Published in Nature on December 11, 2008
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA (2009) 12.35
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
The Drosophila melanogaster Genetic Reference Panel. Nature (2012) 7.94
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
The genetics of quantitative traits: challenges and prospects. Nat Rev Genet (2009) 5.99
Adventures in semantic publishing: exemplar semantic enhancements of a research article. PLoS Comput Biol (2009) 4.72
Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res (2009) 4.62
Association mapping: critical considerations shift from genotyping to experimental design. Plant Cell (2009) 4.59
Race, socioeconomic status, and health: complexities, ongoing challenges, and research opportunities. Ann N Y Acad Sci (2010) 4.50
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Common disorders are quantitative traits. Nat Rev Genet (2009) 4.34
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 3.58
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A (2009) 3.13
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment. Nat Genet (2014) 2.42
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
A decade of systems biology. Annu Rev Cell Dev Biol (2010) 2.30
Methodological challenges of genome-wide association analysis in Africa. Nat Rev Genet (2010) 2.27
Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proc Natl Acad Sci U S A (2010) 2.27
Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach. Neuroimage (2010) 2.27
Anonymization of electronic medical records for validating genome-wide association studies. Proc Natl Acad Sci U S A (2010) 2.24
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
The QTN program and the alleles that matter for evolution: all that's gold does not glitter. Evolution (2011) 2.23
Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics. Pharmacogenomics (2009) 2.23
Current status of genome-wide association studies in cancer. Hum Genet (2011) 2.14
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Ethical issues in human genomics research in developing countries. BMC Med Ethics (2011) 2.02
The Bayesian lasso for genome-wide association studies. Bioinformatics (2010) 1.99
The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci U S A (2012) 1.92
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
Genetic perspectives on crop domestication. Trends Plant Sci (2010) 1.79
Understanding and using quantitative genetic variation. Philos Trans R Soc Lond B Biol Sci (2010) 1.78
Inferences from genomic models in stratified populations. Genetics (2012) 1.76
High-resolution mapping of complex traits with a four-parent advanced intercross yeast population. Genetics (2013) 1.72
Human population dispersal "Out of Africa" estimated from linkage disequilibrium and allele frequencies of SNPs. Genome Res (2011) 1.64
A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis. BMC Bioinformatics (2010) 1.63
The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol (2013) 1.59
Pathophysiology of depression: do we have any solid evidence of interest to clinicians? World Psychiatry (2010) 1.50
The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics. PLoS One (2012) 1.49
Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Ann Neurol (2011) 1.45
A general method for controlling the genome-wide type I error rate in linkage and association mapping experiments in plants. Heredity (Edinb) (2010) 1.44
Polymorphic regions affecting human height also control stature in cattle. Genetics (2011) 1.42
Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. PLoS Genet (2011) 1.41
Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry (2010) 1.41
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. PLoS Genet (2010) 1.39
Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. Am J Hematol (2010) 1.34
Conceptual approaches to the study of health disparities. Annu Rev Public Health (2012) 1.33
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet (2013) 1.30
A genome-wide association study identifies multiple loci associated with mathematics ability and disability. Genes Brain Behav (2009) 1.25
A longitudinal twin study on the association between inattentive and hyperactive-impulsive ADHD symptoms. J Abnorm Child Psychol (2011) 1.13
Inferring causative variants in microRNA target sites. Nucleic Acids Res (2011) 1.12
Identifying functional single nucleotide polymorphisms in the human CArGome. Physiol Genomics (2011) 1.11
Genome-wide association study of sleep in Drosophila melanogaster. BMC Genomics (2013) 1.11
Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res (2013) 1.10
Straightforward inference of ancestry and admixture proportions through ancestry-informative insertion deletion multiplexing. PLoS One (2012) 1.08
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J (2011) 1.07
Being more realistic about the public health impact of genomic medicine. PLoS Med (2010) 1.06
Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays (2013) 1.06
Quantitative genetics in the era of molecular genetics: learning abilities and disabilities as an example. J Am Acad Child Adolesc Psychiatry (2010) 1.05
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences. BMC Med (2012) 1.04
Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol (2009) 1.04
Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer. OMICS (2011) 1.02
Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics. Clin Cancer Res (2010) 1.02
Comparative analysis of methods for detecting interacting loci. BMC Genomics (2011) 1.02
Genetic determinants of depression: recent findings and future directions. Harv Rev Psychiatry (2015) 1.02
A genome-wide association study of prostate cancer in West African men. Hum Genet (2013) 1.02
From genes to function: the next challenge to understanding multiple sclerosis. Nat Rev Immunol (2009) 1.01
Mapping quantitative traits and strategies to find quantitative trait genes. Methods (2010) 1.01
Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. Br J Psychiatry (2010) 1.01
Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach. J Am Med Inform Assoc (2013) 1.00
Combining evidence of selection with association analysis increases power to detect regions influencing complex traits in dairy cattle. BMC Genomics (2012) 0.96
Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics (2011) 0.95
Efficiency of trans-ethnic genome-wide meta-analysis and fine-mapping. Eur J Hum Genet (2012) 0.95
Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle. BMC Genomics (2014) 0.91
A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations. Eur J Hum Genet (2011) 0.89
Characterization of autosomal copy-number variation in African Americans: the HyperGEN Study. Eur J Hum Genet (2011) 0.88
Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. Hum Genet (2009) 0.88
Dissection of genetic associations with language-related traits in population-based cohorts. J Neurodev Disord (2011) 0.87
Unexpected relationships and inbreeding in HapMap phase III populations. PLoS One (2012) 0.86
Systems genetics for drug target discovery. Trends Pharmacol Sci (2011) 0.86
UGT1A1 sequence variants and bilirubin levels in early postnatal life: a quantitative approach. BMC Med Genet (2011) 0.86
Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination. PLoS Genet (2015) 0.85
Testing gene-gene interactions in genome wide association studies. Genet Epidemiol (2014) 0.85
Novel genes for QTc interval. How much heritability is explained, and how much is left to find? Genome Med (2010) 0.84
Accuracy of heritability estimations in presence of hidden population stratification. Sci Rep (2016) 0.83
Application of high-dimensional feature selection: evaluation for genomic prediction in man. Sci Rep (2015) 0.83
Genetic variants and their interactions in disease risk prediction - machine learning and network perspectives. BioData Min (2013) 0.83
A quality control algorithm for filtering SNPs in genome-wide association studies. Bioinformatics (2010) 0.83
Genetics of coronary artery disease: focus on genome-wide association studies. Am J Transl Res (2009) 0.83
Genomics of behavioral diseases. Front Genet (2012) 0.82
Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. Genetics (2011) 0.82
Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer. Hum Hered (2012) 0.82
Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study. Ann Hum Genet (2009) 0.81
Evaluation of the imputation performance of the program IMPUTE in an admixed sample from Mexico City using several model designs. BMC Med Genomics (2012) 0.80
Statistical analysis for genome-wide association study. J Biomed Res (2014) 0.80
Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region. World J Cardiol (2014) 0.79