PubRank

Leonard Guarente

Author PubWeight™ 217.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004 10.32
2 The Sir2 family of protein deacetylases. Annu Rev Biochem 2004 9.28
3 Mammalian SIRT1 represses forkhead transcription factors. Cell 2004 8.89
4 Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006 8.48
5 Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002 8.45
6 Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2011 7.94
7 SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006 6.79
8 Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005 6.34
9 Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 2007 5.94
10 Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2005 5.54
11 SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007 5.30
12 SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 2007 5.01
13 Increase in activity during calorie restriction requires Sirt1. Science 2005 4.90
14 Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 2004 4.51
15 A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 2008 4.43
16 A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell 2005 4.16
17 SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009 3.91
18 How does calorie restriction work? Genes Dev 2003 3.73
19 Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 2007 3.59
20 Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010 3.58
21 The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell 2013 3.50
22 Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 2008 3.46
23 Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem 2005 3.31
24 C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 2006 3.26
25 Genetics and the specificity of the aging process. Science 2003 3.20
26 Aging and disease: connections to sirtuins. Aging Cell 2010 3.15
27 Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci 2010 3.05
28 Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 2004 2.83
29 Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol 2003 2.77
30 Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature 2011 2.60
31 Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 2006 2.47
32 Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med 2013 2.29
33 Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med 2011 2.17
34 Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol 2012 2.12
35 High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol 2002 2.08
36 Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci 2012 2.00
37 Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol 2004 1.99
38 Model organisms as a guide to mammalian aging. Dev Cell 2002 1.96
39 SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 2011 1.86
40 SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest 2012 1.82
41 SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem 2006 1.81
42 High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012 1.77
43 SIR2: a potential target for calorie restriction mimetics. Trends Mol Med 2007 1.71
44 SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell 2013 1.71
45 Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun 2013 1.68
46 Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J 2011 1.65
47 The SirT3 divining rod points to oxidative stress. Mol Cell 2011 1.58
48 Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 2002 1.52
49 Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res 2013 1.49
50 Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem J 2004 1.43
51 Sirtuins at a glance. J Cell Sci 2011 1.41
52 Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol 2013 1.31
53 SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. EMBO Mol Med 2013 1.30
54 SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One 2012 1.27
55 Separation of mother and daughter cells. Methods Enzymol 2002 1.26
56 Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell 2002 1.24
57 SIRT1 shows no substrate specificity in vitro. J Biol Chem 2005 1.20
58 Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem 2010 1.18
59 Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem 2003 1.18
60 SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep 2013 1.17
61 Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep 2005 1.16
62 SIRT1 promotes differentiation of normal human keratinocytes. J Invest Dermatol 2008 1.16
63 Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics 2004 1.14
64 Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res 2013 1.09
65 A novel telomere structure in a human alternative lengthening of telomeres cell line. Cancer Res 2005 1.09
66 The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Exp Gerontol 2008 1.04
67 SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol 2011 1.02
68 Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu Rev Physiol 2012 0.98
69 A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins. Cell Cycle 2006 0.96
70 The place of genetics in ageing research. Nat Rev Genet 2012 0.95
71 Deviation of innate circadian period from 24 h reduces longevity in mice. Aging Cell 2012 0.94
72 Neurogenesis directed by Sirt1. Nat Cell Biol 2008 0.92
73 Life-span extension in yeast. Science 2006 0.92
74 SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 2014 0.91
75 Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet 2006 0.89
76 Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging (Albany NY) 2009 0.89
77 Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. J Biol Chem 2010 0.87
78 SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One 2010 0.84
79 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A 2010 0.84
80 SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol 2013 0.84
81 NO link between calorie restriction and mitochondria. Nat Chem Biol 2005 0.78
82 Metabolic signals regulate SIRT1 expression. EMBO Rep 2011 0.76
83 Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells. PLoS Biol 2015 0.76
84 Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10. Cell 2014 0.76