Published in Proc Natl Acad Sci U S A on November 24, 2008
MYC on the path to cancer. Cell (2012) 8.65
MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64
Nucleolar targeting: the hub of the matter. EMBO Rep (2009) 1.82
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. Biochem Res Int (2010) 1.49
Cancer translocations in human cells induced by zinc finger and TALE nucleases. Genome Res (2013) 1.44
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proc Natl Acad Sci U S A (2010) 1.34
Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest (2015) 1.21
The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis. J Cell Biol (2010) 1.16
The Myc-nucleophosmin-ARF network: a complex web unveiled. Cell Cycle (2009) 1.10
The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harb Perspect Med (2013) 1.10
Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells. J Biol Chem (2011) 1.06
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med (2014) 1.03
Nuclear PI3K signaling in cell growth and tumorigenesis. Front Cell Dev Biol (2015) 0.96
Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem (2009) 0.94
Expression of nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells. J Biomed Sci (2012) 0.91
Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription. Oncogene (2012) 0.91
MYC cofactors: molecular switches controlling diverse biological outcomes. Cold Spring Harb Perspect Med (2014) 0.88
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A (2012) 0.87
Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY) (2010) 0.87
Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization. Int J Radiat Oncol Biol Phys (2014) 0.85
Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways. Histochem Cell Biol (2016) 0.85
A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One (2012) 0.84
The nuclear chaperone nucleophosmin escorts an Epstein-Barr Virus nuclear antigen to establish transcriptional cascades for latent infection in human B cells. PLoS Pathog (2012) 0.82
Ribosomal protein S14 negatively regulates c-Myc activity. J Biol Chem (2013) 0.81
Molecules that target nucleophosmin for cancer treatment: an update. Oncotarget (2016) 0.81
The Myc-ARF-Egr1 pathway: unleashing the apoptotic power of c-Myc. Cell Cycle (2011) 0.80
Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants. ACS Chem Biol (2015) 0.80
Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation. Mol Cancer Res (2014) 0.80
The Quest for Targets Executing MYC-Dependent Cell Transformation. Front Oncol (2016) 0.76
Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. Biochem Biophys Res Commun (2013) 0.76
Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. J Biol Chem (2013) 0.75
Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development. Oncotarget (2016) 0.75
Biological and clinical consequences of NPM1-mutations in AML. Leukemia (2017) 0.75
Effects of salvianolic Acid B on protein expression in human umbilical vein endothelial cells. Evid Based Complement Alternat Med (2011) 0.75
New roles for Dicer in the nucleolus and its relevance to cancer. Cell Cycle (2017) 0.75
Induction of apoptosis in fibroblasts by c-myc protein. Cell (1992) 16.95
MYC oncogenes and human neoplastic disease. Oncogene (1999) 7.28
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol (2005) 4.89
The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol (2001) 4.83
Nucleophosmin and cancer. Nat Rev Cancer (2006) 4.82
Myc influences global chromatin structure. EMBO J (2006) 4.71
Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature (1989) 4.65
Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell (1999) 4.38
Role of nucleophosmin in embryonic development and tumorigenesis. Nature (2005) 4.09
The myc oncogene: MarvelouslY Complex. Adv Cancer Res (2002) 3.68
Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol (2002) 3.67
Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J Biol Chem (2003) 2.66
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol (2005) 2.55
p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature (2004) 2.26
Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10
Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol (2006) 1.91
Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation. J Biol Chem (2001) 1.89
Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. J Cell Sci (2001) 1.59
The ARF tumor suppressor: keeping Myc on a leash. Cell Cycle (2005) 1.39
Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression. Carcinogenesis (2002) 1.29
The great MYC escape in tumorigenesis. Cancer Cell (2005) 1.25
Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels. J Cell Sci (2003) 1.17
Nucleophosmin: a versatile molecule associated with hematological malignancies. Cancer Sci (2006) 1.09
DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer. J Mol Histol (2006) 1.05
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability. Carcinogenesis (2007) 1.05
Regulation of the Arf tumor suppressor in Emicro-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis. Blood (2006) 1.05
Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells. Leuk Res (2005) 1.00
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64
Phosphorylation by glycogen synthase kinase-3 controls c-myc proteolysis and subnuclear localization. J Biol Chem (2003) 2.66
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene (2004) 2.62
Innate immune and chemically triggered oxidative stress modifies translational fidelity. Nature (2009) 2.50
p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature (2004) 2.26
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination. Am J Pathol (2007) 1.94
Mechanisms of thermal adaptation revealed from the genomes of the Antarctic Archaea Methanogenium frigidum and Methanococcoides burtonii. Genome Res (2003) 1.75
The ARF tumor suppressor: keeping Myc on a leash. Cell Cycle (2005) 1.39
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proc Natl Acad Sci U S A (2010) 1.34
Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha. Adv Exp Med Biol (2002) 1.15
The Myc-nucleophosmin-ARF network: a complex web unveiled. Cell Cycle (2009) 1.10
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. J Cell Biochem (2008) 1.01
Interleukin-15 and the regulation of lymphoid homeostasis. Mol Immunol (2002) 0.98
Specificity of the E1-E2-E3 enzymatic cascade for ubiquitin C-terminal sequences identified by phage display. ACS Chem Biol (2012) 0.91
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer. PLoS One (2012) 0.91
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A (2012) 0.87
The alpha1 subunit of GABAA receptor is repressed by c-myc and is pro-apoptotic. J Cell Biochem (2006) 0.81
The Myc-ARF-Egr1 pathway: unleashing the apoptotic power of c-Myc. Cell Cycle (2011) 0.80
Recapitulation of germ cell- and pituitary-specific expression with 1.6 kb of the cystatin-related epididymal spermatogenic (Cres) gene promoter in transgenic mice. J Androl (2005) 0.77
Small-molecule high-throughput screening utilizing Xenopus egg extract. Methods Mol Biol (2015) 0.76