Published in Proc Natl Acad Sci U S A on May 21, 2008
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A (2010) 2.02
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A (2010) 1.99
Iron homeostasis and the inflammatory response. Annu Rev Nutr (2010) 1.40
The unique kinetics of iron release from transferrin: the role of receptor, lobe-lobe interactions, and salt at endosomal pH. J Mol Biol (2009) 1.07
Structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications. J Biol Chem (2009) 1.03
Out of balance--systemic iron homeostasis in iron-related disorders. Nutrients (2013) 0.92
Iron Homeostasis in Health and Disease. Int J Mol Sci (2016) 0.89
Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab (2012) 0.86
Iron transport machinery of human cells: players and their interactions. Curr Top Membr (2012) 0.82
Cellular transport and homeostasis of essential and nonessential metals. Metallomics (2012) 0.82
Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins. J Biol Chem (2015) 0.81
Iron regulation by hepatocytes and free radicals. J Clin Biochem Nutr (2011) 0.81
The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. J Biol Chem (2013) 0.80
Exploring the Fe(III) binding sites of human serum transferrin with EPR at 275 GHz. J Biol Inorg Chem (2014) 0.78
dissectHMMER: a HMMER-based score dissection framework that statistically evaluates fold-critical sequence segments for domain fold similarity. Biol Direct (2015) 0.78
Fe(III) Is Essential for Porcine Embryonic Development via Mitochondrial Function Maintenance. PLoS One (2015) 0.76
Human STEAP3 mutations with no phenotypic red cell changes. Blood (2015) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
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Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52
Maximum-likelihood density modification. Acta Crystallogr D Biol Crystallogr (2000) 20.67
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr (2006) 14.21
Automated main-chain model building by template matching and iterative fragment extension. Acta Crystallogr D Biol Crystallogr (2002) 10.34
Macromolecular TLS refinement in REFMAC at moderate resolutions. Methods Enzymol (2003) 9.69
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Disorders of iron metabolism. N Engl J Med (1999) 7.49
Hereditary hemochromatosis--a new look at an old disease. N Engl J Med (2004) 4.42
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J (1981) 2.68
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci U S A (2005) 2.67
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta (1997) 2.38
The Steap proteins are metalloreductases. Blood (2006) 2.37
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell (2007) 2.35
Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med (2006) 2.25
STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors. Proc Natl Acad Sci U S A (1999) 1.96
Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol (2001) 1.84
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood (2005) 1.38
Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound. EMBO J (2001) 1.17
In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer. Cancer Res (2007) 1.16
Non-HFE hemochromatosis. Hepatology (2004) 1.16
ACRATA: a novel electron transfer domain associated to apoptosis and cancer. BMC Cancer (2004) 1.00
STEAP, a prostate tumor antigen, is a target of human CD8+ T cells. Cancer Immunol Immunother (2006) 0.93
Monoclonal antibodies to six-transmembrane epithelial antigen of the prostate-1 inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo. Cancer Res (2007) 0.93
The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood (2003) 0.90
Theoretical investigation of the [1,2]-sigmatropic hydrogen migration in the mechanism of oxidation of 2-aminobenzoyl-CoA by 2-aminobenzoyl-CoA monooxygenase/reductase. Proc Natl Acad Sci U S A (1999) 0.89
[Human iron deficiency]. Bull Acad Natl Med (2005) 0.86
Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner. Cancer Res (2007) 0.86
STAMPing out Inflammation. Cell (2007) 0.84
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood (2010) 4.96
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nat Genet (2008) 4.02
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood (2002) 3.93
Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80
CRISPR-mediated adaptive immune systems in bacteria and archaea. Annu Rev Biochem (2013) 3.55
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
A mouse model of juvenile hemochromatosis. J Clin Invest (2005) 3.25
Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE). J Biol Chem (2011) 2.86
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell (2002) 2.51
The Steap proteins are metalloreductases. Blood (2006) 2.37
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet (2009) 2.37
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development (2010) 2.31
Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses. Proc Natl Acad Sci U S A (2005) 2.26
Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. Blood (2010) 2.20
Lymphomas of the breast: primary and secondary involvement. Cancer (2002) 2.06
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood (2012) 1.94
Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood (2010) 1.86
T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell (2010) 1.85
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood (2005) 1.63
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice. Blood (2011) 1.49
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet (2006) 1.47
Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. EMBO J (2006) 1.43
Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer (2010) 1.43
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood (2010) 1.41
X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation. Blood (2007) 1.38
nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood (2005) 1.38
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood (2006) 1.28
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest (2005) 1.26
Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1. Mol Cell Biol (2007) 1.26
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Nat Genet (2007) 1.23
SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness. Blood (2004) 1.23
A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus. Virology (2007) 1.20
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nat Genet (2005) 1.16
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood (2005) 1.16
The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system. J Mol Biol (2010) 1.16
Structure of A197 from Sulfolobus turreted icosahedral virus: a crenarchaeal viral glycosyltransferase exhibiting the GT-A fold. J Virol (2006) 1.15
Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. J Clin Oncol (2006) 1.15
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation. Biol Blood Marrow Transplant (2010) 1.13
Induced pluripotent stem cells with a mitochondrial DNA deletion. Stem Cells (2013) 1.13
A new DNA binding protein highly conserved in diverse crenarchaeal viruses. Virology (2007) 1.12
Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120. J Virol (2005) 1.10
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab (2013) 1.09
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature (2012) 1.09
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood (2008) 1.05
Cysteine usage in Sulfolobus spindle-shaped virus 1 and extension to hyperthermophilic viruses in general. Virology (2008) 1.05
Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress. PLoS One (2009) 1.05
Structure of the DPS-like protein from Sulfolobus solfataricus reveals a bacterioferritin-like dimetal binding site within a DPS-like dodecameric assembly. Biochemistry (2006) 1.04
CD4+/CD56+ hematodermic neoplasm ("blastic natural killer cell lymphoma"): neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon. Am J Clin Pathol (2007) 1.03
Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood (2010) 1.03
A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers, and developmental delay (SIFD). Blood (2013) 1.03
Structure of D-63 from sulfolobus spindle-shaped virus 1: surface properties of the dimeric four-helix bundle suggest an adaptor protein function. J Virol (2004) 1.01
Impact of hemochromatosis gene mutations on cardiac status in doxorubicin-treated survivors of childhood high-risk leukemia. Cancer (2013) 0.99
Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography. Proc Natl Acad Sci U S A (2013) 0.98
In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica (2004) 0.98
Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol (2009) 0.97
Male infertility and thiamine-dependent erythroid hypoplasia in mice lacking thiamine transporter Slc19a2. Mol Genet Metab (2003) 0.97
Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein. J Virol (2004) 0.95
Structural studies of E73 from a hyperthermophilic archaeal virus identify the "RH3" domain, an elaborated ribbon-helix-helix motif involved in DNA recognition. Biochemistry (2012) 0.94
Dps-like protein from the hyperthermophilic archaeon Pyrococcus furiosus. J Inorg Biochem (2006) 0.94
Heme transport and erythropoiesis. Curr Opin Chem Biol (2013) 0.94
Femoral artery calcification as a determinant of success for percutaneous access for endovascular abdominal aortic aneurysm repair. J Vasc Surg (2013) 0.93
Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis. Am J Hematol (2015) 0.93
Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin. J Invest Dermatol (2006) 0.92
PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol (2010) 0.92
Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression. Am J Surg Pathol (2014) 0.92
High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res (2013) 0.90
Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. Am J Hematol (2012) 0.90
Equilibrium between metarhodopsin-I and metarhodopsin-II is dependent on the conformation of the third cytoplasmic loop. J Biol Chem (2005) 0.89
Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Biol Reprod (2011) 0.89
Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia. Am J Hematol (2015) 0.89
Identification of a novel mutation (C321X) in HJV. Blood (2004) 0.88
The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily. J Virol (2010) 0.88
Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial. Leuk Lymphoma (2010) 0.87
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Blood (2005) 0.87
Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors. Am J Hematol (2015) 0.86
High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine. Anal Chem (2010) 0.86
Fossil record of an archaeal HK97-like provirus. Virology (2011) 0.84
Characterization of mitochondrial ferritin-deficient mice. Am J Hematol (2010) 0.83
X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations. Am J Hematol (2013) 0.83
Design and validation of a high-throughput matrix-assisted laser desorption ionization time-of-flight mass spectrometry method for quantification of hepcidin in human plasma. Anal Chem (2011) 0.82
Characterization of the Bacteroides fragilis bfr gene product identifies a bacterial DPS-like protein and suggests evolutionary links in the ferritin superfamily. J Bacteriol (2011) 0.82
Hereditary xerocytosis revisited. Am J Hematol (2014) 0.82
SBDS protein expression patterns in the bone marrow. Pediatr Blood Cancer (2010) 0.82
Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice. Haematologica (2011) 0.82
Pathology of the liver in familial hemophagocytic lymphohistiocytosis. Am J Surg Pathol (2010) 0.81
The structure of an archaeal viral integrase reveals an evolutionarily conserved catalytic core yet supports a mechanism of DNA cleavage in trans. J Virol (2012) 0.81
Extrahepatic portal vein aneurysm. J Vasc Surg (2010) 0.80
Identification and characterization of a novel murine allele of Tmprss6. Haematologica (2013) 0.80
QTLs for murine red blood cell parameters in LG/J and SM/J F(2) and advanced intercross lines. Mamm Genome (2012) 0.80
The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site. J Biol Chem (2013) 0.80
Spinal cord protection during open repair of thoracic and thoracoabdominal aortic aneurysms using profound hypothermia and circulatory arrest. J Am Coll Surg (2011) 0.80
Mutations in the serum/glucocorticoid regulated kinase 3 (Sgk3) are responsible for the mouse fuzzy (fz) hair phenotype. J Invest Dermatol (2007) 0.78