Published in Cell Stem Cell on June 07, 2007
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol (2009) 4.60
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC Genomics (2009) 2.15
Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2010) 1.74
Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions. PLoS One (2010) 1.67
A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells. PLoS One (2010) 1.31
Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor. Breast Cancer Res (2011) 1.24
Human neural crest cells display molecular and phenotypic hallmarks of stem cells. Hum Mol Genet (2008) 1.23
mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram (2010) 1.21
The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One (2009) 1.15
Applications of high content screening in life science research. Comb Chem High Throughput Screen (2009) 1.09
Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development (2011) 1.08
Oscillatory protein expression dynamics endows stem cells with robust differentiation potential. PLoS One (2011) 1.00
Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer. PLoS One (2013) 1.00
The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation. Genome Res (2014) 1.00
PCL2 modulates gene regulatory networks controlling self-renewal and commitment in embryonic stem cells. Cell Cycle (2011) 0.94
Transcriptional competence in pluripotency. Genes Dev (2009) 0.89
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives. BMC Genomics (2009) 0.88
Breaking through an epigenetic wall: re-activation of Oct4 by KRAB-containing designer zinc finger transcription factors. Epigenetics (2013) 0.85
Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. EMBO Rep (2015) 0.84
Computational Epigenetics: the new scientific paradigm. Bioinformation (2010) 0.84
Polycomb repressive complex 2 in embryonic stem cells: an overview. Protein Cell (2011) 0.83
Short-term serum-free culture reveals that inhibition of Gsk3β induces the tumor-like growth of mouse embryonic stem cells. PLoS One (2011) 0.81
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens. Exp Hematol (2011) 0.78
An integrative approach to inferring gene regulatory module networks. PLoS One (2012) 0.77
Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans. Development (2016) 0.77
Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape. Aging Cell (2017) 0.76
MKRN1: Uncovering function by an unbiased systems approach. Cell Cycle (2015) 0.75
An efficient weighted graph strategy to identify differentiation associated genes in embryonic stem cells. PLoS One (2013) 0.75
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
Structures of the bacterial ribosome at 3.5 A resolution. Science (2005) 12.63
A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet (2007) 12.21
The DNA-encoded nucleosome organization of a eukaryotic genome. Nature (2008) 11.41
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res (2010) 10.97
Cytoscape Web: an interactive web-based network browser. Bioinformatics (2010) 10.03
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
Diversity and complexity in DNA recognition by transcription factors. Science (2009) 9.07
Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol (2010) 9.01
The first metal-organic framework (MOF) of Imazethapyr and its SHG, piezoelectric and ferroelectric properties. Dalton Trans (2008) 8.86
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell (2007) 8.43
FunSpec: a web-based cluster interpreter for yeast. BMC Bioinformatics (2002) 8.01
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell (2008) 7.93
Revealing global regulatory features of mammalian alternative splicing using a quantitative microarray platform. Mol Cell (2004) 7.32
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21
Hydrogen-bonded ferroelectrics based on metal-organic coordination. J Am Chem Soc (2009) 6.69
Most "dark matter" transcripts are associated with known genes. PLoS Biol (2010) 6.60
Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell (2006) 6.42
GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function. Genome Biol (2008) 5.94
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell (2006) 5.72
Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol (2003) 5.60
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell (2003) 5.57
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Exploration of essential gene functions via titratable promoter alleles. Cell (2004) 5.21
DNA-binding specificities of human transcription factors. Cell (2013) 5.14
Probing microRNAs with microarrays: tissue specificity and functional inference. RNA (2004) 4.91
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
Supramolecular bola-like ferroelectric: 4-methoxyanilinium tetrafluoroborate-18-crown-6. J Am Chem Soc (2011) 4.73
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Nat Genet (2002) 4.68
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58
A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell (2008) 4.49
Diisopropylammonium chloride: a ferroelectric organic salt with a high phase transition temperature and practical utilization level of spontaneous polarization. Adv Mater (2011) 4.30
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96
Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell (2006) 3.86
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol (2004) 3.72
Identification of a bacterial type III effector family with G protein mimicry functions. Cell (2006) 3.47
Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities. Genome Res (2010) 3.46
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol (2009) 3.44
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
Using expression profiling data to identify human microRNA targets. Nat Methods (2007) 3.37
Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30
Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection. Clin Infect Dis (2010) 3.12
A panoramic view of yeast noncoding RNA processing. Cell (2003) 3.11
Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS One (2008) 3.08
The synthetic genetic interaction spectrum of essential genes. Nat Genet (2005) 3.06
G+C content dominates intrinsic nucleosome occupancy. BMC Bioinformatics (2009) 3.05
Concise review: stem cell antigen-1: expression, function, and enigma. Stem Cells (2007) 2.97
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
A multiferroic perdeutero metal-organic framework. Angew Chem Int Ed Engl (2011) 2.88
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87
Conservation of core gene expression in vertebrate tissues. J Biol (2009) 2.84
Prognostic gene signatures for non-small-cell lung cancer. Proc Natl Acad Sci U S A (2009) 2.84
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A (2004) 2.80
GeneMANIA prediction server 2013 update. Nucleic Acids Res (2013) 2.74
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol (2008) 2.73
Why are there still over 1000 uncharacterized yeast genes? Genetics (2007) 2.71
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell (2011) 2.69
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell (2007) 2.64
Net primary production of Chinese croplands from 1950 to 1999. Ecol Appl (2007) 2.61
Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell (2012) 2.58
Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A (2006) 2.55
Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol (2007) 2.54
High nucleosome occupancy is encoded at human regulatory sequences. PLoS One (2010) 2.43
RBPDB: a database of RNA-binding specificities. Nucleic Acids Res (2010) 2.42
RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell (2003) 2.40
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells (2008) 2.34
Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol (2013) 2.34
BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol (2005) 2.32
H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell (2007) 2.32
Alternative splicing of conserved exons is frequently species-specific in human and mouse. Trends Genet (2005) 2.26
Fast integration of heterogeneous data sources for predicting gene function with limited annotation. Bioinformatics (2010) 2.26
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med (2009) 2.23
Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med (2003) 2.16
Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs. Nat Genet (2005) 2.15