Published in Proc Natl Acad Sci U S A on April 01, 1989
Selection of splice sites in pre-mRNAs with short internal exons. Mol Cell Biol (1991) 3.02
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Genes Dev (1998) 2.64
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev (2011) 2.45
Nuclear pre-mRNA introns: analysis and comparison of intron sequences from Tetrahymena thermophila and other eukaryotes. Nucleic Acids Res (1990) 2.25
Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res (1997) 2.05
Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons. Mol Cell Biol (1999) 2.02
Three recognition events at the branch-site adenine. EMBO J (1996) 2.01
Human branch point consensus sequence is yUnAy. Nucleic Acids Res (2008) 1.94
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
Exon as well as intron sequences are cis-regulating elements for the mutually exclusive alternative splicing of the beta tropomyosin gene. Mol Cell Biol (1990) 1.82
Mapping U2 snRNP--pre-mRNA interactions using biotinylated oligonucleotides made of 2'-OMe RNA. EMBO J (1989) 1.73
Cooperation of pre-mRNA sequence elements in splice site selection. Mol Cell Biol (1992) 1.70
T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates. Mol Cell Biol (1993) 1.63
In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit. Mol Cell Biol (1993) 1.60
Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding. Nucleic Acids Res (1994) 1.58
Transient interaction of BBP/ScSF1 and Mud2 with the splicing machinery affects the kinetics of spliceosome assembly. RNA (1999) 1.56
The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors. Mol Cell Biol (1989) 1.48
Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo. RNA (1998) 1.44
Control of BEK and K-SAM splice sites in alternative splicing of the fibroblast growth factor receptor 2 pre-mRNA. Mol Cell Biol (1993) 1.41
Species-specific signals for the splicing of a short Drosophila intron in vitro. Mol Cell Biol (1993) 1.39
Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences. Mol Cell Biol (1992) 1.36
Uridine branch acceptor is a cis-acting element involved in regulation of the alternative processing of calcitonin/CGRP-l pre-mRNA. Nucleic Acids Res (1990) 1.31
A point mutation in an intronic branch site results in aberrant splicing of COL5A1 and in Ehlers-Danlos syndrome type II in two British families. Am J Hum Genet (1998) 1.26
In vivo splicing of the beta tropomyosin pre-mRNA: a role for branch point and donor site competition. Mol Cell Biol (1992) 1.24
The stability and fate of a spliced intron from vertebrate cells. RNA (1999) 1.22
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing. Mol Cell Biol (2001) 1.21
Functional analysis of a C. elegans trans-splice acceptor. Nucleic Acids Res (1993) 1.19
A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Mol Cell Biol (2005) 1.19
The KH domain of the branchpoint sequence binding protein determines specificity for the pre-mRNA branchpoint sequence. RNA (1998) 1.17
A spliced intron accumulates as a lariat in the nucleus of T cells. Nucleic Acids Res (1992) 1.16
Spliceosomal snRNA modifications and their function. RNA Biol (2010) 1.13
The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.12
Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites. Mol Cell Biol (1990) 1.09
Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype. Proc Natl Acad Sci U S A (1991) 1.07
FRET analyses of the U2AF complex localize the U2AF35/U2AF65 interaction in vivo and reveal a novel self-interaction of U2AF35. RNA (2005) 1.06
Genetic selection for balanced retroviral splicing: novel regulation involving the second step can be mediated by transitions in the polypyrimidine tract. Mol Cell Biol (1995) 1.04
Stimulation of gene expression by introns: conversion of an inhibitory intron to a stimulatory intron by alteration of the splice donor sequence. Nucleic Acids Res (1993) 1.03
Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res (2005) 1.02
A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract. Mol Cell Biol (1997) 1.02
Functional crosstalk between exon enhancers, polypyrimidine tracts and branchpoint sequences. EMBO J (1997) 1.02
Recognition of RNA branch point sequences by the KH domain of splicing factor 1 (mammalian branch point binding protein) in a splicing factor complex. Mol Cell Biol (2001) 1.02
U1-like snRNAs lacking complementarity to canonical 5' splice sites. RNA (2006) 1.02
Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda. J Clin Invest (1990) 0.99
Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res (1994) 0.98
Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells (2011) 0.98
The branchpoint residue is recognized during commitment complex formation before being bulged out of the U2 snRNA-pre-mRNA duplex. Mol Cell Biol (1997) 0.98
U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites. Biochem J (2003) 0.95
In vitro splicing of fibronectin pre-mRNAs. Nucleic Acids Res (1990) 0.94
Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo. Nucleic Acids Res (2002) 0.93
Characterization of human RNA splice signals by iterative functional selection of splice sites. RNA (2000) 0.91
Branchpoint and polypyrimidine tract mutations mediating the loss and partial recovery of the Moloney murine sarcoma virus MuSVts110 thermosensitive splicing phenotype. J Virol (1995) 0.90
Sequence requirements in different steps of the pre-mRNA splicing reaction: analysis by the RNA modification-exclusion technique. Mol Cell Biol (1990) 0.90
cis-elements involved in alternative splicing in the rat beta-tropomyosin gene: the 3'-splice site of the skeletal muscle exon 7 is the major site of blockage in nonmuscle cells. Nucleic Acids Res (1993) 0.90
Selection and characterization of replication-competent revertants of a Rous sarcoma virus src gene oversplicing mutant. J Virol (1996) 0.88
Intron definition and a branch site adenosine at nt 385 control RNA splicing of HPV16 E6*I and E7 expression. PLoS One (2012) 0.88
Inhibition of pre-mRNA splicing by synthetic branched nucleic acids. Nucleic Acids Res (2003) 0.87
Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast. Genes Dev (2013) 0.87
Multiple forms of mRNA encoding human pregnancy-associated endometrial alpha 2-globulin, a beta-lactoglobulin homologue. Proc Natl Acad Sci U S A (1991) 0.87
Comparative analysis of teleost genome sequences reveals an ancient intron size expansion in the zebrafish lineage. Genome Biol Evol (2011) 0.86
Mutational analysis of a plant branchpoint and polypyrimidine tract required for constitutive splicing of a mini-exon. RNA (2002) 0.84
Identification of new splice sites used for generation of rev transcripts in human immunodeficiency virus type 1 subtype C primary isolates. PLoS One (2012) 0.84
Transposition of two amino acids changes a promiscuous RNA binding protein into a sequence-specific RNA binding protein. RNA (2007) 0.84
A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity. J Virol (1997) 0.84
Mutational analysis of the U12-dependent branch site consensus sequence. RNA (2008) 0.81
Four exons of the serotonin receptor 4 gene are associated with multiple distant branch points. RNA (2010) 0.80
An SF1 affinity model to identify branch point sequences in human introns. Nucleic Acids Res (2010) 0.79
Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation. World J Biol Chem (2014) 0.79
Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. Nucleic Acids Res (2015) 0.77
Interplay between U2 snRNP and 3' splice factor(s) for branch point selection on human beta-globin pre-mRNA. Nucleic Acids Res (1990) 0.76
Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complex. RNA (2013) 0.76
From the ribosome to the spliceosome and back again. J Biol Chem (2009) 0.76
Vemurafenib-resistant BRAF selects alternative branch points different from its wild-type BRAF in intron 8 for RNA splicing. Cell Biosci (2015) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci U S A (1985) 68.48
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
Pre-mRNA splicing. Annu Rev Genet (1986) 9.86
A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. Cell (1986) 9.65
Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell (1986) 8.06
Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell (1987) 7.44
Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts. Cell (1983) 6.48
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Cell (1988) 6.16
Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell (1987) 6.08
Spliceosome assembly in yeast. Genes Dev (1987) 6.00
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature (1988) 5.48
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes. Nature (1987) 5.13
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs. Proc Natl Acad Sci U S A (1984) 4.71
On the origin of RNA splicing and introns. Cell (1985) 4.70
A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein. Cell (1986) 4.57
The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science (1985) 4.56
An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J (1987) 4.52
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA. Cell (1986) 4.44
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26
The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell (1986) 4.23
An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. Science (1988) 4.16
An RNA processing activity that debranches RNA lariats. Science (1985) 4.14
Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing. Cell (1985) 3.59
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proc Natl Acad Sci U S A (1988) 3.38
Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants. Cell (1985) 3.25
The role of the mammalian branchpoint sequence in pre-mRNA splicing. Genes Dev (1988) 3.14
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol (1987) 3.00
U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs. Cell (1986) 2.77
Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region. EMBO J (1985) 2.69
Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol Cell Biol (1988) 2.64
Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing. Genes Dev (1988) 2.62
Unusual branch point selection in processing of human growth hormone pre-mRNA. Mol Cell Biol (1988) 2.12
Effect of mutations at the lariat branch acceptor site on beta-globin pre-mRNA splicing in vitro. Nature (1987) 2.11
A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev (1987) 1.99
The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. Mol Cell Biol (1987) 1.68
Different small nuclear ribonucleoprotein particles are involved in different steps of splicing complex formation. Cold Spring Harb Symp Quant Biol (1987) 1.67
The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing. EMBO J (1988) 1.66
Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides. Cell (1988) 1.64
Internal sequences that distinguish yeast from metazoan U2 snRNA are unnecessary for pre-mRNA splicing. Nature (1988) 1.34
A role for branchpoints in splicing in vivo. Nature (1985) 1.32
Mutations at the lariat acceptor site allow self-splicing of a group II intron without lariat formation. EMBO J (1987) 1.21
Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information. Annu Rev Biochem (1986) 11.03
A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. Cell (1986) 9.65
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
Germline p16 mutations in familial melanoma. Nat Genet (1994) 5.59
Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet (1997) 5.34
Amino-terminal sequence analysis of proteins purified on a nanomole scale by gel electrophoresis. J Biol Chem (1972) 5.24
Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control (2001) 4.74
Direct repeats flank three small nuclear RNA pseudogenes in the human genome. Cell (1981) 4.53
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature (1989) 4.18
A compensatory base change in human U2 snRNA can suppress a branch site mutation. Genes Dev (1989) 3.79
Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements. Cell (1986) 3.69
Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet (1996) 3.53
Natural read-through at the UGA termination signal of Q-beta coat protein cistron. Nat New Biol (1971) 3.52
CDKN2A mutations in multiple primary melanomas. N Engl J Med (1998) 3.52
An abundant cytoplasmic 7S RNA is complementary to the dominant interspersed middle repetitive DNA sequence family in the human genome. Cell (1980) 3.45
Pseudogenes for human small nuclear RNA U3 appear to arise by integration of self-primed reverse transcripts of the RNA into new chromosomal sites. Cell (1983) 3.12
Upstream sequences modulate the internal promoter of the human 7SL RNA gene. Nature (1985) 2.97
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet (1996) 2.96
Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene. Mol Cell Biol (1985) 2.87
Abundant pseudogenes for small nuclear RNAs are dispersed in the human genome. Proc Natl Acad Sci U S A (1981) 2.66
Sequences required for 3' end formation of human U2 small nuclear RNA. Cell (1985) 2.57
Human genes for U2 small nuclear RNA are tandemly repeated. Mol Cell Biol (1984) 2.52
Dictyostelium small nuclear RNA D2 is homologous to rat nucleolar RNA U3 and is encoded by a dispersed multigene family. Cell (1980) 2.33
Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles. Genes Dev (1990) 2.26
Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing. Nature (1991) 2.24
Human U2 small nuclear RNA genes contain an upstream enhancer. EMBO J (1986) 2.10
Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. EMBO J (1984) 2.05
The 5' end of U3 snRNA can be crosslinked in vivo to the external transcribed spacer of rat ribosomal RNA precursors. J Mol Biol (1989) 2.05
Human U1 RNA pseudogenes may be generated by both DNA- and RNA-mediated mechanisms. Mol Cell Biol (1982) 1.89
Follow-up study of twenty-four families with Li-Fraumeni syndrome. Cancer Res (1991) 1.89
Distinct factors with Sp1 and NF-A specificities bind to adjacent functional elements of the human U2 snRNA gene enhancer. Genes Dev (1987) 1.85
CCA addition by tRNA nucleotidyltransferase: polymerization without translocation? EMBO J (1998) 1.71
A genetic epidemiologic investigation of breast cancer in families with bilateral breast cancer. I. Segregation analysis. J Natl Cancer Inst (1987) 1.70
Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts. Curr Biol (1999) 1.70
Mutations associated with familial melanoma impair p16INK4 function. Nat Genet (1995) 1.69
An irregular satellite sequence is found at the termini of the linear extrachromosomal rDNA in Dictyostelium discoideum. Cell (1981) 1.69
A single UGA codon functions as a natural termination signal in the coliphage q beta coat protein cistron. J Mol Biol (1973) 1.69
The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA. Mol Cell Biol (1987) 1.68
A genome-wide search for loci contributing to smoking and alcoholism. Genet Epidemiol (1999) 1.55
Phylogeny from function: evidence from the molecular fossil record that tRNA originated in replication, not translation. Proc Natl Acad Sci U S A (1994) 1.55
Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. Mol Cell (2000) 1.46
Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. EMBO J (1995) 1.45
Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes Chromosomes Cancer (1998) 1.43
Nonoperative management of blunt abdominal trauma: the role of sequential diagnostic peritoneal lavage, computed tomography, and angiography. Ann Emerg Med (1993) 1.43
Either gene amplification or gene conversion may maintain the homogeneity of the multigene family encoding human U1 small nuclear RNA. Cold Spring Harb Symp Quant Biol (1983) 1.42
Full-field optical coherence microscopy is a novel technique for imaging enteric ganglia in the gastrointestinal tract. Neurogastroenterol Motil (2012) 1.42
5' terminal nucleotide sequences of the messenger RNA's of Dictyostelium discoideum. Cell (1976) 1.40
Increased risk of neuroectodermal tumors and stomach cancer in relatives of patients with Ewing's sarcoma family of tumors. J Natl Cancer Inst (1994) 1.39
Congenital absence of vas deferens with ipsilateral urinary anomalies. Urology (1974) 1.38
Epidemiologic and genetic approaches in the study of gene-environment interaction: an overview of available methods. Epidemiol Rev (1998) 1.38
Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33. Am J Hum Genet (1998) 1.33
Pseudogenes for human U2 small nuclear RNA do not have a fixed site of 3' truncation. Nucleic Acids Res (1984) 1.33
The highly conserved U small nuclear RNA 3'-end formation signal is quite tolerant to mutation. Mol Cell Biol (1987) 1.32
Human genes for U2 small nuclear RNA map to a major adenovirus 12 modification site on chromosome 17. Nature (1985) 1.30
Genes and pseudogenes for rat U3A and U3B small nuclear RNA. J Mol Biol (1985) 1.27
Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition. Mol Cell Biol (1985) 1.27
The CCA-adding enzyme has a single active site. J Biol Chem (1998) 1.20
Allelic loss in esophageal squamous cell carcinoma patients with and without family history of upper gastrointestinal tract cancer. Clin Cancer Res (1999) 1.20
Collaboration between CC- and A-adding enzymes to build and repair the 3'-terminal CCA of tRNA in Aquifex aeolicus. Science (2001) 1.19
Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. Am J Hum Genet (2001) 1.19
The small nuclear RNAs of the cellular slime mold Dictyostelium discoideum. Isolation and characterization. J Biol Chem (1981) 1.19
Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population. Genes Chromosomes Cancer (2000) 1.19
A top-half tDNA minihelix is a good substrate for the eubacterial CCA-adding enzyme. RNA (1998) 1.18
Adverse effects of trichothiodystrophy DNA repair and transcription gene disorder on human fetal development. Clin Genet (2009) 1.18
Structural and functional brain asymmetries in human situs inversus totalis. Neurology (1999) 1.17
Extracardiac anomalies in the heterotaxy syndromes with focus on anomalies of midline-associated structures. Am J Cardiol (2000) 1.17
Effects of fire fighting uniform (modern, modified modern, and traditional) design changes on exercise duration in New York City Firefighters. J Occup Environ Med (1999) 1.17
Cleft lip with or without cleft palate: reanalysis of a three-generation family study from England. Genet Epidemiol (1986) 1.15
U1 small nuclear RNA genes are subject to dosage compensation in mouse cells. Science (1985) 1.15
Genetic analysis of the role of human U1 snRNA in mRNA splicing: I. Effect of mutations in the highly conserved stem-loop I of U1. Genes Dev (1989) 1.15
The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors. Gene (1990) 1.15
Frequent inactivation of the TP53 gene in esophageal squamous cell carcinoma from a high-risk population in China. Clin Cancer Res (2001) 1.14
Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-q22. Mol Cell Biol (1985) 1.14
The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.12
Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients. Cancer Res (1996) 1.12
Structure and evolution of the U2 small nuclear RNA multigene family in primates: gene amplification under natural selection? Mol Cell Biol (1990) 1.12
Femtosecond pulse sequences used for optical manipulation of molecular motion. Science (1990) 1.11
Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene (2007) 1.11
Large scale purification of A-protein from bacterior17. Eur J Biochem (1970) 1.11
A rapid method for determining the molecular weight of a protein bound to nucleic acid in a mobility shift assay. Nucleic Acids Res (1992) 1.08
Analysis of gastrointestinal physiology using a novel intestinal transit assay in zebrafish. Neurogastroenterol Motil (2008) 1.07
Prognostic factors and secondary malignancies in childhood medulloblastoma. J Pediatr Hematol Oncol (2001) 1.06
A novel U1/U5 interaction indicates proximity between U1 and U5 snRNAs during an early step of mRNA splicing. RNA (1997) 1.05
The 'last ribo-organism' was no breakthrough. Nature (1988) 1.05
Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J Natl Cancer Inst (2010) 1.04
Nestin-expressing cells in the gut give rise to enteric neurons and glial cells. Neurogastroenterol Motil (2012) 1.03
Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome. Neurogastroenterol Motil (2012) 1.03
Risk of melanoma and other cancers in melanoma-prone families. J Invest Dermatol (1993) 1.02
Mutation testing in melanoma families: INK4A, CDK4 and INK4D. Br J Cancer (1999) 1.01
Mutation screening of the CDKN2A promoter in melanoma families. Genes Chromosomes Cancer (2000) 1.01
High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China. Carcinogenesis (2000) 1.01
Validation of family history of cancer in deceased family members. J Natl Cancer Inst (1996) 0.99
Counter-matching in studies of gene-environment interaction: efficiency and feasibility. Am J Epidemiol (2001) 0.98
Genetic susceptibility in familial melanoma from northeastern Italy. J Med Genet (2004) 0.98
Genetic steps to organ laterality in zebrafish. Comp Funct Genomics (2001) 0.98
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. J Med Genet (2006) 0.98
A U1 small nuclear ribonucleoprotein particle with altered specificity induces alternative splicing of an adenovirus E1A mRNA precursor. Mol Cell Biol (1989) 0.97