Published in Am J Physiol Heart Circ Physiol on August 19, 2011
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol (2014) 1.60
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
Ischemic preconditioning alters the epigenetic profile of the brain from ischemic intolerance to ischemic tolerance. Neurotherapeutics (2013) 1.01
Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on Sirtuins. Int J Mol Sci (2013) 1.00
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Br J Pharmacol (2012) 0.96
Redox signaling pathways involved in neuronal ischemic preconditioning. Curr Neuropharmacol (2012) 0.95
The NO/ONOO-cycle as the central cause of heart failure. Int J Mol Sci (2013) 0.94
Ischemic preconditioning: the role of mitochondria and aging. Exp Gerontol (2011) 0.93
Adrenergic signaling and oxidative stress: a role for sirtuins? Front Physiol (2013) 0.93
Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med (2011) 0.91
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab (2014) 0.90
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol (2015) 0.89
Role of sirtuins in ischemia-reperfusion injury. World J Gastroenterol (2013) 0.89
Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics. Genome Med (2013) 0.87
Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice. PLoS One (2014) 0.86
Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. PLoS One (2013) 0.84
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. J Mol Cell Cardiol (2015) 0.82
Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway. Int J Clin Exp Pathol (2015) 0.80
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Do we age because we have mitochondria? Protoplasma (2013) 0.77
SIRT Is Required for EDP-Mediated Protective Responses toward Hypoxia-Reoxygenation Injury in Cardiac Cells. Front Pharmacol (2016) 0.75
SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium. Am J Transl Res (2016) 0.75
(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions. Int J Mol Med (2017) 0.75
Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med (2008) 47.90
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature (1999) 13.73
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol (2008) 3.27
Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev (2007) 3.19
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem (2006) 3.18
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol (2008) 3.15
The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol (2005) 2.89
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res (2010) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res (2004) 2.55
Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc (2006) 2.52
Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One (2011) 2.21
Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation (2010) 2.19
Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab (2005) 2.04
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res (2009) 1.74
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy. Sci Signal (2011) 1.69
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J Biol Chem (2007) 1.54
Evidence linking hypoglycemic events to an increased risk of acute cardiovascular events in patients with type 2 diabetes. Diabetes Care (2011) 1.49
Novel roles for GAPDH in cell death and carcinogenesis. Cell Death Differ (2009) 1.47
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol (2009) 1.44
Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther (2010) 1.41
Exercise training promotes SIRT1 activity in aged rats. Rejuvenation Res (2008) 1.40
Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res (2010) 1.38
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch Biochem Biophys (2010) 1.34
Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol (2010) 1.29
Ischaemic preconditioning does not protect the heart in obese and lean animal models of type 2 diabetes. Diabetologia (2004) 1.28
Aging and cardioprotection. J Appl Physiol (1985) (2007) 1.20
Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res (2005) 1.16
Sirtuin-1 regulation of mammalian metabolism. Trends Mol Med (2011) 1.07
Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation. Int J Biochem Cell Biol (2010) 1.02
In vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine. J Mol Cell Cardiol (2009) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology. Circ Res (2009) 1.00
Efficacy of cardioprotective 'conditioning' strategies in aging and diabetic cohorts: the co-morbidity conundrum. Drugs Aging (2011) 0.98
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol (2011) 0.98
Ischemic preconditioning: from the first to the second window of protection. Life Sci (2001) 0.86
Monoclonal antibody cocktail as an enrichment tool for acetylome analysis. Anal Chem (2011) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Modes of p53 regulation. Cell (2009) 9.31
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
p53 ubiquitination: Mdm2 and beyond. Mol Cell (2006) 5.57
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol (2003) 5.46
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
How does calorie restriction work? Genes Dev (2003) 3.73
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59
Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell (2010) 3.58
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med (2007) 3.29
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Genetics and the specificity of the aging process. Science (2003) 3.20
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Aging and disease: connections to sirtuins. Aging Cell (2010) 3.15
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol (2010) 3.08
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
Parc: a cytoplasmic anchor for p53. Cell (2003) 3.06
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell (2013) 2.92
Direct evidence for S-nitrosation of mitochondrial complex I. Biochem J (2006) 2.88
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet (2004) 2.83
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol (2003) 2.77
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol (2006) 2.70
Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol (2006) 2.66
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature (2011) 2.60
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev (2006) 2.47
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med (2013) 2.29
Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med (2003) 2.28
Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol (2005) 2.28
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med (2011) 2.17
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle (2006) 2.17
Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J (2004) 2.14
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol (2002) 2.08
Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint Bone Spine (2013) 2.06
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther (2006) 2.05
The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J (2005) 2.05
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
Microfluidics for flow cytometric analysis of cells and particles. Physiol Meas (2005) 2.00
Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol (2004) 1.99
Model organisms as a guide to mammalian aging. Dev Cell (2002) 1.96
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem (2003) 1.92
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91