Published in Immunology on November 14, 2008
Modulation of adaptive immunity with Toll-like receptors. Semin Immunol (2009) 2.56
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol (2010) 1.25
Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation. Dev Biol (2009) 1.22
Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. Mol Biol Cell (2012) 0.93
Schistosome egg antigens elicit a proinflammatory response by trophoblast cells of the human placenta. Infect Immun (2012) 0.89
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TLR2 mediates immunity to experimental cysticercosis. Int J Biol Sci (2011) 0.85
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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity (2005) 14.95
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Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med (2002) 6.48
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity (2004) 6.46
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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 5.50
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science (2007) 4.90
Helminth parasites--masters of regulation. Immunol Rev (2004) 4.54
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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
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Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity (2007) 2.88
Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol (2004) 2.67
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int Immunol (2002) 2.66
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem (2002) 2.61
Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunol Lett (2003) 2.42
Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J Exp Med (1998) 2.40
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The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood (2006) 2.33
Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol (2004) 2.21
Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol (2002) 2.16
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation. Mol Immunol (2007) 1.98
Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J Immunol (2003) 1.81
The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. J Immunol (2003) 1.67
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A (2006) 1.58
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor. Immunity (2005) 1.53
Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol (2007) 1.52
Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J Immunol (2004) 1.48
Induction of Th2 responses and IgE is largely due to carbohydrates functioning as adjuvants on Schistosoma mansoni egg antigens. J Immunol (1999) 1.47
Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. J Immunol (2001) 1.45
Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem (2004) 1.44
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int J Mol Med (2006) 1.34
Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.33
Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. J Immunol (2001) 1.31
Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune response. Chem Immunol Allergy (2006) 1.31
Priming of the immune response by schistosome eggs. Parasite Immunol (2005) 1.29
A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. J Clin Invest (2004) 1.24
Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J Immunol (2002) 1.23
Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection. Eur J Immunol (2003) 1.20
Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways. Int Immunol (2005) 1.19
A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation. J Immunol (2005) 1.19
Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo. Eur J Immunol (2008) 1.13
Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. J Immunol (2008) 1.11
The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses. FEMS Immunol Med Microbiol (2006) 1.10
Distinct and regulated expression of Notch receptors in hematopoietic lineages and during myeloid differentiation. Eur J Immunol (2001) 1.06
Kupffer cells from Schistosoma mansoni-infected mice participate in the prompt type 2 differentiation of hepatic T cells in response to worm antigens. J Immunol (1999) 1.05
Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J Allergy Clin Immunol (2008) 1.02
Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology. Microbes Infect (2007) 0.98
Toll-like receptor, MHC II, B7 and cytokine expression by porcine monocytes and monocyte-derived dendritic cells in response to microbial pathogen-associated molecular patterns. Vet Immunol Immunopathol (2005) 0.94
Chromatin remodeling and T helper subset differentiation. IUBMB Life (2000) 0.81
Expression of Jagged1 gene in macrophages and its regulation by hematopoietic growth factors. Exp Hematol (2001) 0.76
Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet (2006) 17.19
Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol (2003) 12.34
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science (2009) 6.59
A promoter-level mammalian expression atlas. Nature (2014) 6.25
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
The regulated retrotransposon transcriptome of mammalian cells. Nat Genet (2009) 5.79
Mammalian RNA polymerase II core promoters: insights from genome-wide studies. Nat Rev Genet (2007) 5.75
Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res (2005) 4.86
IFITM3 restricts the morbidity and mortality associated with influenza. Nature (2012) 4.66
Unravelling mononuclear phagocyte heterogeneity. Nat Rev Immunol (2010) 4.25
Tiny RNAs associated with transcription start sites in animals. Nat Genet (2009) 4.19
Somatic retrotransposition alters the genetic landscape of the human brain. Nature (2011) 4.16
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res (2008) 3.54
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50
Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome. Genome Res (2003) 3.21
A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics (2008) 3.19
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med (2009) 3.07
Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis (2011) 2.81
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol (2008) 2.71
Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection. Genome Res (2003) 2.63
Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nat Med (2006) 2.59
Signal integration between IFNgamma and TLR signalling pathways in macrophages. Immunobiology (2006) 2.55
Apoptotic cell removal in development and tissue homeostasis. Trends Immunol (2006) 2.51
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48
Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products. J Leukoc Biol (2010) 2.45
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol (2008) 2.39
Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology (2011) 2.27
Histone deacetylases as regulators of inflammation and immunity. Trends Immunol (2011) 2.18
Development and evaluation of an automated annotation pipeline and cDNA annotation system. Genome Res (2003) 2.15
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. J Leukoc Biol (2010) 2.07
Systematic expression profiling of the mouse transcriptome using RIKEN cDNA microarrays. Genome Res (2003) 1.98
LPS-induced cytokine production in human monocytes and macrophages. Crit Rev Immunol (2011) 1.95
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science (2015) 1.91
A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths. PLoS Negl Trop Dis (2011) 1.81
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res (2011) 1.76
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med (2013) 1.73
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proc Natl Acad Sci U S A (2012) 1.72
Transcriptional network dynamics in macrophage activation. Genomics (2006) 1.72
Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics (2009) 1.71
A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol (2009) 1.70
Diagnosis of human fasciolosis in the Gilan province of Northern Iran: application of cathepsin L-ELISA. Diagn Microbiol Infect Dis (2002) 1.70
The molecular basis for the lack of immunostimulatory activity of vertebrate DNA. J Immunol (2003) 1.67
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc Natl Acad Sci U S A (2009) 1.63
An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host. Mol Cell Proteomics (2009) 1.63
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter. Dev Biol (2007) 1.61
The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Res (2003) 1.61
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biol (2009) 1.60
Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun (2005) 1.59
Simultaneous identification of differential gene expression and connectivity in inflammation, adipogenesis and cancer. Bioinformatics (2006) 1.58
Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice. J Leukoc Biol (2007) 1.57
Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice. Am J Pathol (2006) 1.57
Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases. Philos Trans R Soc Lond B Biol Sci (2009) 1.56
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J (2006) 1.51
Genetic control of the innate immune response. BMC Immunol (2003) 1.50
Mice and men: their promoter properties. PLoS Genet (2006) 1.50
Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J (2008) 1.49
Histone deacetylase inhibitors in inflammatory disease. Curr Top Med Chem (2009) 1.46
T1/ST2--an IL-1 receptor-like modulator of immune responses. Cytokine Growth Factor Rev (2004) 1.43
Renal structural and functional repair in a mouse model of reversal of ureteral obstruction. J Am Soc Nephrol (2005) 1.40
Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha. J Biol Chem (2005) 1.39
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38
Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol (2007) 1.37
Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses. Am J Pathol (2011) 1.37
Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells. J Biol Chem (2004) 1.36
The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini. Proteomics (2010) 1.35
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
Serological prevalence of echinococcosis and risk factors for infection among children in rural communities of southern Ningxia, China. Trop Med Int Health (2008) 1.35
G-protein-coupled receptor expression, function, and signaling in macrophages. J Leukoc Biol (2007) 1.33
FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions. Genome Biol (2009) 1.32
Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations. Immunobiology (2010) 1.32
Uropathogenic Escherichia coli virulence and innate immune responses during urinary tract infection. Curr Opin Microbiol (2013) 1.31