Published in Genes Dev on April 17, 2006
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 5.76
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab (2007) 2.42
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
Nucleolus: the fascinating nuclear body. Histochem Cell Biol (2007) 1.87
Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer (2006) 1.73
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2012) 1.49
Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
Sirtuins at a glance. J Cell Sci (2011) 1.41
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep (2013) 1.41
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 1.40
SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med (2013) 1.30
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
SIRT1 in neurodevelopment and brain senescence. Neuron (2014) 1.22
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci (2009) 1.22
Down-regulation of a SILENT INFORMATION REGULATOR2-related histone deacetylase gene, OsSRT1, induces DNA fragmentation and cell death in rice. Plant Physiol (2007) 1.21
Sirtuin activators and inhibitors. Biofactors (2012) 1.19
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab (2011) 1.18
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma (2013) 1.14
Chromatin: linking structure and function in the nucleolus. Chromosoma (2008) 1.14
NAD⁺ metabolism: a therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol (2013) 1.11
Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09
Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res (2013) 1.09
Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis. Mol Cell Proteomics (2013) 1.08
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2011) 1.07
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06
SIRT2 as a Therapeutic Target for Age-Related Disorders. Front Pharmacol (2012) 1.04
Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae. Nucleic Acids Res (2010) 1.04
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. J Mol Cell Cardiol (2011) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem (2013) 1.02
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions. PLoS One (2012) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
Sirtuin inhibitors as anticancer agents. Future Med Chem (2014) 0.98
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
Structure and function of ribosomal RNA gene chromatin. Biochem Soc Trans (2008) 0.98
SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors. Sci Rep (2015) 0.95
Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii. PLoS Genet (2010) 0.94
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun (2016) 0.94
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep (2013) 0.93
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly. Mol Cell Biol (2007) 0.93
Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by laser capture microdissection. BMC Genomics (2011) 0.93
Adrenergic signaling and oxidative stress: a role for sirtuins? Front Physiol (2013) 0.93
Mitochondrial sirtuins and metabolic homeostasis. Best Pract Res Clin Endocrinol Metab (2012) 0.92
The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (2013) 0.92
SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing. Nat Commun (2016) 0.92
Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol (2011) 0.91
Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91
The human sirtuin family: evolutionary divergences and functions. Hum Genomics (2011) 0.90
Nutraceutical interventions for promoting healthy aging in invertebrate models. Oxid Med Cell Longev (2012) 0.90
Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J (2013) 0.90
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. EMBO J (2016) 0.89
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum. Nat Commun (2013) 0.89
Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med (2013) 0.89
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Mol Cell Biol (2013) 0.89
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet (2014) 0.88
Differential expression of sirtuins in the aging rat brain. Front Cell Neurosci (2015) 0.87
Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nat Commun (2014) 0.87
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One (2011) 0.87
Sirtuins, bioageing, and cancer. J Aging Res (2011) 0.86
The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression. Oxid Med Cell Longev (2015) 0.86
Sirtuins and pyridine nucleotides. Circ Res (2012) 0.86
Regulation of SIRT1 by microRNAs. Mol Cells (2013) 0.86
Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer. Clin Cancer Res (2014) 0.85
Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci (2013) 0.85
Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. Mol Cells (2013) 0.85
Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxid Med Cell Longev (2016) 0.84
Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis. Pharmacol Res (2010) 0.83
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes. Mol Biol Cell (2013) 0.83
Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. Nucleic Acids Res (2015) 0.82
Sirtuins in hematological aging and malignancy. Crit Rev Oncog (2013) 0.82
Sirtuins of parasitic protozoa: in search of function(s). Mol Biochem Parasitol (2012) 0.82
Differential expression of sirtuin family members in the developing, adult, and aged rat brain. Front Aging Neurosci (2014) 0.82
The sirtuins in the pathogenesis of cancer. Clin Epigenetics (2010) 0.81
CTD kinase I is required for the integrity of the rDNA tandem array. Nucleic Acids Res (2006) 0.81
Sirtuins, a promising target in slowing down the ageing process. Biogerontology (2017) 0.80
The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. Arthritis Rheumatol (2015) 0.80
[New treatment strategy for adult T-cell leukemia targeting for anti-tumor immunity and a longevity gene-encoded protein]. Yakugaku Zasshi (2011) 0.80
Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells. Nucleus (2012) 0.80
Respected Sir(2): magic target for diabetes. Cellscience (2008) 0.80
The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin. PLoS Genet (2013) 0.80
Redox control of senescence and age-related disease. Redox Biol (2016) 0.79
SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem Biol (2016) 0.79
Role of sirtuins in stem cell differentiation. Genes Cancer (2013) 0.79
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
Extrachromosomal rDNA circles--a cause of aging in yeast. Cell (1997) 8.68
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun (1999) 5.83
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev (2003) 3.85
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
Genetics and the specificity of the aging process. Science (2003) 3.20
The Sir 2 family of protein deacetylases. Curr Opin Chem Biol (2005) 2.59
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat. Mol Cell Biol (2002) 2.36
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J (2001) 2.24
Regulation of mammalian ribosomal gene transcription by RNA polymerase I. Prog Nucleic Acid Res Mol Biol (1999) 2.20
Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J (1999) 2.04
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell (2003) 1.98
The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep (2006) 1.59
The RNA polymerase I-specific transcription initiation factor UBF is associated with transcriptionally active and inactive ribosomal genes. Chromosoma (1993) 1.51
Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system. Mol Cell Proteomics (2003) 1.49
Constitutive and strong association of PAF53 with RNA polymerase I. Chromosoma (1997) 1.22
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature (2002) 8.45
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature (2007) 5.94
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell (2007) 5.01
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature (2008) 4.43
A kinetic framework for a mammalian RNA polymerase in vivo. Science (2002) 4.42
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell (2005) 4.16
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol (2005) 3.79
How does calorie restriction work? Genes Dev (2003) 3.73
Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet (2007) 3.59
Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell (2010) 3.58
The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nat Genet (2002) 3.58
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol (2008) 3.42
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem (2005) 3.31
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell (2006) 3.26
Genetics and the specificity of the aging process. Science (2003) 3.20
Aging and disease: connections to sirtuins. Aging Cell (2010) 3.15
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev (2010) 2.96
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol Cell (2006) 2.89
Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet (2004) 2.83
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol (2003) 2.77
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes. Nature (2011) 2.60
Nuclear actin and myosin I are required for RNA polymerase I transcription. Nat Cell Biol (2004) 2.49
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46
The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol (2010) 2.45
The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. EMBO J (2002) 2.36
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Nat Med (2013) 2.29
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med (2011) 2.17
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev (2005) 2.13
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol (2002) 2.08
Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol (2004) 1.99
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell (2003) 1.98
TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell (2009) 1.97
Model organisms as a guide to mammalian aging. Dev Cell (2002) 1.96
Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a. Mol Cell (2007) 1.96
CSB is a component of RNA pol I transcription. Mol Cell (2002) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
Cellular stress and nucleolar function. Cell Cycle (2005) 1.88
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell (2011) 1.86
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J Biol Chem (2006) 1.81
Identification of novel functional TBP-binding sites and general factor repertoires. EMBO J (2007) 1.77
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab (2012) 1.77
The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol (2005) 1.75
SIR2: a potential target for calorie restriction mimetics. Trends Mol Med (2007) 1.71
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. Cell (2013) 1.71
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun (2013) 1.68
Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation. Mol Cell Biol (2005) 1.66
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus. EMBO Rep (2008) 1.64
Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription. Genes Dev (2008) 1.63
The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription. EMBO Rep (2006) 1.59
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres. EMBO Rep (2013) 1.55
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics (2002) 1.52
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res (2013) 1.49
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep (2002) 1.48
Modulation of RNA polymerase assembly dynamics in transcriptional regulation. Mol Cell (2008) 1.47
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem J (2004) 1.43
TFIIH plays an essential role in RNA polymerase I transcription. Cell (2002) 1.43
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucleic Acids Res (2007) 1.42
Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7. Mol Cell (2013) 1.41
Sirtuins at a glance. J Cell Sci (2011) 1.41
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A (2009) 1.40
NoRC-dependent nucleosome positioning silences rRNA genes. EMBO J (2006) 1.39
NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells. Stem Cells (2013) 1.35
The chromatin remodeling complex NoRC controls replication timing of rRNA genes. EMBO J (2004) 1.34
Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J Biol Chem (2003) 1.32
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol (2009) 1.30
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. EMBO Mol Med (2013) 1.30
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo. PLoS One (2012) 1.27
Separation of mother and daughter cells. Methods Enzymol (2002) 1.26
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
SIRT1 shows no substrate specificity in vitro. J Biol Chem (2005) 1.20
Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling. J Neurosci (2011) 1.20
Roles of SIRT1 in the acute and restorative phases following induction of inflammation. J Biol Chem (2010) 1.18
Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem (2003) 1.18