Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense.

PubWeight™: 2.70‹?› | Rank: Top 1%

🔗 View Article (PMC 2596683)

Published in J Immunol on November 15, 2008

Authors

Sif Hansdottir1, Martha M Monick, Sara L Hinde, Nina Lovan, Dwight C Look, Gary W Hunninghake

Author Affiliations

1: Department of Medicine, University of Iowa Carver College of Medicine, and Veterans Administration Medical Center, Iowa City, IA 52242, USA. sif-hansdottir@uiowa.edu

Articles citing this

(truncated to the top 100)

Update in vitamin D. J Clin Endocrinol Metab (2010) 4.48

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54

Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proc Natl Acad Sci U S A (2012) 2.05

Antibacterial effects of vitamin D. Nat Rev Endocrinol (2011) 2.03

Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol (2009) 1.65

The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer. Respir Res (2011) 1.65

Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS One (2013) 1.53

Vitamin D regulating TGF-β induced epithelial-mesenchymal transition. Respir Res (2014) 1.51

Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PLoS One (2012) 1.47

Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med (2012) 1.46

Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. Am J Respir Crit Care Med (2016) 1.45

Vitamin D and asthma. Am J Respir Crit Care Med (2011) 1.44

Vitamin D and the anti-viral state. J Clin Virol (2011) 1.40

The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol (2009) 1.40

Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One (2011) 1.39

Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol (2010) 1.36

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells. Eur J Immunol (2012) 1.27

Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol (2009) 1.27

Vitamin D, the immune system and asthma. Expert Rev Clin Immunol (2009) 1.23

CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma. Clin Cancer Res (2010) 1.23

Vitamin D and respiratory health. Clin Exp Immunol (2009) 1.15

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models. BMC Genomics (2012) 1.13

Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm (2011) 1.12

Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents. Clin Infect Dis (2013) 1.09

LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. PLoS One (2011) 1.08

Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One (2010) 1.05

Vitamin d and susceptibility of chronic lung diseases: role of epigenetics. Front Pharmacol (2011) 1.03

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (2017) 1.02

Vitamin d and serum cytokines in a randomized clinical trial. Int J Endocrinol (2010) 1.01

Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. Am J Clin Nutr (2013) 1.00

Vitamin d deficiency in e.N.T. Patients. Indian J Otolaryngol Head Neck Surg (2012) 1.00

Vitamin D-mediated induction of innate immunity in gingival epithelial cells. Infect Immun (2011) 0.99

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins. J Gen Virol (2012) 0.98

Respiratory syncytial virus: current and emerging treatment options. Clinicoecon Outcomes Res (2014) 0.96

1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses. Immunology (2010) 0.96

Calcitriol [1, 25[OH]2 D3] pre- and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells. Eur J Nutr (2012) 0.94

Relationship between serum vitamin D and forced expiratory volume in patients with chronic obstructive pulmonary disease (COPD). Caspian J Intern Med (2012) 0.94

Elevated 1, 25-dihydroxyvitamin D levels are associated with protracted treatment in sarcoidosis. Respir Med (2010) 0.93

Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV. Scientifica (Cairo) (2014) 0.92

Cationic host defence peptides: potential as antiviral therapeutics. BioDrugs (2013) 0.92

Characterization of vitamin D receptor (VDR) in lung adenocarcinoma. Lung Cancer (2012) 0.91

Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease. Front Immunol (2015) 0.91

Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)₂ vitamin D₃. Innate Immun (2011) 0.90

Vitamin D deficiency and the lung: disease initiator or disease modifier? Nutrients (2013) 0.90

Serum vitamin D in patients with chronic obstructive lung disease does not correlate with mortality--results from a 10-year prospective cohort study. PLoS One (2013) 0.90

Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res (2013) 0.89

Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatr (2012) 0.89

Impact of vitamin D on infectious disease. Am J Med Sci (2015) 0.89

Vitamin D and influenza. Adv Nutr (2012) 0.89

The role of vitamin D in prevention and treatment of infection. Inflamm Allergy Drug Targets (2013) 0.89

The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS One (2013) 0.88

Calcium and vitamin D in sarcoidosis: how to assess and manage. Semin Respir Crit Care Med (2010) 0.87

Modulation of the immune response to respiratory viruses by vitamin D. Nutrients (2015) 0.85

Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival. Oncotarget (2015) 0.85

Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication. PLoS One (2014) 0.84

Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration. PLoS One (2012) 0.83

Vitamin D deficiency causes defective resistance to Aspergillus fumigatus in mice via aggravated and sustained inflammation. PLoS One (2014) 0.83

Mechanism of action of vitamin D in the asthmatic lung. J Investig Med (2011) 0.82

Antimicrobial Peptides in Innate Immunity against Mycobacteria. Immune Netw (2011) 0.82

Differential expression of cytokines in response to respiratory syncytial virus infection of calves with high or low circulating 25-hydroxyvitamin D3. PLoS One (2012) 0.82

Serum vitamin D, vitamin D binding protein, and lung cancer survival. Lung Cancer (2014) 0.82

Fall in Vitamin D Levels during Hospitalization in Children. Int J Pediatr (2014) 0.81

Identification of Mycobacterium avium genes associated with resistance to host antimicrobial peptides. J Med Microbiol (2014) 0.81

Predicting Severe Asthma Exacerbations in Children. Am J Respir Crit Care Med (2016) 0.81

1α,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells. Thorax (2012) 0.80

A review of Vitamin D effects on common respiratory diseases: Asthma, chronic obstructive pulmonary disease, and tuberculosis. J Res Pharm Pract (2016) 0.80

Interleukin 13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide 18/LL-37 in bronchial epithelial cells. Infect Immun (2012) 0.80

Vitamin D status and distribution in patients with chronic obstructive pulmonary disease versus healthy controls. Caspian J Intern Med (2015) 0.80

Vitamin D is not linked to folate status and mRNA expression of intestinal proton-coupled folate transporter. Eur J Nutr (2013) 0.80

Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis. Clin Exp Allergy (2014) 0.80

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans. J Immunol (2016) 0.80

Vitamin D/VDR signaling attenuates lipopolysaccharide‑induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Mol Med Rep (2015) 0.79

Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo. Oncotarget (2016) 0.79

Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients. Tuberc Respir Dis (Seoul) (2016) 0.79

Alveolar macrophage cathelicidin deficiency in severe sarcoidosis. J Innate Immun (2012) 0.78

Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC Med Genet (2013) 0.78

1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4(+) Foxp3(-) T cells. Immunology (2015) 0.78

DO IT Trial: vitamin D Outcomes and Interventions in Toddlers - a TARGet Kids! randomized controlled trial. BMC Pediatr (2014) 0.78

Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study. Respir Res (2015) 0.78

Cord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Eur J Epidemiol (2014) 0.78

Vitamin D in organ transplantation. Osteoporos Int (2011) 0.78

Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers. Int J Cancer (2014) 0.78

Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial. Multidiscip Respir Med (2014) 0.78

Vitamin D deficiency does not result in a breach of host defense in murine models of pneumonia. Infect Immun (2016) 0.77

Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33. J Allergy Clin Immunol (2014) 0.77

A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction. J Biol Chem (2015) 0.77

A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort. PLoS One (2014) 0.77

Association between serum 25-hydroxyvitamin D level and type of coccidioidal infection. Med Mycol (2012) 0.77

Dietary diallyl disulfide supplementation attenuates ethanol-mediated pulmonary vitamin D speciate depletion in C57Bl/6 mice. BMC Nutr (2015) 0.76

Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation. Invest Ophthalmol Vis Sci (2015) 0.76

Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma. J Thorac Oncol (2014) 0.76

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment. PLoS One (2015) 0.75

Heterogeneity of glucocorticoid resistance in patients with bronchial asthma. Int J Biomed Sci (2010) 0.75

Admission vitamin D status is associated with discharge destination in critically ill surgical patients. Ann Intensive Care (2015) 0.75

Activation of vitamin D regulates response of human bronchial epithelial cells to Aspergillus fumigatus in an autocrine fashion. Mediators Inflamm (2015) 0.75

House dust mite induced lung inflammation does not alter circulating vitamin D levels. PLoS One (2014) 0.75

Vitamin D3 Supplementation and Antibiotic Consumption - Results from a Prospective, Observational Study at an Immune-Deficiency Unit in Sweden. PLoS One (2016) 0.75

Maternal vitamin D supplementation during pregnancy and lactation to prevent acute respiratory infections in infancy in Dhaka, Bangladesh (MDARI trial): protocol for a prospective cohort study nested within a randomized controlled trial. BMC Pregnancy Childbirth (2016) 0.75

Association of vitamin D receptor gene polymorphisms and vitamin D levels with asthma and atopy in Cypriot adolescents: a case-control study. Multidiscip Respir Med (2015) 0.75

Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients (2017) 0.75

Articles cited by this

Vitamin D deficiency. N Engl J Med (2007) 59.34

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science (2006) 18.74

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science (1990) 17.86

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell (1996) 11.02

Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73

Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet (2000) 7.25

Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19

Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol (2004) 6.35

Unique biosynthesis by kidney of a biological active vitamin D metabolite. Nature (1970) 5.66

The role of vitamin D in cancer prevention. Am J Public Health (2005) 4.99

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J (2005) 4.36

When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology (1996) 4.02

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Natl Acad Sci U S A (2002) 3.99

DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol (2007) 3.96

The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci U S A (1998) 3.83

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest (2007) 3.82

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med (1994) 3.61

Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A (1988) 3.53

Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest (1983) 3.41

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem (2003) 3.13

The SRC family of nuclear receptor coactivators. Gene (2000) 2.96

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J (2004) 2.70

Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J Exp Med (1985) 2.57

The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57

Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients. J Clin Oncol (2007) 2.52

Double-stranded RNA-mediated TLR3 activation is enhanced by CD14. Immunity (2006) 2.51

Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J Invest Dermatol (2007) 2.45

Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol (2007) 2.42

"Activation" of vitamin D by the liver. J Clin Invest (1969) 2.42

The innate immune response of the respiratory epithelium. Immunol Rev (2000) 2.40

The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. Infect Immun (1999) 2.35

A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst (2007) 2.34

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control (2000) 2.24

Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun (1996) 2.23

Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol (2007) 2.20

The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood (1997) 2.16

Vitamin D: more than a "bone-a-fide" hormone. Mol Endocrinol (2003) 2.16

Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions. Gene (2000) 1.99

Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol (2005) 1.82

Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. J Biol Chem (2005) 1.72

Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev (1998) 1.69

25-hydroxyvitamin D-1alpha-hydroxylase in normal and malignant colon tissue. Lancet (2001) 1.61

Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. J Infect Dis (2004) 1.60

Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res (2005) 1.58

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. Am J Respir Crit Care Med (2002) 1.56

Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide. J Immunol (1993) 1.54

25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J Clin Endocrinol Metab (1987) 1.54

Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol (2007) 1.53

Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. Int J Tuberc Lung Dis (2005) 1.50

Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney. J Am Soc Nephrol (1999) 1.47

Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med (1995) 1.46

Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment. J Steroid Biochem Mol Biol (2005) 1.45

Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. J Infect Dis (2004) 1.43

Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene. Mol Cell Biol (1993) 1.36

Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res (2001) 1.36

Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy. Science (1979) 1.34

Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev (2005) 1.33

Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. Mol Immunol (2004) 1.32

1,25-dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood (1993) 1.28

Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr (2006) 1.25

Regulation of CD14 expression during monocytic differentiation induced with 1 alpha,25-dihydroxyvitamin D3. J Immunol (1994) 1.24

Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis. J Clin Endocrinol Metab (1987) 1.24

1 alpha,25-Dihydroxyvitamin D(3) is a preventive factor in the metastasis of lung cancer. Carcinogenesis (2004) 1.23

Immunocytochemical detection of 1,25-dihydroxyvitamin D receptors in normal human tissues. J Clin Endocrinol Metab (1988) 1.22

1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation. J Clin Invest (1986) 1.22

Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role? Lung Cancer (2007) 1.21

Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages. J Biol Chem (1987) 1.15

Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation. J Infect Dis (2008) 1.14

gamma-Interferon-induced resistance to 1,25-(OH)2 D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses. J Clin Endocrinol Metab (1997) 1.13

Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. J Biol Chem (1999) 1.12

Identification of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression in macrophages. Kidney Int (2000) 1.07

The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D. Carcinogenesis (2004) 1.01

Renal and nonrenal 25-hydroxyvitamin D-1alpha-hydroxylases and their clinical significance. J Bone Miner Res (1998) 0.88

Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer. Lancet (2002) 0.88

Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer. J Steroid Biochem Mol Biol (2007) 0.88

Production of 1,25-dihydroxyvitamin D3 by pulmonary alveolar macrophages from patients with sarcoidosis. Ann N Y Acad Sci (1986) 0.83

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2007) 6.71

A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. N Engl J Med (2010) 4.19

Sarcoidosis. JAMA (2003) 2.21

Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol (2006) 1.90

Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem (2003) 1.80

Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66

Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol (2009) 1.65

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol (2006) 1.59

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. Am J Respir Crit Care Med (2002) 1.56

Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem (2001) 1.54

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology (2005) 1.54

Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.49

Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth. J Virol (2006) 1.46

Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.46

Antioxidant therapy for idiopathic pulmonary fibrosis. N Engl J Med (2005) 1.43

Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol (2010) 1.36

Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers. Am J Respir Crit Care Med (2005) 1.34

Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol (2008) 1.30

Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis. J Biol Chem (2004) 1.29

Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J Biol Chem (2011) 1.25

Noninfectious lung pathology in patients with Crohn's disease. Am J Surg Pathol (2003) 1.25

Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol (2003) 1.21

Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1. J Immunol (2006) 1.19

Anti-inflammatory response is associated with mortality and severity of infection in sepsis. Am J Physiol Lung Cell Mol Physiol (2004) 1.17

Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med (2008) 1.14

ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14

Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm (2011) 1.12

Transcriptional induction of the Pseudomonas aeruginosa type III secretion system by low Ca2+ and host cell contact proceeds through two distinct signaling pathways. Infect Immun (2006) 1.11

Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. J Immunol (2007) 1.09

Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface. J Immunol (2007) 1.07

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2009) 1.06

Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem (2002) 1.05

Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. J Immunol (2007) 1.04

Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One (2012) 1.03

Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. J Immunol (2006) 1.02

Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir Res (2009) 1.02

Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. J Biol Chem (2011) 1.01

Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol (2002) 1.00

Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.00

Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1. Am J Physiol Lung Cell Mol Physiol (2004) 0.99

Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses. J Immunol (2014) 0.96

Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. J Immunol (2004) 0.95

Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication. J Biol Chem (2010) 0.95

Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication. Am J Respir Cell Mol Biol (2009) 0.95

Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. J Immunol (2003) 0.94

Transgenic alteration of ethylene biosynthesis increases grain yield in maize under field drought-stress conditions. Plant Biotechnol J (2014) 0.94

Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am J Respir Crit Care Med (2008) 0.93

Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. J Leukoc Biol (2012) 0.93

Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation. J Biol Chem (2005) 0.92

Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism. Am J Physiol Cell Physiol (2002) 0.92

Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke. Respir Res (2010) 0.92

Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins. Infect Immun (2008) 0.91

Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol (2002) 0.89

Severe bacteremia results in a loss of hepatic bacterial clearance. Am J Respir Crit Care Med (2006) 0.89

High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol (2004) 0.89

Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages. J Immunol (2002) 0.88

Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants. J Biol Chem (2005) 0.87

Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis. Crit Care Med (2004) 0.87

A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER. J Biol Chem (2014) 0.87

Inhibition by cigarette smoke of nuclear factor-κB-dependent response to bacteria in the airway. Am J Respir Cell Mol Biol (2010) 0.86

Effect of segmental bronchoalveolar lavage on quantitative computed tomography of the lung. Acad Radiol (2011) 0.85

Chronic liver disease impairs bacterial clearance in a human model of induced bacteremia. Clin Transl Sci (2009) 0.84

Adenovirus vectors activate survival pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 0.84

Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol (2006) 0.84

Interferons increase cell resistance to Staphylococcal alpha-toxin. Infect Immun (2007) 0.84

Second messenger pathways in pulmonary host defense. Annu Rev Physiol (2002) 0.84

Regulation of bacteria-induced intercellular adhesion molecule-1 by CCAAT/enhancer binding proteins. Am J Respir Cell Mol Biol (2008) 0.82

Recognizing the importance of respiratory syncytial virus in chronic obstructive pulmonary disease. COPD (2009) 0.82