Published in Mol Cell Biol on October 06, 2008
In search of adrenocortical stem and progenitor cells. Endocr Rev (2009) 1.51
Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell (2011) 1.17
Adrenocortical stem and progenitor cells: unifying model of two proposed origins. Mol Cell Endocrinol (2010) 1.09
Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus. Mol Cell Biol (2012) 1.04
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife (2015) 0.95
Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis. PLoS Genet (2013) 0.92
Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription. Mol Cell Biol (2009) 0.91
Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1. Mol Biol Cell (2009) 0.88
Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. PLoS Genet (2013) 0.87
Function of the C. elegans T-box factor TBX-2 depends on SUMOylation. Cell Mol Life Sci (2013) 0.84
Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1. Endocrinology (2011) 0.82
A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife (2015) 0.81
Knockdown of SF-1 and RNF31 affects components of steroidogenesis, TGFβ, and Wnt/β-catenin signaling in adrenocortical carcinoma cells. PLoS One (2012) 0.79
Hedgehog signaling and steroidogenesis. Annu Rev Physiol (2015) 0.78
SUMO as a nuclear hormone receptor effector: New insights into combinatorial transcriptional regulation. Worm (2014) 0.77
Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. Biochim Biophys Acta (2013) 0.76
Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination. Sci Rep (2016) 0.75
Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1. Int J Mol Sci (2013) 0.75
Chemical approaches to nuclear receptors in metabolism. Sci Signal (2009) 0.75
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol (2006) 10.74
Protein modification by SUMO. Annu Rev Biochem (2004) 10.59
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature (2005) 6.83
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature (2005) 4.63
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell (1994) 4.55
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell (2007) 4.46
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell (2007) 4.33
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell (2005) 3.96
Modification in reverse: the SUMO proteases. Trends Biochem Sci (2007) 3.84
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell (2005) 3.29
PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A (2005) 3.01
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab (2007) 3.00
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Mol Cell (2005) 2.69
Structure determination of the small ubiquitin-related modifier SUMO-1. J Mol Biol (1998) 2.66
SUMO junction-what's your function? New insights through SUMO-interacting motifs. EMBO Rep (2007) 2.58
Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr Rev (1997) 2.42
Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. Nature (2005) 2.11
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol (2006) 2.07
Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell (1999) 2.01
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol (1993) 1.98
Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci U S A (1995) 1.95
Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Mol Endocrinol (2007) 1.81
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways. Curr Opin Struct Biol (2007) 1.76
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci U S A (2005) 1.67
Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation. Curr Biol (2005) 1.66
A recurrent phospho-sumoyl switch in transcriptional repression and beyond. Mol Cell (2006) 1.60
Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. J Clin Endocrinol Metab (2002) 1.57
PIAS proteins and transcriptional regulation--more than just SUMO E3 ligases? Genes Dev (2006) 1.50
Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Proc Natl Acad Sci U S A (2000) 1.50
SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin. Mol Cell Biol (2005) 1.48
Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol (2004) 1.47
Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol Cell Biol (2006) 1.45
Post-translational modifications of steroid receptors. Biomed Pharmacother (2006) 1.44
The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain. Genes Cells (2004) 1.43
The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol (2005) 1.43
Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun (2006) 1.38
A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes. J Biol Chem (2000) 1.36
SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1). J Biol Chem (2004) 1.36
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol (2003) 1.24
Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex. Mol Endocrinol (2006) 1.23
DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor. J Mol Biol (1998) 1.22
SUMO: the glue that binds. Dev Cell (2006) 1.20
The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One (2008) 1.19
Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency. Hum Mutat (2008) 1.18
Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol (2002) 1.14
SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX. Mol Endocrinol (2008) 1.12
Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. Mol Endocrinol (2007) 1.07
Defining the sequence recognized with BmFTZ-F1, a sequence specific DNA binding factor in the silkworm, Bombyx mori, as revealed by direct sequencing of bound oligonucleotides and gel mobility shift competition analysis. Nucleic Acids Res (1991) 1.05
Sequence-specific deoxyribonucleic acid (DNA) recognition by steroidogenic factor 1: a helix at the carboxy terminus of the DNA binding domain is necessary for complex stability. Mol Endocrinol (2005) 1.00
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. J Mol Biol (2005) 0.98
Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1. Biochemistry (2007) 0.98
Purification and activity assays for Ubc9, the ubiquitin-conjugating enzyme for the small ubiquitin-like modifier SUMO. Methods Enzymol (2005) 0.94
Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. J Biol Chem (2004) 0.89
Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. J Biol Chem (2005) 0.89
Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a. J Biol Chem (2007) 0.83
The structural basis of yeast prion strain variants. Nature (2007) 3.31
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell (2005) 3.29
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature (2011) 2.71
The mRNA cap-binding protein eIF4E in post-transcriptional gene expression. Nat Struct Mol Biol (2004) 2.37
Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology (2002) 2.25
General structural motifs of amyloid protofilaments. Proc Natl Acad Sci U S A (2006) 1.72
An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model. J Mol Biol (2009) 1.62
mRNA decapping is promoted by an RNA-binding channel in Dcp2. Mol Cell (2008) 1.50
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell (2003) 1.47
The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci (2007) 1.46
The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol (2005) 1.43
Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol (2012) 1.42
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
Assigning large proteins in the solid state: a MAS NMR resonance assignment strategy using selectively and extensively 13C-labelled proteins. J Biomol NMR (2009) 1.37
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A (2003) 1.36
Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells. Mol Endocrinol (2007) 1.36
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A (2008) 1.32
The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol (2013) 1.31
Regulated association of protein kinase B/Akt with breast tumor kinase. J Biol Chem (2004) 1.25
CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Mol Cell (2013) 1.23
Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol (2006) 1.22
Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci (2003) 1.21
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol (2008) 1.21
The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One (2008) 1.19
Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab (2010) 1.18
Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell (2011) 1.17
SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction. Nat Struct Mol Biol (2008) 1.16
Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol (2002) 1.14
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK. Sci Signal (2012) 1.13
A split active site couples cap recognition by Dcp2 to activation. Nat Struct Mol Biol (2010) 1.12
Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae. Mol Cell Biol (2010) 1.10
Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol (2004) 1.10
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem (2011) 1.08
Broadband 13C-13C adiabatic mixing in solution optimized for high fields. J Magn Reson (2003) 1.07
Aging and the brown Norway rat leydig cell antioxidant defense system. J Androl (2005) 1.05
Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. RNA (2010) 1.04
Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. J Mol Biol (2005) 1.04
A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. Mol Cell (2005) 1.03
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. PLoS Pathog (2012) 1.02
Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Dev (2009) 0.94
Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. Proc Natl Acad Sci U S A (2012) 0.94
Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol (2002) 0.94
A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc (2002) 0.94
The crystal structure Escherichia coli Spy. Protein Sci (2010) 0.92
A kinetic assay to monitor RNA decapping under single- turnover conditions. Methods Enzymol (2008) 0.90
Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc (2008) 0.89
Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2. Structure (2013) 0.88
Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol (2003) 0.87
Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development. Development (2002) 0.86
Tissue growth and remodeling of the embryonic and adult adrenal gland. Ann N Y Acad Sci (2003) 0.85
Control of mRNA decapping by Dcp2: An open and shut case? RNA Biol (2008) 0.85
Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. Mol Endocrinol (2003) 0.84
Scaffolding actions of membrane-associated progesterone receptors. Steroids (2008) 0.83
From systems to structure: bridging networks and mechanism. Mol Cell (2013) 0.83
NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath). Biochemistry (2004) 0.79
The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA. Protein Sci (2012) 0.78
Metabolism: A lipid for fat disorders. Nature (2011) 0.78
A sequential assignment procedure for proteins that have intermediate line widths in MAS NMR spectra: amyloid fibrils of human CA150.WW2. Chembiochem (2008) 0.77
Protein C inhibitor expression by adult rat Sertoli cells: effects of testosterone withdrawal and replacement. J Androl (2005) 0.76
Judge, jury, and executioner: DXO functions as a decapping enzyme and exoribonuclease in pre-mRNA quality control. Mol Cell (2013) 0.75
Backbone and sidechain methyl Ile (delta1), Leu and Val resonance assignments of the catalytic domain of the yeast mRNA decapping enzyme, Dcp2. Biomol NMR Assign (2007) 0.75
Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor-1 Neurons via Upregulation of Diacylglycerol Lipase-α. Neuroendocrinology (2016) 0.75