Published in Mol Cell on May 23, 2008
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell (2010) 17.87
The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet (2010) 15.87
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46
MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet (2012) 5.38
Revisiting the principles of microRNA target recognition and mode of action. Nat Rev Mol Cell Biol (2009) 4.38
microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J (2008) 4.24
starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res (2010) 3.99
Desperately seeking microRNA targets. Nat Struct Mol Biol (2010) 3.85
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J (2011) 3.55
MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov (2013) 3.33
Experimental strategies for microRNA target identification. Nucleic Acids Res (2011) 3.00
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
microRNA involvement in human cancer. Carcinogenesis (2012) 2.98
Evolution of microRNA diversity and regulation in animals. Nat Rev Genet (2011) 2.92
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res (2010) 2.82
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. Nat Rev Drug Discov (2012) 2.65
MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A (2010) 2.58
New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. Genome Res (2009) 2.56
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A (2012) 2.39
MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol (2011) 2.25
MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle (2010) 2.18
Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA (2009) 2.15
MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol (2011) 2.15
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J (2013) 2.01
Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet (2011) 2.00
An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem (2009) 1.90
The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res (2010) 1.88
Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. BMC Genomics (2010) 1.84
Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res (2011) 1.84
A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs. PLoS Pathog (2010) 1.82
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
MicroRNAs and the regulation of fibrosis. FEBS J (2010) 1.79
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene (2011) 1.76
Context-dependent functions of specific microRNAs in neuronal development. Neural Dev (2010) 1.74
Aberrant expression of microRNAs in bladder cancer. Nat Rev Urol (2013) 1.74
Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells. BMC Cancer (2010) 1.72
Dicer is regulated by cellular stresses and interferons. Mol Immunol (2008) 1.69
miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components. Nucleic Acids Res (2011) 1.67
MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62
MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation. PLoS One (2013) 1.62
Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev (2011) 1.62
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62
MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders. Curr Genomics (2009) 1.60
miR-34: from bench to bedside. Oncotarget (2014) 1.59
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation. Int J Genomics (2014) 1.54
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol (2010) 1.54
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res (2011) 1.53
Causes and consequences of microRNA dysregulation. Cancer J (2012) 1.51
microRNAs and cholesterol metabolism. Trends Endocrinol Metab (2010) 1.49
An overview of microRNAs. Adv Drug Deliv Rev (2015) 1.48
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame. RNA (2010) 1.46
Emerging role of microRNAs in liver diseases. World J Gastroenterol (2009) 1.45
The complexity of miRNA-mediated repression. Cell Death Differ (2014) 1.44
MicroRNAs: critical mediators of differentiation, development and disease. Swiss Med Wkly (2009) 1.43
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest (2012) 1.43
Human Ago2 is required for efficient microRNA 122 regulation of hepatitis C virus RNA accumulation and translation. J Virol (2010) 1.42
Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Mol Biol (2009) 1.42
miR-490-3p modulates cell growth and epithelial to mesenchymal transition of hepatocellular carcinoma cells by targeting endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3). J Biol Chem (2012) 1.39
A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. PLoS Biol (2010) 1.39
Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm (2016) 1.39
miRNA regulation of cytokine genes. Cytokine (2009) 1.39
Small RNA and transcriptional upregulation. Wiley Interdiscip Rev RNA (2011) 1.36
Novel classes of non-coding RNAs and cancer. J Transl Med (2012) 1.35
Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell lines. PLoS One (2009) 1.35
Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis. PLoS Pathog (2011) 1.33
Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol (2010) 1.32
Tandem affinity purification of miRNA target mRNAs (TAP-Tar). Nucleic Acids Res (2009) 1.32
miRTar: an integrated system for identifying miRNA-target interactions in human. BMC Bioinformatics (2011) 1.30
The role of microRNAs in cholesterol efflux and hepatic lipid metabolism. Annu Rev Nutr (2011) 1.30
Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. RNA (2008) 1.29
5' isomiR variation is of functional and evolutionary importance. Nucleic Acids Res (2014) 1.28
microRNAs in heart disease: putative novel therapeutic targets? Eur Heart J (2010) 1.27
Abundant conserved microRNA target sites in the 5'-untranslated region and coding sequence. Genetica (2009) 1.26
Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome. Epigenetics (2010) 1.26
Promises and challenges of MicroRNA-based treatment of multiple myeloma. Curr Cancer Drug Targets (2012) 1.26
MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS One (2012) 1.25
MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro. Oncogene (2010) 1.25
RNA binding protein/RNA element interactions and the control of translation. Curr Protein Pept Sci (2012) 1.24
General principals of miRNA biogenesis and regulation in the brain. Neuropsychopharmacology (2012) 1.23
MicroRNA Processing and Human Cancer. J Clin Med (2015) 1.23
MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med (2009) 1.22
Computational methods to identify miRNA targets. Semin Cell Dev Biol (2010) 1.21
miRNA-transcription factor interactions: a combinatorial regulation of gene expression. Mol Genet Genomics (2013) 1.21
miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death. Mol Cancer (2012) 1.21
miR-10a contributes to retinoid acid-induced smooth muscle cell differentiation. J Biol Chem (2010) 1.21
A systematic analysis of the skeletal muscle miRNA transcriptome of chicken varieties with divergent skeletal muscle growth identifies novel miRNAs and differentially expressed miRNAs. BMC Genomics (2011) 1.20
The impact of microRNAs on colorectal cancer. Virchows Arch (2009) 1.20
MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications. ScientificWorldJournal (2013) 1.16
Insect microRNAs: biogenesis, expression profiling and biological functions. Insect Biochem Mol Biol (2012) 1.15
Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile. Cell Rep (2013) 1.15
Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression. Brief Funct Genomics (2010) 1.14
The Impact of MicroRNAs on Brain Aging and Neurodegeneration. Curr Gerontol Geriatr Res (2012) 1.14
MicroRNAs and HIV-1: complex interactions. J Biol Chem (2012) 1.13
MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cells. PLoS One (2012) 1.13
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem (2007) 7.46
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06
LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene (2006) 3.49
MicroRNA and cancer. Mol Oncol (2012) 3.10
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A (2005) 2.81
miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67
Ascertainment biases in SNP chips affect measures of population divergence. Mol Biol Evol (2010) 2.56
NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev (2008) 2.26
Relatedness mapping and tracts of relatedness for genome-wide data in the presence of linkage disequilibrium. Genet Epidemiol (2009) 2.02
microRNA-101 is a potent inhibitor of autophagy. EMBO J (2011) 2.00
Quantitative miRNA expression analysis: comparing microarrays with next-generation sequencing. RNA (2009) 1.96
A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nat Protoc (2009) 1.95
MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle (2011) 1.89
The transcriptional program of terminal granulocytic differentiation. Blood (2004) 1.80
A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation. Dev Cell (2012) 1.72
Isolation of microRNA targets using biotinylated synthetic microRNAs. Methods (2007) 1.69
MicroRNA-145 targets YES and STAT1 in colon cancer cells. PLoS One (2010) 1.64
MicroRNA regulation of autophagy. Carcinogenesis (2012) 1.56
miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer (2011) 1.46
Experimental identification of microRNA targets. Gene (2009) 1.36
PRDM proteins: important players in differentiation and disease. Bioessays (2011) 1.28
Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood. J Bone Miner Metab (2007) 1.26
microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus. Sci Rep (2013) 1.18
Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability. Nucleic Acids Res (2004) 1.17
MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats. PLoS One (2009) 1.16
MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells. BMC Cancer (2012) 1.16
Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res (2009) 1.14
Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma. J Mol Endocrinol (2012) 1.10
MicroRNA 10a marks regulatory T cells. PLoS One (2012) 1.09
Chromatin-modifying proteins in cancer. APMIS (2007) 1.04
Hereditary non-polyposis colorectal cancer (HNPCC): phenotype-genotype correlation between patients with and without identified mutation. Hum Mutat (2002) 1.03
Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses. J Clin Invest (2014) 1.03
ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice. Am J Pathol (2002) 1.03
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res (2010) 1.02
Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn's disease. Scand J Gastroenterol (2007) 0.98
Microarray-based classification of diffuse large B-cell lymphoma. Eur J Haematol (2005) 0.97
The miR-10 microRNA precursor family. RNA Biol (2011) 0.97
De novo mutations in familial adenomatous polyposis (FAP). Eur J Hum Genet (2002) 0.96
microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer. Mol Cancer (2012) 0.95
Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1). Nucleic Acids Res (2007) 0.94
Gene expression profiling of placentas affected by pre-eclampsia. J Biomed Biotechnol (2010) 0.93
Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis. J Neurochem (2005) 0.93
Functional analysis of HNPCC-related missense mutations in MSH2. Mutat Res (2008) 0.93
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth. J Cell Sci (2013) 0.91
Loss of miR-10a activates lpo and collaborates with activated Wnt signaling in inducing intestinal neoplasia in female mice. PLoS Genet (2013) 0.91
Nuclear translocation contributes to regulation of DNA excision repair activities. DNA Repair (Amst) (2009) 0.90
Personalized oncology: genomic screening in phase 1. APMIS (2014) 0.89
Identification of expressed and conserved human noncoding RNAs. RNA (2013) 0.89
A maternal low protein diet has pronounced effects on mitochondrial gene expression in offspring liver and skeletal muscle; protective effect of taurine. J Biomed Sci (2010) 0.89
Molecular signatures of thyroid follicular neoplasia. Endocr Relat Cancer (2010) 0.88
Gestational protein restriction in mice has pronounced effects on gene expression in newborn offspring's liver and skeletal muscle; protective effect of taurine. Pediatr Res (2010) 0.88
Influence of smoking on colonic gene expression profile in Crohn's disease. PLoS One (2009) 0.88
The BTNL2 A allele variant is frequent in Danish patients with sarcoidosis. Clin Respir J (2011) 0.88
Deregulated genes in sporadic vestibular schwannomas. Otol Neurotol (2010) 0.87
Differential expression of cellular microRNAs in HPV 11, -16, and -45 transfected cells. Biochem Biophys Res Commun (2011) 0.86
Prognostic significance of metallothionein in B-cell lymphomas. Blood (2006) 0.86
MiR-492 impairs the angiogenic potential of endothelial cells. J Cell Mol Med (2013) 0.86
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst) (2012) 0.85
Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. J Neurosci Res (2007) 0.85
Characterization of miRNA expression in human degenerative lumbar disks. Connect Tissue Res (2013) 0.85
Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR. Biochem Biophys Res Commun (2010) 0.85
IMP3 expression in human ovarian cancer is associated with improved survival. Int J Gynecol Pathol (2009) 0.85
Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Dev Neurobiol (2008) 0.84
Clinical phenotype and gene expression profile in Crohn's disease. Am J Physiol Gastrointest Liver Physiol (2006) 0.84
Polyposis and early cancer in a patient with low penetrant mutations in MSH6 and APC: hereditary colorectal cancer as a polygenic trait. Int J Colorectal Dis (2006) 0.84
miRConnect: identifying effector genes of miRNAs and miRNA families in cancer cells. PLoS One (2011) 0.82
Integrative analyses reveal novel strategies in HPV11,-16 and -45 early infection. Sci Rep (2012) 0.82
Target-cell-derived tRNA-like primers for reverse transcription support retroviral infection at low efficiency. Virology (2002) 0.81
Na(v)1.8 channelopathy in mutant mice deficient for myelin protein zero is detrimental to motor axons. Brain (2010) 0.81
Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus. Retrovirology (2007) 0.81
Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer. Mutat Res (2005) 0.80
Frequency of the HFE C282Y and H63D mutations in Danish patients with clinical haemochromatosis initially diagnosed by phenotypic methods. Eur J Haematol (2003) 0.79
Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I + II knockout mice. J Neurosci Res (2006) 0.78
Treatment response and colonic gene expression in patients with Crohn's disease. Scand J Gastroenterol (2007) 0.78
Embryonic expression of Drosophila IMP in the developing CNS and PNS. Gene Expr Patterns (2008) 0.78
The synthetic NCAM-derived peptide, FGL, modulates the transcriptional response to traumatic brain injury. Neurosci Lett (2008) 0.78
Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome. Proc Natl Acad Sci U S A (2013) 0.78
Blau syndrome-associated mutations in exon 4 of the caspase activating recruitment domain 15 (CARD 15) gene are not found in ethnic Danes with sarcoidosis. Clin Respir J (2007) 0.77
Frequency of the hemochromatosis HFE mutations C282Y, H63D, and S65C in blood donors in the Faroe Islands. Ann Hematol (2004) 0.77
Microarrays and Crohn's disease: collecting reliable information. Scand J Gastroenterol (2005) 0.77
PRDM11 is dispensable for the maintenance and function of hematopoietic stem and progenitor cells. Stem Cell Res (2013) 0.77
Gene expression in the human endolymphatic sac: the solute carrier molecules in endolymphatic fluid homeostasis. Otol Neurotol (2015) 0.77
CARD15 status and familial predisposition for Crohn's disease and colonic gene expression. Dig Dis Sci (2007) 0.77
Epigenetic dynamics across the cell cycle. Essays Biochem (2010) 0.76
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Neuronal Fibers and Neurotransmitter Receptor Expression in the Human Endolymphatic Sac. Otol Neurotol (2017) 0.75
Unexpectedly high but still asymptomatic iron overload in a patient with pyruvate kinase deficiency. Hematol J (2004) 0.75
Functional characterization of MLH1 missense variants identified in Lynch syndrome patients. Hum Mutat (2012) 0.75
Modeling tissue contamination to improve molecular identification of the primary tumor site of metastases. Bioinformatics (2014) 0.75
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