Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.

PubWeight™: 5.76‹?› | Rank: Top 1%

🔗 View Article (PMID 2406906)

Published in Science on February 23, 1990

Authors

M V Milburn1, L Tong, A M deVos, A Brünger, Z Yamaizumi, S Nishimura, S H Kim

Author Affiliations

1: Department of Chemistry, University of California, Berkeley.

Articles citing this

(truncated to the top 100)

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J (1990) 6.51

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature (2013) 4.43

Rab 7: an important regulator of late endocytic membrane traffic. J Cell Biol (1995) 4.23

Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol Cell Biol (1991) 3.68

The Rab GTPase family. Genome Biol (2001) 3.37

Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Res (2010) 3.24

Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. J Cell Biol (1991) 3.22

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A (2012) 3.21

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol (2010) 2.83

Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus. EMBO J (1994) 2.78

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP. Mol Cell Biol (1991) 2.76

The small GTP-binding protein rab4 is associated with early endosomes. Proc Natl Acad Sci U S A (1991) 2.69

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci U S A (2008) 2.36

Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol (1990) 2.25

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation. EMBO J (1998) 2.22

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. Proc Natl Acad Sci U S A (1990) 2.22

Phospholipase C(epsilon): a novel Ras effector. EMBO J (2001) 2.14

Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants. Proc Natl Acad Sci U S A (1994) 2.04

Switches, latches, and amplifiers: common themes of G proteins and molecular motors. J Cell Biol (1996) 2.02

A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on ARF1. EMBO J (1998) 2.01

Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc Natl Acad Sci U S A (2001) 1.99

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc Natl Acad Sci U S A (1996) 1.97

Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21. Proc Natl Acad Sci U S A (1997) 1.95

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity. Mol Cell Biol (1992) 1.93

Structural model of the nucleotide-binding conserved component of periplasmic permeases. Proc Natl Acad Sci U S A (1991) 1.92

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.90

Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol (1993) 1.86

Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.82

Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor. Proc Natl Acad Sci U S A (2002) 1.81

Active site comparisons highlight structural similarities between myosin and other P-loop proteins. Biophys J (1996) 1.80

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Am J Hum Genet (2006) 1.78

Distinct structural elements of rab5 define its functional specificity. EMBO J (1994) 1.72

Synthetic peptides of the Rab effector domain inhibit vesicular transport through the secretory pathway. EMBO J (1990) 1.71

Activation of the phosphosignaling protein CheY. II. Analysis of activated mutants by 19F NMR and protein engineering. J Biol Chem (1993) 1.68

Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. J Cell Biol (2008) 1.66

The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output. Genes Dev (2007) 1.65

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64

Allosteric modulation of Ras positions Q61 for a direct role in catalysis. Proc Natl Acad Sci U S A (2010) 1.62

Model for eukaryotic tail-anchored protein binding based on the structure of Get3. Proc Natl Acad Sci U S A (2009) 1.59

DNA-strand exchange promoted by RecA protein in the absence of ATP: implications for the mechanism of energy transduction in protein-promoted nucleic acid transactions. Proc Natl Acad Sci U S A (1995) 1.55

Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity. EMBO J (1991) 1.49

GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. Proc Natl Acad Sci U S A (1993) 1.48

Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem J (2000) 1.45

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci Signal (2011) 1.43

Biochemical characterization of the essential GTP-binding protein Obg of Bacillus subtilis. J Bacteriol (1994) 1.40

MgATP binding and hydrolysis determinants of NtrC, a bacterial enhancer-binding protein. J Bacteriol (1999) 1.38

An inquiry into protein structure and genetic disease: introducing undergraduates to bioinformatics in a large introductory course. Cell Biol Educ (2005) 1.37

Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol (1994) 1.36

Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif. Proc Natl Acad Sci U S A (1999) 1.36

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc Natl Acad Sci U S A (1992) 1.34

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angew Chem Int Ed Engl (2013) 1.34

Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proc Natl Acad Sci U S A (2006) 1.33

The structural basis for the transition from Ras-GTP to Ras-GDP. Proc Natl Acad Sci U S A (2002) 1.32

Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J (1998) 1.30

Functional specificity of ras isoforms: so similar but so different. Genes Cancer (2011) 1.30

A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini. Proc Natl Acad Sci U S A (1992) 1.29

The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription. EMBO J (1992) 1.28

Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol (2010) 1.25

Rac GTPase interacts with GAPs and target proteins through multiple effector sites. EMBO J (1995) 1.25

Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Res (2000) 1.24

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24

The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase. Structure (2001) 1.23

Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans. Cell Regul (1991) 1.23

The Saccharomyces cerevisiae CDC25 gene product binds specifically to catalytically inactive ras proteins in vivo. Mol Cell Biol (1992) 1.23

Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol (2011) 1.22

Identification of an essential Caulobacter crescentus gene encoding a member of the Obg family of GTP-binding proteins. J Bacteriol (1997) 1.21

The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition. J Biol Chem (2008) 1.17

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain. Proc Natl Acad Sci U S A (1990) 1.16

Computation of conformational coupling in allosteric proteins. PLoS Comput Biol (2009) 1.16

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Hum Mol Genet (2014) 1.15

GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport. Mol Cell Biol (1998) 1.15

Identification of regulators for Ypt1 GTPase nucleotide cycling. Mol Biol Cell (1998) 1.14

Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc Natl Acad Sci U S A (1997) 1.13

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS. EMBO J (2007) 1.11

Tryptophan W207 in transducin T alpha is the fluorescence sensor of the G protein activation switch and is involved in the effector binding. EMBO J (1993) 1.11

Crystal structure of YjeQ from Thermotoga maritima contains a circularly permuted GTPase domain. Proc Natl Acad Sci U S A (2004) 1.11

Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors. Mol Cell Biol (1994) 1.09

The GTP-binding protein Rho1p is required for cell cycle progression and polarization of the yeast cell. J Cell Biol (1999) 1.09

Molecular evolution of SRP cycle components: functional implications. Nucleic Acids Res (1994) 1.09

Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering. J Biol Chem (1993) 1.09

Nuclear transport is becoming crystal clear. Chromosoma (2006) 1.09

Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies. World J Clin Oncol (2011) 1.08

The biochemistry of ras p21. Biochem J (1991) 1.08

Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases. Mol Microbiol (2008) 1.07

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator. EMBO J (1992) 1.07

Dual amino acid-selective and site-directed stable-isotope labeling of the human c-Ha-Ras protein by cell-free synthesis. J Biomol NMR (1998) 1.07

The distinct conformational dynamics of K-Ras and H-Ras A59G. PLoS Comput Biol (2010) 1.06

Increasing nitrogenase catalytic efficiency for MgATP by changing serine 16 of its Fe protein to threonine: use of Mn2+ to show interaction of serine 16 with Mg2+. Protein Sci (1993) 1.05

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J (1997) 1.05

Nucleotide-dependent movements of the kinesin motor domain predicted by simulated annealing. Biophys J (1998) 1.05

GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor. J Cell Biol (1993) 1.04

Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteins. Biophys J (1995) 1.04

TC21 causes transformation by Raf-independent signaling pathways. Mol Cell Biol (1996) 1.03

Effector proteins exert an important influence on the signaling-active state of the small GTPase Cdc42. J Biol Chem (2008) 1.02

Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A (2012) 1.02

Revealing conformational substates of lipidated N-Ras protein by pressure modulation. Proc Natl Acad Sci U S A (2011) 1.02

GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites. Proc Natl Acad Sci U S A (1991) 1.01

Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state. Proc Natl Acad Sci U S A (2004) 1.00

Articles by these authors

Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science (1974) 11.02

Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP. Nucleic Acids Res (1986) 10.13

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet (2000) 7.39

Minor components in transfer RNA: their characterization, location, and function. Prog Nucleic Acid Res Mol Biol (1972) 6.97

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem (1992) 6.20

Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature (1989) 6.07

Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor. Nature (1999) 5.38

Crystal structure of cyclin-dependent kinase 2. Nature (1993) 5.21

Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand. Science (1991) 4.71

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55

Crystal structure of the ATP-binding subunit of an ABC transporter. Nature (1998) 4.47

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature (2000) 4.36

Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain. Science (1973) 4.31

The general structure of transfer RNA molecules. Proc Natl Acad Sci U S A (1974) 4.30

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc Natl Acad Sci U S A (1991) 4.25

Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion. Nature (1991) 4.24

Codon and amino-acid specificities of a transfer RNA are both converted by a single post-transcriptional modification. Nature (1988) 4.17

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res (1984) 4.15

Electron transfer by domain movement in cytochrome bc1. Nature (1998) 4.08

Crystal structure of a small heat-shock protein. Nature (1998) 4.07

Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21. Science (1988) 3.99

Crystal structure of dimeric HIV-1 capsid protein. Nat Struct Biol (1996) 3.93

Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (1989) 3.90

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis (1986) 3.76

Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Biochemistry (1975) 3.73

The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med (1999) 3.72

Studies on polynucleotides, XLIX. Stimulation of the binding of aminoacyl-sRNA's to ribosomes by ribotrinucleotides and a survey of codon assignments for 20 amino acids. Proc Natl Acad Sci U S A (1965) 3.71

Sequential folding of transfer RNA. A nuclear magnetic resonance study of successively longer tRNA fragments with a common 5' end. J Mol Biol (1980) 3.63

Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction. J Mol Diagn (2000) 3.59

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature (1987) 3.55

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science (1998) 3.53

Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem (2000) 3.45

Protein factors in pre-mRNA 3'-end processing. Cell Mol Life Sci (2008) 3.44

Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity (1999) 3.43

Crystal structure of yeast phenylalanine transfer RNA. II. Structural features and functional implications. J Mol Biol (1978) 3.41

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell (1997) 3.23

Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement. J Mol Biol (1978) 3.19

In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry (1994) 3.18

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell (2001) 2.97

Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Dev Biol (2000) 2.93

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron (2001) 2.92

Burn wound infections: current status. World J Surg (1998) 2.86

Three-dimensional structure of yeast phenylalanine transfer RNA at 3.0angstroms resolution. Nature (1974) 2.85

Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain (1994) 2.80

RNA-ligant interactions. (I) Magnesium binding sites in yeast tRNAPhe. Nucleic Acids Res (1977) 2.79

Structural basis for self-association and receptor recognition of human TRAF2. Nature (1999) 2.74

Structure-based assignment of the biochemical function of a hypothetical protein: a test case of structural genomics. Proc Natl Acad Sci U S A (1998) 2.70

Mutanolysin, bacteriolytic agent for cariogenic Streptococci: partial purification and properties. Antimicrob Agents Chemother (1974) 2.68

Demonstration of diastolic and presystolic Purkinje potentials as critical potentials in a macroreentry circuit of verapamil-sensitive idiopathic left ventricular tachycardia. J Am Coll Cardiol (2000) 2.67

Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon. Proc Natl Acad Sci U S A (1985) 2.66

Crystal structure of an RNA double helix incorporating a track of non-Watson-Crick base pairs. Nature (1991) 2.65

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur J Biochem (1997) 2.65

BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res (2001) 2.64

DNA sequences of structural genes for Eco RI DNA restriction and modification enzymes. J Biol Chem (1981) 2.63

Purification of methionine-, valine-, phenylalanine- and tyrosine-specific tRNA from Escherichia coli. Biochim Biophys Acta (1967) 2.60

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature (1998) 2.52

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem (1994) 2.46

Active site dynamics in protein molecules: a stochastic boundary molecular-dynamics approach. Biopolymers (1985) 2.43

Clp P represents a unique family of serine proteases. J Biol Chem (1990) 2.42

Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp). Proc Natl Acad Sci U S A (1997) 2.39

Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev (2000) 2.38

Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids. Biochemistry (1972) 2.36

Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1). EMBO J (1999) 2.31

Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol (2001) 2.30

Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol (2000) 2.30

Primary structure of AUA-specific isoleucine transfer ribonucleic acid from Escherichia coli. Biochemistry (1980) 2.29

Natural UAG suppressor glutamine tRNA is elevated in mouse cells infected with Moloney murine leukemia virus. Proc Natl Acad Sci U S A (1987) 2.28

Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand. J Biol Chem (1993) 2.27

Dietary information improves cardiovascular disease risk prediction models. Eur J Clin Nutr (2012) 2.26

Retained surgical sponge: diagnosis with CT and sonography. AJR Am J Roentgenol (1988) 2.25

Cataract in leprosy patients: cataract surgical coverage, barriers to acceptance of surgery, and outcome of surgery in a population based survey in Korea. Br J Ophthalmol (2001) 2.22

Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. EMBO J (2000) 2.20

"Soft docking": matching of molecular surface cubes. J Mol Biol (1991) 2.19

Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A (2000) 2.19

Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations. Brain (2006) 2.16

Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol (2001) 2.14

Outdoor activity and myopia in Singapore teenage children. Br J Ophthalmol (2009) 2.13

Dramatic events in ciliate evolution: alteration of UAA and UAG termination codons to glutamine codons due to anticodon mutations in two Tetrahymena tRNAs. EMBO J (1986) 2.11

Distribution of the modified nucleoside Q and its derivatives in animal and plant transfer RNA's. Nucleic Acids Res (1975) 2.10

Nucleotide sequence of starfish initiator tRNA. Nucleic Acids Res (1979) 2.06

Mammalian tRNA genes: nucleotide sequence of rat genes for tRNAAsp, tRNAGly and tRNAGlu. Nucleic Acids Res (1981) 2.06

Heart rate variability dynamics during controlled hypotension with nicardipine, remifentanil and dexmedetomidine. Acta Anaesthesiol Scand (2013) 2.05

Molecular models for DNA damaged by photoreaction. Science (1985) 2.05

Role of conventional angiography in evaluation of patients with carotid artery stenosis demonstrated by Doppler ultrasound in general practice. Stroke (2001) 2.05

Database comparison of the adult-to-adult living donor liver transplantation cohort study (A2ALL) and the SRTR U.S. Transplant Registry. Am J Transplant (2010) 2.04

Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Science (1990) 2.04

NMR studies of a DNA containing 8-hydroxydeoxyguanosine. Nucleic Acids Res (1991) 2.03

Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B. Neurology (2011) 2.03

Tetrahymena thermophila glutamine tRNA and its gene that corresponds to UAA termination codon. Proc Natl Acad Sci U S A (1985) 2.01

Prediction of protein folding class using global description of amino acid sequence. Proc Natl Acad Sci U S A (1995) 2.00

Overview of interleukin-18: more than an interferon-gamma inducing factor. J Leukoc Biol (1998) 2.00

The nucleotide sequence of nuclear 4.8S RNA of mouse cells. Biochem Biophys Res Commun (1980) 2.00

Nucleotide sequence of the Escherichia coli dnaJ gene and purification of the gene product. J Biol Chem (1986) 1.99

Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol (2001) 1.98

3-(3-Amino-3-carboxypropyl)uridine: a novel modified nucleoside isolated from Escherichia coli phenylalanine transfer ribonucleic acid. Biochemistry (1974) 1.96

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. Proc Natl Acad Sci U S A (1984) 1.95

Analysis of modified nucleosides and nucleotide sequence of tRNA. Methods Enzymol (1987) 1.93