Published in Nature on January 24, 1991
Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med (1993) 5.49
Receptor editing in self-reactive bone marrow B cells. J Exp Med (1993) 5.49
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones. Blood (2010) 3.52
B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med (1993) 2.78
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med (2003) 2.77
Peripheral deletion of self-reactive B cells. Nature (1991) 2.34
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci U S A (1996) 2.34
Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest (2001) 2.26
Autoreactive B cells in the marginal zone that express dual receptors. J Exp Med (2002) 2.16
Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. J Exp Med (2003) 2.09
Human anti-self antibodies with high specificity from phage display libraries. EMBO J (1993) 2.08
B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol (2007) 2.08
Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites. Eur J Immunol (2007) 2.00
The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help. J Exp Med (1996) 1.96
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci U S A (2009) 1.93
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med (2008) 1.88
A transgenic model of autoimmune hemolytic anemia. J Exp Med (1992) 1.87
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin Immunol (2007) 1.69
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med (2013) 1.68
B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J Exp Med (1996) 1.66
Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle. J Exp Med (1997) 1.63
A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J Exp Med (1996) 1.58
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J Exp Med (1994) 1.49
Receptor selection in B and T lymphocytes. Annu Rev Immunol (2000) 1.49
Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. J Exp Med (1998) 1.48
DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med (2002) 1.40
Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med (1999) 1.36
Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. Proc Natl Acad Sci U S A (1997) 1.33
MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells. J Exp Med (1999) 1.33
Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen. J Exp Med (1992) 1.33
Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance. J Exp Med (1994) 1.29
Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med (2002) 1.28
Autoimmunity in wiskott-Aldrich syndrome: an unsolved enigma. Front Immunol (2012) 1.27
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity (2011) 1.27
Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. J Immunol (2011) 1.25
Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice. J Exp Med (2010) 1.25
Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice. J Exp Med (1999) 1.23
Molecular underpinning of B-cell anergy. Immunol Rev (2010) 1.20
Induction of tolerance to an IgG autoantibody. Proc Natl Acad Sci U S A (1992) 1.19
Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol (2010) 1.19
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J Exp Med (1995) 1.18
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. J Exp Med (2006) 1.17
A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly. J Exp Med (1998) 1.16
Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med (2003) 1.16
Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity (2008) 1.14
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity (1999) 1.10
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol (2013) 1.10
Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020. J Immunol (2011) 1.10
Regulation of anti-DNA B cells in recombination-activating gene-deficient mice. J Exp Med (1998) 1.09
TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation. J Immunol (2013) 1.07
Editing anti-DNA B cells by Vlambdax. J Exp Med (2004) 1.06
Intrinsic B cell defects in NZB and NZW mice contribute to systemic lupus erythematosus in (NZB x NZW)F1 mice. J Exp Med (1996) 1.06
Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A (2009) 1.06
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J Exp Med (1999) 1.06
Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther (2006) 1.06
Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus. J Clin Invest (1996) 1.05
Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen. J Exp Med (1995) 1.05
Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion. Proc Natl Acad Sci U S A (2006) 1.03
Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells. J Exp Med (2003) 1.03
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. J Exp Med (2006) 1.02
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes. EMBO J (1994) 1.02
Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination. J Exp Med (1997) 1.02
Loss of the proapoptotic protein, Bim, breaks B cell anergy. J Exp Med (2006) 1.01
B cell receptor editing in tolerance and autoimmunity. Ann N Y Acad Sci (2011) 1.01
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation. Autoimmunity (2010) 1.01
B-cell antigen-receptor signalling in lymphocyte development. Immunology (2003) 0.99
B cell tolerance in mice transgenic for anti-CD8 immunoglobulin mu chain. J Exp Med (1991) 0.98
B cells and transplantation tolerance. Nat Rev Nephrol (2010) 0.97
Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses. J Autoimmun (2010) 0.96
Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. J Exp Med (2014) 0.94
The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A (2007) 0.94
Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction. J Immunol (2015) 0.93
Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc Natl Acad Sci U S A (1993) 0.93
Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice. J Exp Med (1993) 0.93
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. J Immunol Methods (2010) 0.92
Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes. J Exp Med (1998) 0.92
Extended duration of DH-JH rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion. J Exp Med (1999) 0.91
Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J Exp Med (1997) 0.91
Virus-induced maturation and activation of autoreactive memory B cells. J Exp Med (2000) 0.90
The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells. J Exp Med (2003) 0.89
Contributions of B cells to lupus pathogenesis. Mol Immunol (2013) 0.87
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape. J Immunol (2011) 0.87
BAFF overexpression promotes anti-dsDNA B-cell maturation and antibody secretion. Cell Immunol (2009) 0.87
Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG. Proc Natl Acad Sci U S A (1997) 0.86
HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development. PLoS Pathog (2014) 0.85
Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion. J Immunol (2007) 0.85
Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells. Proc Natl Acad Sci U S A (2012) 0.85
Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. J Immunol (2014) 0.85
Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes. BMC Immunol (2002) 0.84
Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice. J Immunol (2013) 0.84
Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy. Mol Immunol (2010) 0.84
Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. J Exp Med (2012) 0.83
Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes. Genes Immun (2011) 0.83
Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies. J Immunol (2014) 0.83
Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies. Vaccines (Basel) (2014) 0.82
Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol (2009) 0.82
Autoimmunity to isomerized histone H2B in systemic lupus erythematosus. Autoimmunity (2012) 0.81
Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement. J Immunol (2009) 0.81
Mechanisms of central tolerance for B cells. Nat Rev Immunol (2017) 0.81
B-cell tolerance in transplantation: is repertoire remodeling the answer? Expert Rev Clin Immunol (2009) 0.80
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med (1983) 5.74
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci U S A (1984) 5.49
Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med (1993) 5.49
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A (1984) 5.15
Mediating variable framework in physical activity interventions. How are we doing? How might we do better? Am J Prev Med (1998) 4.82
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature (1981) 4.78
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med (1990) 4.46
Genetics of the antibody response to dextran in mice. Science (1972) 4.37
Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes. Nucleic Acids Res (2001) 4.29
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature (1981) 4.19
Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J Exp Med (1985) 4.16
Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol (2001) 3.92
The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell (1996) 3.82
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med (1993) 3.57
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med (1985) 3.54
Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science (1987) 3.44
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene. Science (1998) 3.39
Transcription of mouse kappa chain genes: implications for allelic exclusion. Proc Natl Acad Sci U S A (1980) 3.38
Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell (1986) 3.34
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature (1986) 3.24
Dosage requirement of Pitx2 for development of multiple organs. Development (1999) 3.08
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev (1994) 3.00
Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3. Science (1998) 3.00
Positive selection of natural autoreactive B cells. Science (1999) 2.91
Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucleic Acids Res (1982) 2.91
Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84
B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med (1993) 2.78
Rheumatoid factor secretion from human Leu-1+ B cells. Science (1987) 2.65
Identification of the earliest B lineage stage in mouse bone marrow. Immunity (1996) 2.62
Role of Ahch in gonadal development and gametogenesis. Nat Genet (1998) 2.60
Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity (1995) 2.56
Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage? Annu Rev Immunol (1988) 2.50
Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol (1994) 2.45
Residues that mediate DNA binding of autoimmune antibodies. J Immunol (1993) 2.37
DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus. Proc Natl Acad Sci U S A (1982) 2.36
Genetic control of antibody variable regions. Cold Spring Harb Symp Quant Biol (1977) 2.35
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med (1987) 2.34
Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol (1986) 2.30
The joining of V and J gene segments creates antibody diversity. Nature (1980) 2.28
Both E12 and E47 allow commitment to the B cell lineage. Immunity (1997) 2.27
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med (1986) 2.25
Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science (1986) 2.24
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. Proc Natl Acad Sci U S A (1973) 2.21
Reconstitution of functional receptor for human interleukin-2 in mouse cells. Nature (1986) 2.14
Development and physiology of Ly-1 B and its human homolog, Leu-1 B. Immunol Rev (1986) 2.12
B-cell subpopulations identified by two-colour fluorescence analysis. Nature (1982) 2.06
Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature (1975) 2.01
Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2. Genomics (1999) 1.97
Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2. Science (1999) 1.97
Revising B cell receptors. J Exp Med (2000) 1.96
Ig H and L chain contributions to autoimmune specificities. J Immunol (1991) 1.96
Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med (2000) 1.96
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. J Immunol (1982) 1.95
Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1. J Exp Med (1996) 1.95
A rheumatoid factor transgenic mouse model of autoantibody regulation. Int Immunol (1993) 1.95
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev (1996) 1.94
Light chain replacement: a new model for antibody gene rearrangement. J Exp Med (1995) 1.90
Editors and editing of anti-DNA receptors. Immunity (2001) 1.90
The site and stage of anti-DNA B-cell deletion. Nature (1995) 1.87
Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity. Nature (1979) 1.85
Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells. Proc Natl Acad Sci U S A (1987) 1.82
Editing disease-associated autoantibodies. Immunity (1997) 1.81
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. J Immunol (1990) 1.79
The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens. J Immunol (1984) 1.79
A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes. J Immunol (1987) 1.79
Development and function of B-1 cells. Curr Opin Immunol (2000) 1.78
Mouse lambda-chain sequences. Proc Natl Acad Sci U S A (1973) 1.78
Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur J Immunol (1986) 1.78
Murine thymic CD4+ T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the V beta 8 T cell receptor gene family. J Exp Med (1992) 1.72
Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci U S A (1995) 1.69
How immunoglobulin V kappa genes rearrange. J Immunol (1987) 1.68
Genetics of mouse antibodies. I. Linkage of the dextran response locus, VH-DEX, to allotype. Eur J Immunol (1975) 1.68
The health status and health care utilization of deaf and hard-of-hearing persons. Arch Fam Med (1993) 1.65
Deletion and editing of B cells that express antibodies to DNA. J Immunol (1994) 1.62
Murine CD4+ T cell subsets defined. J Exp Med (1988) 1.62
Probability binning comparison: a metric for quantitating multivariate distribution differences. Cytometry (2001) 1.60
Murine B cell differentiation lineages. J Exp Med (1984) 1.60
Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice. Genes Dev (1995) 1.58
A Shannon entropy analysis of immunoglobulin and T cell receptor. Mol Immunol (1997) 1.58
Rearrangement and selection of VH11 in the Ly-1 B cell lineage. J Exp Med (1990) 1.54
Frequency difference gating: a multivariate method for identifying subsets that differ between samples. Cytometry (2001) 1.54
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. Immunity (1996) 1.54
Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome. J Immunol (1989) 1.53
Effect of undermethylation on mRNA cytoplasmic appearance and half-life. Mol Cell Biol (1984) 1.46
Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development (2001) 1.46
The bicoid-related Pitx gene family in development. Mamm Genome (1999) 1.43
Frequent lambda light chain gene rearrangement and expression in a Ly-1 B lymphoma with a productive kappa chain allele. Proc Natl Acad Sci U S A (1986) 1.42
Curvature of mouse satellite DNA and condensation of heterochromatin. Cell (1987) 1.41
B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome. J Exp Med (1990) 1.41