Published in J Exp Med on October 05, 1998
The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci U S A (2005) 1.53
Receptor selection in B and T lymphocytes. Annu Rev Immunol (2000) 1.49
A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc Natl Acad Sci U S A (2000) 1.42
DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med (2002) 1.40
Somatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice. J Exp Med (1999) 1.36
Human autoantibody silencing by immunoglobulin light chains. J Exp Med (2004) 1.34
Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. J Exp Med (2002) 1.28
Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls. J Immunol (2011) 1.25
Autoantigen-specific B cell activation in Fas-deficient rheumatoid factor immunoglobulin transgenic mice. J Exp Med (1999) 1.23
Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci U S A (2001) 1.15
Rearrangement of mouse immunoglobulin kappa deleting element recombining sequence promotes immune tolerance and lambda B cell production. Immunity (2008) 1.14
B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection. Proc Natl Acad Sci U S A (2000) 1.04
B cell receptor editing in tolerance and autoimmunity. Ann N Y Acad Sci (2011) 1.01
Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity. Semin Immunopathol (2013) 0.99
Central B-cell tolerance: where selection begins. Cold Spring Harb Perspect Biol (2012) 0.92
Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance. Blood (2006) 0.90
Editing and escape from editing in anti-DNA B cells. Proc Natl Acad Sci U S A (2008) 0.89
Lupus nephritis: enigmas, conflicting models and an emerging concept. Mol Med (2013) 0.85
Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol (2008) 0.83
Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure. Mol Immunol (2007) 0.75
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature (1988) 9.17
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med (1996) 8.54
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med (1994) 8.21
Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med (1993) 5.49
Receptor editing in self-reactive bone marrow B cells. J Exp Med (1993) 5.49
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature (1989) 5.48
The role of clonal selection and somatic mutation in autoimmunity. Nature (1987) 4.66
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature (1991) 4.04
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A (1987) 3.90
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med (1993) 3.57
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature (1991) 3.32
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell (1993) 3.09
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev (1994) 3.00
B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med (1993) 2.78
Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity (1995) 2.56
The lupus autoantigens and the pathogenesis of systemic lupus erythematosus. Arthritis Rheum (1986) 2.49
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J Exp Med (1994) 2.23
Reduced life span of anergic self-reactive B cells in a double-transgenic model. J Exp Med (1994) 2.15
Light chain replacement: a new model for antibody gene rearrangement. J Exp Med (1995) 1.90
The site and stage of anti-DNA B-cell deletion. Nature (1995) 1.87
Editing disease-associated autoantibodies. Immunity (1997) 1.81
CD43 (S7) expression identifies peripheral B cell subsets. J Immunol (1994) 1.64
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev (1994) 1.58
Propagation and regulation of systemic autoimmunity by gammadelta T cells. J Immunol (1996) 1.52
Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry. J Immunol Methods (1991) 1.43
Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation. J Immunol (1988) 1.35
Biology of germinal centers in lymphoid tissue. FASEB J (1994) 1.31
Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance. J Exp Med (1994) 1.29
Apoptosis and macrophage-mediated deletion of precursor B cells in the bone marrow of E mu-myc transgenic mice. Blood (1994) 1.23
Apoptosis and macrophage-mediated cell deletion in the regulation of B lymphopoiesis in mouse bone marrow. Immunol Rev (1994) 1.12
Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice. Blood (1992) 1.09
Characterization of anti-single-stranded DNA B cells in a non-autoimmune background. J Immunol (1997) 1.03
Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity (1995) 1.02
Linked sets of antinuclear antibodies: what do they mean? J Rheumatol Suppl (1987) 0.97
Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius. J Exp Med (1995) 0.90
Antinuclear antibodies: diagnostic markers and clues to the basis of systemic autoimmunity. Pediatr Infect Dis J (1988) 0.90
In-vitro analyses of mechanisms of B-cell development. Semin Immunol (1995) 0.88
Stimulation by T cell independent antigens can relieve the arrest of differentiation of immature auto-reactive B cells in the bone marrow. Scand J Immunol (1995) 0.85
B-cell tolerance. Curr Opin Immunol (1992) 0.82
Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet (1994) 10.14
Modular chemistry: secondary building units as a basis for the design of highly porous and robust metal-organic carboxylate frameworks. Acc Chem Res (2001) 9.19
Regulatory element detection using correlation with expression. Nat Genet (2001) 8.92
Notch signalling controls pancreatic cell differentiation. Nature (1999) 7.18
Crystal structure of a T-cell receptor beta-chain complexed with a superantigen. Nature (1996) 7.11
Refined structure of alpha beta-tubulin at 3.5 A resolution. J Mol Biol (2001) 7.08
Mechanical unfolding intermediates in titin modules. Nature (1999) 6.12
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene (2006) 5.86
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice. J Exp Med (1983) 5.74
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci U S A (1984) 5.49
Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med (1993) 5.49
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies. Proc Natl Acad Sci U S A (1984) 5.15
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest (2001) 4.98
Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature (1981) 4.78
An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl Environ Microbiol (2001) 4.59
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med (1990) 4.46
A mouse model for spinal muscular atrophy. Nat Genet (2000) 4.37
Genetics of the antibody response to dextran in mice. Science (1972) 4.37
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature (1981) 4.19
Progenitors for Ly-1 B cells are distinct from progenitors for other B cells. J Exp Med (1985) 4.16
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. J Virol (2007) 4.13
Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol (2001) 3.92
Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res (2001) 3.89
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol (2000) 3.81
Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res (1999) 3.69
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J Exp Med (1993) 3.57
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med (1985) 3.54
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45
Transcription of mouse kappa chain genes: implications for allelic exclusion. Proc Natl Acad Sci U S A (1980) 3.38
Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Engl J Med (1999) 3.38
Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell (1986) 3.34
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature (1991) 3.32
Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int (2016) 3.30
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature (1986) 3.24
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell (1998) 3.20
Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysis. Proc Natl Acad Sci U S A (2000) 3.18
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol (1997) 3.14
Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Curr Biol (2001) 3.09
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol (1999) 3.08
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev (1994) 3.00
Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. Prog Biophys Mol Biol (2000) 3.00
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene (2008) 2.94
Positive selection of natural autoreactive B cells. Science (1999) 2.91
Identification of coryneform bacterial isolates by ribosomal DNA sequence analysis. J Clin Microbiol (2000) 2.87
Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84
B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med (1993) 2.78
Validation of near-infrared spectroscopy in humans. J Appl Physiol (1985) (1994) 2.77
tRNA splicing. J Biol Chem (1998) 2.77
Current neurosurgical management and the impact of the extent of resection in the treatment of malignant gliomas of childhood: a report of the Children's Cancer Group trial no. CCG-945. J Neurosurg (1998) 2.75
Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med (2001) 2.69
Rheumatoid factor secretion from human Leu-1+ B cells. Science (1987) 2.65
Identification of the earliest B lineage stage in mouse bone marrow. Immunity (1996) 2.62
Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev (1995) 2.61
Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell (1999) 2.58
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A (2001) 2.56
Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity (1995) 2.56
Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol (1999) 2.52
Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage? Annu Rev Immunol (1988) 2.50
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50
Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol (1994) 2.45
Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int (2007) 2.44
Residues that mediate DNA binding of autoimmune antibodies. J Immunol (1993) 2.37
DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus. Proc Natl Acad Sci U S A (1982) 2.36
Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes (1999) 2.36
Changing sexual attitudes and behaviour in China: implications for the spread of HIV and other sexually transmitted diseases. AIDS Care (1999) 2.35
An Arabidopsis mutant defective in the plastid general protein import apparatus. Science (1998) 2.35
Genetic control of antibody variable regions. Cold Spring Harb Symp Quant Biol (1977) 2.35
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med (1987) 2.34
Model-based methods for identifying periodically expressed genes based on time course microarray gene expression data. Bioinformatics (2004) 2.32
Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression. Eur J Immunol (1986) 2.30
Structure of a cytochrome P450-redox partner electron-transfer complex. Proc Natl Acad Sci U S A (1999) 2.30
The joining of V and J gene segments creates antibody diversity. Nature (1980) 2.28
Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J Natl Cancer Inst (2000) 2.27
Both E12 and E47 allow commitment to the B cell lineage. Immunity (1997) 2.27
Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching. J Exp Med (1986) 2.25
Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation (2001) 2.24
Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice. Science (1986) 2.24
An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. Am J Hum Genet (2006) 2.23
Survival and prognostic factors following radiation therapy and chemotherapy for ependymomas in children: a report of the Children's Cancer Group. J Neurosurg (1998) 2.22
Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. Proc Natl Acad Sci U S A (1973) 2.21
Attitudes to HIV and HIV testing in high prevalence areas of China: informing the introduction of voluntary counselling and testing programmes. Sex Transm Infect (2005) 2.14
Reconstitution of functional receptor for human interleukin-2 in mouse cells. Nature (1986) 2.14
Development and physiology of Ly-1 B and its human homolog, Leu-1 B. Immunol Rev (1986) 2.12
Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem (1994) 2.09
B-cell subpopulations identified by two-colour fluorescence analysis. Nature (1982) 2.06
Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility. Development (1995) 2.03
Comparison of protein A gene sequencing with pulsed-field gel electrophoresis and epidemiologic data for molecular typing of methicillin-resistant Staphylococcus aureus. J Clin Microbiol (2000) 2.03
Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse. Nature (1975) 2.01
Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China. FEMS Microbiol Lett (2001) 2.01
Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. Cancer Res (1997) 2.00
Vaginal bilateral cervical lips suture in combination with intrauterine Foley catheter to arrest postpartum hemorrhage. Clin Exp Obstet Gynecol (2015) 2.00
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res (2000) 2.00
Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2. Science (1999) 1.97
Revising B cell receptors. J Exp Med (2000) 1.96