PubRank

Willem H Ouwehand

Author PubWeight™ 288.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
2 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
3 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
4 Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008 16.92
5 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
6 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011 13.25
7 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007 12.62
8 Dindel: accurate indel calls from short-read data. Genome Res 2010 8.62
9 Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012 7.59
10 A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet 2009 6.31
11 The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data. Nucleic Acids Res 2013 5.66
12 Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet 2012 5.16
13 New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009 5.12
14 Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell 2010 5.05
15 Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 2012 4.63
16 Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 2009 4.61
17 Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet 2009 4.28
18 Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet 2009 4.24
19 A HaemAtlas: characterizing gene expression in differentiated human blood cells. Blood 2009 3.63
20 Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009 3.59
21 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
22 BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol 2012 3.24
23 New gene functions in megakaryopoiesis and platelet formation. Nature 2011 3.14
24 A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 2010 2.88
25 Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet 2012 2.80
26 Seventy-five genetic loci influencing the human red blood cell. Nature 2012 2.77
27 Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013 2.73
28 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell 2011 2.30
29 A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood 2009 2.25
30 Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol 2010 2.17
31 Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat Med 2005 2.01
32 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet 2012 1.96
33 Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Blood 2006 1.91
34 Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome. Nat Genet 2011 1.91
35 A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood 2009 1.85
36 A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet 2008 1.81
37 Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011 1.78
38 Multiple loci are associated with white blood cell phenotypes. PLoS Genet 2011 1.65
39 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2008 1.64
40 A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood 2012 1.59
41 Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers. Blood 2013 1.49
42 Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation. Epigenetics 2014 1.47
43 Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood 2008 1.45
44 Blood pressure loci identified with a gene-centric array. Am J Hum Genet 2011 1.44
45 Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. PLoS Genet 2011 1.41
46 Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet 2011 1.40
47 Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens. J Biol Chem 2004 1.33
48 Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets. J Biol Chem 2006 1.32
49 Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet 2011 1.29
50 Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet 2013 1.27
51 Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med 2012 1.27
52 Platelet genomics and proteomics in human health and disease. J Clin Invest 2005 1.24
53 Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br J Haematol 2009 1.21
54 Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood. Blood 2003 1.18
55 Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood 2010 1.16
56 Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody. Blood 2003 1.14
57 A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia. Blood 2007 1.12
58 Microarray-based genotyping for blood groups: comparison of gene array and 5'-nuclease assay techniques with human platelet antigen as a model. Transfusion 2005 1.10
59 Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res 2013 1.10
60 Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI. FASEB J 2005 1.09
61 Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS One 2010 1.09
62 Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia. Transfusion 2007 1.07
63 The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. Blood 2007 1.06
64 Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes. PLoS Genet 2013 1.03
65 Comparison of methods for competitive tests of pathway analysis. PLoS One 2012 1.03
66 The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood 2003 1.00
67 Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Biochem J 2009 1.00
68 Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circ Cardiovasc Genet 2011 0.99
69 Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression. PLoS One 2012 0.98
70 Silencing of RhoA nucleotide exchange factor, ARHGEF3, reveals its unexpected role in iron uptake. Blood 2011 0.95
71 New insights into the genetic basis of TAR (thrombocytopenia-absent radii) syndrome. Curr Opin Genet Dev 2013 0.92
72 The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica 2010 0.90
73 A single-nucleotide polymorphism in the human ITGB3 gene is associated with the platelet-specific alloantigen Va (HPA-17bw) involved in fetal maternal alloimmune thrombocytopenia. Transfusion 2008 0.88
74 Platelet alphaIIbbeta3 recombinant autoantibodies from the B-cell repertoire of a post-transfusion purpura patient. Br J Haematol 2002 0.87
75 Developing recombinant HPA-1a-specific antibodies with abrogated Fcgamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia. J Clin Invest 2008 0.87
76 Monocyte gene expression signature of patients with early onset coronary artery disease. PLoS One 2012 0.87
77 HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope. Blood 2002 0.86
78 Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases. Transfusion 2009 0.86
79 A naturally occurring LeuVal mutation in beta3-integrin impairs the HPA-1a epitope: the third allele of HPA-1. Transfusion 2006 0.86
80 A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens. Blood 2002 0.86
81 The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function. Thromb Haemost 2004 0.85
82 Identification of variation in the platelet transcriptome associated with glycoprotein 6 haplotype. Platelets 2008 0.84
83 Single-chain antibody fragments derived from a human synthetic phage-display library bind thrombospondin and inhibit sickle cell adhesion. Blood 2003 0.84
84 Image-based characterization of thrombus formation in time-lapse DIC microscopy. Med Image Anal 2012 0.82
85 PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Lett 2009 0.82
86 Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study. BMC Med Genomics 2011 0.81
87 Hepatitis C virus interacts with human platelet glycoprotein VI. J Gen Virol 2006 0.81
88 Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia. Blood 2002 0.81
89 Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. PLoS One 2012 0.80
90 Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality. Transfusion 2008 0.80
91 HPA-1a antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia. Transfusion 2007 0.80
92 Selective blockade of glycoprotein VI clustering on collagen helices. J Biol Chem 2006 0.79
93 Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation. Platelets 2009 0.79
94 The dilemma of screening for antibodies against low-frequency human platelet antigens. Transfusion 2005 0.78
95 Acquired thrombasthenia due to GPIIbIIIa platelet autoantibodies in a 4-yr-old child. Eur J Haematol 2006 0.78
96 Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolation. J Immunol Methods 2006 0.76
97 Detection of human platelet antigen-1a alloantibodies in cases of fetomaternal alloimmune thrombocytopenia using recombinant β3 integrin fragments coupled to fluorescently labeled beads. Transfusion 2010 0.76
98 Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display. Thromb Haemost 2005 0.76
99 Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest 2017 0.75
100 Teicoplanin-dependent antibodies: detection and characterization. Br J Haematol 2005 0.75
101 Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun 2015 0.75
102 Expression of a single-chain human leukocyte antigen-DRA/DRB3*01:01 molecule and differential binding of a monoclonal antibody in the presence of specifically bound human platelet antigen-1a peptide. Transfusion 2013 0.75
103 Molecular characterization of the variable domains of an alphaIIbbeta3-specific immunoglobulin M kappa platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between alphaIIbbeta3 integrin antibodies. Transfusion 2007 0.75
104 Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs. Nature 2017 0.75
105 Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nat Commun 2017 0.75