Published in Nucleic Acids Res on October 01, 2008
Site-specific integrase-mediated transgenesis in mice via pronuclear injection. Proc Natl Acad Sci U S A (2011) 1.58
PhiC31 integrase induces a DNA damage response and chromosomal rearrangements in human adult fibroblasts. BMC Biotechnol (2009) 0.97
Transgene excision in zebrafish using the phiC31 integrase. Genesis (2010) 0.93
Comparison and optimization of ten phage encoded serine integrases for genome engineering in Saccharomyces cerevisiae. BMC Biotechnol (2016) 0.76
Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells. FEBS Lett (2016) 0.75
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22
Widespread recombinase expression using FLPeR (flipper) mice. Genesis (2001) 7.08
A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A (2000) 5.13
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Mechanisms of site-specific recombination. Annu Rev Biochem (2006) 4.29
High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One (2007) 3.84
Targeting genes for self-excision in the germ line. Genes Dev (1999) 3.59
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol (2001) 3.39
Mammalian genomes contain active recombinase recognition sites. Gene (2000) 3.08
Long-range disruption of gene expression by a selectable marker cassette. Proc Natl Acad Sci U S A (1996) 2.83
Control of directionality in the site-specific recombination system of the Streptomyces phage phiC31. Mol Microbiol (2000) 2.78
Site-specific genomic integration produces therapeutic Factor IX levels in mice. Nat Biotechnol (2002) 2.54
Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat Biotechnol (2003) 2.28
Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. Nucleic Acids Res (2002) 2.14
Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell (2007) 2.06
Phi c31 integrase induces chromosomal aberrations in primary human fibroblasts. Gene Ther (2006) 1.86
Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet (2007) 1.77
Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell (2008) 1.60
In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery. Mol Ther (2005) 1.59
Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice. Genesis (2001) 1.46
Sequences in attB that affect the ability of phiC31 integrase to synapse and to activate DNA cleavage. Nucleic Acids Res (2007) 1.15
Rearranging the centromere of the human Y chromosome with phiC31 integrase. Nucleic Acids Res (2005) 0.99
Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res (2008) 0.99
Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression. Dev Dyn (2002) 0.95
Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Nat Med (2009) 3.82
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci U S A (2011) 3.80
Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell (2010) 3.28
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev (2004) 2.91
A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell (2007) 2.83
Hoxb8 is required for normal grooming behavior in mice. Neuron (2002) 2.67
Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev (2004) 2.54
Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science (2003) 2.53
Virtual histology of transgenic mouse embryos for high-throughput phenotyping. PLoS Genet (2006) 2.45
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development (2002) 2.31
Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J (2009) 2.31
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo. Development (2006) 2.21
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell (2012) 1.99
Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell (2011) 1.96
Hox patterning of the vertebrate rib cage. Development (2007) 1.78
Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet (2007) 1.77
Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem (2003) 1.72
Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer (2009) 1.72
A protocol for constructing gene targeting vectors: generating knockout mice for the cadherin family and beyond. Nat Protoc (2008) 1.69
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors. Mol Imaging (2005) 1.65
Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death. Am J Pathol (2004) 1.64
Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Dev Cell (2008) 1.60
The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol (2004) 1.59
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59
Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development (2003) 1.57
Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. Proc Natl Acad Sci U S A (2009) 1.56
Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev (2002) 1.55
T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.54
The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev (2002) 1.50
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes. PLoS One (2009) 1.50
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A (2009) 1.47
Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol (2003) 1.44
ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J Biol Chem (2005) 1.35
Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development (2003) 1.34
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development (2008) 1.34
Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. Am J Pathol (2007) 1.30
Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae. Dev Biol (2003) 1.29
BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol (2013) 1.26
Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure. Circ Res (2002) 1.19
Hoxb1 neural crest preferentially form glia of the PNS. Dev Dyn (2003) 1.19
Reversal of Hox1 gene subfunctionalization in the mouse. Dev Cell (2006) 1.19
New genetic tactics to model alveolar rhabdomyosarcoma in the mouse. Cancer Res (2005) 1.16
Synovial sarcoma: from genetics to genetic-based animal modeling. Clin Orthop Relat Res (2008) 1.14
Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. Free Radic Biol Med (2007) 1.13
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice. J Biol Chem (2004) 1.13
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. J Lipid Res (2010) 1.10
Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. J Mol Cell Biol (2012) 1.09
Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo. Hypertension (2007) 1.08
Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. J Biol Chem (2012) 1.06
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II. Hypertension (2003) 1.05
Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev (2004) 1.04
A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res (2009) 1.03
Evolution of the mammary gland from the innate immune system? Bioessays (2006) 1.02
Cardiovascular defects in a mouse model of HOXA1 syndrome. Hum Mol Genet (2011) 1.01
Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol (2007) 0.99
Male fertility is dependent on dipeptidase activity of testis ACE. Nat Med (2005) 0.98
An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci (2010) 0.97
Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell (2013) 0.96
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1. Free Radic Biol Med (2011) 0.96
Fundamental cellular processes do not require vertebrate-specific sequences within the TATA-binding protein. J Biol Chem (2002) 0.95
Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol (2010) 0.93
Contribution of Hox genes to the diversity of the hindbrain sensory system. Development (2004) 0.93
Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system. Cell (2002) 0.92
The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain. Mol Cell Biol (2009) 0.91
Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol (2012) 0.91
Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development (2003) 0.90
Targeting the Wnt pathway in synovial sarcoma models. Cancer Discov (2013) 0.90
Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms. Anat Rec (Hoboken) (2008) 0.90
Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res (2012) 0.89
Hepatocytes lacking thioredoxin reductase 1 have normal replicative potential during development and regeneration. J Cell Sci (2010) 0.88
Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Dev Biol (2002) 0.87
Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol (2011) 0.87
Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei. Mamm Genome (2013) 0.85
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. PLoS One (2013) 0.84
Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A (2012) 0.83
A Nobel lesson: the grant behind the prize. Response. Science (2008) 0.83
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification. Free Radic Biol Med (2013) 0.83
Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus. Am J Physiol Renal Physiol (2008) 0.82
A functional Jak2 tyrosine kinase domain is essential for mouse development. Exp Cell Res (2006) 0.81
In vivo and in vitro tissue-specific expression of green fluorescent protein using the cre-lox system in mouse embryonic stem cells. Stem Cells (2005) 0.80
Hoxa11 regulates stromal cell death and proliferation during neonatal uterine development. Mol Endocrinol (2003) 0.80
Midline signaling regulates kidney positioning but not nephrogenesis through Shh. Dev Biol (2010) 0.78
Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. Cancer Control (2011) 0.78
Syngeneic immune-dependent abortions in mice suggest paternal alloantigen-independent mechanisms. Am J Reprod Immunol (2008) 0.75