Published in J Med Chem on June 26, 2008
Synthesis and pharmacological activities of some new 3-substituted-4-amino-5-mercapto-1,2,4-triazoles. Indian J Pharm Sci (2011) 0.94
Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery. Future Med Chem (2011) 0.85
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. ACS Med Chem Lett (2012) 0.77
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep. Nat Genet (2006) 8.37
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog (2009) 3.05
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res (2009) 3.03
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Inhibition of myostatin in adult mice increases skeletal muscle mass and strength. Biochem Biophys Res Commun (2003) 2.82
Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. Eur J Med Chem (2006) 2.78
Enamines as novel antibacterials and their structure-activity relationships. Eur J Med Chem (2007) 2.65
A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet (2004) 2.47
Endothelial cell recovery between comparator polymer-based drug-eluting stents. J Am Coll Cardiol (2008) 2.45
Synthesis, structure, and structure-activity relationship analysis of enamines as potential antibacterials. Bioorg Med Chem (2007) 2.29
Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol (2002) 2.26
Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25
Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease. Bioorg Med Chem (2007) 2.13
Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles. Arterioscler Thromb Vasc Biol (2006) 2.12
An MRI-based atlas and database of the developing mouse brain. Neuroimage (2010) 1.99
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res (2010) 1.86
Disposition of caspofungin: role of distribution in determining pharmacokinetics in plasma. Antimicrob Agents Chemother (2004) 1.86
Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.83
Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum (2005) 1.79
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res (2007) 1.73
Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. Diabetes (2010) 1.70
The effects of light on bleaching and tooth sensitivity during in-office vital bleaching: a systematic review and meta-analysis. J Dent (2012) 1.67
Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases. Atherosclerosis (2007) 1.67
Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones. ChemMedChem (2008) 1.64
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. J Allergy Clin Immunol (2007) 1.63
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One (2008) 1.63
Stent graft-induced new entry after endovascular repair for Stanford type B aortic dissection. J Vasc Surg (2010) 1.62
Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells. J Biol Chem (2005) 1.59
Anesthesia with nontracheal intubation in thoracic surgery. J Thorac Dis (2012) 1.56
Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation (2010) 1.54
AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension (2008) 1.54
Kinase-inactive glycogen synthase kinase 3beta promotes Wnt signaling and mammary tumorigenesis. Cancer Res (2005) 1.50
Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development (2002) 1.49
PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal (2010) 1.48
Disposition of caspofungin, a novel antifungal agent, in mice, rats, rabbits, and monkeys. Antimicrob Agents Chemother (2004) 1.48
Doubly hybrid density functional xDH-PBE0 from a parameter-free global hybrid model PBE0. J Chem Phys (2012) 1.44
A potential probe set of fluorescence in situ hybridization for detection of lung cancer in bronchial brushing specimens. J Cancer Res Clin Oncol (2012) 1.43
Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors. Oncogene (2002) 1.43
A longitudinal assessment of coronary interventional program quality: a report from the American College of Cardiology-National Cardiovascular Data Registry. JACC Cardiovasc Interv (2009) 1.41
Long-term outcome of hybrid surgical approach of video-assisted minithoracotomy sleeve lobectomy for non-small-cell lung cancer. Surg Endosc (2011) 1.40
Long-term outcome and cost-effectiveness of complete versus assisted video-assisted thoracic surgery for non-small cell lung cancer. J Surg Oncol (2011) 1.40
Origins of phase contrast in the atomic force microscope in liquids. Proc Natl Acad Sci U S A (2009) 1.38
Functional genomic screens identify CINP as a genome maintenance protein. Proc Natl Acad Sci U S A (2009) 1.38
A new multimarker test for family-based association studies. Genet Epidemiol (2007) 1.34
Retrograde type A aortic dissection after endovascular stent graft placement for treatment of type B dissection. Circulation (2009) 1.33
Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Māori, Pacific Island, and Caucasian case-control sample sets. Arthritis Rheum (2009) 1.32
Power estimation of multiple SNP association test of case-control study and application. Genet Epidemiol (2004) 1.31
Differential regulation of membrane guanylyl cyclases in congestive heart failure: natriuretic peptide receptor (NPR)-B, Not NPR-A, is the predominant natriuretic peptide receptor in the failing heart. Endocrinology (2007) 1.31
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30
Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res (2006) 1.29
Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radic Biol Med (2007) 1.29
Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem (2011) 1.28
Problems with the microbial production of butanol. J Ind Microbiol Biotechnol (2009) 1.28
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage. Cancer Res (2007) 1.27
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron (2012) 1.27
Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int J Cancer (2002) 1.26
Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate. Biochemistry (2003) 1.25
New alkali doped pillared carbon materials designed to achieve practical reversible hydrogen storage for transportation. Phys Rev Lett (2004) 1.25
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase. J Med Chem (2007) 1.25
Prevalence of metabolic syndrome and its relation to body composition in a Chinese rural population. Obesity (Silver Spring) (2006) 1.24
Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation (2008) 1.24
Overexpression of PLK1 is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamous cell carcinoma. Int J Cancer (2009) 1.23
A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector. Mol Ther (2008) 1.23
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem (2012) 1.23
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One (2012) 1.23
Mechanism for antibody catalysis of the oxidation of water by singlet dioxygen. Proc Natl Acad Sci U S A (2002) 1.23
A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods. Hum Mol Genet (2004) 1.23
In situ growth of Co(0.85)Se and Ni(0.85)Se on conductive substrates as high-performance counter electrodes for dye-sensitized solar cells. J Am Chem Soc (2012) 1.22
Treatment of symptomatic isolated dissection of superior mesenteric artery. J Vasc Surg (2013) 1.22
Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists. Vascul Pharmacol (2006) 1.20
Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma. Genes Chromosomes Cancer (2008) 1.20
Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Curr Top Med Chem (2014) 1.19
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol (2011) 1.19
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med (2014) 1.18
Phenotypic screens as a renewed approach for drug discovery. Drug Discov Today (2013) 1.18
Hybrid inhibitors of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin-rapamycin conjugates. J Med Chem (2010) 1.17
Spermatogenesis of mice lacking CK2alpha': failure of germ cell survival and characteristic modifications of the spermatid nucleus. Mol Reprod Dev (2003) 1.17
Revealing the molecular structure of single-molecule junctions in different conductance states by fishing-mode tip-enhanced Raman spectroscopy. Nat Commun (2011) 1.17
Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents. Eur J Med Chem (2009) 1.17
The scope and mechanism of phosphonium-mediated S(N)Ar reactions in heterocyclic amides and ureas. J Org Chem (2007) 1.16
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts. Am J Physiol Heart Circ Physiol (2005) 1.16
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases. Bioorg Med Chem (2007) 1.16
Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteine. J Med Chem (2009) 1.15
VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology (2005) 1.15
Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors. Bioorg Med Chem (2009) 1.14
Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice. Mech Ageing Dev (2007) 1.14
Feasibility of complete video-assisted thoracoscopic surgery following neoadjuvant therapy for locally advanced non-small cell lung cancer. J Thorac Dis (2013) 1.13
Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations. Am J Physiol Renal Physiol (2007) 1.13
Synthesis of resveratrol analogues, and evaluation of their cytotoxic and xanthine oxidase inhibitory activities. Chem Biodivers (2008) 1.13
miR-26a inhibits proliferation and motility in bladder cancer by targeting HMGA1. FEBS Lett (2013) 1.12
In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors. Antimicrob Agents Chemother (2004) 1.12
Visual saliency based on scale-space analysis in the frequency domain. IEEE Trans Pattern Anal Mach Intell (2013) 1.12