Published in Nature on June 14, 2017
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Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
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Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
The Bioperl toolkit: Perl modules for the life sciences. Genome Res (2002) 58.63
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics (2010) 52.01
The Pfam protein families database. Nucleic Acids Res (2002) 51.34
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Pfam: clans, web tools and services. Nucleic Acids Res (2006) 34.83
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
The variant call format and VCFtools. Bioinformatics (2011) 25.88
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics (2005) 24.54
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol (2005) 18.20
GeneWise and Genomewise. Genome Res (2004) 17.87
EnsMart: a generic system for fast and flexible access to biological data. Genome Res (2004) 17.64
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res (2008) 15.69
A large genome center's improvements to the Illumina sequencing system. Nat Methods (2008) 15.56
The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res (2009) 14.90
Ensembl 2011. Nucleic Acids Res (2010) 14.68
The International Protein Index: an integrated database for proteomics experiments. Proteomics (2004) 14.67
Ensembl 2012. Nucleic Acids Res (2011) 14.55
Reactome: a knowledge base of biologic pathways and processes. Genome Biol (2007) 13.36
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebrates. Genome Res (2008) 12.72
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Ensembl 2014. Nucleic Acids Res (2013) 12.62
Prepublication data sharing. Nature (2009) 12.24
The Ensembl automatic gene annotation system. Genome Res (2004) 12.24
Population genomics of domestic and wild yeasts. Nature (2009) 11.79
Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72
Ensembl 2013. Nucleic Acids Res (2012) 11.70
Optimized design and assessment of whole genome tiling arrays. Bioinformatics (2007) 11.38
Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res (2010) 11.23
Ensembl's 10th year. Nucleic Acids Res (2009) 10.82
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
An overview of Ensembl. Genome Res (2004) 10.35
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels. Bioinformatics (2012) 9.68
Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science (2002) 9.43
QuickTree: building huge Neighbour-Joining trees of protein sequences. Bioinformatics (2002) 9.36
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
The BioPAX community standard for pathway data sharing. Nat Biotechnol (2010) 9.19
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83
A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67
Dindel: accurate indel calls from short-read data. Genome Res (2010) 8.62
The Reactome pathway knowledgebase. Nucleic Acids Res (2013) 8.56
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
Inference of human population history from individual whole-genome sequences. Nature (2011) 8.05
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Enredo and Pecan: genome-wide mammalian consistency-based multiple alignment with paralogs. Genome Res (2008) 7.35
Nucleolar proteome dynamics. Nature (2005) 7.32
The Ensembl core software libraries. Genome Res (2004) 7.30
The HGNC Database in 2008: a resource for the human genome. Nucleic Acids Res (2007) 7.29
The multifunctional nucleolus. Nat Rev Mol Cell Biol (2007) 7.08
EGASP: the human ENCODE Genome Annotation Assessment Project. Genome Biol (2006) 7.06
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res (2007) 7.05
Directed proteomic analysis of the human nucleolus. Curr Biol (2002) 7.04
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80