Published in Proc Natl Acad Sci U S A on December 01, 1976
Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system. Proc Natl Acad Sci U S A (1978) 5.49
Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev (1992) 5.15
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase. Proc Natl Acad Sci U S A (1978) 4.85
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A. Proc Natl Acad Sci U S A (1978) 3.84
Bacterial toxins: cellular mechanisms of action. Microbiol Rev (1984) 3.42
Purification of cholera toxin and its subunits: new methods of preparation and the use of hypertoxinogenic mutants. Infect Immun (1978) 2.16
Activation of adenylate cyclase by heat-labile Escherichia coli enterotoxin. Evidence for ADP-ribosyltransferase activity similar to that of choleragen. J Clin Invest (1978) 2.07
Vibrio fischeri genes hvnA and hvnB encode secreted NAD(+)-glycohydrolases. J Bacteriol (2001) 1.78
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity. Proc Natl Acad Sci U S A (1988) 1.61
Choleragen activation of solubilized adenylate cyclase: requirement for GTP and protein activator for demonstration of enzymatic activity. Proc Natl Acad Sci U S A (1977) 1.54
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells. Microbiol Rev (1978) 1.39
ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect Immun (1988) 1.30
Purification and characterization of a molluscan egg-specific NADase, a second-messenger enzyme. Cell Regul (1991) 1.28
Gangliosides sensitize unresponsive fibroblasts to Escherichia coli heat-labile enterotoxin. J Clin Invest (1979) 1.27
Transfer of ADP-ribose from NAD to choleragen: a subunit acts as catalyst and acceptor protein. Proc Natl Acad Sci U S A (1977) 1.26
Isolation of an avian erythrocyte protein possessing ADP-ribosyltransferase activity and capable of activating adenylate cyclase. Proc Natl Acad Sci U S A (1978) 1.24
Reconstitution of cholera toxin-activated adenylate cyclase. Proc Natl Acad Sci U S A (1978) 1.20
Enhancement of choleragen ADP-ribosyltransferase activities by guanyl nucleotides and a 19-kDa membrane protein. Proc Natl Acad Sci U S A (1987) 1.19
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen. Proc Natl Acad Sci U S A (1977) 1.11
Nonenzymic ADP-ribosylation of specific mitochondrial polypeptides. Proc Natl Acad Sci U S A (1984) 1.11
Histone-dependent and histone-independent forms of an ADP-ribosyltransferase from human and turkey erythrocytes. Proc Natl Acad Sci U S A (1981) 1.03
Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme. Proc Natl Acad Sci U S A (1985) 1.01
Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice. Mol Cell Biol (2007) 0.94
Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197. Proc Natl Acad Sci U S A (2012) 0.93
Photolabeling of Glu-129 of the S-1 subunit of pertussis toxin with NAD. Infect Immun (1989) 0.89
Exohemagglutinins: new products of vibrios. Appl Environ Microbiol (1979) 0.89
Toxins from bacteria. EXS (2010) 0.87
ADP-ribosylation of microtubule proteins as catalyzed by cholera toxin. EMBO J (1982) 0.86
Identification of an iron-sulfur cluster that modulates the enzymatic activity in NarE, a Neisseria meningitidis ADP-ribosyltransferase. J Biol Chem (2009) 0.84
Structural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidis. J Biol Chem (2011) 0.83
Prevention and reversal of cholera enterotoxin effects in rabbit jejunum by nicotinic acid. J Clin Invest (1978) 0.83
Demonstration of cell envelope-bound exotoxin A in Pseudomonas aeruginosa. Infect Immun (1980) 0.83
The hydrophobicities of cholera toxin, tetanus toxin and their components. Biochem J (1981) 0.82
Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins. PLoS One (2012) 0.80
Characterization of a unique ADP-ribosyltransferase of Mycoplasma penetrans. Infect Immun (2009) 0.80
Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes. Biochem J (1977) 0.79
NAD metabolism in Vibrio cholerae. J Bacteriol (1982) 0.77
The adenylate cyclase-activating activity of cholera toxin is not associated with a nicotinamide--adenine dinucleotide glycohydrolase activity. Biochem J (1978) 0.77
Comparison of effects of nicked and unnicked Escherichia coli heat-labile enterotoxin on Chinese hamster ovary cells. Infect Immun (1984) 0.76
Effects of cholera toxin and guanosine 5'-[betagamma-imido]triphosphate on beta-adrenergic-receptor affinity. Biochem J (1978) 0.76
Design, synthesis, and evaluation of bisubstrate analog inhibitors of cholera toxin. Bioorg Med Chem Lett (2008) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Interaction of Vibrio cholerae enterotoxin with cell membranes. Biochemistry (1973) 4.84
Gangliosides and membrane receptors for cholera toxin. Biochemistry (1973) 4.81
The mechanism of action of cholera toxin in pigeon erythrocyte lysates. J Biol Chem (1975) 4.22
Tissue receptor for cholera exotoxin: postulated structure from studies with GM1 ganglioside and related glycolipids. Infect Immun (1973) 4.08
Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule. J Biol Chem (1971) 3.27
Deactivation of cholera toxin by ganglioside. J Infect Dis (1971) 3.16
Cholera toxin: interaction of subunits with ganglioside GM1. Science (1974) 3.11
Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro. Proc Natl Acad Sci U S A (1975) 3.04
Dissociation and recombination of the subunits of the cholera enterotoxin (choleragen). J Immunol (1974) 2.66
Interaction of fragment A from diphtheria toxin with nicotinamide adenine dinucleotide. J Biol Chem (1974) 2.55
Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. J Biol Chem (1971) 2.23
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness. Proc Natl Acad Sci U S A (1976) 2.14
Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes. Biochem J (1975) 1.98
Mechanism of activation of adenylate cyclase by cholera toxin. Proc Natl Acad Sci U S A (1975) 1.65
Mechanism of action of cholera toxin and the mobile receptor theory of hormone receptor-adenylate cyclase interactions. Proc Natl Acad Sci U S A (1975) 1.51
Cholera toxin activation of adenylate cyclase in cancer cell membrane fragments. Proc Natl Acad Sci U S A (1975) 1.14
Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. Proc Natl Acad Sci U S A (1996) 5.84
Herbal medicines and perioperative care. JAMA (2001) 5.05
Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J Clin Invest (1971) 3.39
Activation of adenylate cyclase by choleragen. Annu Rev Biochem (1979) 3.16
Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J Lipid Res (1978) 2.92
Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest (1972) 2.88
Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptor. J Biol Chem (1977) 2.76
Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res (1969) 2.73
Molecules in the ARF orbit. J Biol Chem (1998) 2.66
Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest (1999) 2.65
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site. J Biol Chem (1985) 2.64
The biotin-dependent enzymes. Adv Enzymol Relat Areas Mol Biol (1971) 2.45
Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res (2000) 2.37
Stimulation of glycerol production in fat cells by cholera toxin. Nature (1970) 2.34
ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins. Adv Enzymol Relat Areas Mol Biol (1988) 2.27
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci U S A (2000) 2.21
Structure and function of ARF proteins: activators of cholera toxin and critical components of intracellular vesicular transport processes. J Biol Chem (1995) 2.18
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness. Proc Natl Acad Sci U S A (1976) 2.14
A standardized psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatr Scand (1977) 2.13
Rapid, reliable ligation-independent cloning of PCR products using modified plasmid vectors. Biotechniques (1992) 2.09
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A (1998) 2.08
Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia. Am J Surg Pathol (2000) 2.07
Activation of adenylate cyclase by heat-labile Escherichia coli enterotoxin. Evidence for ADP-ribosyltransferase activity similar to that of choleragen. J Clin Invest (1978) 2.07
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. J Biol Chem (1991) 1.99
Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyltransferase, and carboxyl carrier protein components. J Biol Chem (1974) 1.99
Mortality variation across Australia: descriptive data for states and territories, and statistical divisions. Aust N Z J Public Health (2000) 1.98
Regulation of glycogen metabolism in polymorphonuclear leukocytes. J Biol Chem (1970) 1.98
Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. N Engl J Med (1972) 1.96
Acetyl coenzyme A carboxylase. Curr Top Cell Regul (1974) 1.94
Extrapulmonary lymphangioleiomyomatosis (LAM): clinicopathologic features in 22 cases. Hum Pathol (2000) 1.93
Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles. J Clin Invest (1972) 1.84
Isolation and properties of phagocytic vesicles. II. Alveolar macrophages. J Clin Invest (1972) 1.82
Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem (2000) 1.82
Identification of antigens and antibodies specific for Pneumocystis carinii. J Immunol (1988) 1.81
Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor kappaB-binding sites. J Biol Chem (1998) 1.81
Climate change and the integrity of science. Science (2010) 1.80
Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J Biol Chem (1999) 1.78
Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes. Proc Natl Acad Sci U S A (1994) 1.74
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein). J Biol Chem (1983) 1.74
Lymphangioleiomyomatosis: what do we know and what are we looking for? Eur Respir Rev (2011) 1.73
Prophylaxis against ampicillin-associated diarrhea with a lactobacillus preparation. Am J Hosp Pharm (1979) 1.72
Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues). Proc Natl Acad Sci U S A (1972) 1.68
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. J Biol Chem (1984) 1.67
Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem (1988) 1.67
Lymphangioleiomyomatosis: CT of diurnal variation of lymphangioleiomyomas. Radiology (2001) 1.67
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc Natl Acad Sci U S A (2000) 1.62
Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc Natl Acad Sci U S A (1997) 1.62
Effect of myristoylation on GTP-dependent binding of ADP-ribosylation factor to Golgi. J Biol Chem (1993) 1.61
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution. Mol Cell Biol (1991) 1.61
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. J Biol Chem (1989) 1.61
Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions. Anesthesiology (1998) 1.61
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Antihistamine prophylaxis permits rapid vancomycin infusion. Crit Care Med (1999) 1.57
A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A (1971) 1.57
Correction of the PNH defect by GPI-anchored protein transfer. Blood (1998) 1.55
Hydroxylamine-stable covalent linkage of myristic acid in G0 alpha, a guanine nucleotide-binding protein of bovine brain. Biochem Biophys Res Commun (1987) 1.55
Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem (1999) 1.54
Angioplasty and STent for Renal Artery Lesions (ASTRAL trial): rationale, methods and results so far. J Hum Hypertens (2007) 1.54
Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors. Proc Natl Acad Sci U S A (1998) 1.54
Choleragen activation of solubilized adenylate cyclase: requirement for GTP and protein activator for demonstration of enzymatic activity. Proc Natl Acad Sci U S A (1977) 1.54
Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM). Hum Pathol (1997) 1.53
Conservative management of fibroadenoma of the breast. Br J Surg (1996) 1.51
Interaction of choleragen with the oligosaccharide of ganglioside GM1: evidence for multiple oligosaccharide binding sites. Biochemistry (1978) 1.50
Plasma catecholamines in stress and exercise. JAMA (1980) 1.50
The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes. J Clin Invest (1971) 1.49
Lymphangioleiomyomatosis: abdominopelvic CT and US findings. Radiology (2000) 1.49
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J Biol Chem (1997) 1.49
Effects of lipolytic and antilipolytic agents on cyclic 3',5'-adenosine monophosphate in fat cells. J Biol Chem (1971) 1.49
Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study. Am J Respir Crit Care Med (2000) 1.49
Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res (2006) 1.48
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. J Biol Chem (2000) 1.47
Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci U S A (1981) 1.47
Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi. J Biol Chem (1993) 1.46
An effect of insulin on cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in fat cells. J Biol Chem (1973) 1.46
Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation. J Biol Chem (2000) 1.45
The effect of sevoflurane and desflurane on upper airway reactivity. Anesthesiology (2001) 1.44
Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc Natl Acad Sci U S A (1997) 1.44