Published in Nat Rev Genet on April 01, 2009
Premature Coronary Artery Disease - Clinical and Molecular Genetic Aspects (PIHS) | NCT02146872
Sequencing technologies - the next generation. Nat Rev Genet (2009) 40.57
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Targeted capture and massively parallel sequencing of 12 human exomes. Nature (2009) 33.96
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
Pooled association tests for rare variants in exon-resequencing studies. Am J Hum Genet (2010) 13.18
The genetics of inbreeding depression. Nat Rev Genet (2009) 7.13
Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet (2010) 6.79
The genetics of quantitative traits: challenges and prospects. Nat Rev Genet (2009) 5.99
Recent explosive human population growth has resulted in an excess of rare genetic variants. Science (2012) 5.58
Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53
Human genetics shape the gut microbiome. Cell (2014) 4.91
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85
Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nat Biotechnol (2009) 4.80
Genome-wide association studies in diverse populations. Nat Rev Genet (2010) 4.68
The predictive capacity of personal genome sequencing. Sci Transl Med (2012) 4.64
An agenda for personalized medicine. Nature (2009) 4.14
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Fast identification and removal of sequence contamination from genomic and metagenomic datasets. PLoS One (2011) 3.74
8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37
GATES: a rapid and powerful gene-based association test using extended Simes procedure. Am J Hum Genet (2011) 3.34
Genomics and the future of conservation genetics. Nat Rev Genet (2010) 3.23
Autoinflammatory disease reloaded: a clinical perspective. Cell (2010) 3.04
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat Genet (2012) 2.86
Individualized medicine from prewomb to tomb. Cell (2014) 2.76
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol (1985) (2010) 2.74
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (2013) 2.71
Association screening of common and rare genetic variants by penalized regression. Bioinformatics (2010) 2.67
To identify associations with rare variants, just WHaIT: Weighted haplotype and imputation-based tests. Am J Hum Genet (2010) 2.63
Transethnic meta-analysis of genomewide association studies. Genet Epidemiol (2011) 2.53
A statistical framework for joint eQTL analysis in multiple tissues. PLoS Genet (2013) 2.46
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45
Mapping human epigenomes. Cell (2013) 2.44
The impact of next-generation sequencing on genomics. J Genet Genomics (2011) 2.41
Enrichment of sequencing targets from the human genome by solution hybridization. Genome Biol (2009) 2.32
Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat Methods (2011) 2.30
Bioinformatics challenges for personalized medicine. Bioinformatics (2011) 2.28
SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data. Nucleic Acids Res (2011) 2.27
Human genetic susceptibility to infectious disease. Nat Rev Genet (2012) 2.25
The importance of phase information for human genomics. Nat Rev Genet (2011) 2.25
The QTN program and the alleles that matter for evolution: all that's gold does not glitter. Evolution (2011) 2.23
Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nat Genet (2010) 2.08
Design of association studies with pooled or un-pooled next-generation sequencing data. Genet Epidemiol (2010) 2.06
Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Estimation of allele frequency and association mapping using next-generation sequencing data. BMC Bioinformatics (2011) 1.93
Association studies for next-generation sequencing. Genome Res (2011) 1.89
Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Nat Commun (2014) 1.88
Genome-wide association studies for agronomical traits in a world wide spring barley collection. BMC Plant Biol (2012) 1.79
Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. PLoS Genet (2010) 1.74
'Systems biology' in human exercise physiology: is it something different from integrative physiology? J Physiol (2011) 1.73
The evolution of human genetic and phenotypic variation in Africa. Curr Biol (2010) 1.65
Enhancer-promoter interactions are encoded by complex genomic signatures on looping chromatin. Nat Genet (2016) 1.64
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. PLoS Genet (2009) 1.57
Sex-dependent association of common variants of microcephaly genes with brain structure. Proc Natl Acad Sci U S A (2009) 1.55
Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol (2012) 1.55
Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies. PLoS Genet (2016) 1.53
Bioinformatics for personal genome interpretation. Brief Bioinform (2012) 1.51
The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol (2010) 1.49
Cancer pharmacoethnicity: ethnic differences in susceptibility to the effects of chemotherapy. Clin Cancer Res (2009) 1.48
Transforming growth factor-beta signaling pathway in patients with Kawasaki disease. Circ Cardiovasc Genet (2010) 1.45
The epidemiology of diabetes in Korea: from the economics to genetics. Korean Diabetes J (2010) 1.45
Network properties of complex human disease genes identified through genome-wide association studies. PLoS One (2009) 1.42
Genetic vulnerability and susceptibility to substance dependence. Neuron (2011) 1.40
Complex inheritance of melanoma and pigmentation of coat and skin in Grey horses. PLoS Genet (2013) 1.39
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study. PLoS Genet (2010) 1.39
Efficient and cost effective population resequencing by pooling and in-solution hybridization. PLoS One (2011) 1.38
Synthetic associations in the context of genome-wide association scan signals. Hum Mol Genet (2010) 1.36
Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Res (2012) 1.35
Identification of a gene associated with avian migratory behaviour. Proc Biol Sci (2011) 1.35
An evolutionary perspective on epistasis and the missing heritability. PLoS Genet (2013) 1.33
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations. PLoS Genet (2012) 1.31
Transgenerational genetic effects of the paternal Y chromosome on daughters' phenotypes. Epigenomics (2010) 1.31
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin Exp Res (2011) 1.30
Regions of homozygosity and their impact on complex diseases and traits. Hum Genet (2010) 1.30
Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension. Hypertension (2012) 1.28
Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum (2012) 1.28
Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies. Genet Epidemiol (2011) 1.25
Unraveling the genetic component of systemic sclerosis. Hum Genet (2012) 1.25
Gene-based testing of interactions in association studies of quantitative traits. PLoS Genet (2013) 1.23
USING POPULATION GENOMICS TO DETECT SELECTION IN NATURAL POPULATIONS: KEY CONCEPTS AND METHODOLOGICAL CONSIDERATIONS. Int J Plant Sci (2010) 1.23
Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genet (2009) 1.23
Child development and molecular genetics: 14 years later. Child Dev (2012) 1.23
Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression. J Virol (2011) 1.21
Finding common susceptibility variants for complex disease: past, present and future. Brief Funct Genomic Proteomic (2009) 1.20
Likelihood ratios for genome medicine. Genome Med (2010) 1.20
miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cell (2013) 1.19
A novel statistic for genome-wide interaction analysis. PLoS Genet (2010) 1.19
Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence. Neuropsychopharmacology (2010) 1.17
Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol (2011) 1.16
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci U S A (2012) 1.16
Genome-wide epigenetic data facilitate understanding of disease susceptibility association studies. J Biol Chem (2012) 1.15
Cancer evolution and individual susceptibility. Integr Biol (Camb) (2011) 1.15
Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease. PLoS Genet (2013) 1.14
Recent findings in the genetics of blood pressure and hypertension traits. Am J Hypertens (2010) 1.14
Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics (2011) 1.12
Large-scale de novo prediction of physical protein-protein association. Mol Cell Proteomics (2011) 1.11
Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review. Am J Epidemiol (2013) 1.11
Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues. Science (2012) 1.11
Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. Diabetes (2010) 1.11
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
A haplotype map of the human genome. Nature (2005) 105.70
The sequence of the human genome. Science (2001) 101.55
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Global variation in copy number in the human genome. Nature (2006) 57.50
The complete genome of an individual by massively parallel DNA sequencing. Nature (2008) 52.81
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Large-scale copy number polymorphism in the human genome. Science (2004) 34.64
Evolutionary rate at the molecular level. Nature (1968) 33.15
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Paired-end mapping reveals extensive structural variation in the human genome. Science (2007) 30.46
Mapping and sequencing of structural variation from eight human genomes. Nature (2008) 30.28
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Fine-scale structural variation of the human genome. Nat Genet (2005) 24.31
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science (2004) 21.65
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet (2003) 21.52
Structural variation in the human genome. Nat Rev Genet (2006) 21.40
Recent segmental duplications in the human genome. Science (2002) 21.30
Whole-genome patterns of common DNA variation in three human populations. Science (2005) 21.22
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (2008) 20.68
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature (2008) 20.31
Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25
Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet (2008) 19.55
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
A high-resolution survey of deletion polymorphism in the human genome. Nat Genet (2005) 16.99
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
On the allelic spectrum of human disease. Trends Genet (2001) 16.26
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet (2008) 15.89
Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66
Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet (2008) 15.51
Genetic mapping in human disease. Science (2008) 15.12
Evaluating and improving power in whole-genome association studies using fixed marker sets. Nat Genet (2006) 14.76
Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet (2008) 13.95
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78
A common inversion under selection in Europeans. Nat Genet (2005) 13.66
A common variant associated with prostate cancer in European and African populations. Nat Genet (2006) 13.47
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Many sequence variants affecting diversity of adult human height. Nat Genet (2008) 12.80
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genotype, haplotype and copy-number variation in worldwide human populations. Nature (2008) 12.40
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Evaluating coverage of genome-wide association studies. Nat Genet (2006) 11.40
SLCO1B1 variants and statin-induced myopathy--a genomewide study. N Engl J Med (2008) 11.31
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
The new genomics: global views of biology. Science (1996) 10.77
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
The allelic architecture of human disease genes: common disease-common variant...or not? Hum Mol Genet (2002) 10.08
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet (2005) 9.61
Genetic determinants of hair, eye and skin pigmentation in Europeans. Nat Genet (2007) 8.79
Copy-number variation and association studies of human disease. Nat Genet (2007) 8.50
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89
Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome. Am J Hum Genet (2006) 7.70
Variation is the spice of life. Nat Genet (2001) 7.62
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science (2007) 7.55
How to interpret a genome-wide association study. JAMA (2008) 7.54
Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet (2006) 7.49
Mapping complex disease traits with global gene expression. Nat Rev Genet (2009) 7.44
Progress and challenges in genome-wide association studies in humans. Nature (2008) 7.32
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. Nat Rev Genet (2008) 7.08
Genome assembly comparison identifies structural variants in the human genome. Nat Genet (2006) 6.93
A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87
Recurrent 16p11.2 microdeletions in autism. Hum Mol Genet (2007) 6.75
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
Genetic variation in an individual human exome. PLoS Genet (2008) 6.68
Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet (2007) 6.55
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet (2005) 6.48
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet (2008) 6.42
Challenges and standards in integrating surveys of structural variation. Nat Genet (2007) 6.05
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
Population genetics--making sense out of sequence. Nat Genet (1999) 5.28
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
A robust statistical method for case-control association testing with copy number variation. Nat Genet (2008) 4.78
Guilt beyond a reasonable doubt. Nat Genet (2007) 4.56
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med (2006) 18.25
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA (2002) 11.06
Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol (2009) 9.59
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med (2011) 6.90
Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet (2003) 6.85
Common vs. rare allele hypotheses for complex diseases. Curr Opin Genet Dev (2009) 6.85
Prevalence of conventional risk factors in patients with coronary heart disease. JAMA (2003) 6.84
Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet (2010) 6.79
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA (2011) 6.39
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med (2003) 5.89
A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease. J Am Coll Cardiol (2003) 5.51
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet (2003) 5.34
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA (2004) 5.11
Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet (2002) 5.04
Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nat Biotechnol (2009) 4.80
Can mobile health technologies transform health care? JAMA (2013) 4.75
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med (2003) 4.72
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet (2005) 4.45
Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med (2007) 4.30
Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA (2005) 4.23
Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology (2005) 4.21
An agenda for personalized medicine. Nature (2009) 4.14
Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Accommodating linkage disequilibrium in genetic-association analyses via ridge regression. Am J Hum Genet (2008) 3.86
Generalized genomic distance-based regression methodology for multilocus association analysis. Am J Hum Genet (2006) 3.79
Transgenerational epigenetic instability is a source of novel methylation variants. Science (2011) 3.66
Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA (2008) 3.64
A second-generation combined linkage physical map of the human genome. Genome Res (2007) 3.60
Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation (2003) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science (2003) 3.34
Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genet (2007) 3.29
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med (2010) 3.17
Heritability of nonalcoholic fatty liver disease. Gastroenterology (2009) 3.17
Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol (2005) 3.05
Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med (2002) 3.01
Economic evaluation of bivalirudin with provisional glycoprotein IIB/IIIA inhibition versus heparin with routine glycoprotein IIB/IIIA inhibition for percutaneous coronary intervention: results from the REPLACE-2 trial. J Am Coll Cardiol (2004) 2.97
Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med (2012) 2.91
Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry (2007) 2.91
Arthritis medicines and cardiovascular events--"house of coxibs". JAMA (2004) 2.89
Accurate detection and genotyping of SNPs utilizing population sequencing data. Genome Res (2010) 2.84
Aspirin and clopidogrel resistance: an emerging clinical entity. Eur Heart J (2005) 2.80
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell (2009) 2.79
A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans. Am J Hypertens (2003) 2.76
Patterns of population epigenomic diversity. Nature (2013) 2.70
Methods for handling multiple testing. Adv Genet (2008) 2.67
Facilitated PCI in patients with ST-elevation myocardial infarction. N Engl J Med (2008) 2.61
Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol (2005) 2.59
Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol (2007) 2.56
Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk features. Circulation (2004) 2.54
Long-term outcome and its predictors among patients with ST-segment elevation myocardial infarction complicated by shock: insights from the GUSTO-I trial. J Am Coll Cardiol (2007) 2.47
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc Natl Acad Sci U S A (2010) 2.47
International differences in evolution of early discharge after acute myocardial infarction. Lancet (2004) 2.47
A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease. Arterioscler Thromb Vasc Biol (2007) 2.47
Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull (2006) 2.46
The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Per Med (2011) 2.43
Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet (2005) 2.41
Neuroanatomical assessment of biological maturity. Curr Biol (2012) 2.40
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet (2004) 2.36
The genomics gold rush. JAMA (2007) 2.35
Enrichment of sequencing targets from the human genome by solution hybridization. Genome Biol (2009) 2.32
An analysis of mortality rates with dual-antiplatelet therapy in the primary prevention population of the CHARISMA trial. Eur Heart J (2007) 2.31
Abciximab as adjunctive therapy to reperfusion in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized trials. JAMA (2005) 2.26
The importance of phase information for human genomics. Nat Rev Genet (2011) 2.25
Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke (2004) 2.24
Consumer perceptions of direct-to-consumer personalized genomic risk assessments. Genet Med (2010) 2.23
CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A (2011) 2.23
The case for routine genotyping in dual-antiplatelet therapy. J Am Coll Cardiol (2010) 2.19
Sex differences in mortality following acute coronary syndromes. JAMA (2009) 2.17