Published in Mol Cell Biol on October 01, 1991
The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol Cell Biol (1995) 7.23
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol (1998) 5.21
Effects of mutant rat dynamin on endocytosis. J Cell Biol (1993) 5.05
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature (2013) 4.43
Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol (1997) 3.94
Rac homologues and compartmentalized phosphatidylinositol 4, 5-bisphosphate act in a common pathway to regulate polar pollen tube growth. J Cell Biol (1999) 3.69
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev (1999) 3.25
Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol (1994) 2.95
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J (1996) 2.44
Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport. J Cell Biol (1995) 2.28
A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol (1994) 2.21
ralGDS family members interact with the effector loop of ras p21. Mol Cell Biol (1994) 2.05
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol (2002) 1.93
A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus. J Cell Biol (1994) 1.91
Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc Natl Acad Sci U S A (1992) 1.91
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A (1992) 1.83
mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases. Genetics (1994) 1.79
Large-scale structure-function analysis of the Arabidopsis RPM1 disease resistance protein. Plant Cell (2002) 1.72
Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol (1996) 1.63
Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J Exp Med (1995) 1.59
Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms. EMBO J (2001) 1.52
The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol (1996) 1.51
ADP-ribosylation factor and coatomer couple fusion to vesicle budding. J Cell Biol (1994) 1.50
Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol Cell Biol (1997) 1.41
The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17. Mol Cell Biol (1993) 1.39
Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol (1994) 1.36
Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages. Mol Cell Biol (1995) 1.29
A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions. Mol Cell Biol (1993) 1.28
Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol Cell Biol (1999) 1.27
Splice variants of SmgGDS control small GTPase prenylation and membrane localization. J Biol Chem (2010) 1.25
The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. J Cell Biol (1999) 1.25
Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Mol Cell Biol (2006) 1.25
Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein. Mol Biol Cell (1997) 1.23
The chemotactic response to PDGF-BB: evidence of a role for Ras. J Cell Biol (1995) 1.20
Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. J Neurosci (2010) 1.17
Molecular mechanism for orienting membrane and actin dynamics to nascent cell-cell contacts in epithelial cells. J Biol Chem (2002) 1.17
A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Aging (Albany NY) (2009) 1.14
Rac-related GTP-binding protein in elicitor-induced reactive oxygen generation by suspension-cultured soybean cells. Plant Physiol (2000) 1.11
Molecular evolution of SRP cycle components: functional implications. Nucleic Acids Res (1994) 1.09
Evidence for a recycling role for Rab7 in regulating a late step in endocytosis and in retention of lysosomal enzymes in Dictyostelium discoideum. Mol Biol Cell (1997) 1.08
Interference with endogenous ras function inhibits cellular responses to wounding. J Cell Biol (1993) 1.07
Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway. Proc Natl Acad Sci U S A (1994) 1.06
The Ras mutant D119N is both dominant negative and activated. Mol Cell Biol (1999) 1.05
Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes Brain Behav (2007) 1.02
Dominant inhibitory Ras delays Sindbis virus-induced apoptosis in neuronal cells. J Virol (1996) 0.97
Determination of dissociation constants in living zebrafish embryos with single wavelength fluorescence cross-correlation spectroscopy. Biophys J (2009) 0.97
TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem (2008) 0.97
Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J (1994) 0.96
In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1. Mol Genet Genomics (2007) 0.95
A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors. Mol Cell Biol (1991) 0.95
Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway. Mol Cell Biol (1996) 0.95
Inhibition of thyrotropin-stimulated DNA synthesis by microinjection of inhibitors of cellular Ras and cyclic AMP-dependent protein kinase. Mol Cell Biol (1993) 0.94
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov (2016) 0.88
Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. Mol Cell Biol (2001) 0.87
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma. Nat Genet (2015) 0.87
Structure of the dominant negative S17N mutant of Ras. Biochemistry (2010) 0.87
The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1994) 0.86
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase. Mol Cell Biol (1992) 0.85
Effects of site-directed mutagenesis of mglA on motility and swarming of Myxococcus xanthus. BMC Microbiol (2010) 0.84
Ras mediates Src but not epidermal growth factor-receptor tyrosine kinase signaling pathways in GH4 neuroendocrine cells. Proc Natl Acad Sci U S A (1994) 0.83
A rab protein regulates the localization of secretory granules in AtT-20 cells. Mol Biol Cell (1993) 0.83
A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development. Am J Med Genet A (2012) 0.82
Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element. Mol Cell Biol (1994) 0.82
The C. elegans rab family: identification, classification and toolkit construction. PLoS One (2012) 0.82
An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences. Am J Med Genet A (2015) 0.80
Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro. J Biol Chem (2009) 0.78
Rab13 Traffics on Vesicles Independent of Prenylation. J Biol Chem (2016) 0.76
The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases. J Biol Chem (2016) 0.76
Vesicular Trafficking Defects, Developmental Abnormalities, and Alterations in the Cellular Death Process Occur in Cell Lines that Over-Express Dictyostelium GTPase, Rab2, and Rab2 Mutants. Biology (Basel) (2014) 0.75
Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor. Small GTPases (2016) 0.75
The Architecture of the Rag GTPase Signaling Network. Biomolecules (2017) 0.75
The P-loop--a common motif in ATP- and GTP-binding proteins. Trends Biochem Sci (1990) 14.55
Functional homology of mammalian and yeast RAS genes. Cell (1985) 14.01
Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell (1984) 13.91
The GTPase superfamily: a conserved switch for diverse cell functions. Nature (1990) 11.71
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science (1987) 7.69
Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol (1988) 7.06
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science (1990) 5.76
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature (1989) 5.38
Requirement for c-ras proteins during viral oncogene transformation. Nature (1986) 5.24
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell (1987) 4.74
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Nature (1980) 4.43
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature (1990) 3.47
Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus. Cell (1981) 3.26
Adenylate cyclase assay. Adv Cyclic Nucleotide Res (1979) 3.08
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.57
Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Mol Cell Biol (1988) 2.57
Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature (1986) 2.48
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol (1990) 2.46
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.45
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol Cell Biol (1990) 2.42
Isolation of ras GTP-binding mutants using an in situ colony-binding assay. Proc Natl Acad Sci U S A (1986) 2.35
Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25. Science (1990) 2.24
A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins. FEBS Lett (1990) 1.76
Mutations of the ras gene product p21 that abolish guanine nucleotide binding. Proc Natl Acad Sci U S A (1986) 1.71
Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol Cell Biol (1991) 1.62
Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain. Cell (1991) 1.57
Ras interaction with the GTPase-activating protein (GAP). Proteins (1989) 1.35
G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions. Cell (1990) 1.03
A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors. Mol Cell Biol (1991) 0.95
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature (1992) 3.48
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature (1995) 2.47
Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol Cell Biol (1995) 2.45
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J (1996) 2.44
Isolation of ras GTP-binding mutants using an in situ colony-binding assay. Proc Natl Acad Sci U S A (1986) 2.35
Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature (1995) 2.16
The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium. Mol Cell Biol (1996) 2.06
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A (1992) 1.83
Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol Cell Biol (1991) 1.62
Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain. Cell (1991) 1.57
An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. EMBO J (2000) 1.43
Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts. Mol Cell Biol (2000) 1.39
Dominant inhibitory Ras mutants demonstrate the requirement for Ras activity in the action of tyrosine kinase oncogenes. Oncogene (1991) 1.35
p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem (2000) 1.31
Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol Cell Biol (1999) 1.27
Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B. Infect Immun (1995) 1.26
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. J Biol Chem (1997) 1.26
Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology (2001) 1.24
Functional association between Arf and RalA in active phospholipase D complex. Proc Natl Acad Sci U S A (1998) 1.24
The chemotactic response to PDGF-BB: evidence of a role for Ras. J Cell Biol (1995) 1.20
RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem Biophys Res Commun (1997) 1.16
Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting. Mol Cell Biol (1999) 1.13
RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases. Oncogene (1999) 1.09
Characterization of a GTPase-activating protein for the Ras-related Ral protein. J Biol Chem (1991) 1.07
Signal transduction. The hunt for Ras targets. Nature (1994) 1.06
Somatic activation of rasK gene in a human ovarian carcinoma. Science (1984) 1.05
Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain. FEBS Lett (1997) 1.05
Purification and assay of recombinant C3 transferase. Methods Enzymol (1995) 1.02
Ral and Rho-dependent activation of phospholipase D in v-Raf-transformed cells. Biochem Biophys Res Commun (1999) 1.01
Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences. Biochemistry (2001) 0.97
Regulation of Ras signaling specificity by protein kinase C. Mol Cell Biol (2001) 0.95
Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals. Oncogene (1995) 0.95
A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors. Mol Cell Biol (1991) 0.95
Sertoli cells contain a mitogenic polypeptide. Proc Natl Acad Sci U S A (1980) 0.90
Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors. J Biol Chem (2001) 0.89
RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene (2009) 0.86
Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors. J Biol Chem (2001) 0.84
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Mitogenic polypeptide of the mammalian seminiferous epithelium: biochemical characterization and partial purification. J Cell Biol (1983) 0.79
RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts. Biochem Biophys Res Commun (2001) 0.78
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Cell proliferation in the mammalian testis: biology of the seminiferous growth factor (SGF). Recent Prog Horm Res (1984) 0.75
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