Published in Cold Spring Harb Perspect Med on June 17, 2014
An overview of MYC and its interactome. Cold Spring Harb Perspect Med (2014) 1.53
Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med (2014) 1.19
Genome recognition by MYC. Cold Spring Harb Perspect Med (2014) 1.10
MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell (2015) 0.88
Synthetic lethal screens as a means to understand and treat MYC-driven cancers. Cold Spring Harb Perspect Med (2014) 0.86
c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function. PLoS One (2015) 0.79
ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data. Genome Biol (2016) 0.78
MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation. Cell Cycle (2016) 0.75
E3 Ubiquitin Ligase RLIM Negatively Regulates c-Myc Transcriptional Activity and Restrains Cell Proliferation. PLoS One (2016) 0.75
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation. Mol Neurobiol (2016) 0.75
MB0 and MBI Are Independent and Distinct Transactivation Domains in MYC that Are Essential for Transformation. Genes (Basel) (2017) 0.75
Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft. Invest New Drugs (2017) 0.75
Variation in transcription factor binding among humans. Science (2010) 9.33
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03
MYC on the path to cancer. Cell (2012) 8.65
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell (1998) 8.33
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol (2005) 7.54
Reflecting on 25 years with MYC. Nat Rev Cancer (2008) 7.44
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev (2001) 6.36
Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol Cell Biol (1984) 5.79
Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A (2004) 5.55
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
CIP2A inhibits PP2A in human malignancies. Cell (2007) 5.28
Divorcing ARF and p53: an unsettled case. Nat Rev Cancer (2006) 5.17
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature (2005) 4.97
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J (2004) 4.95
How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol (2003) 4.90
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol (2005) 4.89
Nucleophosmin and cancer. Nat Rev Cancer (2006) 4.82
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
Myc influences global chromatin structure. EMBO J (2006) 4.71
An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell (2008) 4.27
Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol (2001) 4.22
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
Control of cell growth by c-Myc in the absence of cell division. Curr Biol (1999) 3.90
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature (1984) 3.86
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol (2000) 3.86
Skp2 regulates Myc protein stability and activity. Mol Cell (2003) 3.85
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol (2005) 3.79
Proteins encoded by v-myc and c-myc oncogenes: identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines. Cell (1983) 3.79
The myc oncogene: MarvelouslY Complex. Adv Cancer Res (2002) 3.68
A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev (1993) 3.60
c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc Natl Acad Sci U S A (1999) 3.48
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat Cell Biol (2007) 3.26
MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev (2001) 3.15
Aberrations of EZH2 in cancer. Clin Cancer Res (2011) 3.13
Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3. Proc Natl Acad Sci U S A (2001) 3.02
c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J (1994) 3.01
Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol Cell (2002) 2.99
Skp2 is oncogenic and overexpressed in human cancers. Proc Natl Acad Sci U S A (2001) 2.98
c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nat Genet (1999) 2.95
BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet (1996) 2.88
An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell (2000) 2.84
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell (2008) 2.83
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature (1997) 2.78
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Mol Cell Biol (2003) 2.72
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev (2009) 2.69
Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem (2002) 2.68
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response. Nature (2007) 2.54
Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell (2011) 2.53
The multi-tasking P-TEFb complex. Curr Opin Cell Biol (2008) 2.53
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol (2004) 2.45
An alternative pathway for gene regulation by Myc. EMBO J (1997) 2.43
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem (2001) 2.36
Myc target genes. Trends Biochem Sci (1997) 2.34
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol (2008) 2.32
Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29
Cellular functions of TIP60. Int J Biochem Cell Biol (2006) 2.28
c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. Genes Dev (1998) 2.27
p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature (2004) 2.26
c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. J Virol (2007) 2.24
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. EMBO Rep (2003) 2.21
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19
Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol Cell Biol (2001) 2.15
Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. PLoS One (2008) 2.12
The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat (2010) 2.09
Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol Cell Biol (1994) 2.01
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem (2006) 1.96
VP16 and ubiquitin; binding of P-TEFb via its activation domain and ubiquitin facilitates elongation of transcription of target genes. Curr Biol (2004) 1.94
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics (2009) 1.92
Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol (2006) 1.91
Myc represses primitive endoderm differentiation in pluripotent stem cells. Cell Stem Cell (2010) 1.90
Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle (2005) 1.88
Binding and suppression of the Myc transcriptional activation domain by p107. Science (1994) 1.84
Conditional transgenic models define how MYC initiates and maintains tumorigenesis. Semin Cancer Biol (2006) 1.82
TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol (2002) 1.80
Proteomic profiling of Myc-associated proteins. Cell Cycle (2010) 1.80
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol Cell Biol (2007) 1.78
Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.75
Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. Genes Dev (1998) 1.74
Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol (2008) 1.72
Overlapping roles for the histone acetyltransferase activities of SAGA and elongator in vivo. EMBO J (2000) 1.71
Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins. Mol Cell Biol (1997) 1.69
BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol (2002) 1.69
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69
Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell (2013) 1.67
Ubiquitin and proteasomes in transcription. Annu Rev Biochem (2012) 1.67
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell (2010) 1.67
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas. Cancer Cell (2012) 1.65
Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. Cancer Res (2006) 1.64
c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell (2006) 1.64
Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events. J Biol Chem (2011) 1.63
A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. Proc Natl Acad Sci U S A (2000) 1.61
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60