Published in Proc Natl Acad Sci U S A on August 11, 2008
Reward improves long-term retention of a motor memory through induction of offline memory gains. Curr Biol (2011) 2.35
Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology (2010) 2.34
Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci (2010) 1.48
Serotonergic transcriptional networks and potential importance to mental health. Nat Neurosci (2012) 1.28
Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry (2012) 1.26
Serotonin: a regulator of neuronal morphology and circuitry. Trends Neurosci (2010) 1.22
Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Neuropsychopharmacology (2011) 1.03
Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PLoS One (2011) 1.03
Inducible gene manipulations in brain serotonergic neurons of transgenic rats. PLoS One (2011) 0.94
Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors. Neuropsychopharmacology (2014) 0.93
Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour. Philos Trans R Soc Lond B Biol Sci (2012) 0.92
Molecular genetics of mouse serotonin neurons across the lifespan. Neuroscience (2011) 0.87
Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle. Front Behav Neurosci (2013) 0.86
Stimulation of serotonin 2A receptors facilitates consolidation and extinction of fear memory in C57BL/6J mice. Neuropharmacology (2012) 0.86
The transcription factor RBP-J is essential for retinal cell differentiation and lamination. Mol Brain (2009) 0.85
Adenoviral vectors for highly selective gene expression in central serotonergic neurons reveal quantal characteristics of serotonin release in the rat brain. BMC Biotechnol (2009) 0.84
GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochem Cell Biol (2012) 0.83
Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. Exp Brain Res (2013) 0.82
Regulation of hippocampus-dependent memory by the zinc finger protein Zbtb20 in mature CA1 neurons. J Physiol (2012) 0.81
Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Front Behav Neurosci (2014) 0.80
Conversion of short-term to long-term memory in the novel object recognition paradigm. Neurobiol Learn Mem (2013) 0.80
Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacology (Berl) (2015) 0.80
Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. PLoS One (2013) 0.80
Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. Exp Neurol (2013) 0.80
Serotonergic modulation of conditioned fear. Scientifica (Cairo) (2012) 0.80
Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice. PLoS One (2011) 0.79
Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity. Neuropsychopharmacology (2016) 0.79
Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS Spectr (2015) 0.78
A preliminary study on progesterone antioxidation in promoting learning and memory of young ovariectomized mice. Arch Med Sci (2011) 0.78
Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling. Behav Brain Res (2011) 0.78
Reducing central serotonin in adulthood promotes hippocampal neurogenesis. Sci Rep (2016) 0.78
Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proc Natl Acad Sci U S A (2015) 0.77
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci (2015) 0.77
Light exposure before learning improves memory consolidation at night. Sci Rep (2015) 0.76
Using the conditioned fear stress (CFS) animal model to understand the neurobiological mechanisms and pharmacological treatment of anxiety. Shanghai Arch Psychiatry (2012) 0.76
α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions. Int J Mol Sci (2016) 0.75
Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory. Front Hum Neurosci (2016) 0.75
Firing Properties of Genetically Identified Dorsal Raphe Serotonergic Neurons in Brain Slices. Front Cell Neurosci (2016) 0.75
Tetracycline inducible gene manipulation in serotonergic neurons. PLoS One (2012) 0.75
A mouse line for inducible and reversible silencing of specific neurons. Mol Brain (2014) 0.75
Neuromodulation, Emotional Feelings and Affective Disorders. Mens Sana Monogr (2016) 0.75
Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis. Front Cell Neurosci (2017) 0.75
Serotonin depletion eliminates sex differences with respect to context-conditioned immobility in rat. Psychopharmacology (Berl) (2016) 0.75
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods (1984) 16.43
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (2003) 16.14
Place navigation impaired in rats with hippocampal lesions. Nature (1982) 15.79
Long-term potentiation--a decade of progress? Science (1999) 10.24
Modality-specific retrograde amnesia of fear. Science (1992) 9.36
Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci (2000) 8.20
Stress and hippocampal plasticity. Annu Rev Neurosci (1999) 6.31
Descending control of pain. Prog Neurobiol (2002) 6.20
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci (2002) 5.45
The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl) (1987) 5.35
Structure and function of the brain serotonin system. Physiol Rev (1992) 5.30
A cortical-hippocampal system for declarative memory. Nat Rev Neurosci (2000) 4.95
The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci (2002) 4.14
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry (2000) 4.03
Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval. Science (2003) 3.50
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science (2007) 3.13
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus (2006) 3.02
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment. Nat Neurosci (2006) 3.00
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci U S A (1998) 2.54
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (2006) 2.49
The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci (2004) 2.43
Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus (1992) 2.19
The developmental origins of anxiety. Nat Rev Neurosci (2004) 2.17
Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature (1997) 1.94
Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci (2006) 1.92
Inescapable versus escapable shock modulates long-term potentiation in the rat hippocampus. Science (1989) 1.90
Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation. Proc Natl Acad Sci U S A (1996) 1.75
Role of serotonin in memory impairment. Ann Med (2000) 1.62
The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Biol Psychiatry (2004) 1.59
Building and burying fear memories in the brain. Neuroscientist (2005) 1.57
Stress: metaplastic effects in the hippocampus. Trends Neurosci (1998) 1.56
Serotonin and brain development. Int Rev Neurobiol (2004) 1.51
Behavioral stress impairs long-term potentiation in rodent hippocampus. Behav Neural Biol (1987) 1.48
The revised monoamine theory of depression: a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry (1996) 1.43
Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Res (2001) 1.33
The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res (2008) 1.28
Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci (2007) 1.26
Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation. Psychopharmacology (Berl) (1999) 1.22
Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development (2006) 1.20
Antidepressant-like effects in various mice strains in the forced swimming test. Psychopharmacology (Berl) (2003) 1.19
A review of the role of serotonin receptors in psychiatric disorders. Hum Psychopharmacol (2000) 1.15
Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents. J Neurosci (2002) 1.13
Stimulation at 1-5 Hz does not produce long-term depression or depotentiation in the hippocampus of the adult rat in vivo. J Neurophysiol (1995) 1.04
Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat. Eur J Neurosci (2002) 1.01
Serotonergic targets in depression. Curr Opin Pharmacol (2002) 0.99
Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse models. Dev Neurosci (2003) 0.99
Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring. Hippocampus (2006) 0.96
Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. J Neurosci (2004) 0.94
Effects of unconditioned and conditioned aversive stimuli in an intense fear conditioning paradigm on synaptic plasticity in the hippocampal CA1 area in vivo. Hippocampus (2005) 0.87
Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats. Cereb Cortex (2002) 0.87
What is the nature of the role of the serotonergic nervous system in learning and memory: prospects for development of an effective treatment strategy for senile dementia. Neurobiol Aging (1989) 0.84
Treatment of posttraumatic stress disorder: the impact of paroxetine. Psychopharmacol Bull (2003) 0.78
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol (2008) 5.55
The Arabidopsis lyrata genome sequence and the basis of rapid genome size change. Nat Genet (2011) 4.65
Integrating the predictiveness of a marker with its performance as a classifier. Am J Epidemiol (2007) 4.59
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology (2007) 3.87
Detection of large numbers of novel sequences in the metatranscriptomes of complex marine microbial communities. PLoS One (2008) 3.83
Rationally designed, polymeric, extended metal-ciprofloxacin complexes. Chemistry (2005) 3.56
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography. Genome Res (2006) 3.53
Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest (2008) 3.53
ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res (2005) 3.52
Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks. Arterioscler Thromb Vasc Biol (2013) 3.07
Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials. J Infect Dis (2012) 2.89
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
Transgenic plants expressing two Bacillus thuringiensis toxins delay insect resistance evolution. Nat Biotechnol (2003) 2.80
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol (2012) 2.74
Reference-guided assembly of four diverse Arabidopsis thaliana genomes. Proc Natl Acad Sci U S A (2011) 2.67
Dielectrophoretic Separation of Cancer Cells from Blood. IEEE Trans Ind Appl (1997) 2.45
Selective epigenetic control of retrotransposition in Arabidopsis. Nature (2009) 2.41
Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell (2013) 2.40
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33
Protein intake and incident frailty in the Women's Health Initiative observational study. J Am Geriatr Soc (2010) 2.28
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. Cytometry A (2011) 2.14
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell (2008) 2.12
Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport (2006) 2.08
Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol (2013) 2.07
Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron (2005) 2.07
Evaluation and comparison of food records, recalls, and frequencies for energy and protein assessment by using recovery biomarkers. Am J Epidemiol (2011) 2.04
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer (2011) 2.01
[2,6-Bis(4,5-dihydro-1H-imidazol-2-yl)pyridine]dichloridomanganese(II). Acta Crystallogr Sect E Struct Rep Online (2009) 2.00
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
Obesity and hypertriglyceridemia produce cognitive impairment. Endocrinology (2008) 1.94
A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese. Cancer Epidemiol Biomarkers Prev (2009) 1.93
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci (2008) 1.92
Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults. Am J Hypertens (2011) 1.91
Semaphorin-3A guides radial migration of cortical neurons during development. Nat Neurosci (2007) 1.89
Functional characterization of Narc 1, a novel proteinase related to proteinase K. Arch Biochem Biophys (2003) 1.88
Activity-dependent development of callosal projections in the somatosensory cortex. J Neurosci (2007) 1.87
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci (2005) 1.87
Characterization of MADS-domain transcription factor complexes in Arabidopsis flower development. Proc Natl Acad Sci U S A (2012) 1.83
Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene (2008) 1.82
Entangled coordination networks with inherent features of polycatenation, polythreading, and polyknotting. Angew Chem Int Ed Engl (2005) 1.81
Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest (2013) 1.81
The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development. Plant Cell (2005) 1.80
The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation. Plant Cell (2006) 1.80
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. Nat Cell Biol (2005) 1.74
Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle (2012) 1.71
A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab (2010) 1.69
Biases introduced by choosing controls to match risk factors of cases in biomarker research. Clin Chem (2012) 1.69
Average gene length is highly conserved in prokaryotes and eukaryotes and diverges only between the two kingdoms. Mol Biol Evol (2006) 1.67
Effects of native and myeloperoxidase-modified apolipoprotein a-I on reverse cholesterol transport and atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2014) 1.66
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal (2012) 1.64
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer (2008) 1.64
Hospitalizations for pediatric stone disease in United States, 2002-2007. J Urol (2010) 1.62
Autoantibody induction by DNA-containing immune complexes requires HMGB1 with the TLR2/microRNA-155 pathway. J Immunol (2013) 1.61
Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease. J Neurosci (2006) 1.59
Occurrence of phosphate acquisition genes in Prochlorococcus cells from different ocean regions. Environ Microbiol (2009) 1.55
Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci (2011) 1.55
Myosin X regulates netrin receptors and functions in axonal path-finding. Nat Cell Biol (2007) 1.55
Genome of the Chinese tree shrew. Nat Commun (2013) 1.55
Microtubule-dependent distribution of mRNA in adult cardiocytes. Am J Physiol Heart Circ Physiol (2008) 1.55
Hierarchical MnMoO(4)/CoMoO(4) heterostructured nanowires with enhanced supercapacitor performance. Nat Commun (2011) 1.55
Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol (2007) 1.54
Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells. J Virol (2005) 1.53
GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection. Protein Eng Des Sel (2010) 1.53
A facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli. Angew Chem Int Ed Engl (2010) 1.52
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. Genes Dev (2010) 1.52
Smoking and mortality in a prospective cohort study of elderly Chinese in Hong Kong. Addiction (2014) 1.52
A nonproton ligand sensor in the acid-sensing ion channel. Neuron (2010) 1.52
Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis. BMC Biol (2011) 1.51
Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. J Biol Chem (2009) 1.51
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat Genet (2012) 1.49
Neurite outgrowth and in vivo sensory innervation mediated by a Ca(V)2.2-laminin beta 2 stop signal. J Neurosci (2008) 1.49
Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. PLoS One (2011) 1.49
Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis. Eur J Haematol (2015) 1.48
Adaptation of a visualized loop-mediated isothermal amplification technique for field detection of Plasmodium vivax infection. Parasit Vectors (2011) 1.48
PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A (2010) 1.48
Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population. Carcinogenesis (2009) 1.48
Variation in the FGFR2 gene and the effects of postmenopausal hormone therapy on invasive breast cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.46
Assessment of Clostridium difficile infections by quantitative detection of tcdB toxin by use of a real-time cell analysis system. J Clin Microbiol (2010) 1.45
Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology (2002) 1.45
Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol (2011) 1.45
Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica (2005) 1.44
Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS One (2010) 1.44
Ovarian torsion: diagnosis of inclusion mandates earlier intervention. J Pediatr Surg (2012) 1.43
FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiol Dis (2008) 1.43
White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. Am J Psychiatry (2007) 1.43
An optimized murine model of ferric chloride-induced arterial thrombosis for thrombosis research. Thromb Res (2005) 1.43
A cross-sectional survey of participation of asthmatic children in physical activity. World J Pediatr (2010) 1.43
Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One (2010) 1.43
Endoscopic findings and clinicopathologic characteristics of ischemic colitis: a report of 85 cases. Dig Dis Sci (2008) 1.43
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol (2009) 1.43
Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes. J Org Chem (2002) 1.42
Blood lymphocyte-to-monocyte ratio identifies high-risk patients in diffuse large B-cell lymphoma treated with R-CHOP. PLoS One (2012) 1.42