Published in J Biol Chem on November 17, 2006
A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res (2008) 4.06
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet (2010) 3.57
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol (2009) 2.67
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis (2008) 1.64
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Cancer Epidemiol Biomarkers Prev (2008) 1.51
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J Cell Biol (2009) 1.41
Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination. Genetics (2008) 1.41
The interplay of RecA-related proteins and the MND1-HOP2 complex during meiosis in Arabidopsis thaliana. PLoS Genet (2007) 1.32
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res (2009) 1.25
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol (2012) 1.21
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene (2013) 1.20
The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet (2008) 1.17
Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. PLoS Genet (2008) 1.13
The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Nucleic Acids Res (2010) 1.12
Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant. Genetics (2009) 1.01
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses. Biochim Biophys Acta (2014) 1.01
Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell lines. Cancer Genet (2011) 0.98
ruvA Mutants that resolve Holliday junctions but do not reverse replication forks. PLoS Genet (2008) 0.97
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. J Biol Chem (2011) 0.95
Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer. Br J Pharmacol (2013) 0.93
Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol (2011) 0.93
hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery. J Biol Chem (2007) 0.91
The RecU Holliday junction resolvase acts at early stages of homologous recombination. Nucleic Acids Res (2008) 0.91
Homologous recombination repair protects against particulate chromate-induced chromosome instability in Chinese hamster cells. Mutat Res (2007) 0.90
Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity. J Mol Biol (2009) 0.89
A role for homologous recombination proteins in cell cycle regulation. Cell Cycle (2015) 0.87
OsRAD51C is essential for double-strand break repair in rice meiosis. Front Plant Sci (2014) 0.87
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana. PLoS Genet (2012) 0.86
Resolving RAD51C function in late stages of homologous recombination. Cell Div (2007) 0.85
Telomerase-independent paths to immortality in predictable cancer subtypes. J Cancer (2012) 0.84
Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination. PLoS Genet (2013) 0.83
Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates. Genome Dyn Stab (2008) 0.83
Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Mol Microbiol (2011) 0.82
Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli. Elife (2016) 0.81
Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy. Mol Cells (2015) 0.80
Identification of a breast cancer family double heterozygote for RAD51C and BRCA2 gene mutations. Fam Cancer (2015) 0.77
What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II - information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy. Biotechnol Biotechnol Equip (2014) 0.77
Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications. Curr Genomics (2010) 0.77
A new era of allele-specific diagnostics? Front Genet (2013) 0.75
Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. Br J Cancer (2017) 0.75
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol (2010) 5.59
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol (2007) 3.45
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell (2005) 3.16
RAD51C is required for Holliday junction processing in mammalian cells. Science (2004) 3.05
Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev (2009) 2.91
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
Defective DNA repair and neurodegenerative disease. Cell (2007) 2.57
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell (2009) 2.29
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell (2010) 2.24
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene (2003) 2.03
Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature (2011) 1.97
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J (2002) 1.93
Telomere maintenance requires the RAD51D recombination/repair protein. Cell (2004) 1.89
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Nat Struct Mol Biol (2010) 1.85
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet (2004) 1.73
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres. EMBO J (2012) 1.69
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol (2010) 1.69
BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A (2005) 1.68
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol Cell (2013) 1.67
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis. Semin Cell Dev Biol (2011) 1.67
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol (2004) 1.47
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol (2010) 1.44
TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J (2009) 1.42
DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Mol Cell (2008) 1.41
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem (2002) 1.41
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. J Cell Biol (2009) 1.41
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J (2007) 1.33
RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci (2004) 1.29
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol (2012) 1.27
Conformational changes modulate the activity of human RAD51 protein. J Mol Biol (2004) 1.26
Actions of aprataxin in multiple DNA repair pathways. J Biol Chem (2007) 1.24
Risk factors for persistent problems following acute whiplash injury: update of a systematic review and meta-analysis. J Orthop Sports Phys Ther (2013) 1.22
p53 prevents entry into mitosis with uncapped telomeres. Curr Biol (2010) 1.21
Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J (2002) 1.19
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat Struct Mol Biol (2010) 1.19
More complexity to the Bloom's syndrome complex. Genes Dev (2008) 1.16
Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange. Mol Cell Biol (2012) 1.15
The DNA translocase activity of FANCM protects stalled replication forks. Hum Mol Genet (2012) 1.15
Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation. Cell Rep (2013) 1.12
Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin. J Biol Chem (2008) 1.06
Synthetic junctions as tools to identify and characterize Holliday junction resolvases. Methods Enzymol (2006) 1.04
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant. Nucleic Acids Res (2009) 1.03
Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res (2001) 0.98
Telomere regulation and function during meiosis. Chromosome Res (2007) 0.97
Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96
ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets. Nat Commun (2013) 0.91
PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. Chromosoma (2003) 0.88
Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. Cell Cycle (2005) 0.87
Substrate specificity of the MUS81-EME2 structure selective endonuclease. Nucleic Acids Res (2013) 0.83
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J (2015) 0.82
How homologous recombination maintains telomere integrity. Chromosoma (2014) 0.81
DNA-dependent SUMO modification of PARP-1. DNA Repair (Amst) (2013) 0.81
Holliday junction branch migration and resolution assays. Methods Mol Biol (2004) 0.81
Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex. Structure (2013) 0.81
Corrigendum: MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells. Nat Commun (2017) 0.75
Vasculitis of the female genital tract: not always a localized condition. J Rheumatol (2012) 0.75