Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.

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Published in J Innate Immun on March 18, 2016

Authors

Laurent Meijer1, Deborah J Nelson, Vladimir Riazanski, Aida G Gabdoulkhakova, Geneviève Hery-Arnaud, Rozenn Le Berre, Nadège Loaëc, Nassima Oumata, Hervé Galons, Emmanuel Nowak, Laetitia Gueganton, Guillaume Dorothée, Michaela Prochazkova, Bradford Hall, Ashok B Kulkarni, Robert D Gray, Adriano G Rossi, Véronique Witko-Sarsat, Caroline Norez, Frédéric Becq, Denis Ravel, Dominique Mottier, Gilles Rault

Author Affiliations

1: Centre de Perharidy, ManRos Therapeutics, Roscoff, France.

Associated clinical trials:

Safety and Intraocular Pressure (IOP)-Lowering Efficacy of AL-39256 in Patients With Open-Angle Glaucoma or Ocular Hypertension | NCT00761709

Treatment of Cushing's Disease With R-roscovitine | NCT02160730

Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation (ROSCO-CF) | NCT02649751

Cystic Fibrosis Blood Neutrophils (MUCO-PNN) | NCT04970225

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