Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

PubWeight™: 2.79‹?› | Rank: Top 1%

🔗 View Article (PMC 3652804)

Published in Aging Cell on May 31, 2009

Authors

Ludmila Pawlikowska1, Donglei Hu, Scott Huntsman, Andrew Sung, Catherine Chu, Justin Chen, Alexander H Joyner, Nicholas J Schork, Wen-Chi Hsueh, Alexander P Reiner, Bruce M Psaty, Gil Atzmon, Nir Barzilai, Steven R Cummings, Warren S Browner, Pui-Yan Kwok, Elad Ziv, Study of Osteoporotic Fractures

Author Affiliations

1: Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA.

Articles citing this

(truncated to the top 100)

The genetics of ageing. Nature (2010) 12.08

Genetic signatures of exceptional longevity in humans. PLoS One (2012) 3.20

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell (2011) 2.37

Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab (2009) 2.20

The aging stress response. Mol Cell (2010) 2.19

Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell (2010) 1.84

The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY) (2011) 1.65

A genome-wide association study of aging. Neurobiol Aging (2011) 1.54

Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev (2013) 1.50

The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals. J Gerontol A Biol Sci Med Sci (2012) 1.49

Genome-wide association study of extreme longevity in Drosophila melanogaster. Genome Biol Evol (2014) 1.43

The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol (2013) 1.41

Effects of FOXO genotypes on longevity: a biodemographic analysis. J Gerontol A Biol Sci Med Sci (2010) 1.38

Drugs that modulate aging: the promising yet difficult path ahead. Transl Res (2013) 1.38

Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell (2012) 1.36

Insulin in central nervous system: more than just a peripheral hormone. J Aging Res (2012) 1.33

FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci (2014) 1.32

A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet (2009) 1.27

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) (2011) 1.26

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges. Bioessays (2013) 1.26

New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell (2011) 1.24

Longevity and aging. F1000Prime Rep (2013) 1.18

Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci (2011) 1.16

The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16

FoxO6 regulates memory consolidation and synaptic function. Genes Dev (2012) 1.14

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene (2011) 1.13

Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci (2011) 1.13

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate. J Cell Sci (2012) 1.12

Insulin signaling mediates sexual attractiveness in Drosophila. PLoS Genet (2012) 1.11

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10

MicroRNAs and the genetic network in aging. J Mol Biol (2013) 1.10

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Exp Gerontol (2012) 1.10

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell (2011) 1.09

The epidemiology of longevity and exceptional survival. Epidemiol Rev (2013) 1.09

Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS One (2011) 1.07

Mammalian models of extended healthy lifespan. Philos Trans R Soc Lond B Biol Sci (2011) 1.05

Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell (2011) 1.05

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nat Genet (2013) 1.04

FOXO3 gene variants and human aging: coding variants may not be key players. J Gerontol A Biol Sci Med Sci (2012) 1.03

Between destiny and disease: genetics and molecular pathways of human central nervous system aging. Prog Neurobiol (2010) 1.03

Whole-Genome Sequencing of a Healthy Aging Cohort. Cell (2016) 1.03

Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci (2012) 1.02

Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. Front Genet (2012) 1.01

Insulin, IGF-1 and longevity. Aging Dis (2010) 1.01

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). Dose Response (2014) 1.00

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene. J Gerontol A Biol Sci Med Sci (2012) 0.97

Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96

Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster. PLoS Genet (2014) 0.94

Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) (2012) 0.93

Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol (2009) 0.93

Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis. Asian J Androl (2014) 0.92

Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals. Exp Gerontol (2014) 0.91

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation. Aging Cell (2013) 0.91

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study. Aging (Albany NY) (2011) 0.91

Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet. Mech Ageing Dev (2014) 0.91

Human longevity and common variations in the LMNA gene: a meta-analysis. Aging Cell (2012) 0.90

Neuronal inputs and outputs of aging and longevity. Front Genet (2013) 0.90

Nutraceutical interventions for promoting healthy aging in invertebrate models. Oxid Med Cell Longev (2012) 0.90

Contemporary human genetic strategies in aging research. Ageing Res Rev (2010) 0.89

High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS One (2010) 0.89

Parental longevity and diabetes risk in the Diabetes Prevention Program. J Gerontol A Biol Sci Med Sci (2011) 0.89

Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89

Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population. PLoS One (2014) 0.89

Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity. Int J Mol Sci (2013) 0.89

Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS One (2010) 0.89

Adult Stem Cells and Diseases of Aging. J Clin Med (2014) 0.88

Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci (2016) 0.87

Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol (2011) 0.87

Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun Ageing (2012) 0.87

Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals. Aging Cell (2014) 0.87

EAK proteins: novel conserved regulators of C. elegans lifespan. Aging (Albany NY) (2010) 0.86

Molecular mechanisms of biological aging in intervertebral discs. J Orthop Res (2016) 0.85

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection. J Bioenerg Biomembr (2014) 0.85

LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism. J Proteome Res (2014) 0.85

The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations. Immun Ageing (2012) 0.85

Genome-wide analysis of germline signaling genes regulating longevity and innate immunity in the nematode Pristionchus pacificus. PLoS Pathog (2012) 0.85

Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr) (2011) 0.85

Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neurosci (2014) 0.84

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B. Eur J Hum Genet (2012) 0.83

Extending healthy ageing: nutrient sensitive pathway and centenarian population. Immun Ageing (2012) 0.83

FoxO6 in glucose metabolism (FoxO6). J Diabetes (2013) 0.83

GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol A Biol Sci Med Sci (2014) 0.83

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? Clin Sci (Lond) (2016) 0.82

Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. BMC Geriatr (2016) 0.82

Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing. Mech Ageing Dev (2013) 0.82

Centenarian studies: important contributors to our understanding of the aging process and longevity. Curr Gerontol Geriatr Res (2011) 0.82

Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. Age (Dordr) (2012) 0.82

The FoxO3 gene and cause-specific mortality. Aging Cell (2016) 0.82

The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway. Evol Bioinform Online (2013) 0.81

Human longevity: Genetics or Lifestyle? It takes two to tango. Immun Ageing (2016) 0.81

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study. Aging (Albany NY) (2015) 0.80

Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans. Genetics (2015) 0.80

DAF-16 target identification in C. elegans: past, present and future. Biogerontology (2014) 0.80

Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population. Oncotarget (2016) 0.80

Copy number variations in alternative splicing gene networks impact lifespan. PLoS One (2013) 0.80

Integration of immunity with physical and cognitive function in definitions of successful aging. Aging Dis (2012) 0.80

Comparative endocrinology of aging and longevity regulation. Front Endocrinol (Lausanne) (2011) 0.79

Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. Cold Spring Harb Perspect Med (2015) 0.79

Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects. Int J Mol Sci (2016) 0.78

FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis. Sci Rep (2015) 0.78

Articles cited by this

Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23

A haplotype map of the human genome. Nature (2005) 105.70

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32

Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23

The Cardiovascular Health Study: design and rationale. Ann Epidemiol (1991) 27.24

Efficiency and power in genetic association studies. Nat Genet (2005) 25.56

A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42

RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science (2007) 18.59

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (1997) 13.09

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51

Surveillance and ascertainment of cardiovascular events. The Cardiovascular Health Study. Ann Epidemiol (1995) 10.26

The endocrine regulation of aging by insulin-like signals. Science (2003) 8.10

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85

Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study. Ann Epidemiol (1993) 7.49

Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences. Genome Res (2005) 7.09

Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet (2007) 6.55

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature (1996) 6.32

Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA (1990) 6.25

Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA (2003) 6.17

FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71

Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14

Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics (1995) 5.09

Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01

The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics (1995) 3.33

Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol (2006) 3.12

Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology (2005) 2.84

Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet (2007) 2.25

Reduced insulin/IGF-1 signalling and human longevity. Aging Cell (2005) 2.13

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J (1996) 1.95

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur J Hum Genet (2007) 1.85

Genes encoding longevity: from model organisms to humans. Aging Cell (2008) 1.53

Homogeneous primer extension assay with fluorescence polarization detection. Methods Mol Biol (2003) 1.31

Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem (2000) 1.29

In vivo mutagenesis of the insulin receptor. J Biol Chem (2003) 0.91

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med (2007) 18.27

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA (2006) 12.47

Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11

Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09

Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med (2010) 11.99

Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54

Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med (2014) 11.30

Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol (2009) 9.59

Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45

Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med (2005) 8.77

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med (2003) 7.94

Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38

Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA (2003) 7.01

Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med (2011) 6.90

Statistical analysis strategies for association studies involving rare variants. Nat Rev Genet (2010) 6.79

Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet (2009) 6.66

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA (2008) 6.50

Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA (2011) 6.39

C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39

Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA (2003) 6.17

Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet (2009) 5.93

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet (2008) 5.85

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Genomewide association studies of stroke. N Engl J Med (2009) 5.29

Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol (2006) 5.28

Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20

Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14

Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med (2008) 5.14

High-trauma fractures and low bone mineral density in older women and men. JAMA (2007) 5.00

Inflammation as a risk factor for atrial fibrillation. Circulation (2003) 4.95

Categorization of humans in biomedical research: genes, race and disease. Genome Biol (2002) 4.84

Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model. Ann Intern Med (2008) 4.81

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72

BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res (2003) 4.64

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med (2005) 4.57

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet (2008) 4.33

Personalizing mammography by breast density and other risk factors for breast cancer: analysis of health benefits and cost-effectiveness. Ann Intern Med (2011) 4.28

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28

Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology (2005) 4.21

The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res (2012) 4.15

Pathway analysis of seven common diseases assessed by genome-wide association. Genomics (2008) 4.11

Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene. J Natl Cancer Inst (2004) 4.09

Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA (2003) 4.07

Personalized medicine in the era of genomics. JAMA (2007) 4.02

Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93

Association of renal insufficiency with treatment and outcomes after myocardial infarction in elderly patients. Ann Intern Med (2002) 3.92

Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90

Accommodating linkage disequilibrium in genetic-association analyses via ridge regression. Am J Hum Genet (2008) 3.86

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80

Generalized genomic distance-based regression methodology for multilocus association analysis. Am J Hum Genet (2006) 3.79

Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation (2003) 3.76

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67

Transgenerational epigenetic instability is a source of novel methylation variants. Science (2011) 3.66

Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med (2004) 3.64

Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet (2009) 3.60

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55

Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative. Am J Epidemiol (2004) 3.53

A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet (2003) 3.52

Association of genetic variations with nonfatal venous thrombosis in postmenopausal women. JAMA (2007) 3.50

Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research. Am J Public Health (2005) 3.50

Estrogen plus progestin and risk of venous thrombosis. JAMA (2004) 3.46

Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly. Nat Biotechnol (2012) 3.43

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

A comparison of prediction models for fractures in older women: is more better? Arch Intern Med (2009) 3.37

Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem (2004) 3.31

Genetic ancestry in lung-function predictions. N Engl J Med (2010) 3.30

Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA (2005) 3.30