Published in J Pharmacol Exp Ther on December 19, 2008
Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev (2010) 2.97
Pharmacogenomic discovery using cell-based models. Pharmacol Rev (2009) 1.96
Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther (2011) 1.14
A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clin Pharmacol Ther (2011) 1.07
The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clin Pharmacol Ther (2009) 1.01
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PLoS One (2009) 0.96
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J (2012) 0.86
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. Pharmacogenomics J (2011) 0.82
Pharmacogenomics of membrane transporters: past, present and future. Pharmacogenomics (2010) 0.80
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics (2009) 0.80
Multiple functional SNPs in differentially expressed genes modify risk and survival of non-small cell lung cancer in Chinese female non-smokers. Oncotarget (2017) 0.75
A new statistical method for haplotype reconstruction from population data. Am J Hum Genet (2001) 59.30
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther (1999) 5.17
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters. Science (1987) 4.59
The concentrative nucleoside transporter family, SLC28. Pflugers Arch (2003) 2.06
Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol (2004) 1.37
Functional genomics of membrane transporters in human populations. Genome Res (2005) 1.27
Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res (1991) 1.24
A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer. EMBO J (1992) 1.19
Regional distribution of solute carrier mRNA expression along the human intestinal tract. Drug Metab Dispos (2007) 1.15
Pharmacokinetics of ribavirin in patients with hepatitis C virus. Br J Clin Pharmacol (2006) 1.07
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. Mol Pharmacol (2006) 1.04
Extracellular adenosine activates AMP-dependent protein kinase (AMPK). J Cell Sci (2006) 0.95
Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells. J Pharmacol Exp Ther (2007) 0.95
Localization of broadly selective equilibrative and concentrative nucleoside transporters, hENT1 and hCNT3, in human kidney. Am J Physiol Renal Physiol (2007) 0.95
Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. Blood (2002) 0.94
Singleton SNPs in the human genome and implications for genome-wide association studies. Eur J Hum Genet (2008) 0.94
Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. Eur J Pharmacol (2003) 0.93
Physiological and pharmacological roles of nucleoside transporter proteins. Nucleosides Nucleotides Nucleic Acids (2008) 0.91
Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochem J (2003) 0.90
Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenet Genomics (2005) 0.86
Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. Biochem Biophys Res Commun (2006) 0.82
Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures. Cancer Chemother Pharmacol (2008) 0.81
Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Biochem J (2006) 0.80
Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics (2007) 0.78
Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Biol Pharm Bull (2006) 0.78
UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem (2004) 112.47
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
A human genome diversity cell line panel. Science (2002) 14.11
In vivo enhancer analysis of human conserved non-coding sequences. Nature (2006) 10.60
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Membrane transporters in drug development. Nat Rev Drug Discov (2010) 8.56
A distal enhancer and an ultraconserved exon are derived from a novel retroposon. Nature (2006) 5.98
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet (2009) 5.93
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet (2008) 5.85
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proc Natl Acad Sci U S A (2003) 5.77
Visualizing density maps with UCSF Chimera. J Struct Biol (2006) 5.75
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res (2003) 4.83
MODBASE, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2004) 4.54
Massively parallel functional dissection of mammalian enhancers in vivo. Nat Biotechnol (2012) 4.51
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest (2007) 4.47
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Res (2008) 4.08
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res (2005) 3.85
Postmeiotic sex chromatin in the male germline of mice. Curr Biol (2006) 3.80
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol (2005) 3.58
A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet (2003) 3.52
Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly. Nat Biotechnol (2012) 3.43
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
The genome-wide structure of the Jewish people. Nature (2010) 3.37
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med (2002) 3.31
Population stratification confounds genetic association studies among Latinos. Hum Genet (2005) 3.19
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
Designed divergent evolution of enzyme function. Nature (2006) 3.09
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol (2005) 3.03
Using sequence similarity networks for visualization of relationships across diverse protein superfamilies. PLoS One (2009) 3.03
ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res (2010) 2.96
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A (2013) 2.93
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels. Am J Hum Genet (2007) 2.91
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell (2009) 2.79
Sequence variations in the public human genome data reflect a bottlenecked population history. Proc Natl Acad Sci U S A (2002) 2.70
Large-scale discovery of enhancers from human heart tissue. Nat Genet (2011) 2.70
Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development (2004) 2.68
Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage. Stroke (2006) 2.68
Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database. Biochemistry (2006) 2.65
A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell (2013) 2.60
Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell (2008) 2.60
clusterMaker: a multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics (2011) 2.56
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res (2011) 2.52
Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev (2008) 2.44
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (2006) 2.41
Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study. Am J Hum Genet (2005) 2.41
Temporal dissection of tumorigenesis in primary cancers. Cancer Discov (2011) 2.40
Tools for integrated sequence-structure analysis with UCSF Chimera. BMC Bioinformatics (2006) 2.38
Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res (2006) 2.37
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat Rev Drug Discov (2007) 2.32
Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics (2011) 2.31
Androgens regulate the permeability of the blood-testis barrier. Proc Natl Acad Sci U S A (2005) 2.25
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol (2009) 2.20
The matrilineal ancestry of Ashkenazi Jewry: portrait of a recent founder event. Am J Hum Genet (2006) 2.18
Software extensions to UCSF chimera for interactive visualization of large molecular assemblies. Structure (2005) 2.12
Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12
UCSF Chimera, MODELLER, and IMP: an integrated modeling system. J Struct Biol (2011) 2.10
The concentrative nucleoside transporter family, SLC28. Pflugers Arch (2003) 2.06
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc Natl Acad Sci U S A (2003) 2.03
Pharmacogenomics: challenges and opportunities. Ann Intern Med (2006) 1.96
Counting the founders: the matrilineal genetic ancestry of the Jewish Diaspora. PLoS One (2008) 1.92
Profiling gene expression during the differentiation and development of the murine embryonic gonad. Biol Reprod (2004) 1.91
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (2005) 1.90
Recommendations of the 2006 Human Variome Project meeting. Nat Genet (2007) 1.90
Serum response factor binding sites differ in three human cell types. Genome Res (2007) 1.85
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development (2005) 1.82
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol (2010) 1.82
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics (2003) 1.79
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Nature (2012) 1.72
Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. Eur J Hum Genet (2009) 1.67