Published in Stem Cells on June 26, 2008
Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci U S A (2009) 2.56
Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circ Res (2012) 2.51
Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells. Blood (2009) 1.73
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells. Nat Methods (2014) 1.70
Microfabricated biomaterials for engineering 3D tissues. Adv Mater (2012) 1.65
Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation. Biotechnol Prog (2009) 1.61
The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46
Bioprinting for stem cell research. Trends Biotechnol (2012) 1.46
Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells (2013) 1.28
Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A (2011) 1.25
Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells. Integr Biol (Camb) (2012) 1.20
Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array. Biomaterials (2011) 1.16
Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplant (2010) 1.11
Preconditioning stem cells for in vivo delivery. Biores Open Access (2014) 1.09
Applications of high content screening in life science research. Comb Chem High Throughput Screen (2009) 1.09
The multiparametric effects of hydrodynamic environments on stem cell culture. Tissue Eng Part B Rev (2011) 1.06
Chaotic expression dynamics implies pluripotency: when theory and experiment meet. Biol Direct (2009) 1.00
Probing embryonic stem cell autocrine and paracrine signaling using microfluidics. Annu Rev Anal Chem (Palo Alto Calif) (2012) 0.98
Standardized generation and differentiation of neural precursor cells from human pluripotent stem cells. Stem Cell Rev (2013) 0.96
The billion cell construct: will three-dimensional printing get us there? PLoS Biol (2014) 0.96
Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol (Camb) (2012) 0.96
Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One (2012) 0.95
Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics. Ann Biomed Eng (2013) 0.94
A hollow sphere soft lithography approach for long-term hanging drop methods. Tissue Eng Part C Methods (2010) 0.94
Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications. J Tissue Eng Regen Med (2012) 0.94
Development of Scalable Culture Systems for Human Embryonic Stem Cells. Biochem Eng J (2010) 0.91
A 3D sphere culture system containing functional polymers for large-scale human pluripotent stem cell production. Stem Cell Reports (2014) 0.91
Directed differentiation of size-controlled embryoid bodies towards endothelial and cardiac lineages in RGD-modified poly(ethylene glycol) hydrogels. Adv Healthc Mater (2012) 0.90
Microfluidic devices for cell cultivation and proliferation. Biomicrofluidics (2013) 0.90
Direct reprogramming of mouse fibroblasts to cardiomyocyte-like cells using Yamanaka factors on engineered poly(ethylene glycol) (PEG) hydrogels. Biomaterials (2013) 0.89
Multilayered heparin hydrogel microwells for cultivation of primary hepatocytes. Adv Healthc Mater (2013) 0.89
Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation. Biomicrofluidics (2011) 0.88
Spatial and temporal expression pattern of germ layer markers during human embryonic stem cell differentiation in embryoid bodies. Histochem Cell Biol (2010) 0.87
Engineering the human pluripotent stem cell microenvironment to direct cell fate. Biotechnol Adv (2013) 0.87
Transwells with microstamped membranes produce micropatterned two-dimensional and three-dimensional co-cultures. Tissue Eng Part C Methods (2010) 0.87
Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation. Organogenesis (2014) 0.86
Controlled embryoid body formation via surface modification and avidin-biotin cross-linking. Cytotechnology (2010) 0.86
Microscale technologies for regulating human stem cell differentiation. Exp Biol Med (Maywood) (2014) 0.85
Human iPS cell-derived hematopoietic progenitor cells induce T-cell anergy in in vitro-generated alloreactive CD8(+) T cells. Blood (2013) 0.85
Applications of microscale technologies for regenerative dentistry. J Dent Res (2009) 0.85
A fast and accessible methodology for micro-patterning cells on standard culture substrates using Parafilm™ inserts. PLoS One (2011) 0.84
Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies. Tissue Eng Part A (2014) 0.84
On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. Biomaterials (2015) 0.84
Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates. Biotechnol Bioeng (2013) 0.84
Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells. Stem Cells Transl Med (2014) 0.84
Effects of 3D microwell culture on growth kinetics and metabolism of human embryonic stem cells. Biotechnol Appl Biochem (2012) 0.83
Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays. Sci Rep (2014) 0.83
Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell (2016) 0.83
Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLoS One (2012) 0.83
Differentiation of human embryonic stem cells using size-controlled embryoid bodies and negative cell selection in the production of photoreceptor precursor cells. Tissue Eng Part C Methods (2013) 0.83
Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools. Biomed Res Int (2014) 0.83
Effects of 3D microwell culture on initial fate specification in human embryonic stem cells. AIChE J (2014) 0.83
Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells. Heart Vessels (2013) 0.82
Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning. Integr Biol (Camb) (2013) 0.82
Single-cell analysis of embryoid body heterogeneity using microfluidic trapping array. Biomed Microdevices (2014) 0.82
Dishing out mini-brains: Current progress and future prospects in brain organoid research. Dev Biol (2016) 0.81
Biophysical regulation of stem cell behavior within the niche. Stem Cell Res Ther (2012) 0.81
In vitro differentiation and maturation of human embryonic stem cell into multipotent cells. Stem Cells Int (2011) 0.81
Loss of Oct4 expression during the development of murine embryoid bodies. Dev Biol (2012) 0.81
Gene expression profiles in CHA3 and CHA4 human embryonic stem cells and embryoid bodies. Mol Cells (2011) 0.81
Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells. Stem Cells Dev (2011) 0.81
Self-organizing human cardiac microchambers mediated by geometric confinement. Nat Commun (2015) 0.81
State of the art in stem cell research: human embryonic stem cells, induced pluripotent stem cells, and transdifferentiation. J Blood Transfus (2012) 0.80
Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate. Exp Neurol (2013) 0.80
Density-dependent separation of encapsulated cells in a microfluidic channel by using a standing surface acoustic wave. Biomicrofluidics (2012) 0.80
Conjoint propagation and differentiation of human embryonic stem cells to cardiomyocytes in a defined microcarrier spinner culture. Stem Cell Res Ther (2014) 0.80
Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential. Stem Cells Int (2012) 0.79
Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation. Stem Cell Res (2014) 0.79
Detection of calcium transients in embryonic stem cells and their differentiated progeny. Cell Mol Neurobiol (2009) 0.78
Prepatterning in the stem cell compartment. PLoS One (2010) 0.78
Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells. Biochem Biophys Res Commun (2014) 0.78
Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells. Stem Cell Res (2015) 0.78
In vitro cardiac tissue models: Current status and future prospects. Adv Drug Deliv Rev (2015) 0.78
Induction of primitive streak and mesendoderm formation in monolayer hESC culture by activation of TGF-β signaling pathway by Activin B. Saudi J Biol Sci (2015) 0.78
Tissue engineering approaches to cell-based type 1 diabetes therapy. Tissue Eng Part B Rev (2014) 0.77
A spatially and chemically defined platform for the uniform growth of human pluripotent stem cells. Mater Sci Eng C Mater Biol Appl (2012) 0.77
Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. Stem Cells Transl Med (2015) 0.76
Context clues: the importance of stem cell-material interactions. ACS Chem Biol (2014) 0.76
Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells. Sci Rep (2016) 0.76
Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells. Stem Cells Dev (2014) 0.76
Inverting microwell array chip for the cultivation of human induced pluripotent stem cells with controlled aggregate size and geometrical arrangement. Biomicrofluidics (2014) 0.76
Concise Review: Stem Cell Microenvironment on a Chip: Current Technologies for Tissue Engineering and Stem Cell Biology. Stem Cells Transl Med (2015) 0.75
Large particle multiphoton flow cytometry to purify intact embryoid bodies exhibiting enhanced potential for cardiomyocyte differentiation. Integr Biol (Camb) (2013) 0.75
Generating size-controlled embryoid bodies using laser direct-write. Biofabrication (2014) 0.75
Deriving retinal pigment epithelium (RPE) from induced pluripotent stem (iPS) cells by different sizes of embryoid bodies. J Vis Exp (2015) 0.75
Next-generation models of human cardiogenesis via genome editing. Cold Spring Harb Perspect Med (2014) 0.75
Nanoengineered Platforms to Guide Pluripotent Stem Cell Fate. J Nanomed Nanotechnol (2014) 0.75
Quantitative multivariate analysis of dynamic multicellular morphogenic trajectories. Integr Biol (Camb) (2015) 0.75
Early retinal differentiation of human pluripotent stem cells in microwell suspension cultures. Biotechnol Lett (2016) 0.75
Aggregate Size Optimization in Microwells for Suspension-based Cardiac Differentiation of Human Pluripotent Stem Cells. J Vis Exp (2016) 0.75
Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells. Stem Cells Dev (2015) 0.75
Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells. Sci Rep (2017) 0.75
Protein Adsorption Alters Hydrophobic Surfaces Used for Suspension Culture of Pluripotent Stem Cells. J Phys Chem Lett (2015) 0.75
A design principle of group-level decision making in cell populations. PLoS Comput Biol (2013) 0.75
Large-scale generation of differentiated cells to achieve regenerative medicine. Stem Cell Res Ther (2014) 0.75
From Bench to Market: Preparing Human Pluripotent Stem Cells Derived Cardiomyocytes for Various Applications. Int J Stem Cells (2017) 0.75
Distinct carbon sources affect structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Sci Rep (2017) 0.75
A computational study of VEGF production by patterned retinal epithelial cell colonies as a model for neovascular macular degeneration. J Biol Eng (2017) 0.75
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation (2008) 4.22
Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med (2013) 4.14
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS One (2008) 3.08
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell (2012) 2.58
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes (2009) 2.58
Patterning surfaces with functional polymers. Nat Mater (2008) 2.54
Properties and emerging applications of self-assembled structures made from inorganic nanoparticles. Nat Nanotechnol (2009) 2.33
Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew Chem Int Ed Engl (2005) 2.30
Self-assembly of metal-polymer analogues of amphiphilic triblock copolymers. Nat Mater (2007) 2.24
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
Plasma membrane calcium ATPase overexpression in arterial smooth muscle increases vasomotor responsiveness and blood pressure. Circ Res (2003) 1.99
A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Eng Part A (2012) 1.95
Controlled, scalable embryonic stem cell differentiation culture. Stem Cells (2004) 1.87
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng (2002) 1.85
Step-growth polymerization of inorganic nanoparticles. Science (2010) 1.79
A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res (2005) 1.76
The systematic production of cells for cell therapies. Cell Stem Cell (2008) 1.71
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes (2010) 1.71
Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest (2002) 1.70
Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation (2006) 1.69
Janus and ternary particles generated by microfluidic synthesis: design, synthesis, and self-assembly. J Am Chem Soc (2006) 1.67
Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor. Biotechnol Bioeng (2009) 1.61
Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc Res (2011) 1.59
Prediction and testing of novel transcriptional networks regulating embryonic stem cell self-renewal and commitment. Cell Stem Cell (2007) 1.56
Functional immobilization of signaling proteins enables control of stem cell fate. Nat Methods (2008) 1.52
Dynamic interaction networks in a hierarchically organized tissue. Mol Syst Biol (2010) 1.51
Growth differentiation factor 5 regulates cardiac repair after myocardial infarction. J Am Coll Cardiol (2010) 1.51
Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation. Stem Cells (2005) 1.51
Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties. Biopolymers (2003) 1.50
Sepsis-induced myocardial depression is associated with transcriptional changes in energy metabolism and contractile related genes: a physiological and gene expression-based approach. Crit Care Med (2010) 1.50
Cell-cell interaction networks regulate blood stem and progenitor cell fate. Mol Syst Biol (2009) 1.49
Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells. Cardiovasc Res (2012) 1.47
The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. J Am Coll Cardiol (2011) 1.46
The Janus faces of iNOS. Circ Res (2003) 1.43
Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology (2010) 1.42
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation (2012) 1.39
Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation (2002) 1.39
A global assessment of stem cell engineering. Tissue Eng Part A (2014) 1.38
High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation. Biomaterials (2010) 1.37
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res (2005) 1.37
Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell (2009) 1.36
Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation. Biomaterials (2010) 1.35
Don't look: growing clonal versus nonclonal neural stem cell colonies. Stem Cells (2008) 1.33
Polymer particles with various shapes and morphologies produced in continuous microfluidic reactors. J Am Chem Soc (2005) 1.31
Enabling stem cell therapies through synthetic stem cell-niche engineering. J Clin Invest (2010) 1.31
Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A (2013) 1.29
Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control. Biotechnol Bioeng (2005) 1.28
Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output. Biotechnol Bioeng (2005) 1.28
Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production. Circulation (2005) 1.28
A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials (2010) 1.28
Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology (2003) 1.28
Understanding cellular networks to improve hematopoietic stem cell expansion cultures. Curr Opin Biotechnol (2006) 1.25
High-throughput combinatorial cell co-culture using microfluidics. Integr Biol (Camb) (2011) 1.25
Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche. Stem Cells (2006) 1.24
Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures. Nat Methods (2012) 1.23
Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control. PLoS Comput Biol (2007) 1.22
Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. Circulation (2004) 1.22
Three-dimensional shape transformations of hydrogel sheets induced by small-scale modulation of internal stresses. Nat Commun (2013) 1.21
Cardiovascular consequences of drugs used for the treatment of diabetes: potential promise of incretin-based therapies. J Am Soc Hypertens (2009) 1.21
LIF-mediated control of embryonic stem cell self-renewal emerges due to an autoregulatory loop. FASEB J (2007) 1.21
Microfluidic production of biopolymer microcapsules with controlled morphology. J Am Chem Soc (2006) 1.20
Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair. J Biomed Mater Res A (2003) 1.19
PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions. PLoS Comput Biol (2012) 1.18
Polymer microgels: reactors for semiconductor, metal, and magnetic nanoparticles. J Am Chem Soc (2004) 1.17
Conditional expression of a dominant-negative c-Myb in vascular smooth muscle cells inhibits arterial remodeling after injury. Circ Res (2003) 1.16
Sustained in vitro expansion of bone progenitors is cell density dependent. Stem Cells (2004) 1.12
Geometric control of cardiomyogenic induction in human pluripotent stem cells. Tissue Eng Part A (2011) 1.11
Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue. Proc Natl Acad Sci U S A (2009) 1.10
Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice. Diabetes (2013) 1.09
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6. Stem Cells (2002) 1.09
Monodisperse chitosan nanoparticles for mucosal drug delivery. Biomacromolecules (2004) 1.09
Dynamic changes in cellular and microenvironmental composition can be controlled to elicit in vitro human hematopoietic stem cell expansion. Exp Hematol (2005) 1.09
The role of NOS in heart failure: lessons from murine genetic models. Heart Fail Rev (2002) 1.08
Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol (2013) 1.08
Multiple shape transformations of composite hydrogel sheets. J Am Chem Soc (2013) 1.07
Decellularized placental matrices for adipose tissue engineering. J Biomed Mater Res A (2006) 1.04
Self-assembly of inorganic nanorods. Chem Soc Rev (2011) 1.04
Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. Circ Res (2010) 1.04
Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens. PLoS One (2009) 1.03
Reversible regional wall motion abnormalities on exercise technetium-99m-gated cardiac single photon emission computed tomography predict high-grade angiographic stenoses. J Am Coll Cardiol (2002) 1.03
Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion. Exp Hematol (2003) 1.02
Elafin-overexpressing mice have improved cardiac function after myocardial infarction. Am J Physiol Heart Circ Physiol (2003) 1.02
Microfluidic encapsulation of cells in polymer microgels. Small (2012) 1.02
Adipose tissue engineering with naturally derived scaffolds and adipose-derived stem cells. Biomaterials (2007) 1.02
The use of vascular endothelial growth factor functionalized agarose to guide pluripotent stem cell aggregates toward blood progenitor cells. Biomaterials (2010) 1.01