Published in Cell Stem Cell on September 11, 2008
Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science (2011) 3.72
Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn (2009) 2.42
The cellular basis for animal regeneration. Dev Cell (2011) 2.14
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem Biol (2011) 2.07
Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis. Cell Stem Cell (2012) 2.03
Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Dev Biol (2010) 1.93
A wound-induced Wnt expression program controls planarian regeneration polarity. Proc Natl Acad Sci U S A (2009) 1.88
Cell death and tissue remodeling in planarian regeneration. Dev Biol (2009) 1.87
A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development (2010) 1.83
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol (2010) 1.68
Adult somatic stem cells in the human parasite Schistosoma mansoni. Nature (2013) 1.61
A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians. Dev Cell (2015) 1.54
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
Stem cell systems and regeneration in planaria. Dev Genes Evol (2012) 1.51
JNK controls the onset of mitosis in planarian stem cells and triggers apoptotic cell death required for regeneration and remodeling. PLoS Genet (2014) 1.51
A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals. Stem Cells (2012) 1.48
A molecular wound response program associated with regeneration initiation in planarians. Genes Dev (2012) 1.41
The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea. Development (2010) 1.40
In situ hybridization protocol for enhanced detection of gene expression in the planarian Schmidtea mediterranea. BMC Dev Biol (2013) 1.35
Reactivating head regrowth in a regeneration-deficient planarian species. Nature (2013) 1.35
Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNAseq, RNA interference and irradiation approach. Genome Biol (2012) 1.31
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J (2012) 1.31
Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends Genet (2011) 1.30
dlx and sp6-9 Control optic cup regeneration in a prototypic eye. PLoS Genet (2011) 1.29
The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol (2012) 1.28
Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell (2014) 1.19
The cell biology of regeneration. J Cell Biol (2012) 1.18
Stem cell-based growth, regeneration, and remodeling of the planarian intestine. Dev Biol (2011) 1.17
A dual platform approach to transcript discovery for the planarian Schmidtea mediterranea to establish RNAseq for stem cell and regeneration biology. PLoS One (2010) 1.16
Modeling planarian regeneration: a primer for reverse-engineering the worm. PLoS Comput Biol (2012) 1.15
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria. Elife (2014) 1.13
PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells. Development (2012) 1.13
Muscle cells provide instructions for planarian regeneration. Cell Rep (2013) 1.13
Deep sequencing identifies new and regulated microRNAs in Schmidtea mediterranea. RNA (2009) 1.13
Emerging patterns in planarian regeneration. Curr Opin Genet Dev (2009) 1.13
An RNAi screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planarians. Dev Cell (2012) 1.12
SmedGD 2.0: The Schmidtea mediterranea genome database. Genesis (2015) 1.12
Bioelectric signaling regulates head and organ size during planarian regeneration. Development (2013) 1.12
Neoblast specialization in regeneration of the planarian Schmidtea mediterranea. Stem Cell Reports (2014) 1.11
Specialized progenitors and regeneration. Development (2013) 1.10
The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration. Dis Model Mech (2010) 1.09
New approaches for understanding mechanisms of drug resistance in schistosomes. Parasitology (2013) 1.07
Transcriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea. PLoS One (2012) 1.04
Characterization of the stem cell system of the acoel Isodiametra pulchra. BMC Dev Biol (2009) 1.02
Smed454 dataset: unravelling the transcriptome of Schmidtea mediterranea. BMC Genomics (2010) 1.01
Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors. Elife (2014) 0.98
Tissue absence initiates regeneration through follistatin-mediated inhibition of activin signaling. Elife (2013) 0.98
Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration. Proc Natl Acad Sci U S A (2013) 0.97
Amputation induces stem cell mobilization to sites of injury during planarian regeneration. Development (2012) 0.96
SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians. PLoS Genet (2012) 0.95
A mex3 homolog is required for differentiation during planarian stem cell lineage development. Elife (2015) 0.95
PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration. Development (2013) 0.94
Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. J Cell Biol (2013) 0.92
Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases. Epigenetics (2012) 0.92
Stem cell progeny contribute to the schistosome host-parasite interface. Elife (2016) 0.91
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns (2009) 0.89
The planarian regeneration transcriptome reveals a shared but temporally shifted regulatory program between opposing head and tail scenarios. BMC Genomics (2013) 0.89
Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. Elife (2015) 0.87
TORC1 is required to balance cell proliferation and cell death in planarians. Dev Biol (2012) 0.87
A sex-specific transcription factor controls male identity in a simultaneous hermaphrodite. Nat Commun (2013) 0.86
Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development. Stem Cells Dev (2012) 0.85
Novel monoclonal antibodies to study tissue regeneration in planarians. BMC Dev Biol (2015) 0.84
Argonaute-2 regulates the proliferation of adult stem cells in planarian. Cell Res (2011) 0.84
Optical coherence tomography: a new strategy to image planarian regeneration. Sci Rep (2014) 0.84
The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. PLoS Genet (2013) 0.84
zic-1 Expression in Planarian neoblasts after injury controls anterior pole regeneration. PLoS Genet (2014) 0.84
Q&A: what is regeneration, and why look to planarians for answers? BMC Biol (2012) 0.84
Identification of neoblast- and regeneration-specific miRNAs in the planarian Schmidtea mediterranea. RNA (2013) 0.81
Potential of Macrostomum lignano to recover from gamma-ray irradiation. Cell Tissue Res (2010) 0.81
In silico lineage tracing through single cell transcriptomics identifies a neural stem cell population in planarians. Genome Biol (2016) 0.80
Molecular cloning and characterization of SL3: a stem cell-specific SL RNA from the planarian Schmidtea mediterranea. Gene (2013) 0.80
Exploring the evolutionary history of centrosomes. Philos Trans R Soc Lond B Biol Sci (2014) 0.80
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes. BMC Genomics (2013) 0.80
Reactive Oxygen Species in Planarian Regeneration: An Upstream Necessity for Correct Patterning and Brain Formation. Oxid Med Cell Longev (2015) 0.80
Stem cell proliferation during in vitro development of the model cestode Mesocestoides corti from larva to adult worm. Front Zool (2010) 0.79
Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo. Cell Rep (2015) 0.79
Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation. Dev Biol (2013) 0.79
Acoel and platyhelminth models for stem-cell research. J Biol (2010) 0.78
Mesodermal gene expression in the acoel Isodiametra pulchra indicates a low number of mesodermal cell types and the endomesodermal origin of the gonads. PLoS One (2013) 0.78
Planarians as a model to assess in vivo the role of matrix metalloproteinase genes during homeostasis and regeneration. PLoS One (2013) 0.78
Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians. Elife (2016) 0.78
Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells. PLoS One (2011) 0.78
An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations. Stem Cell Reports (2015) 0.78
A functional genomics screen identifies an Importin-α homolog as a regulator of stem cell function and tissue patterning during planarian regeneration. BMC Genomics (2015) 0.77
Reference genes for qPCR assays in toxic metal and salinity stress in two flatworm model organisms. Ecotoxicology (2011) 0.77
Hedgehog signaling regulates gene expression in planarian glia. Elife (2016) 0.76
The Evolution of the Secreted Regulatory Protein Progranulin. PLoS One (2015) 0.76
iTRAQ-Based Quantitative Proteomic Analysis of the Initiation of Head Regeneration in Planarians. PLoS One (2015) 0.76
Yorkie is required to restrict the injury responses in planarians. PLoS Genet (2017) 0.76
SmedOB1 is Required for Planarian Homeostasis and Regeneration. Sci Rep (2016) 0.75
The NuRD complex component p66 suppresses photoreceptor neuron regeneration in planarians. Regeneration (Oxf) (2016) 0.75
Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age. J Cell Biol (2011) 0.75
Embryonic origin of adult stem cells required for tissue homeostasis and regeneration. Elife (2017) 0.75
Planarians: an In Vivo Model for Regenerative Medicine. Int J Stem Cells (2015) 0.75
Transcriptional signatures of somatic neoblasts and germline cells in Macrostomum lignano. Elife (2016) 0.75
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. PLoS Negl Trop Dis (2017) 0.75
Integrins are required for tissue organization and restriction of neurogenesis in regenerating planarians. Development (2017) 0.75
Alternative flow cytometry strategies to analyze stem cells and cell death in planarians. Regeneration (Oxf) (2016) 0.75
Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea. BMC Genomics (2015) 0.75
Essential role for the planarian intestinal GATA transcription factor in stem cells and regeneration. Dev Biol (2016) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
Translating the histone code. Science (2001) 56.77
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63
Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01
Stem cells: units of development, units of regeneration, and units in evolution. Cell (2000) 7.36
The aging of hematopoietic stem cells. Nat Med (1996) 6.67
The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature (2005) 6.20
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78
A niche maintaining germ line stem cells in the Drosophila ovary. Science (2000) 5.04
Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol (2004) 4.60
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol (2008) 4.30
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science (2005) 3.83
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature (2004) 3.69
Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny. Cell (2001) 3.55
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity (2007) 3.26
Identification of a lineage of multipotent hematopoietic progenitors. Development (1997) 3.01
Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev Biol (2000) 2.94
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development (2002) 2.71
The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev (2006) 2.62
Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits. J Biol Chem (1985) 2.47
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A (2003) 2.44
Cell turnover and adult tissue homeostasis: from humans to planarians. Annu Rev Genet (2007) 2.10
Can stem cells cross lineage boundaries? Nat Med (2001) 2.08
A Bruno-like gene is required for stem cell maintenance in planarians. Dev Cell (2006) 2.08
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol Cell Biol (1991) 2.04
Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting. Dev Growth Differ (2006) 1.94
Regulation of temporal identity transitions in Drosophila neuroblasts. Dev Cell (2005) 1.93
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain. Proc Natl Acad Sci U S A (2005) 1.85
Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene (1999) 1.78
Stem cell self-renewal controlled by chromatin remodeling factors. Science (2005) 1.73
RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene (2004) 1.70
Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex. J Biol Chem (2002) 1.41
A signaling role of histone-binding proteins and INHAT subunits pp32 and Set/TAF-Ibeta in integrating chromatin hypoacetylation and transcriptional repression. J Biol Chem (2004) 1.41
Stem cell potential: can anything make anything? Curr Biol (2001) 1.35
smedinx-11 is a planarian stem cell gap junction gene required for regeneration and homeostasis. Development (2007) 1.23
The role of combinational coding by homeodomain and bHLH transcription factors in retinal cell fate specification. Dev Biol (2005) 1.23
Roles of the mammalian subventricular zone in cell replacement after brain injury. Prog Neurobiol (2004) 1.19
Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy. Genesis (2002) 1.18
Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. Genome Biol (2007) 1.18
Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1. BMC Dev Biol (2005) 1.13
Characterization and categorization of fluorescence activated cell sorted planarian stem cells by ultrastructural analysis. Dev Growth Differ (2007) 1.07
Upregulation of the creatine synthetic pathway in skeletal muscles of mature mdx mice. Neuromuscul Disord (2007) 1.07
The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments. Dev Biol (2002) 0.96
Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. Am J Pathol (2004) 0.89
Creatine synthesis and transport systems in the male rat reproductive tract. Biol Reprod (1998) 0.85
Cytological approach to morphogenesis in the planarian blastema. II. The effect of neuropeptides. J Submicrosc Cytol Pathol (1997) 0.83
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Highly conserved sequences mediate the dynamic interplay of basic helix-loop-helix proteins regulating retinogenesis. J Biol Chem (2007) 0.83
MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res (2007) 6.48
Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol (2004) 4.60
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell (2005) 4.35
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science (2005) 3.83
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science (2007) 3.26
Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet (2002) 3.06
SmedGD: the Schmidtea mediterranea genome database. Nucleic Acids Res (2007) 3.02
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci U S A (2003) 2.44
Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn (2009) 2.42
Planarian Hh signaling regulates regeneration polarity and links Hh pathway evolution to cilia. Science (2009) 2.25
Slicing across kingdoms: regeneration in plants and animals. Cell (2008) 2.18
Cell turnover and adult tissue homeostasis: from humans to planarians. Annu Rev Genet (2007) 2.10
Cell death and tissue remodeling in planarian regeneration. Dev Biol (2009) 1.87
A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development (2010) 1.83
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature (2002) 1.80
De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res (2011) 1.70
Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response. Dev Biol (2010) 1.68
BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development (2007) 1.66
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea. Dev Dyn (2003) 1.49
Centrosome loss in the evolution of planarians. Science (2012) 1.29
Morphological and functional recovery of the planarian photosensing system during head regeneration. Zoolog Sci (2004) 1.28
The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol (2012) 1.28
The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling. Development (2011) 1.27
Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A (2012) 1.21
Identification of immunological reagents for use in the study of freshwater planarians by means of whole-mount immunofluorescence and confocal microscopy. Genesis (2002) 1.18
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria. Elife (2014) 1.13
Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea. Exp Cell Res (2005) 1.10
Amputation induces stem cell mobilization to sites of injury during planarian regeneration. Development (2012) 0.96
miR-15b induced by platelet-derived growth factor signaling is required for vascular smooth muscle cell proliferation. BMB Rep (2013) 0.95
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. Dis Model Mech (2008) 0.93
TORC1 is required to balance cell proliferation and cell death in planarians. Dev Biol (2012) 0.87
Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells. Dev Dyn (2009) 0.87
Gene nomenclature guidelines for the planarian Schmidtea mediterranea. Dev Dyn (2008) 0.82
The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol (2010) 0.82
Molecular cloning and characterization of SL3: a stem cell-specific SL RNA from the planarian Schmidtea mediterranea. Gene (2013) 0.80
Planarian immobilization, partial irradiation, and tissue transplantation. J Vis Exp (2012) 0.79
Down-regulation of miR-96 by bone morphogenetic protein signaling is critical for vascular smooth muscle cell phenotype modulation. J Cell Biochem (2014) 0.78
Developmental biology: A cellular view of regeneration. Nature (2009) 0.78
Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells. Mol Cell Biochem (2012) 0.78
Alejandro Sánchez Alvarado: bootstrapping flatworms into the molecular age. J Cell Biol (2011) 0.75
Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression. Mol Cell Biochem (2015) 0.75