Published in Cancer Res on January 20, 2009
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet (2010) 5.48
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57
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Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. Nucleic Acids Res (2015) 0.83
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Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Mol Microbiol (2011) 0.82
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The homologous recombination protein RAD51D protects the genome from large deletions. Nucleic Acids Res (2016) 0.75
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RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
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Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. Mutat Res (2005) 1.14
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Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. Cancer Res (2004) 0.98
Different genetic pathways in the development of periocular sebaceous gland carcinomas in presumptive Muir-Torre syndrome patients. Hum Mutat (2006) 0.90
A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst) (2006) 0.90
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Sequence, chromosomal location and expression analysis of the murine homologue of human RAD51L2/RAD51C. Gene (2001) 0.80
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Rad51C-deficient CL-V4B cells exhibit normal levels of mitomycin C-induced SCEs but reduced levels of UVC-induced SCEs. Biochem Biophys Res Commun (2005) 0.77
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Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2. Proc Natl Acad Sci U S A (2009) 2.28
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
Mini-lambda: a tractable system for chromosome and BAC engineering. Gene (2003) 2.25
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
A handcuff model for the cohesin complex. J Cell Biol (2008) 1.64
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development (2003) 1.55
Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis (2002) 1.52
Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1. Cancer Res (2005) 1.50
Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2. Nat Med (2008) 1.47
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A (2011) 1.41
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations. J Clin Invest (2009) 1.37
Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms. Cancer Res (2003) 1.37
TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell (2012) 1.34
Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. J Neurosci (2006) 1.32
Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res (2009) 1.27
A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments. Nucleic Acids Res (2003) 1.26
Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model. Hum Mol Genet (2003) 1.24
Itch genetically interacts with Notch1 in a mouse autoimmune disease model. Hum Mol Genet (2006) 1.06
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines. J Immunol (2013) 0.91
Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer. Med Sci Sports Exerc (2009) 0.91
BRCA1 and microRNAs: emerging networks and potential therapeutic targets. Mol Cells (2012) 0.90
Epigenetic control of an oncogenic microRNA, miR-155, by BRCA1. Oncotarget (2012) 0.89
A comprehensive functional characterization of BRCA2 variants associated with Fanconi anemia using mouse ES cell-based assay. Blood (2011) 0.88
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet (2012) 0.88
Exercise and intestinal polyp development in APCMin mice. Med Sci Sports Exerc (2003) 0.87
Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Cell Rep (2013) 0.86
Functional redundancy of exon 12 of BRCA2 revealed by a comprehensive analysis of the c.6853A>G (p.I2285V) variant. Hum Mutat (2009) 0.86
Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. J Cell Sci (2010) 0.82
The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression. Transcription (2012) 0.81
A novel splice site mutation in the noncoding region of BRCA2: implications for Fanconi anemia and familial breast cancer diagnostics. Hum Mutat (2014) 0.80
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer Res (2008) 0.79
Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. Mol Carcinog (2009) 0.78
The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy. Respir Res (2012) 0.77
An efficient pipeline for the generation and functional analysis of human BRCA2 variants of uncertain significance. Hum Mutat (2014) 0.77
Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. Mol Cancer Res (2013) 0.76
Carcinoma initiation via RB tumor suppressor inactivation: a versatile approach to epithelial subtype-dependent cancer initiation in diverse tissues. PLoS One (2013) 0.76
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature (2016) 0.75
BAC rescue: a tool for functional analysis of the mouse genome. Methods Mol Biol (2004) 0.75
Using recombineering to generate point mutations:galK-based positive-negative selection method. Methods Mol Biol (2012) 0.75
Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay. Methods Mol Biol (2010) 0.75
Bacterial artificial chromosome engineering. Methods Mol Biol (2004) 0.75
Using recombineering to generate point mutations: the oligonucleotide-based "hit and fix" method. Methods Mol Biol (2012) 0.75