Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

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Published in PLoS Genet on September 08, 2011

Authors

Petra Langerak1, Eva Mejia-Ramirez, Oliver Limbo, Paul Russell

Author Affiliations

1: Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America.

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BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint. Mol Cell Biol (2010) 0.98

Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe. Genetics (2007) 0.98

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol (2010) 0.98

Role of substratum stiffness in modulating genes associated with extracellular matrix and mechanotransducers YAP and TAZ. Invest Ophthalmol Vis Sci (2013) 0.98

DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe. J Biol Chem (2004) 0.98

Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res (2008) 0.97

A spontaneous mutation affects programmed cell death during development of the rat eye. Exp Eye Res (2005) 0.95

Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1. J Biol Chem (2004) 0.94

Modulation of osteogenic differentiation in hMSCs cells by submicron topographically-patterned ridges and grooves. Biomaterials (2011) 0.93

Transgenic studies on the role of optineurin in the mouse eye. Exp Eye Res (2006) 0.92

Substratum topography modulates corneal fibroblast to myofibroblast transformation. Invest Ophthalmol Vis Sci (2012) 0.91

Substratum compliance regulates human trabecular meshwork cell behaviors and response to latrunculin B. Invest Ophthalmol Vis Sci (2011) 0.91

What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease. Exp Eye Res (2013) 0.90

Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation. Exp Cell Res (2003) 0.90

Periocular and intra-articular injection of canine adipose-derived mesenchymal stem cells: an in vivo imaging and migration study. J Ocul Pharmacol Ther (2011) 0.90

Protective effect of corticosteroid against the cytotoxicity of aminoglycoside otic drops on isolated cochlear outer hair cells. Laryngoscope (2004) 0.89

Effects of prostaglandin analogues on human ciliary muscle and trabecular meshwork cells. Invest Ophthalmol Vis Sci (2003) 0.89

Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant. Mol Cell Biol (2012) 0.89

Analysis of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human ciliary body after latanoprost. Invest Ophthalmol Vis Sci (2006) 0.89

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks. Cell Cycle (2010) 0.89

Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage. Nat Struct Mol Biol (2013) 0.89

Elastic modulus determination of normal and glaucomatous human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 0.89

Integration of basal topographic cues and apical shear stress in vascular endothelial cells. Biomaterials (2012) 0.88

Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe. DNA Repair (Amst) (2009) 0.88