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1
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
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Nature
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2008
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18.20
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2
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Regulation of progenitor cell proliferation and granulocyte function by microRNA-223.
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Nature
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2008
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8.69
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3
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Recurrent BRAF mutations in Langerhans cell histiocytosis.
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Blood
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2010
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4.96
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4
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Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
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Diabetes
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2010
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4.07
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5
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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).
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Nat Genet
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2008
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4.02
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6
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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.
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Blood
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2002
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3.93
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7
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Immortalization and transformation of primary human airway epithelial cells by gene transfer.
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Oncogene
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2002
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3.80
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8
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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.
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Nat Genet
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2005
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3.28
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9
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A mouse model of juvenile hemochromatosis.
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J Clin Invest
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2005
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3.25
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10
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Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5.
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Cancer Cell
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2002
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2.51
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11
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The Steap proteins are metalloreductases.
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Blood
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2006
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2.37
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12
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Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia.
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Nat Genet
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2009
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2.37
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13
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Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.
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Development
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2010
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2.31
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14
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Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.
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Blood
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2010
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2.20
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15
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Lymphomas of the breast: primary and secondary involvement.
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Cancer
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2002
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2.06
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16
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Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
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Nature
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2008
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1.95
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17
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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.
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Blood
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2012
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1.94
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18
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Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.
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Blood
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2010
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1.86
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19
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T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.
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Cancer Cell
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2010
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1.85
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20
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Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.
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Blood
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2008
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1.78
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21
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Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway.
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Blood
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2005
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1.63
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22
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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.
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Blood
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2011
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1.49
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23
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The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.
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Hum Mol Genet
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2006
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1.47
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24
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Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.
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EMBO J
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2006
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1.43
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25
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Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations.
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Pediatr Blood Cancer
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2010
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1.43
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26
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Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice.
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Blood
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2010
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1.41
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27
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nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse.
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Blood
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2005
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1.38
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28
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X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation.
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Blood
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2007
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1.38
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29
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Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.
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Blood
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2006
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1.28
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30
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Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.
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J Clin Invest
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2005
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1.26
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31
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Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.
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Mol Cell Biol
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2007
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1.26
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32
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AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.
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Blood
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2005
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1.25
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33
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SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness.
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Blood
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2004
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1.23
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34
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Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.
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Nat Genet
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2007
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1.23
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35
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Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.
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Blood
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2005
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1.16
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36
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A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.
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Nat Genet
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2005
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1.16
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37
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Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma.
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J Clin Oncol
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2006
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1.15
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38
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The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.
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Cell Metab
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2013
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1.14
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39
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Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation.
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Biol Blood Marrow Transplant
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2010
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1.13
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40
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Induced pluripotent stem cells with a mitochondrial DNA deletion.
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Stem Cells
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2013
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1.13
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41
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HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis.
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Cell Metab
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2013
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1.09
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42
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Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
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Nature
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2012
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1.09
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43
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Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
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Blood
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2008
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1.05
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44
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Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle.
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Proc Natl Acad Sci U S A
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2008
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1.04
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45
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CD4+/CD56+ hematodermic neoplasm ("blastic natural killer cell lymphoma"): neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon.
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Am J Clin Pathol
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2007
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1.03
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46
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Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
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Blood
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2010
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1.03
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47
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A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD).
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Blood
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2013
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1.03
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48
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Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia.
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Cancer
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2013
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0.99
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49
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In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.
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Haematologica
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2004
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0.98
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50
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Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
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Mol Cell Biol
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2009
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0.97
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51
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Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2.
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Mol Genet Metab
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2003
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0.97
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52
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Heme transport and erythropoiesis.
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Curr Opin Chem Biol
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2013
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0.94
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53
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Femoral artery calcification as a determinant of success for percutaneous access for endovascular abdominal aortic aneurysm repair.
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J Vasc Surg
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2013
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0.93
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54
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Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.
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Am J Hematol
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2015
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0.93
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55
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Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.
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J Invest Dermatol
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2006
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0.92
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56
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Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression.
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Am J Surg Pathol
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2014
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0.92
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57
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High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma.
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Cancer Res
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2013
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0.90
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58
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Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.
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Am J Hematol
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2012
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0.90
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59
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Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia.
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Biol Reprod
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2011
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0.89
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60
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Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia.
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Am J Hematol
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2015
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0.89
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61
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Identification of a novel mutation (C321X) in HJV.
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Blood
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2004
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0.88
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62
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Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial.
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Leuk Lymphoma
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2010
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0.87
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63
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Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.
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Blood
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2005
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0.87
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64
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Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors.
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Am J Hematol
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2015
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0.86
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65
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High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine.
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Anal Chem
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2010
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0.86
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66
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Characterization of mitochondrial ferritin-deficient mice.
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Am J Hematol
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2010
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0.83
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67
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X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations.
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Am J Hematol
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2013
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0.83
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68
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Design and validation of a high-throughput matrix-assisted laser desorption ionization time-of-flight mass spectrometry method for quantification of hepcidin in human plasma.
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Anal Chem
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2011
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0.82
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69
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SBDS protein expression patterns in the bone marrow.
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Pediatr Blood Cancer
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2010
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0.82
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70
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Hereditary xerocytosis revisited.
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Am J Hematol
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2014
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0.82
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71
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Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice.
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Haematologica
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2011
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0.82
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72
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Pathology of the liver in familial hemophagocytic lymphohistiocytosis.
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Am J Surg Pathol
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2010
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0.81
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73
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Extrahepatic portal vein aneurysm.
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J Vasc Surg
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2010
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0.80
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74
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QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines.
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Mamm Genome
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2012
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0.80
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75
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Spinal cord protection during open repair of thoracic and thoracoabdominal aortic aneurysms using profound hypothermia and circulatory arrest.
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J Am Coll Surg
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2011
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0.80
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76
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The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site.
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J Biol Chem
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2013
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0.80
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77
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Identification and characterization of a novel murine allele of Tmprss6.
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Haematologica
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2013
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0.80
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78
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Mutations in the serum/glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse fuzzy (fz) hair phenotype.
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J Invest Dermatol
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2007
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0.78
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79
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A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.
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Comp Med
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2013
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0.78
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80
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A tincture of hepcidin cures all: the potential for hepcidin therapeutics.
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J Clin Invest
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2010
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0.78
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81
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hem6: an ENU-induced recessive hypochromic microcytic anemia mutation in the mouse.
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Blood
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2008
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0.77
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82
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Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
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Am J Hematol
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2008
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0.75
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83
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Radioactive seed localization for excision of non-palpable in-transit metastatic melanoma.
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Radiol Case Rep
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2015
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0.75
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84
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Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances.
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Biochim Biophys Acta
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2012
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0.75
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85
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Percutaneous removal of a Bard Simon nitinol permanent inferior vena cava filter.
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Perspect Vasc Surg Endovasc Ther
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2013
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0.75
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