Published in Proc Natl Acad Sci U S A on April 04, 2011
A molecular basis for classic blond hair color in Europeans. Nat Genet (2014) 2.45
Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron (2013) 1.33
Viral-genetic tracing of the input-output organization of a central noradrenaline circuit. Nature (2015) 1.32
Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med (2014) 1.17
Extensions of MADM (mosaic analysis with double markers) in mice. PLoS One (2012) 1.06
Beyond knockouts: cre resources for conditional mutagenesis. Mamm Genome (2012) 1.04
Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes Dev (2015) 1.00
New applications for phage integrases. J Mol Biol (2014) 0.98
Measuring In Vivo Mitophagy. Mol Cell (2015) 0.96
DICE, an efficient system for iterative genomic editing in human pluripotent stem cells. Nucleic Acids Res (2013) 0.92
Insertion of sequences at the original provirus integration site of mouse ROSA26 locus using the CRISPR/Cas9 system. FEBS Open Bio (2015) 0.90
Mouse transgenic approaches in optogenetics. Prog Brain Res (2012) 0.89
Recombineering strategies for developing next generation BAC transgenic tools for optogenetics and beyond. Front Behav Neurosci (2014) 0.88
Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs. Sci Rep (2015) 0.86
Transient, inducible, placenta-specific gene expression in mice. Endocrinology (2012) 0.85
Genetic dissection of GABAergic neural circuits in mouse neocortex. Front Cell Neurosci (2014) 0.84
Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice. PLoS One (2014) 0.84
Engineering the embryo. Proc Natl Acad Sci U S A (2011) 0.81
In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining. Nucleic Acids Res (2016) 0.81
Assessment of fecundity and germ line transmission in two transgenic pig lines produced by sleeping beauty transposition. Genes (Basel) (2012) 0.81
Adjusting the attB site in donor plasmid improves the efficiency of ΦC31 integrase system. DNA Cell Biol (2012) 0.81
Study human pancreatic cancer in mice: how close are they? Biochim Biophys Acta (2012) 0.80
Pseudo attP sites in favor of transgene integration and expression in cultured porcine cells identified by Streptomyces phage phiC31 integrase. BMC Mol Biol (2013) 0.80
Modelling human regulatory variation in mouse: finding the function in genome-wide association studies and whole-genome sequencing. PLoS Genet (2012) 0.80
Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation. Transgenic Res (2015) 0.80
The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma. Oncotarget (2015) 0.79
One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT). BMC Genomics (2015) 0.79
Precise Correction of Disease Mutations in Induced Pluripotent Stem Cells Derived From Patients With Limb Girdle Muscular Dystrophy. Mol Ther (2016) 0.78
One-step Multiplex Transgenesis via Sleeping Beauty Transposition in Cattle. Sci Rep (2016) 0.78
Genomic divergence and brain evolution: How regulatory DNA influences development of the cerebral cortex. Bioessays (2015) 0.78
Strategies for designing transgenic DNA constructs. Methods Mol Biol (2013) 0.77
Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity. Yonago Acta Med (2016) 0.77
Inducible and reversible lentiviral and Recombination Mediated Cassette Exchange (RMCE) systems for controlling gene expression. PLoS One (2015) 0.76
Differentiation of Induced Pluripotent Stem Cells to Lentoid Bodies Expressing a Lens Cell-Specific Fluorescent Reporter. PLoS One (2016) 0.75
PhiC31 integrase induces efficient site-specific recombination in the Capra hircus genome. DNA Cell Biol (2014) 0.75
Serine integrase chimeras with activity in E. coli and HeLa cells. Biol Open (2014) 0.75
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development (2017) 0.75
Pronuclear Injection-Based Targeted Transgenesis. Curr Protoc Hum Genet (2016) 0.75
Intersectional illumination of neural circuit function. Neuron (2015) 0.75
Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice. Sci Rep (2017) 0.75
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. Elife (2017) 0.75
Development of Humanized Mice in the Age of Genome Editing. J Cell Biochem (2017) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A (1993) 20.33
A global double-fluorescent Cre reporter mouse. Genesis (2007) 17.86
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Altering the genome by homologous recombination. Science (1989) 12.73
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics (2004) 9.98
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell (2005) 7.29
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science (2006) 7.03
Comprehensive algorithm for quantitative real-time polymerase chain reaction. J Comput Biol (2005) 6.18
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature (1988) 6.12
Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J (1985) 5.84
Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat Biotechnol (2010) 5.60
Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci U S A (1980) 5.47
Mosaic analysis with double markers in mice. Cell (2005) 5.32
A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A (2000) 5.13
In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family. Proc Natl Acad Sci U S A (1998) 5.04
Repeat-induced gene silencing in mammals. Nat Genet (1998) 4.74
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell (1981) 4.23
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev (1995) 4.11
Mutations that suppress the thermosensitivity of green fluorescent protein. Curr Biol (1996) 4.00
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A (2010) 3.90
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet (2009) 3.86
High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One (2007) 3.84
Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol Ther (2003) 2.95
Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription. Cell (1996) 2.77
Site-specific genomic integration produces therapeutic Factor IX levels in mice. Nat Biotechnol (2002) 2.54
Integration and stable germ line transmission of genes injected into mouse pronuclei. Science (1981) 2.31
Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat Biotechnol (2003) 2.28
Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre. Genesis (2007) 2.08
Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Ther (2004) 1.90
Imaging cells in the developing nervous system with retrovirus expressing modified green fluorescent protein. Exp Neurol (1999) 1.71
Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron (2010) 1.58
Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay. Biochemistry (1997) 1.47
Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol (2006) 1.47
Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS One (2010) 1.26
A diversity of serine phage integrases mediate site-specific recombination in mammalian cells. Mol Genet Genomics (2006) 1.26
Pronuclear injection-based mouse targeted transgenesis for reproducible and highly efficient transgene expression. Nucleic Acids Res (2010) 1.17
Phage integrases for the construction and manipulation of transgenic mammals. Reprod Biol Endocrinol (2003) 1.12
Plasmid DNA sequences present in conventional herpes simplex virus amplicon vectors cause rapid transgene silencing by forming inactive chromatin. J Virol (2006) 1.10
Position effect variegation and imprinting of transgenes in lymphocytes. Nucleic Acids Res (2008) 1.05
Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells (2007) 1.01
In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette. Nucleic Acids Res (2008) 0.90
Variegation associated with lacZ in transgenic animals: a warning note. Transgenic Res (2000) 0.88
lacZ and ubiquitously expressed genes: should divorce be pronounced? Transgenic Res (2000) 0.80
A global double-fluorescent Cre reporter mouse. Genesis (2007) 17.86
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science (2011) 7.92
Mosaic analysis with double markers in mice. Cell (2005) 5.32
Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78
Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation. Cell (2007) 4.55
Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron (2003) 3.78
The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis. Cell (2010) 3.75
Representation of the glomerular olfactory map in the Drosophila brain. Cell (2002) 3.42
Cortical representations of olfactory input by trans-synaptic tracing. Nature (2010) 3.27
Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning. Neuron (2006) 3.15
Rac function and regulation during Drosophila development. Nature (2002) 2.89
Conformational changes in the Arp2/3 complex leading to actin nucleation. Nat Struct Mol Biol (2004) 2.77
piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning. Dev Cell (2008) 2.56
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron (2003) 2.51
A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining. Nat Protoc (2006) 2.44
Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nat Neurosci (2010) 2.23
Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat Neurosci (2006) 2.19
Rac GTPases control axon growth, guidance and branching. Nature (2002) 2.14
Developmentally programmed remodeling of the Drosophila olfactory circuit. Development (2005) 1.99
Developmental origin of wiring specificity in the olfactory system of Drosophila. Development (2003) 1.97
Dissecting local circuits: parvalbumin interneurons underlie broad feedback control of olfactory bulb output. Neuron (2013) 1.95
Development of a method for the purification and culture of rodent astrocytes. Neuron (2011) 1.92
A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron (2011) 1.90
Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions. Neuron (2007) 1.89
Luminal mitosis drives epithelial cell dispersal within the branching ureteric bud. Dev Cell (2013) 1.79
Glia engulf degenerating axons during developmental axon pruning. Curr Biol (2004) 1.79
Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons. Cell (2007) 1.77
PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood (2009) 1.74
Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions. Nat Neurosci (2004) 1.71
A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila. Nat Protoc (2006) 1.68
Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron (2010) 1.58
From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons. Cell (2003) 1.57
Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell (2010) 1.57
Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuit. Curr Biol (2005) 1.57
Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron (2004) 1.55
Role of leucine-rich repeat proteins in the development and function of neural circuits. Annu Rev Cell Dev Biol (2011) 1.55
Development of wiring specificity in the olfactory system. Curr Opin Neurobiol (2006) 1.46
Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons. Neuron (2004) 1.45
Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B. Neuron (2009) 1.45
Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site. J Virol (2012) 1.44
Development of the monosynaptic stretch reflex circuit. Curr Opin Neurobiol (2003) 1.42
Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A (2011) 1.40
Wiring stability of the adult Drosophila olfactory circuit after lesion. J Neurosci (2006) 1.37
Dorsoventral patterning of the mouse coat by Tbx15. PLoS Biol (2004) 1.36
Teneurins instruct synaptic partner matching in an olfactory map. Nature (2012) 1.35
Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map. Nat Neurosci (2009) 1.34
Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron (2013) 1.33
Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. Nature (2012) 1.32
Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Nat Neurosci (2007) 1.32
Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc Natl Acad Sci U S A (2005) 1.30
Splinkerette PCR for mapping transposable elements in Drosophila. PLoS One (2010) 1.29
Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). Proc Natl Acad Sci U S A (2007) 1.29
Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci (2003) 1.28
Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural Dev (2007) 1.28
Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS One (2010) 1.26
Structure of the vertical and horizontal system neurons of the lobula plate in Drosophila. J Comp Neurol (2002) 1.25
MicroRNA processing pathway regulates olfactory neuron morphogenesis. Curr Biol (2008) 1.25
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype. Blood (2007) 1.25
Intrinsic control of precise dendritic targeting by an ensemble of transcription factors. Curr Biol (2007) 1.24
Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA. Genes Dev (2013) 1.24
Controlling gene expression with the Q repressible binary expression system in Caenorhabditis elegans. Nat Methods (2012) 1.22
Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells. J Neurosci (2008) 1.19
B7-H5 costimulates human T cells via CD28H. Nat Commun (2013) 1.19
Doxorubicin plus interleukin-2 chemoimmunotherapy against breast cancer in mice. Cancer Res (2006) 1.18
B7-h2 is a costimulatory ligand for CD28 in human. Immunity (2011) 1.17
B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood (2008) 1.17
A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis. Development (2003) 1.16
Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain. Development (2010) 1.14
GABAergic projection neurons route selective olfactory inputs to specific higher-order neurons. Neuron (2013) 1.13
Phage integrases for the construction and manipulation of transgenic mammals. Reprod Biol Endocrinol (2003) 1.12
Development of neuronal connectivity in Drosophila antennal lobes and mushroom bodies. Curr Opin Neurobiol (2002) 1.09
Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron (2011) 1.06
Extensions of MADM (mosaic analysis with double markers) in mice. PLoS One (2012) 1.06
Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. J Neurosci (2008) 1.03
CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood (2010) 1.03
The chromatin remodeling factor Bap55 functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting. Neural Dev (2011) 1.01
Genetic control of wiring specificity in the fly olfactory system. Genetics (2014) 0.96
Identification of pseudo attP sites for phage phiC31 integrase in bovine genome. Biochem Biophys Res Commun (2006) 0.96
DICE, an efficient system for iterative genomic editing in human pluripotent stem cells. Nucleic Acids Res (2013) 0.92
A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors. Biol Open (2012) 0.91
Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling. Neuron (2013) 0.91
Specific kinematics and motor-related neurons for aversive chemotaxis in Drosophila. Curr Biol (2013) 0.90
Linking cell fate, trajectory choice, and target selection: genetic analysis of Sema-2b in olfactory axon targeting. Neuron (2013) 0.90
Developmental origins of brain tumors. Curr Opin Neurobiol (2012) 0.89
Site-specific recombinase strategy to create induced pluripotent stem cells efficiently with plasmid DNA. Stem Cells (2011) 0.89
Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance. Cell Rep (2013) 0.89
Using the Q system in Drosophila melanogaster. Nat Protoc (2011) 0.89
Circadian rhythms in Neurospora crassa: Downstream effectors. Fungal Genet Biol (2009) 0.88
Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Cell Rep (2012) 0.87
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero. J Neurosci (2010) 0.87
Transient, inducible, placenta-specific gene expression in mice. Endocrinology (2012) 0.85