Published in Curr Protoc Cell Biol on March 01, 2009
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Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A (2006) 1.31
Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J Biol Chem (2001) 1.30
Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res (2012) 1.30
Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35. J Biol Chem (2008) 1.30
Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res (2009) 1.24
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc Natl Acad Sci U S A (2005) 1.21
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DSPP effects on in vivo bone mineralization. Bone (2008) 1.19
Partial rescue of the amelogenin null dental enamel phenotype. J Biol Chem (2008) 1.19
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Mol Cell Biol (2006) 1.16
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Transgenic mouse expressing human mutant alpha-galactosidase A in an endogenous enzyme deficient background: a biochemical animal model for studying active-site specific chaperone therapy for Fabry disease. Biochim Biophys Acta (2004) 1.14
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Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J (2002) 1.13
Cdk5: a new player in pain signaling. Cell Cycle (2006) 1.10
Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol (2009) 1.09
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest (2010) 1.08
Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol (2004) 1.08
Comparison of body weight and gene expression in amelogenin null and wild-type mice. Eur J Oral Sci (2006) 1.08
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem (2003) 1.07
A novel role of periostin in postnatal tooth formation and mineralization. J Biol Chem (2010) 1.03
A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel. Eur J Oral Sci (2006) 1.03
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone. J Neurosci (2007) 1.01
Amelogenin: a potential regulator of cementum-associated genes. J Periodontol (2003) 1.00
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A (2004) 1.00
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle (2007) 0.99
Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med (2010) 0.99
The leucine-rich amelogenin peptide alters the amelogenin null enamel phenotype. Cells Tissues Organs (2008) 0.97
Rescue of the murine amelogenin null phenotype with two amelogenin transgenes. Eur J Oral Sci (2011) 0.97
Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues. Arch Oral Biol (2012) 0.96
The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice. J Biol Chem (2003) 0.95
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol (2009) 0.95
Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix Biol (2009) 0.94
Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects. Eur J Oral Sci (2006) 0.93
Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases. J Neurochem (2008) 0.93
Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1. Biochem Biophys Res Commun (2010) 0.92
Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Mol Pain (2011) 0.92
Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. J Biol Chem (2012) 0.91
Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma. Apoptosis (2014) 0.91
Shaken, not stirred: collapsing a peptoid monolayer to produce free-floating, stable nanosheets. J Am Chem Soc (2011) 0.90
Molecular Roles of Cdk5 in Pain Signaling. Drug Discov Today Ther Strateg (2009) 0.90
Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands. Arthritis Rheum (2007) 0.90
Large Sample Group Independent Component Analysis of Functional Magnetic Resonance Imaging Using Anatomical Atlas-Based Reduction and Bootstrapped Clustering. Int J Imaging Syst Technol (2011) 0.90
Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. Cytokine (2002) 0.89
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. J Neurosci Res (2011) 0.88
Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci (2002) 0.88
Generation of gene knockout mice by ES cell microinjection. Curr Protoc Cell Biol (2009) 0.88
Generation of transgenic mice. Curr Protoc Cell Biol (2009) 0.88
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Mol Biol Cell (2010) 0.87
Antibody-mimetic peptoid nanosheets for molecular recognition. ACS Nano (2013) 0.87
Manipulation of mouse embryonic stem cells for knockout mouse production. Curr Protoc Cell Biol (2009) 0.86
Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem (2010) 0.86
Overview: generation of gene knockout mice. Curr Protoc Cell Biol (2009) 0.86
The use of animal models to explore amelogenin variants in amelogenesis imperfecta. Cells Tissues Organs (2005) 0.85
Neuron-specific TGF-beta signaling deficiency results in retinal detachment and cataracts in mice. Biochem Biophys Res Commun (2006) 0.85
TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One (2013) 0.84
A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis. Biochem J (2013) 0.84
Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling. J Transl Med (2013) 0.84
Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell Cycle (2008) 0.83
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Mol Pain (2013) 0.83
Inhibition of mTOR reduces anal carcinogenesis in transgenic mouse model. PLoS One (2013) 0.82
Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance. J Biol Chem (2013) 0.81
Cdk5 regulates Rap1 activity. Neurochem Int (2013) 0.81
An amelogenin mutation leads to disruption of the odontogenic apparatus and aberrant expression of Notch1. J Oral Pathol Med (2010) 0.81
A method for rapid demineralization of teeth and bones. Open Dent J (2010) 0.81
Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. Neurochem Res (2011) 0.81
Naked plasmid DNA-based alpha-galactosidase A gene transfer partially reduces systemic accumulation of globotriaosylceramide in Fabry mice. Mol Biotechnol (2007) 0.80
Amelogenins: Multi-Functional Enamel Matrix Proteins and Their Binding Partners. J Oral Biosci (2011) 0.80
Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neurosignals (2006) 0.80
Amelogenin- and enamelysin (Mmp-20)-deficient mice display altered birefringence in the secretory-stage enamel organic extracellular matrix. Connect Tissue Res (2007) 0.79
Transforming growth factor-beta1 negatively regulates crystallin expression in teeth. J Bone Miner Res (2002) 0.79
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. J Neurochem (2004) 0.79
Mouse genetic background influences the dental phenotype. Cells Tissues Organs (2014) 0.78
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality. J Neuroinflammation (2014) 0.78
Structure-determining step in the hierarchical assembly of peptoid nanosheets. ACS Nano (2014) 0.77
The role of amelogenin during enamel-crystallite growth and organization in vivo. Eur J Oral Sci (2011) 0.77
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. J Innate Immun (2016) 0.75
Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons. Pain (2016) 0.75
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Pain (2017) 0.75