Published in Annu Rev Biochem on January 01, 2004
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest (2009) 4.29
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol (2006) 3.73
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A (2007) 3.60
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev (2006) 3.31
Chemical probes for histone-modifying enzymes. Nat Chem Biol (2008) 3.30
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J (2007) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol (2005) 3.05
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature (2010) 2.67
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab (2008) 2.47
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
Metabolic flux and the regulation of mammalian cell growth. Cell Metab (2011) 2.27
Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep (2011) 2.20
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging Cell (2007) 2.18
DNA replication in the archaea. Microbiol Mol Biol Rev (2006) 2.17
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem (2008) 2.04
Activity-based probes for proteomic profiling of histone deacetylase complexes. Proc Natl Acad Sci U S A (2007) 2.03
Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res (2010) 2.01
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. EMBO Rep (2007) 2.01
Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol (2006) 2.01
Mating-type genes and MAT switching in Saccharomyces cerevisiae. Genetics (2012) 1.96
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J (2011) 1.96
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes. Arthritis Rheum (2011) 1.88
Early developmental conditioning of later health and disease: physiology or pathophysiology? Physiol Rev (2014) 1.86
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem (2010) 1.86
Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. J Mol Cell Cardiol (2007) 1.81
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}. Proc Natl Acad Sci U S A (2008) 1.80
Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev (2008) 1.80
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A (2004) 1.80
Genome destabilization by homologous recombination in the germ line. Nat Rev Mol Cell Biol (2010) 1.76
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab (2010) 1.73
Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor. Mol Endocrinol (2006) 1.73
Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. Curr Pharm Des (2009) 1.69
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol Cell Biol (2005) 1.67
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med (2009) 1.66
Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem (2008) 1.66
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem (2010) 1.65
Sirtuin 1 in lipid metabolism and obesity. Ann Med (2011) 1.65
Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One (2011) 1.65
Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.61
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol (2009) 1.60
Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem (2009) 1.60
The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance. Cell Biochem Biophys (2009) 1.58
Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci (2007) 1.58
Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57
NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J (2006) 1.57
Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53
SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae. Genes Dev (2006) 1.51
Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis. Gastroenterology (2013) 1.50
Circulating microRNAs in cancer: origin, function and application. J Exp Clin Cancer Res (2012) 1.50
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2012) 1.49
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis. J Pharmacol Exp Ther (2009) 1.48
Retracted The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners. BMC Physiol (2010) 1.47
JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI. Breast Cancer Res (2014) 1.47
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci (2009) 1.46
NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem (2011) 1.46
Bacterial protein acetylation: the dawning of a new age. Mol Microbiol (2010) 1.45
SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes (2009) 1.44
Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing. Mol Cell Biol (2007) 1.43
SIRT1 activation confers neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci (2007) 1.41
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. J Biol Chem (2006) 1.40
Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Plant Physiol (2011) 1.40
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem (2009) 1.39
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus. Cell Metab (2015) 1.38
miR-34a regulates mouse neural stem cell differentiation. PLoS One (2011) 1.37
Silent chromatin at the middle and ends: lessons from yeasts. EMBO J (2009) 1.36
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
How does calorie restriction work? Genes Dev (2003) 3.73
Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59
Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell (2010) 3.58
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Genetics and the specificity of the aging process. Science (2003) 3.20
Aging and disease: connections to sirtuins. Aging Cell (2010) 3.15
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet (2004) 2.83
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol (2003) 2.77
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature (2011) 2.60
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med (2013) 2.29
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med (2011) 2.17
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol (2002) 2.08
Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol (2004) 1.99
Model organisms as a guide to mammalian aging. Dev Cell (2002) 1.96
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell (2011) 1.86
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem (2006) 1.81
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab (2012) 1.77
SIR2: a potential target for calorie restriction mimetics. Trends Mol Med (2007) 1.71
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun (2013) 1.68
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics (2002) 1.52
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res (2013) 1.49
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem J (2004) 1.43
Sirtuins at a glance. J Cell Sci (2011) 1.41
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. EMBO Mol Med (2013) 1.30
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One (2012) 1.27
Separation of mother and daughter cells. Methods Enzymol (2002) 1.26
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
SIRT1 shows no substrate specificity in vitro. J Biol Chem (2005) 1.20
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem (2003) 1.18
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. Cell Rep (2013) 1.17
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep (2005) 1.16
SIRT1 promotes differentiation of normal human keratinocytes. J Invest Dermatol (2008) 1.16
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics (2004) 1.14
Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res (2013) 1.09
A novel telomere structure in a human alternative lengthening of telomeres cell line. Cancer Res (2005) 1.09
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Exp Gerontol (2008) 1.04
SIRT1-mediated acute cardioprotection. Am J Physiol Heart Circ Physiol (2011) 1.02
Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu Rev Physiol (2012) 0.98
A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins. Cell Cycle (2006) 0.96
The place of genetics in ageing research. Nat Rev Genet (2012) 0.95
Deviation of innate circadian period from 24 h reduces longevity in mice. Aging Cell (2012) 0.94
Neurogenesis directed by Sirt1. Nat Cell Biol (2008) 0.92
Life-span extension in yeast. Science (2006) 0.92
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet (2006) 0.89
Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging (Albany NY) (2009) 0.89
Acute oxidative stress can reverse insulin resistance by inactivation of cytoplasmic JNK. J Biol Chem (2010) 0.87
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One (2010) 0.84
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A (2010) 0.84
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
NO link between calorie restriction and mitochondria. Nat Chem Biol (2005) 0.78
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells. PLoS Biol (2015) 0.76
Metabolic signals regulate SIRT1 expression. EMBO Rep (2011) 0.76
Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10. Cell (2014) 0.76