Zebrafish as a cancer model.

Quantitative proteomics by metabolic labeling of model organisms. Mol Cell Proteomics (2009) 1.42

The zebrafish as a model for cancer. Dis Model Mech (2010) 1.25

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era. Dis Model Mech (2014) 1.14

Behaviour of telomere and telomerase during aging and regeneration in zebrafish. PLoS One (2011) 1.12

Models for prevention and treatment of cancer: problems vs promises. Biochem Pharmacol (2009) 1.04

A new hypothesis for the cancer mechanism. Cancer Metastasis Rev (2012) 1.03

Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics (2010) 0.99

Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proc Natl Acad Sci U S A (2010) 0.96

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma. Mol Cancer Res (2009) 0.96

Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech (2010) 0.95

Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. J Neurosci Res (2011) 0.94

Constructing a fish metabolic network model. Genome Biol (2010) 0.91

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates. Dev Comp Immunol (2010) 0.90

Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish. J Biol Chem (2010) 0.90

Mutations in LRRC50 predispose zebrafish and humans to seminomas. PLoS Genet (2013) 0.87

Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One (2013) 0.86

A new model system swims into focus: using the zebrafish to visualize intestinal metabolism in vivo. Clin Lipidol (2009) 0.85

Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PLoS One (2011) 0.85

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Med Genomics (2011) 0.84

Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research. Oral Oncol (2009) 0.83

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res (2015) 0.83

The Study of Glioma by Xenotransplantation in Zebrafish Early Life Stages. J Histochem Cytochem (2015) 0.82

Aquatic animal models of human disease: selected papers and recommendations from the 4th Conference. Comp Biochem Physiol C Toxicol Pharmacol (2008) 0.81

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia. Haematologica (2014) 0.80

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS One (2013) 0.80

Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials. Drug Discov Today (2012) 0.80

In vivo angiogenesis screening and mechanism of action of novel tanshinone derivatives produced by one-pot combinatorial modification of natural tanshinone mixture from Salvia miltiorrhiza. PLoS One (2014) 0.80

AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING. Proc IEEE Int Symp Biomed Imaging (2013) 0.80

Activity of Antibiotics against Mycobacterium Species Commonly Found in Laboratory Zebrafish. J Aquat Anim Health (2015) 0.80

"Casting" light on the role of glycosylation during embryonic development: insights from zebrafish. Glycoconj J (2012) 0.79

A novel zebrafish embryo xenotransplantation model to study primary human fibroblast motility in health and disease. Zebrafish (2012) 0.79

Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget (2014) 0.79

A fresh look at zebrafish from the perspective of cancer research. J Exp Clin Cancer Res (2015) 0.78

Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.78

Zebrafish and Medaka: new model organisms for modern biomedical research. J Biomed Sci (2016) 0.78

Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Dis Model Mech (2011) 0.78

The Zebrafish as a Tool to Cancer Drug Discovery. Austin J Pharmacol Ther (2015) 0.78

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish. Dis Model Mech (2013) 0.78

Transgenic expression of walleye dermal sarcoma virus rv-cyclin (orfA) in zebrafish does not result in tissue proliferation. Mar Biotechnol (NY) (2010) 0.77

A proteoliposome containing apolipoprotein A-I mutant (V156K) enhances rapid tumor regression activity of human origin oncolytic adenovirus in tumor-bearing zebrafish and mice. Mol Cells (2012) 0.77

Loss of wwox expression in zebrafish embryos causes edema and alters Ca(2+) dynamics. PeerJ (2015) 0.77

Murine Tumor Models for Oncolytic Rhabdo-Virotherapy. ILAR J (2016) 0.77

Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1). PLoS One (2013) 0.77

Zebrafish xenotransplantation as a tool for in vivo cancer study. Fam Cancer (2015) 0.76

Infection, Inflammation and Healing in Zebrafish: Intestinal Inflammation. Curr Pathobiol Rep (2015) 0.76

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1. Oncotarget (2016) 0.76

Manipulating galectin expression in zebrafish (Danio rerio). Methods Mol Biol (2015) 0.76

The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochim Biophys Acta (2015) 0.75

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genet (2016) 0.75

Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin. Dis Aquat Organ (2015) 0.75

ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN. Green Chem (2016) 0.75

Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio). J Vis Exp (2016) 0.75

Antibiotic treatment of zebrafish mycobacteriosis: tolerance and efficacy of treatments with tigecycline and clarithromycin. J Fish Dis (2017) 0.75

Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24

Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57

Progress and prospects in rat genetics: a community view. Nat Genet (2008) 6.01

Mammalian mirtron genes. Mol Cell (2007) 5.75

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. Genome Res (2006) 5.23

The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97

Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods (2009) 4.34

Approaches to microRNA discovery. Nat Genet (2006) 4.32

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97

Disclosure of individual genetic data to research participants: the debate reconsidered. Trends Genet (2010) 3.83

Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61

A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature (2013) 3.52

Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries. Nucleic Acids Res (2010) 3.23

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02

SNP and haplotype mapping for genetic analysis in the rat. Nat Genet (2008) 2.96

The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89

Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms. Cell Rep (2012) 2.67

Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45

Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline. Hum Mol Genet (2011) 2.43

Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology. J Clin Oncol (2013) 2.36

Genetic variation in the zebrafish. Genome Res (2006) 2.22

Distribution and functional impact of DNA copy number variation in the rat. Nat Genet (2008) 2.20

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol (2011) 2.11

Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94

Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans. Curr Biol (2008) 1.80

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nat Methods (2010) 1.77

Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes. Genome Biol (2014) 1.66

Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res (2011) 1.64

Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res (2009) 1.64

Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics (2006) 1.60

CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res (2003) 1.57

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat. Cell (2013) 1.53

Dominant missense mutations in ABCC9 cause Cantú syndrome. Nat Genet (2012) 1.50

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obesity (Silver Spring) (2011) 1.50

Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biol (2009) 1.46

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Genome Res (2010) 1.45

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol (2011) 1.45

Single nucleotide polymorphisms associated with rat expressed sequences. Genome Res (2004) 1.43

Systematic biases in DNA copy number originate from isolation procedures. Genome Biol (2013) 1.39

Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing. Nat Protoc (2011) 1.36

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30

Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol (2006) 1.30

Target-selected mutagenesis of the rat. Genomics (2004) 1.26

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Res (2011) 1.26

GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics (2002) 1.25

CONREAL web server: identification and visualization of conserved transcription factor binding sites. Nucleic Acids Res (2005) 1.25

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development (2010) 1.23

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq. Bioinformatics (2010) 1.18

Small RNA expression and strain specificity in the rat. BMC Genomics (2010) 1.16

Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. Genome Res (2013) 1.15

High-throughput target-selected gene inactivation in zebrafish. Methods Cell Biol (2011) 1.15

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals. BMC Genomics (2008) 1.14

Expanding the spectrum of phenotypes associated with germline PIGA mutations: a child with developmental delay, accelerated linear growth, facial dysmorphisms, elevated alkaline phosphatase, and progressive CNS abnormalities. Am J Med Genet A (2013) 1.14

Dominant-negative ALK2 allele associates with congenital heart defects. Circulation (2009) 1.14

Haplotype block structure is conserved across mammals. PLoS Genet (2006) 1.13

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles. PLoS One (2010) 1.12

High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors. Genome Res (2011) 1.12

Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach. BMC Genomics (2011) 1.10

Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. Eur J Neurosci (2007) 1.08

FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol (2010) 1.08

Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa. Mol Biol Evol (2009) 1.07

Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology (2008) 1.06

Chromothripsis in congenital disorders and cancer: similarities and differences. Curr Opin Cell Biol (2013) 1.05

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain. Epigenetics Chromatin (2013) 1.05

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J (2014) 1.05

Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations. J Cardiovasc Transl Res (2011) 1.04

A deep sequencing approach to uncover the miRNOME in the human heart. PLoS One (2013) 1.04

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04

CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences. BMC Genomics (2005) 1.03

Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats. Psychopharmacology (Berl) (2007) 1.03

Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes. Nucleic Acids Res (2011) 1.02

Discovery of variants unmasked by hemizygous deletions. Eur J Hum Genet (2012) 1.02

Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res (2004) 1.01

A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability. PLoS One (2012) 1.00

miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. PLoS One (2012) 1.00

A genome-wide SNP panel for mapping and association studies in the rat. BMC Genomics (2008) 1.00

ENU mutagenesis to generate genetically modified rat models. Methods Mol Biol (2010) 1.00

The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology (2008) 0.99

Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates. BMC Genomics (2005) 0.98

X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face. J Med Genet (2012) 0.97

NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis. Hum Mol Genet (2012) 0.97

Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. Am J Physiol Endocrinol Metab (2012) 0.95

Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus. Eur J Hum Genet (2012) 0.95

Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects. Eur J Hum Genet (2015) 0.94

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. Carcinogenesis (2008) 0.94

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. Am J Pathol (2011) 0.93

Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors. Cancer Res (2008) 0.93

Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology (Berl) (2008) 0.93

Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics (2005) 0.92

Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females. Genetics (2007) 0.92

Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol Metab (2009) 0.92

Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation. FEBS Lett (2009) 0.91

The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders. PLoS One (2012) 0.90

Improving mammalian genome scaffolding using large insert mate-pair next-generation sequencing. BMC Genomics (2013) 0.90

Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing. Am J Hum Genet (2012) 0.90

Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol (2012) 0.90

A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat. J Biol Chem (2011) 0.89

Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol (2003) 0.89