Published in Proc Natl Acad Sci U S A on November 01, 1992
Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol (1993) 4.57
Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med (2003) 4.20
Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76
Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol (1994) 3.51
Kinetic and structural analyses of hepatitis C virus polyprotein processing. J Virol (1994) 3.35
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25
Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58
An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol (1995) 1.78
Hepatitis C: progress and problems. Clin Microbiol Rev (1994) 1.37
Virological features of hepatitis C virus infection in hemodialysis patients. J Clin Microbiol (1993) 1.32
Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol (1996) 1.32
Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase. J Virol (1995) 1.31
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA. J Virol (1996) 1.29
A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants. J Virol (1993) 1.23
Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity. J Virol (2001) 1.17
Antigenic structure of the complete nonstructural (NS) 2 and 5 proteins of hepatitis C virus (HCV): anti-HCV NS2 and NS5 antibody reactivities in relation to HCV serotype, presence of HCV RNA, and acute HCV infection. Clin Diagn Lab Immunol (1994) 1.00
Rapid multiplexed immunoassay for simultaneous serodiagnosis of HIV-1 and coinfections. J Clin Microbiol (2011) 0.96
Chimeric Sindbis viruses dependent on the NS3 protease of hepatitis C virus. J Virol (1997) 0.93
Evidence for hepatitis C viral infection in patients with primary hepatocellular carcinoma. West J Med (1994) 0.92
Role of signal-to-cutoff ratios in hepatitis C virus antibody detection. Clin Vaccine Immunol (2012) 0.86
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires. J Virol (1997) 0.84
Artificial mosaic protein containing antigenic epitopes of hepatitis E virus. J Virol (1994) 0.82
Vaccines to prevent chronic hepatitis C virus infection: current experimental and preclinical developments. J Gastroenterol (2007) 0.81
Use of a novel hepatitis C virus (HCV) major-epitope chimeric polypeptide for diagnosis of HCV infection. J Clin Microbiol (1999) 0.81
Design of novel conformational and genotype-specific antigens for improving sensitivity of immunoassays for hepatitis C virus-specific antibodies. J Clin Microbiol (2005) 0.79
Improved reactivity of hepatitis C virus core protein epitopes in a conformational antigen-presenting system. Clin Diagn Lab Immunol (1997) 0.79
Enzyme-linked immunosorbent assay based on a chimeric antigen bearing antigenic regions of structural proteins Erns and E2 for serodiagnosis of classical swine fever virus infection. Clin Diagn Lab Immunol (2005) 0.78
Affinity labeling of hepatitis C virus replicase with a nucleotide analogue: identification of binding site. Biochemistry (2013) 0.77
Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment. J Clin Microbiol (1994) 0.77
Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity. PLoS One (2013) 0.76
Expression and immunoreactivity of an epitope of HCV in a foreign epitope presenting system. World J Gastroenterol (2005) 0.76
Staufen1 promotes HCV replication by inhibiting protein kinase R and transporting viral RNA to the site of translation and replication in the cells. Nucleic Acids Res (2016) 0.75
Improving antigenicity of the recombinant hepatitis C virus core protein via random mutagenesis. J Biomed Biotechnol (2011) 0.75
Antigenic structure of the hepatitis C virus envelope 2 protein. Clin Exp Immunol (1994) 0.75
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79
Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A (1991) 14.05
Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A (1990) 9.98
Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56
Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol (1991) 8.33
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med (1989) 8.10
Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology (1991) 7.33
Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A (1991) 7.15
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 6.96
Production of human beta interferon in insect cells infected with a baculovirus expression vector. Mol Cell Biol (1983) 5.00
Infectivity of blood seropositive for hepatitis C virus antibodies. Lancet (1990) 4.99
Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis. Br Med Bull (1990) 4.16
Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet (1991) 3.97
Hepatitis C virus antibodies among risk groups in Spain. Lancet (1989) 3.66
Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection. JAMA (1990) 3.41
Evaluation of antibodies to hepatitis C virus in a study of transfusion-associated hepatitis. N Engl J Med (1990) 2.50
Modification and secretion of human interleukin 2 produced in insect cells by a baculovirus expression vector. Proc Natl Acad Sci U S A (1985) 2.46
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis. Proc Natl Acad Sci U S A (1990) 2.12
Hepatitis C-associated hepatocellular carcinoma. Hepatology (1990) 2.07
Anti-hepatitis C antibodies and non-A, non-B post-transfusion hepatitis in The Netherlands. Lancet (1989) 1.82
Hepatocellular carcinoma. Diagnostic and prognostic features in North American patients. Cancer (1984) 1.54
A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan. Cancer (1991) 1.45
Serodiagnosis of hepatitis C virus (HCV) infection with an HCV core protein molecularly expressed by a recombinant baculovirus. Proc Natl Acad Sci U S A (1991) 1.36
The role of chronic viral hepatitis in hepatocellular carcinoma in the United States. Am J Gastroenterol (1991) 1.24
Association of hepatitis B virus infection with hepatocellular carcinoma in American patients. Int J Cancer (1980) 1.18
Identification of an immunodominant epitope within the capsid protein of hepatitis C virus. Proc Natl Acad Sci U S A (1991) 1.18
Detection of antibodies to hepatitis C virus in U.S. blood donors. J Clin Microbiol (1991) 1.17
Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay. Transfusion (1990) 1.12
Long-term follow-up of posttransfusion and sporadic chronic hepatitis non-A, non-B and frequency of circulating antibodies to hepatitis C virus (HCV). J Hepatol (1990) 1.09
A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Cancer Res (1986) 1.02
High level expression of proinsulin in the yeast, Saccharomyces cerevisiae. Gene (1987) 0.95
Antibodies to hepatitis C virus in non-A, non-B post-transfusion and cryptogenetic chronic liver disease. Lancet (1989) 0.86
The sequence of the human genome. Science (2001) 101.55
An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79
TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: VII. Factors Causing Acidosis in Chronic Nephritis. A Preliminary Report. J Clin Invest (1926) 14.83
Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A (1991) 14.05
TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: X. The Acidosis of Nephritis. J Clin Invest (1929) 10.24
TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: VI. Studies of Diabetes. J Clin Invest (1925) 9.92
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84
Boron nitride substrates for high-quality graphene electronics. Nat Nanotechnol (2010) 9.72
Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56
Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med (1989) 8.10
Structure, sequence and expression of the hepatitis delta (delta) viral genome. Nature (1986) 7.38
Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology (1991) 7.33
Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res (2001) 7.27
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end. Proc Natl Acad Sci U S A (1991) 7.13
Primary isolation of TRIC organisms in HeLa 229 cells treated with DEAE-dextran. J Infect Dis (1972) 6.85
Evolution and transmission of stable CTL escape mutations in HIV infection. Nature (2001) 6.57
TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XII. A Study of Renal Edema. J Clin Invest (1929) 6.48
Neuroligin 1: a splice site-specific ligand for beta-neurexins. Cell (1995) 5.97
TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene (2007) 5.79
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation (2000) 4.96
Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology (1991) 4.47
Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem (1996) 4.31
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Nucleic Acids Res (1989) 4.29
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res (1995) 4.28
Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet (1996) 4.05
Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data. Am J Med Genet (1999) 3.82
Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med (2001) 3.44
Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet (1989) 3.42
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron (1999) 3.37
Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell (1989) 3.33
A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25
Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J Gen Virol (1993) 3.18
Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1. Cell (1989) 3.11
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol (1998) 3.01
A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta. J Virol (1988) 2.99
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92
Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89
Prevention of corticosteroid osteoporosis. A comparison of calcium, calcitriol, and calcitonin. N Engl J Med (1993) 2.80
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology (2005) 2.79
Criteria for diagnosing Parkinson's disease. Ann Neurol (1992) 2.78
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res (1990) 2.76
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70
Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol (2000) 2.69
The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem Biophys Res Commun (1993) 2.67
HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest (1995) 2.66
TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XI. Hypochloremia and Total Salt Deficiency in Nephritis. J Clin Invest (1929) 2.64
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (1993) 2.59
Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58
Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology (1992) 2.58
Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol (1993) 2.57
Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry (1996) 2.53
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene (2010) 2.53
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene (1995) 2.50
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48
Soybean nodulin genes: Analysis of cDNA clones reveals several major tissue-specific sequences in nitrogen-fixing root nodules. Proc Natl Acad Sci U S A (1983) 2.48
Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron (1998) 2.46
Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology (2000) 2.45
A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet (1998) 2.44
Hepatitis C antibody and chronic liver disease in haemophilia. Lancet (1990) 2.44
Developing and deploying a patient safety program in a large health care delivery system: you can't fix what you don't know about. Jt Comm J Qual Improv (2001) 2.42
Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain (2000) 2.41
The human olfactory receptor repertoire. Genome Biol (2001) 2.41
T-lymphocyte response to hepatitis C virus in different clinical courses of infection. Gastroenterology (1993) 2.39
Gastric distention: a mechanism for postprandial gastroesophageal reflux. Gastroenterology (1985) 2.37
Differentiation of TRIC and LGV organisms based on enhancement of infectivity by DEAE-dextran in cell culture. J Infect Dis (1972) 2.36
Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology (2000) 2.34
The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study. BJU Int (2003) 2.32
Effect of a media-led education campaign on breast and cervical cancer screening among Vietnamese-American women. Prev Med (1999) 2.28
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res (2000) 2.28
Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. Mol Cell Biol (2001) 2.26
Structure of two related rat pancreatic trypsin genes. J Biol Chem (1984) 2.24
Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology (2010) 2.21
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A (2000) 2.20
Women's Health Australia: recruitment for a national longitudinal cohort study. Women Health (1998) 2.16
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis. Proc Natl Acad Sci U S A (1990) 2.12
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene (1990) 2.12
Characterization of apelin, the ligand for the APJ receptor. J Neurochem (2000) 2.11
Evidence-based recommendations for the use of Negative Pressure Wound Therapy in traumatic wounds and reconstructive surgery: steps towards an international consensus. Injury (2011) 2.07
Hepatitis C-associated hepatocellular carcinoma. Hepatology (1990) 2.07
Effect of vitamin D receptor gene alleles on bone loss in early rheumatoid arthritis. J Rheumatol (1998) 2.05
Analgesia nociception index: evaluation as a new parameter for acute postoperative pain. Br J Anaesth (2013) 2.04
CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med (2000) 2.02
Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas. Ann Surg Oncol (2001) 2.01