Published in Protein Sci on March 01, 2010
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem (2012) 2.23
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A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells. Cell (2014) 1.62
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Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
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Predictive Bcl-2 family binding models rooted in experiment or structure. J Mol Biol (2012) 1.09
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells. ACS Chem Biol (2014) 1.07
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Intrinsically disordered proteins in bcl-2 regulated apoptosis. Int J Mol Sci (2010) 1.00
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2. Biochemistry (2012) 0.96
Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods. Protein Sci (2012) 0.93
Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening. ACS Chem Biol (2013) 0.93
Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors. ACS Med Chem Lett (2012) 0.89
High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug design. PLoS One (2014) 0.86
Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. PLoS Comput Biol (2014) 0.85
Heterodimerization of BAK and MCL-1 activated by detergent micelles. J Biol Chem (2010) 0.83
DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J Med Chem (2015) 0.82
Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins. J Mol Biol (2015) 0.82
Insights into the structural stability of Bax from molecular dynamics simulations at high temperatures. Protein Sci (2011) 0.80
The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane. FEBS J (2016) 0.78
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors. Eur J Med Chem (2014) 0.77
Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain. Cell Death Dis (2015) 0.76
Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim. Mar Drugs (2014) 0.76
Heavy lessons in protein allostery. Nat Struct Mol Biol (2016) 0.75
Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain. J Biol Chem (2015) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
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PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids. Nucleic Acids Res (2007) 37.31
Substructure solution with SHELXD. Acta Crystallogr D Biol Crystallogr (2002) 27.16
Likelihood-enhanced fast rotation functions. Acta Crystallogr D Biol Crystallogr (2004) 23.86
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol (1993) 11.24
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell (2006) 10.29
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res (2008) 9.65
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell (2005) 8.73
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell (2006) 8.59
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A (1993) 5.13
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell (2007) 4.55
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. Immunity (2003) 3.19
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00
Solution structure of the antiapoptotic protein bcl-2. Proc Natl Acad Sci U S A (2001) 2.60
The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol (2003) 2.36
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Cell Death Differ (2007) 2.12
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol (2007) 2.08
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol (2008) 1.94
Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL. J Mol Biol (2007) 1.62
Structural plasticity underpins promiscuous binding of the prosurvival protein A1. Structure (2008) 1.42
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Mcl-1: a highly regulated cell death and survival controller. J Biomed Sci (2006) 1.17
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. FEBS Lett (2008) 1.13
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Biochemistry (2006) 1.08
Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci (2008) 1.08
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science (2003) 3.56
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat Chem Biol (2010) 3.17
Design of protein-interaction specificity gives selective bZIP-binding peptides. Nature (2009) 2.88
Allosteric activation of DegS, a stress sensor PDZ protease. Cell (2007) 2.32
A structural basis for 14-3-3sigma functional specificity. J Biol Chem (2005) 2.20
Structural specificity in coiled-coil interactions. Curr Opin Struct Biol (2008) 2.15
The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains. Nat Struct Biol (2002) 1.82
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
Modeling backbone flexibility to achieve sequence diversity: the design of novel alpha-helical ligands for Bcl-xL. J Mol Biol (2007) 1.62
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag. Mol Cell (2003) 1.57
Protein binding specificity versus promiscuity. Curr Opin Struct Biol (2010) 1.52
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
Predicting specificity in bZIP coiled-coil protein interactions. Genome Biol (2004) 1.47
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering. J Am Chem Soc (2010) 1.32
Structure-based prediction of bZIP partnering specificity. J Mol Biol (2005) 1.30
Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science (2009) 1.27
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat Struct Mol Biol (2005) 1.22
Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure. Structure (2005) 1.11
Ultra-fast evaluation of protein energies directly from sequence. PLoS Comput Biol (2006) 1.11
Predictive Bcl-2 family binding models rooted in experiment or structure. J Mol Biol (2012) 1.09
Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science (2013) 1.08
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells. ACS Chem Biol (2014) 1.07
Predicting helix orientation for coiled-coil dimers. Proteins (2008) 1.06
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure (2009) 1.06
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc Natl Acad Sci U S A (2009) 1.05
Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell (2011) 1.02
Orientation and oligomerization specificity of the Bcr coiled-coil oligomerization domain. Biochemistry (2005) 1.02
bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (2012) 1.01
Determinants of homodimerization specificity in histidine kinases. J Mol Biol (2011) 1.01
SYNZIP protein interaction toolbox: in vitro and in vivo specifications of heterospecific coiled-coil interaction domains. ACS Synth Biol (2012) 1.01
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry (2010) 1.00
Computing van der Waals energies in the context of the rotamer approximation. Proteins (2007) 1.00
Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J Biol Chem (2010) 1.00
Structure of a designed dimeric zinc finger protein bound to DNA. Biochemistry (2003) 0.99
Multicoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone. PLoS One (2011) 0.97
Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans. J Mol Biol (2013) 0.96
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2. Biochemistry (2012) 0.96
X-ray vs. NMR structures as templates for computational protein design. Proteins (2009) 0.95
Cluster expansion models for flexible-backbone protein energetics. J Comput Chem (2009) 0.94
The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell (2011) 0.94
Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods. Protein Sci (2012) 0.93
Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening. ACS Chem Biol (2013) 0.93
Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure (2007) 0.92
Coarse-graining protein energetics in sequence variables. Phys Rev Lett (2005) 0.91
Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L). J Mol Biol (2012) 0.88
A set of computationally designed orthogonal antiparallel homodimers that expands the synthetic coiled-coil toolkit. J Am Chem Soc (2014) 0.87
A computationally guided protein-interaction screen uncovers coiled-coil interactions involved in vesicular trafficking. J Mol Biol (2009) 0.86
Increasing the affinity of selective bZIP-binding peptides through surface residue redesign. Protein Sci (2014) 0.86
AVID: an integrative framework for discovering functional relationships among proteins. BMC Bioinformatics (2005) 0.86
Design of peptide inhibitors that bind the bZIP domain of Epstein-Barr virus protein BZLF1. J Mol Biol (2011) 0.84
Identifying and reducing error in cluster-expansion approximations of protein energies. J Comput Chem (2010) 0.81
Specific coiled-coil interactions contribute to a global model of the structure of the spindle pole body. J Struct Biol (2010) 0.80
Analysis of coiled-coil interactions between core proteins of the spindle pole body. Biochemistry (2008) 0.80
Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure. Proc Natl Acad Sci U S A (2005) 0.78
Multistate protein design using CLEVER and CLASSY. Methods Enzymol (2013) 0.78
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell (2015) 0.75