) 1.58
Metastamirs: a stepping stone towards improved cancer management. Nat Rev Clin Oncol (2010) 1.58
miR-210: the master hypoxamir. Microcirculation (2012) 1.56
miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J Biol Chem (2010) 1.53
Hypoxia-induced angiogenesis: good and evil. Genes Cancer (2011) 1.52
MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol (2010) 1.52
Placental microRNA expression in pregnancies complicated by preeclampsia. Am J Obstet Gynecol (2010) 1.52
MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics (2010) 1.48
Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc Res (2011) 1.47
Expression profile of microRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor. Reprod Sci (2010) 1.45
microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am J Physiol Heart Circ Physiol (2011) 1.45
MicroRNA: a new frontier in kidney and blood pressure research. Am J Physiol Renal Physiol (2009) 1.41
MicroRNAs and cardiovascular diseases. FEBS J (2011) 1.41
Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J Biol Chem (2013) 1.40
MicroRNAome genome: a treasure for cancer diagnosis and therapy. CA Cancer J Clin (2014) 1.40
Novel functions for small RNA molecules. Curr Opin Mol Ther (2009) 1.39
MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis (2013) 1.37
A critical evaluation of microRNA biomarkers in non-neoplastic disease. PLoS One (2014) 1.35
MicroRNAs: molecular features and role in cancer. Front Biosci (Landmark Ed) (2012) 1.32
Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res (2009) 1.31
MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes (2012) 1.31
Differential expression of microRNAs in different disease states. Circ Res (2012) 1.30
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest (2013) 1.30
A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like. Mol Cell Biol (2011) 1.26
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. BMC Syst Biol (2010) 1.26
Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet (2013) 1.25
miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med (2013) 1.21
The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenviron (2010) 1.21
Role of specific microRNAs for endothelial function and angiogenesis. Biochem Biophys Res Commun (2009) 1.21
Microenvironmental regulation of cancer metastasis by miRNAs. Trends Cell Biol (2013) 1.20
Circulating microRNAs and aerobic fitness--the HUNT-Study. PLoS One (2013) 1.20
MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res (2013) 1.19
MiR-205 silences MED1 in hypoxic primary human trophoblasts. FASEB J (2010) 1.17
Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem (2012) 1.15
MicroRNAs and their target genes in gingival tissues. J Dent Res (2012) 1.14
Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis. BMC Med Genomics (2009) 1.13
Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. RNA (2012) 1.13
Invited review: decoding the microRNA response to hypoxia. Pflugers Arch (2011) 1.12
Multiple functions of hypoxia-regulated miR-210 in cancer. J Exp Clin Cancer Res (2014) 1.12
MicroRNAs in vascular disease. J Cardiovasc Pharmacol (2011) 1.11
The cellular response to hypoxia: tuning the system with microRNAs. J Clin Invest (2010) 1.11
MicroRNA profiling of diverse endothelial cell types. BMC Med Genomics (2011) 1.11
MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes. Nucleic Acids Res (2012) 1.11
Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci (2013) 1.10
miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am J Physiol Lung Cell Mol Physiol (2012) 1.09
Synthetic miRNA-mowers targeting miR-183-96-182 cluster or miR-210 inhibit growth and migration and induce apoptosis in bladder cancer cells. PLoS One (2012) 1.08
MicroRNAs in vascular biology and vascular disease. J Cardiovasc Transl Res (2010) 1.07
miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies. Am J Pathol (2011) 1.06
Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs. Front Mol Neurosci (2011) 1.06
MicroRNAs: novel players in cancer diagnosis and therapies. Biomed Res Int (2014) 1.05
The Role of MicroRNAs in Human Diseases. Avicenna J Med Biotechnol (2010) 1.04
Hypoxia-regulated microRNAs in human cancer. Acta Pharmacol Sin (2013) 1.04
Stability of miRNA in human urine supports its biomarker potential. Biomark Med (2013) 1.02
MicroRNA 130 family regulates the hypoxia response signal through the P-body protein DDX6. Nucleic Acids Res (2011) 1.02
Gene expression and hypoxia in breast cancer. Genome Med (2011) 1.02
Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1. J Vet Sci (2013) 1.02
Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis. PLoS One (2014) 1.01
mir-210: a sensor for hypoxic stress during tumorigenesis. Mol Cell (2009) 1.01
Up-regulation of miR-210 by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell-mediated angiogenesis. J Cell Mol Med (2012) 1.01
EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination. Oncogene (2014) 1.00
Priming adult stem cells by hypoxic pretreatments for applications in regenerative medicine. J Biomed Sci (2013) 1.00
MicroRNAs in skin and wound healing. Physiol Genomics (2010) 1.00
Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. PLoS One (2014) 1.00
Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing. BMC Genomics (2014) 1.00
MicroRNAs in pulmonary arterial remodeling. Cell Mol Life Sci (2013) 0.99
Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium. J Biol Chem (2013) 0.99
Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD). PLoS One (2013) 0.97
Acute kidney injury in 2011: Biomarkers are transforming our understanding of AKI. Nat Rev Nephrol (2012) 0.96
miR-210: fine-tuning the hypoxic response. Adv Exp Med Biol (2014) 0.95
Hypoxia-inducible factor 1-α induces miR-210 in normoxic differentiating myoblasts. J Biol Chem (2012) 0.95
MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1. J Am Soc Nephrol (2011) 0.95
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
microRNA target predictions in animals. Nat Genet (2006) 10.76
Ribo-gnome: the big world of small RNAs. Science (2005) 10.10
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res (2005) 9.80
Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med (2003) 8.54
Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature (2006) 8.16
A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods (2006) 7.00
hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res (2008) 4.84
Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol (1988) 4.33
MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29
miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther (2007) 3.93
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol (2006) 3.61
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science (1994) 3.53
High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer (2007) 3.24
Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis. Science (1995) 2.88
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev (2004) 2.77
A microRNA component of the hypoxic response. Cell Death Differ (2008) 2.59
Regulation of angiogenesis by Eph-ephrin interactions. Trends Cardiovasc Med (2007) 2.15
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res (2003) 2.00
The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts. Mol Hum Reprod (2007) 1.49
p66ShcA modulates tissue response to hindlimb ischemia. Circulation (2004) 1.43
Hypoxia-inducible transcription factor-1alpha promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway. BMC Cancer (2006) 1.21
Oxygen sensing by H+: implications for HIF and hypoxic cell memory. Cell Cycle (2004) 1.01
Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J (2010) 4.47
Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet (2010) 3.66
Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. Int J Cardiol (2012) 3.20
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood (2004) 3.16
MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation (2010) 2.32
Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res (2005) 2.32
Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction. Circulation (2008) 2.23
Common micro-RNA signature in skeletal muscle damage and regeneration induced by Duchenne muscular dystrophy and acute ischemia. FASEB J (2009) 2.22
Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critical limb ischemia. Mol Ther (2008) 2.13
Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res (2007) 2.08
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation (2011) 1.99
Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med (2008) 1.93
An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem (2009) 1.90
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc Natl Acad Sci U S A (2008) 1.80
Microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells. PLoS One (2009) 1.79
Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase. Circ Res (2008) 1.75
miR-210: More than a silent player in hypoxia. IUBMB Life (2011) 1.74
Enhanced arteriogenesis and wound repair in dystrophin-deficient mdx mice. Circulation (2004) 1.73
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF. Proc Natl Acad Sci U S A (2006) 1.66
Pivotal advances: high-mobility group box 1 protein--a cytokine with a role in cardiac repair. J Leukoc Biol (2006) 1.65
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells. J Cell Biol (2006) 1.62
p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose. Cardiovasc Res (2009) 1.62
Myocardial infarction induces embryonic reprogramming of epicardial c-kit(+) cells: role of the pericardial fluid. J Mol Cell Cardiol (2009) 1.57
Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Mol Cell (2003) 1.55
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J Clin Invest (2009) 1.51
Vascular endothelial growth factor modulates skeletal myoblast function. Am J Pathol (2003) 1.50
Autologous peripheral blood stem cell transplantation for myocardial regeneration: a novel strategy for cell collection and surgical injection. Ann Thorac Surg (2004) 1.48
p21(Waf1/Cip1/Sdi1) mediates shear stress-dependent antiapoptotic function. Cardiovasc Res (2004) 1.48
Granulocyte colony-stimulating factor attenuates left ventricular remodelling after acute anterior STEMI: results of the single-blind, randomized, placebo-controlled multicentre STem cEll Mobilization in Acute Myocardial Infarction (STEM-AMI) Trial. Eur J Heart Fail (2010) 1.45
microRNA: emerging therapeutic targets in acute ischemic diseases. Pharmacol Ther (2009) 1.45
[Current perspectives in cell therapy in cardiology: an overview of ongoing trials]. G Ital Cardiol (Rome) (2010) 1.44
p66ShcA modulates tissue response to hindlimb ischemia. Circulation (2004) 1.43
Functional properties of cells obtained from human cord blood CD34+ stem cells and mouse cardiac myocytes in coculture. Am J Physiol Heart Circ Physiol (2008) 1.42
Myogenic potential of adipose-tissue-derived cells. J Cell Sci (2006) 1.39
High-mobility group box 1 protein in human and murine skin: involvement in wound healing. J Invest Dermatol (2008) 1.36
Myoendothelial differentiation of human umbilical cord blood-derived stem cells in ischemic limb tissues. Circ Res (2003) 1.32
MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes (2012) 1.31
Analysis of the role of chemokines in angiogenesis. J Immunol Methods (2003) 1.30
Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res (2005) 1.29
p66(ShcA) and oxidative stress modulate myogenic differentiation and skeletal muscle regeneration after hind limb ischemia. J Biol Chem (2007) 1.27
Oxidative stress and epigenetic regulation in ageing and age-related diseases. Int J Mol Sci (2013) 1.25
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling. Circ Res (2007) 1.24
Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. Circ Res (2003) 1.22
MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients. Physiol Genomics (2010) 1.17
HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells. J Mol Cell Cardiol (2008) 1.15
Multiple effects of high mobility group box protein 1 in skeletal muscle regeneration. Arterioscler Thromb Vasc Biol (2007) 1.14
Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. RNA (2012) 1.13
Dysregulation and cellular mislocalization of specific miRNAs in myotonic dystrophy type 1. Neuromuscul Disord (2010) 1.13
The epicardium in cardiac repair: from the stem cell view. Pharmacol Ther (2010) 1.12
The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation. Cell Cycle (2005) 1.12
MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. Mol Cell Biol (2003) 1.10
Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am J Pathol (2006) 1.10
Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci (2013) 1.10
MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation. J Cell Sci (2010) 1.09
Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart. Proc Natl Acad Sci U S A (2011) 1.09
Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina. PLoS One (2013) 1.09
C-kit+ cardiac progenitors exhibit mesenchymal markers and preferential cardiovascular commitment. Cardiovasc Res (2010) 1.08
Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg (2002) 1.08
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. J Biol Chem (2003) 1.08
Gene expression profiles in peripheral blood mononuclear cells of chronic heart failure patients. Physiol Genomics (2009) 1.07
HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3. PLoS One (2011) 1.07
Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation. Cancer Res (2010) 1.07
The SDF-1/CXCR4 axis in stem cell preconditioning. Cardiovasc Res (2012) 1.07
Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer. J Gene Med (2004) 1.05
Impaired T- and B-cell development in Tcl1-deficient mice. Blood (2004) 1.04
Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation. Mol Cell Biol (2007) 1.04