Published in Nat Neurosci on January 25, 2009
Mechanisms and molecules of neuronal wiring: a primer. Cold Spring Harb Perspect Biol (2011) 2.62
UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. J Cell Biol (2014) 1.50
Netrin (UNC-6) mediates dendritic self-avoidance. Nat Neurosci (2012) 1.18
TGF-β signaling in C. elegans. WormBook (2013) 0.99
UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans. Development (2011) 0.93
The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons. J Neurosci (2011) 0.92
The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP. Development (2014) 0.87
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite. Wiley Interdiscip Rev Dev Biol (2013) 0.86
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. PLoS One (2013) 0.85
Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife (2015) 0.85
Extension of the Caenorhabditis elegans Pharyngeal M1 neuron axon is regulated by multiple mechanisms. G3 (Bethesda) (2013) 0.78
The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans. Genetics (2016) 0.76
The NCLX-type Na(+)/Ca(2+) Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans. J Biol Chem (2017) 0.75
EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans. Development (2016) 0.75
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity. PLoS One (2015) 0.75
Hypergravity hinders axonal development of motor neurons in Caenorhabditis elegans. PeerJ (2016) 0.75
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. Nat Commun (2016) 0.75
Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans. Genetics (2016) 0.75
Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans. Nat Neurosci (2017) 0.75
Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. PLoS Genet (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron (1990) 4.36
Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J Biol Chem (1984) 4.20
UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell (1996) 2.78
Lipid rafts mediate chemotropic guidance of nerve growth cones. Neuron (2004) 2.46
Molecular mechanisms of axon guidance. Dev Biol (2006) 2.18
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol Cell Biol (1994) 2.16
Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron (2001) 1.92
Pioneer axon guidance by UNC-129, a C. elegans TGF-beta. Science (1998) 1.76
BMPs as mediators of roof plate repulsion of commissural neurons. Neuron (1999) 1.74
Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol (2004) 1.65
The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development. Dev Biol (2004) 1.57
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature (1993) 1.56
Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol (1998) 1.21
Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo. Genetics (2001) 1.16
Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. Dev Cell (2004) 1.11
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain. J Biol Chem (2001) 1.08
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat Cell Biol (2003) 7.74
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
PreBIND and Textomy--mining the biomedical literature for protein-protein interactions using a support vector machine. BMC Bioinformatics (2003) 6.31
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
Signal transduction by the TGF-beta superfamily. Science (2002) 5.61
Dynamic modularity in protein interaction networks predicts breast cancer outcome. Nat Biotechnol (2009) 5.41
Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A (2004) 5.34
An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27
High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
Histone recognition and large-scale structural analysis of the human bromodomain family. Cell (2012) 5.15
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell (2006) 4.77
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science (2005) 4.70
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. Dev Cell (2010) 4.59
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell (2010) 4.49
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol (2005) 4.48
The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods (2013) 4.34
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature (2004) 4.09
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Cell signaling in space and time: where proteins come together and when they're apart. Science (2009) 3.88
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science (2004) 3.73
Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell (2009) 3.50
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol (2004) 3.45
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene (2004) 3.44
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell (2006) 3.38
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med (2002) 3.24
Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci (2005) 3.19
A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol (2003) 3.11
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell (2008) 2.85
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
Identification and characterization of NleA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbiol (2004) 2.51
The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. Mol Cell (2006) 2.51
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation. Cell (2008) 2.46
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet (2004) 2.44
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat Biotechnol (2003) 2.34
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
Positive selection of tyrosine loss in metazoan evolution. Science (2009) 2.28
Post-translational modifications in signal integration. Nat Struct Mol Biol (2010) 2.23
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol (2012) 2.16
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. Sci Signal (2009) 2.16
Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Cell (2011) 2.11
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev (2003) 2.10
Phosphotyrosine signaling: evolving a new cellular communication system. Cell (2010) 2.09
Tissue-specific alternative splicing remodels protein-protein interaction networks. Mol Cell (2012) 2.08
Eukaryotic protein domains as functional units of cellular evolution. Sci Signal (2009) 2.06
Modification of the Creator recombination system for proteomics applications--improved expression by addition of splice sites. BMC Biotechnol (2006) 2.01
WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol (2005) 1.97
Turning it up a Notch: cross-talk between TGF beta and Notch signaling. Bioessays (2005) 1.95
Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration. Curr Biol (2009) 1.93
The disparate role of BMP in stem cell biology. Oncogene (2005) 1.92
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science (2009) 1.91
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nat Biotechnol (2011) 1.90
Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis. Development (2005) 1.88
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol (2003) 1.86
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J (2008) 1.82
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. EMBO J (2004) 1.79
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell (2012) 1.79
Defining the specificity space of the human SRC homology 2 domain. Mol Cell Proteomics (2007) 1.78
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol (2002) 1.77
Foxh1 is essential for development of the anterior heart field. Dev Cell (2004) 1.74
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network. Cell Stem Cell (2012) 1.72
High-throughput phosphotyrosine profiling using SH2 domains. Mol Cell (2007) 1.72
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol (2011) 1.69
Polarity proteins in axon specification and synaptogenesis. Dev Cell (2005) 1.66
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. J Biol Chem (2008) 1.60
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52