Published in J Biol Chem on April 10, 1971
Mechanisms regulating adipose-tissue pyruvate dehydrogenase. Biochem J (1972) 2.01
Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues). Proc Natl Acad Sci U S A (1972) 1.68
Cyclic adenosine monophosphate in the nervous system of Aplysia californica. II. Effect of serotonin and dopamine. J Gen Physiol (1972) 1.66
Guanosine 3':5'-cyclic monophosphate and the action of insulin and acetylcholine. Proc Natl Acad Sci U S A (1973) 1.47
Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices. Proc Natl Acad Sci U S A (1973) 1.18
The effects of glucagon and insulin on adenosine 3':5'-cyclic monophosphate concentrations in an organ culture of mature rat liver. Biochem J (1973) 1.13
Comparative effects of angiotensin and ACTH on cyclic AMP and steroidogenesis in isolated bovine adrenal cells. J Clin Invest (1973) 1.04
Reduced sensitivity of the hepatic adenylate cyclase-cyclic AMP system to glucagon during sustained hormonal stimulation. J Clin Invest (1976) 1.00
Changes in cyclic AMP and cyclic GMP concentrations during the action of 5-hydroxytryptamine on an insect salivary gland. Biochem J (1980) 0.97
Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action. J Clin Invest (1975) 0.97
The mechanism of activation of hormone-sensitive lipase in human adipose tissue. J Clin Invest (1974) 0.91
Effects of epinephrine, adrenocorticotrophic hormone, and theophylline on adenosine 3', 5'-monophosphate phosphodiesterase activity in fat cells. Proc Natl Acad Sci U S A (1974) 0.84
Modulation of intracellular cyclic AMP content and rate of lipogenesis in mammary acini in vitro. Biochem J (1986) 0.83
Cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase activities of rat mammary tissue. Biochem J (1984) 0.82
The relationship between the concentration of adenosine 3':5'-cyclic monophosphate and the anti-lipolytic action of insulin in isolated rat fat-cells. Biochem J (1974) 0.82
The effect of glucose, insulin and noradrenaline on lipolysis, and on the concentrations of adenosine 3':5'-cyclic monophosphate and adenosine 5'-triphosphate in adipose tissue. Biochem J (1973) 0.77
Cellular levels of feedback regulator of adenylate cyclase and the effect of epinephrine and insulin. Proc Natl Acad Sci U S A (1975) 0.76
Catecholamines--a symposium. Calif Med (1972) 0.75
Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res (1983) 6.42
Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain. Proc Natl Acad Sci U S A (1996) 5.84
Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A (1977) 4.90
Cyclic GMP synthesis and function. Pharmacol Rev (1987) 4.89
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 4.50
Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res (1977) 3.70
Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature (1978) 3.60
Cyclic guanosine monophosphate as a mediator of vasodilation. J Clin Invest (1986) 3.59
Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J Clin Invest (1971) 3.39
Activation of adenylate cyclase by choleragen. Annu Rev Biochem (1979) 3.16
Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc Natl Acad Sci U S A (1991) 3.15
Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase. Proc Natl Acad Sci U S A (1976) 2.98
Procedure for determination of free and total cholesterol in micro- or nanogram amounts suitable for studies with cultured cells. J Lipid Res (1978) 2.92
Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest (1972) 2.88
Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature (1984) 2.77
Mechanism of action of choleragen. Evidence for ADP-ribosyltransferase activity with arginine as an acceptor. J Biol Chem (1977) 2.76
Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res (1969) 2.73
Molecules in the ARF orbit. J Biol Chem (1998) 2.66
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site. J Biol Chem (1985) 2.64
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A (1991) 2.58
Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. J Infect Dis (1980) 2.52
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Guanylate cyclase: activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotide Res (1978) 2.43
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation. Eur J Pharmacol (1990) 2.40
Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol (1991) 2.34
Stimulation of glycerol production in fat cells by cholera toxin. Nature (1970) 2.34
Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. J Cyclic Nucleotide Protein Phosphor Res (1983) 2.34
ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins. Adv Enzymol Relat Areas Mol Biol (1988) 2.27
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci U S A (1984) 2.26
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science (1992) 2.25
Structure and function of ARF proteins: activators of cholera toxin and critical components of intracellular vesicular transport processes. J Biol Chem (1995) 2.18
Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. J Biol Chem (1984) 2.15
Functional incorporation of ganglioside into intact cells: induction of choleragen responsiveness. Proc Natl Acad Sci U S A (1976) 2.14
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett (1993) 2.14
A standardized psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatr Scand (1977) 2.13
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A (1998) 2.08
Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol (2001) 2.08
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. J Biol Chem (1991) 1.99
Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol (1977) 1.98
Regulation of glycogen metabolism in polymorphonuclear leukocytes. J Biol Chem (1970) 1.98
Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. N Engl J Med (1972) 1.96
Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci U S A (1992) 1.93
Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles. J Clin Invest (1972) 1.84
Isolation and properties of phagocytic vesicles. II. Alveolar macrophages. J Clin Invest (1972) 1.82
Climate change and the integrity of science. Science (2010) 1.80
Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. J Biol Chem (1999) 1.78
Activation of guanylate cyclase from rat liver and other tissues by sodium azide. J Biol Chem (1975) 1.77
Activation of rat brain phospholipase D by ADP-ribosylation factors 1,5, and 6: separation of ADP-ribosylation factor-dependent and oleate-dependent enzymes. Proc Natl Acad Sci U S A (1994) 1.74
Evidence for two different forms of guanylate cyclase in rat heart. J Biol Chem (1974) 1.68
Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues). Proc Natl Acad Sci U S A (1972) 1.68
Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem (1988) 1.67
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. J Biol Chem (1984) 1.67
Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. J Histochem Cytochem (1992) 1.65
Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol Pharmacol (1992) 1.63
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc Natl Acad Sci U S A (2000) 1.62
Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc Natl Acad Sci U S A (1997) 1.62
Effect of myristoylation on GTP-dependent binding of ADP-ribosylation factor to Golgi. J Biol Chem (1993) 1.61
Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem Biophys Res Commun (1990) 1.61
Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J Immunol (2000) 1.59
Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J Biol Chem (1986) 1.58
A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. Proc Natl Acad Sci U S A (1971) 1.57
Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. J Cyclic Nucleotide Res (1977) 1.57
Hydroxylamine-stable covalent linkage of myristic acid in G0 alpha, a guanine nucleotide-binding protein of bovine brain. Biochem Biophys Res Commun (1987) 1.55
Brefeldin A-inhibited guanine nucleotide-exchange activity of Sec7 domain from yeast Sec7 with yeast and mammalian ADP ribosylation factors. Proc Natl Acad Sci U S A (1998) 1.54
Choleragen activation of solubilized adenylate cyclase: requirement for GTP and protein activator for demonstration of enzymatic activity. Proc Natl Acad Sci U S A (1977) 1.54
Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation. Proc Natl Acad Sci U S A (1977) 1.49
The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes. J Clin Invest (1971) 1.49
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3). J Biol Chem (1997) 1.49
An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci U S A (1998) 1.49
GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. J Biol Chem (2000) 1.47
Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci U S A (1981) 1.47
A simple and sensitive bioassay method for detection of EDRF with RFL-6 rat lung fibroblasts. Am J Physiol (1991) 1.47
Reversible inactivation of guanylate cyclase by mixed disulfide formation. J Biol Chem (1981) 1.46
Effects of brefeldin A and accessory proteins on association of ADP-ribosylation factors 1, 3, and 5 with Golgi. J Biol Chem (1993) 1.46
An effect of insulin on cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in fat cells. J Biol Chem (1973) 1.46
Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor. Proc Natl Acad Sci U S A (1997) 1.44
NO, nitrotyrosine, and cyclic GMP in signal transduction. Med Sci Monit (2001) 1.42
Nonenzymatic formation of guanosine 3':5'-monophosphate from guanosine triphosphate. J Biol Chem (1974) 1.42
Pertussis toxin inhibits enkephalin stimulation of GTPase of NG108-15 cells. J Biol Chem (1983) 1.41
Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Mol Pharmacol (1990) 1.41
ARF-GEP(100), a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc Natl Acad Sci U S A (2001) 1.41
Colocalization of nitric oxide synthase and NADPH-diaphorase in the myenteric plexus of the rat gut. Neurosci Lett (1992) 1.40
Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase. Biochem Biophys Res Commun (1991) 1.39
Identification of a brefeldin A-insensitive guanine nucleotide-exchange protein for ADP-ribosylation factor in bovine brain. Proc Natl Acad Sci U S A (1994) 1.38
Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung. J Biol Chem (1978) 1.37
Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. J Biol Chem (1990) 1.34
Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase. J Biol Chem (1984) 1.33
Cyclic nucleotide levels in incubations of guinea pig trachea. Biochim Biophys Acta (1974) 1.30
Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion. J Immunol (1978) 1.29
Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am J Physiol (1993) 1.29
Soluble guanylate cyclase from rat lung exists as a heterodimer. J Biol Chem (1986) 1.28
Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. J Cardiovasc Pharmacol (1987) 1.27
Effects of Na+,K+-pump inhibitors and membrane depolarizing agents on acetylcholine-induced endothelium-dependent relaxation and cyclic GMP accumulation in rat aorta. Eur J Pharmacol (1985) 1.27
Nitric oxide and cGMP signaling. Adv Pharmacol (1995) 1.26
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP. Proc Natl Acad Sci U S A (1982) 1.26